From crucial to negligible: Functional CD8+T-cell responses and their dependence on CD4+T-cell help

Signal 3 requirement for memory CD8+T-cell activation is determined by the infectious pathogen

(2011) Selina J. Keppler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-cell help permits memory CD8+ T-cell inflation during cytomegalovirus latency

(2011) Senta M. Walton et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load

(2011) Erin E. West et al.   IMMUNITY

Buffered memory: a hypothesis for the maintenance of functional, virus-specific CD8+ T cells during cytomegalovirus infection

(2011) Christopher M. Snyder   IMMUNOLOGIC RESEARCH

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells

(2011) Laura M. Fahey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immunodominant CD8 T Cell Response to the Human Cytomegalovirus Tegument Phosphoprotein pp65495-503 Epitope Critically Depends on CD4 T Cell Help in Vaccinated HLA-A*0201 Transgenic Mice

(2011) M. Reiser et al.   JOURNAL OF IMMUNOLOGY

Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells

(2011) Sonia Feau et al.   NATURE IMMUNOLOGY

Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens

(2011) George A. Punkosdy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points

(2011) K. K. Dietze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

(2011) J. A. Harker et al.   SCIENCE

Non-Hematopoietic Cells in Lymph Nodes Drive Memory CD8 T Cell Inflation during Murine Cytomegalovirus Infection

(2011) Nicole Torti et al.   PLoS Pathogens

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

(2010) Vandana Kalia et al.   IMMUNITY

Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation

(2010) Thomas C. Wirth et al.   IMMUNITY

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

Th Cells Act Via Two Synergistic Pathways To Promote Antiviral CD8+ T Cell Responses

(2010) M. Wiesel et al.   JOURNAL OF IMMUNOLOGY

Type I IFN Substitutes for T Cell Help during Viral Infections

(2010) M. Wiesel et al.   JOURNAL OF IMMUNOLOGY

HIV-Specific IL-21 Producing CD4+ T Cells Are Induced in Acute and Chronic Progressive HIV Infection and Are Associated with Relative Viral Control

(2010) F. Y. Yue et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Granulocyte-Macrophage Colony-Stimulating Factor Is the Major CD8+ T Cell-Derived Licensing Factor for Dendritic Cell Activation

(2010) L. Min et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells in the Control of Host-Microorganism Interactions

(2009) Yasmine Belkaid et al.   Annual Review of Immunology

Virus-specific CD8 T cells: activation, differentiation and memory formation

(2009) MELANIE WIESEL et al.   APMIS

Unravelling the mechanisms of help for CD8+ T cell responses

(2009) Alexandra M. Livingstone et al.   IMMUNOLOGIC RESEARCH

CD4+ T Cell Help Has an Epitope-Dependent Impact on CD8+ T Cell Memory Inflation during Murine Cytomegalovirus Infection

(2009) C. M. Snyder et al.   JOURNAL OF IMMUNOLOGY

Dynamics and Consequences of IL-21 Production in HIV-Infected Individuals: A Longitudinal and Cross-Sectional Study

(2009) Alexandre Iannello et al.   JOURNAL OF IMMUNOLOGY

Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

(2009) P. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Promote Early Influx of CD8+ T Cells in the Lungs of Respiratory Syncytial Virus-Infected Mice and Diminish Immunodominance Disparities

(2009) T. J. Ruckwardt et al.   JOURNAL OF VIROLOGY

CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

(2009) Yusuke Nakanishi et al.   NATURE

CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses

(2009) J. J. Obar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High antigen levels are the cause of T cell exhaustion during chronic viral infection

(2009) S. N. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY