Article
Dermatology
Lazaro Emilio Aira, Gudrun Fiona Debes
Summary: The study found that IL-10(+) Bregs in the skin play a crucial role in suppressing skin inflammation, as a decrease in IL-10(+) Bregs entering the skin leads to exacerbation of inflammation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kyong Hoon Kim, Aryeong Choi, Sang Hoon Kim, Heonju Song, Seohoon Jin, Kyungim Kim, Jaebong Jang, Hanbyeul Choi, Yong Woo Jung
Summary: The study revealed that N-cadherin plays a crucial role in the development of CD127(hi)CD62L(hi) T-M cells and the homing of CD127(lo)KLRG1(hi) T-M cells to lymphoid organs.
MOLECULES AND CELLS
(2021)
Editorial Material
Hematology
Miriam Y. Kim
Summary: The study found that enforcing CXCR4 expression on CD33-targeting CAR CIK cells enhances their homing to the bone marrow and improves their activity against AML.
Review
Biochemistry & Molecular Biology
Emanuela Guerra, Roberta Di Pietro, Mariangela Basile, Marco Trerotola, Saverio Alberti
Summary: CAR-T therapy, which utilizes engineered patient blood cells, has shown great success in treating leukemia but faces challenges in treating solid tumors, including difficulties in trafficking the CAR-T cells to the tumor site and the hostile environment presented by cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Stephen Iwanowycz, Soo Ngoi, Yingqi Li, Megan Hill, Christopher Koivisto, Melodie Parrish, Beichu Guo, Zihai Li, Bei Liu
Summary: DC2s, the majority of conventional DCs within most tumors, have the potential to initiate and sustain antitumor immunity, showing significant correlation with survival across multiple human cancers. Impairment of DC1s and enhancement of DC2 functionality leads to improved tumor control, highlighting the therapeutic and prognostic potential of DC2s within checkpoint blockade-resistant tumors.
Review
Immunology
Jaehwan Kim, Ariana Moreno, James G. G. Krueger
Summary: Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults in the US, with immunopathogenesis paradigms rapidly evolving due to advancements in technology. Single-cell RNA sequencing technology is now being applied to clinical trials of biologics to test the expansion of regulatory immune cell subsets involved in skin homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiaoxue Deng, Lingxia Wang, Yunze Zhai, Qiuyue Liu, Fengxue Du, Yu Zhang, Wenxing Zhao, Tingtao Wu, Yiwen Tao, Jie Deng, Yongbing Cao, Pei Hao, Jiazi Ren, Yunli Shen, Zuoren Yu, Yuejuan Zheng, Haibing Zhang, Haikun Wang
Summary: Regulatory T (T-reg) cells are important for maintaining immune balance, and RIPK1 plays a critical role in regulating T-reg cell survival and homeostasis by controlling both apoptosis and necroptosis mechanisms.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Microbiology
Stella G. G. Hoft, Keith D. D. Kauffman, Shunsuke Sakai, Cecilia S. Lindestam S. Arlehamn, Alessandro Sette, Daniel F. F. Hoft, Richard Herbert, Daniel L. L. Barber
Summary: Alternative delivery routes of BCG vaccine for tuberculosis, such as intradermal injection, may provide better protection. In this study, rhesus macaques were used to compare the airway immune response induced by intradermal versus intragastric delivery of BCG. The results showed that intragastric delivery induced lower T cell response in the airways, possibly due to the imprinting of gut-homing receptors on T cells.
