IL-27 enhances the survival of tumor antigen-specific CD8+T cells and programs them into IL-10-producing, memory precursor-like effector cells

Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T Cells

(2014) M. Batten et al.   JOURNAL OF IMMUNOLOGY

Increased Th17 and Regulatory T Cell Responses in EBV-Induced Gene 3-Deficient Mice Lead to Marginally Enhanced Development of Autoimmune Encephalomyelitis

(2012) J.-Q. Liu et al.   JOURNAL OF IMMUNOLOGY

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

(2011) John B. Mumm et al.   CANCER CELL

Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis

(2011) T. Tanikawa et al.   CANCER RESEARCH

A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory

(2011) Andrea M. Siegel et al.   IMMUNITY

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns

(2011) Kenneth J. Oestreich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly Activated Cytotoxic CD8 T Cells Express Protective IL-10 at the Peak of Coronavirus-Induced Encephalitis

(2011) K. Trandem et al.   JOURNAL OF IMMUNOLOGY

IL-10 Contributes to the Suppressive Function of Tumour-Associated Myeloid Cells and Enhances Myeloid Cell Accumulation in Tumours

(2011) L.-X. Wang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Human TH17 Cells Are Long-Lived Effector Memory Cells

(2011) I. Kryczek et al.   Science Translational Medicine

Tumor expression of CD200 inhibits IL-10 production by tumor-associated myeloid cells and prevents tumor immune evasion of CTL therapy

(2010) Lixin Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-27 increases the proliferation and effector functions of human naïve CD8+ T lymphocytes and promotes their development into Tc1 cells

(2010) Raphael Schneider et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Pivotal Role for Interleukin-27 in CD8+T Cell Functions and Generation of Cytotoxic T Lymphocytes

(2010) Noriko Morishima et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

IL-12 and IL-27 Sequential Gene Therapy via Intramuscular Electroporation Delivery for Eliminating Distal Aggressive Tumors

(2010) Shiguo Zhu et al.   JOURNAL OF IMMUNOLOGY

Targeting Activation-Induced Cytidine Deaminase Overcome Tumor Evasion of Immunotherapy by CTLs

(2010) J. Q. Liu et al.   JOURNAL OF IMMUNOLOGY

Immunologic and Therapeutic Synergy of IL-27 and IL-2: Enhancement of T Cell Sensitization, Tumor-Specific CTL Reactivity and Complete Regression of Disseminated Neuroblastoma Metastases in the Liver and Bone Marrow

(2009) R. Salcedo et al.   JOURNAL OF IMMUNOLOGY

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

(2009) Luca Gattinoni et al.   NATURE MEDICINE

Overcoming Immune Evasion in T Cell Therapy of Cancer: Lessons from Animal Models

(2008) Xue-Feng Bai et al.   CURRENT MOLECULAR MEDICINE

Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity

(2008) Yukari Shinozaki et al.   INTERNATIONAL JOURNAL OF CANCER