Article
Biochemistry & Molecular Biology
Daiki Karigane, Miho Haraguchi, Noriko Toyama-Sorimachi, Emi K. Nishimura, Keiyo Takubo
Summary: Thymic dendritic cells (DCs) play a pivotal role in immune tolerance by regulating negative selection of autoreactive T cells in the thymus. This study reveals that the transcription factor Mitf is involved in the regulation of DC homing to the thymus and maintenance of thymic DC population.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Steven C. Koetzier, Jamie van Langelaar, Annet F. Wierenga-Wolf, Marie-Jose Melief, Kim Pol, Suzanne Musters, Erik Lubberts, Willem A. Dik, Joost Smolders, Marvin M. van Luijn
Summary: The study demonstrates that glucocorticoid sensitivity of Th17.1 cells can be enhanced through treatment with calcitriol and further improved with progesterone. This finding opens up a new therapeutic avenue for Th17.1-associated inflammatory diseases, including multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Benjamin G. Wiggins, Laura J. Pallett, Xiaoyan Li, Scott P. Davies, Oliver E. Amin, Upkar S. Gill, Stephanie Kucykowicz, Arzoo M. Patel, Konstantinos Aliazis, Yuxin S. Liu, Gary M. Reynolds, Brian R. Davidson, Amir Gander, Tu Vinh Luong, Gideon M. Hirschfield, Patrick T. F. Kennedy, Yuehua Huang, Mala K. Maini, Zania Stamataki
Summary: This study found that high and intermediate CD69 expressions marked human hepatic CD4(+) T-RM and a novel functionally distinct recirculating population, both shaped by the liver microenvironment to achieve diverse immunosurveillance.
Article
Biology
Jieqiong Zhang, Tatsuya Tsukui, Xiumin Wu, Alyssa Brito, John Maxwell Trumble, Juan C. Caraballo, Greg M. Allen, Jose Zavala-Solorio, Chunlian Zhang, Jonathan Paw, Wendell A. Lim, Jiefei Geng, Yuliya Kutskova, Adam Freund, Ganesh Kolumam, Dean Sheppard, Robert L. Cohen
Summary: Immunological targeting of pathological cells has shown success in oncology and is expanding to other pathobiological contexts. A flexible platform has been presented that allows labeling cells of interest with a model antigen, ovalbumin (OVA), and can be eliminated by antigen-specific T cells or newly developed OVA antibodies. This platform facilitates the development of immune-based approaches to clear potential pathological cell types in vivo.
LIFE SCIENCE ALLIANCE
(2023)
Review
Immunology
Justin Jacobse, Jing Li, Edmond H. H. M. Rings, Janneke N. Samsom, Jeremy A. Goettel
Summary: Intestinal FOXP3(+) regulatory T cells play a crucial role in maintaining immune balance and preventing autoimmunity in the gut. Dysregulation of these cells can lead to chronic inflammatory disorders, including inflammatory bowel disease, highlighting the importance of understanding their biology for therapeutic interventions. Intestinal Treg cells are not fixed subsets, but rather plastic and responsive to microenvironmental cues, similar to T helper cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mariana Borsa, Niculo Barandun, Fabienne Graebnitz, Isabel Barnstorf, Nicolas S. Baumann, Katharina Pallmer, Samira Baumann, Dominique Stark, Miroslav Balaz, Nathalie Oetiker, Franziska Wagen, Christian Wolfrum, Anna Katharina Simon, Nicole Joller, Yves Barral, Roman Spoerri, Annette Oxenius
Summary: Impaired asymmetric cell division in CD8(+) T cells during aging can be rescued by transient mTOR inhibition, restoring expansion and memory potential of cellular progenies. Virtual memory T cells (T-VM cells) in aged individuals display unique proliferation and metabolic profiles, retaining the ability to divide asymmetrically and having increased memory potential.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Camila P. Camargo, Abir K. Muhuri, Yunus Alapan, Lauren F. Sestito, Megha Khosla, Margaret P. Manspeaker, Aubrey S. Smith, Chrystal M. Paulos, Susan N. Thomas
Summary: By utilizing an engineered microfluidic device to replicate the hemodynamic microenvironment of tumor vasculature, it has been found that CD8(+) T cells can interact with adhesive ligands and improve their ability to infiltrate tumors, leading to enhanced tumor control in adoptive cell therapy combined with immune checkpoint blockade.