Article
Biochemistry & Molecular Biology
Sumika Toyama, Catharina Sagita Moniaga, Susumu Nakae, Masaru Kurosawa, Hideoki Ogawa, Mitsutoshi Tominaga, Kenji Takamori
Summary: This study found that skin barrier disruption increases the number of Tregs, and IL-33 plays a role in promoting the migration of Tregs into barrier-disrupted skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Darya Malko, Tarek Elmzzahi, Marc Beyer
Summary: Treg cells play a crucial role in controlling autoimmunity, immune responses during infections and tumor development, and tissue homeostasis. This review highlights the recent findings on the differentiation and function of tissue Treg cells, emphasizing their importance in tissue maintenance, regeneration, and repair in various organs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Murilo Delgobo, Emil Weiss, DiyaaElDin, Ashour Leon Richter, Lisa Popiolkowski, Panagiota Arampatzi, Verena Stangl, Paula Arias-Loza, Encarnita Mariotti-Ferrandiz, Peter P. Rainer, Antoine-Emmanuel Saliba, Burkhard Ludewig, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: In this study, the researchers investigated how antigen-specific T-helper cells differentiate in the myocardial environment. They used a transgenic T cell receptor model and single-cell transcriptomics to study the cells in the murine infarcted myocardium. The results showed that these cells acquired a regulatory phenotype and influenced tissue repair.
CIRCULATION RESEARCH
(2023)
Article
Immunology
Carlos Plaza-Sirvent, Bei Zhao, Alisha W. Bronietzki, Marina C. Pils, Neda Tafrishi, Marc Schuster, Till Strowig, Ingo Schmitz
Summary: Autophagy plays a crucial role in regulating T cells, especially in maintaining gut homeostasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Konstantin Kotschenreuther, Shuaifeng Yan, David M. Kofler
Summary: Regulatory T (T-reg) cells are crucial in the pathogenesis of rheumatoid arthritis (RA), contributing to immune homeostasis and tissue migration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Ahmed Rakib, Mousumi Mandal, Anaum Showkat, Sonia Kiran, Soumi Mazumdar, Bhupesh Singla, Aman Bajwa, Santosh Kumar, Frank Park, Udai P. Singh
Summary: The polyphenolic compound piceatannol (PC) has been found to have beneficial effects on metabolic diseases, antiproliferative, antioxidant, and anti-cancer properties. This study investigated the effects of PC on inflammatory responses and adipogenesis. The results showed that PC induced apoptosis in activated T cells, reduced immune cell activation and inflammatory response, and hindered adipogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Dandan Yang, Xueqiang Zhao, Xin Lin
Summary: Bcl10 plays a critical role in the development and function of regulatory T (Treg) cells, deficiency of which leads to impaired development and suppressive function of Treg cells, even causing lethal autoimmunity. Bcl10-deficient Treg cells can undergo conversion into proinflammatory cells and decrease in effector Treg cell populations. The study provides genetic evidence that Bcl10 is essential for Treg cell development and function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Lourdes Rocamora-Reverte, Franz Leonard Melzer, Reinhard Wuerzner, Birgit Weinberger
Summary: The immune system is a tightly regulated network, where regulatory T cells play an important role in maintaining immune homeostasis. Different types of T cells have regulatory functions in modulating immune responses, and the aging process can affect the composition of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biology
Alexey V. Churov, Yegor S. Chegodaev, Victoria A. Khotina, Vladimir P. Ofitserov, Alexander N. Orekhov
Summary: Atherosclerosis is a vascular disease characterized by a long asymptomatic period and gradual development. The disease involves immune cell infiltration and inflammation in the vessel walls, but regulatory T cells help maintain immune balance and play a positive role in controlling the initiation and progression of atherosclerosis.
Review
Immunology
Juyeun Lee, Dongkyun Kim, Booki Min
Summary: Foxp3(+) regulatory T (Treg) cells are crucial for immune regulation and tolerance, and tissue resident Treg cells play a central role in regulating tissue homeostasis, inflammation, and repair.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jan-Hendrik Schroeder, Katrin Meissl, Dominika Hromadova, Jonathan W. Lo, Joana F. Neves, Jane K. Howard, Helena Helmby, Nick Powell, Birgit Strobl, Graham M. Lord
Summary: T-bet deficient mice show an increase in ILC3 cellularity but do not have a greater risk of developing spontaneous colitis. T-bet appears to control the number of ILC3 cells, but does not drive a pathogenic role of ILC3 in mice with a conventional specific pathogen-free microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zhiqiang Jiang, Chuan Wu
Summary: Intestinal Treg cells play a crucial role in immune repression and tolerance, with distinct functional and phenotypical characteristics compared to Treg cells in other organs. The interactions between intestinal Treg cells, microbiota, and gut epithelium contribute to controlling intestinal physiology and maintaining gut immune tolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ariella Glasner, George Plitas
Summary: The immune system provides strong defense mechanisms against pathogens, but inadequate regulatory control can lead to various inflammatory disorders, including cancer. Treg cells play an important role in the tumor microenvironment, promoting tumor development by suppressing anti-tumor immune responses.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Siawosh K. Eskandari, Hazim Allos, Basmah S. Al Dulaijan, Gandolina Melhem, Ina Sulkaj, Juliano B. Alhaddad, Anis J. Saad, Christa Deban, Philip Chu, John Y. Choi, Branislav Kollar, Bohdan Pomahac, Leonardo V. Riella, Stefan P. Berger, Jan S. F. Sanders, Judy Lieberman, Li Li, Jamil R. Azzi
Summary: Regulatory T cells (T-regs) have shown promise as cellular therapy for various immune diseases, but their clinical efficacy is limited by poor in vivo homeostasis. In this study, inhibiting mTORC1 effectively reduced intracytoplasmic expression and functionality of GrB in host T-regs, leading to decreased apoptosis and improved stability and homeostasis of T-regs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Esther Neelis, Stefanie Kouwenhoven, Joanne Olieman, Merit Tabbers, Cora Jonkers, Jonathan Wells, Mary Fewtrell, Rene Wijnen, Edmond Rings, Barbara de Koning, Jessie Hulst
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2020)
Review
Medicine, General & Internal
Changsen Leng, Edmond H. H. M. Rings, Saskia N. de Wildt, Sven C. D. van IJzendoorn
Summary: Microvillus inclusion disease (MVID) is a rare genetic disorder that leads to severe diarrhea and malabsorption, often resulting in death during infancy due to treatment-related complications. There is currently no cure available for this devastating disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Esther G. Neelis, Barbara A. E. de Koning, Jessie M. Hulst, Rodanthi Papadopoulou, Caroline Kerbiriou, Edmond H. H. M. Rings, Rene M. H. Wijnen, Ben Nichols, Konstantinos Gerasimidis
Summary: Children with intestinal failure receiving parenteral nutrition show alterations in gut microbiota composition and function, with depletion of beneficial SCFAs and species and an increase in potentially harmful pathobionts. Nutrient intake and enteral nutrition have significant impacts on microbial community structure.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Lotte E. Vlug, Esther G. Neelis, Jonathan C. K. Wells, Mary S. Fewtrell, Wendy L. M. Kastelijn, Joanne F. Olieman, Marijn J. Vermeulen, Jorine A. Roelants, Dimitris Rizopoulos, Rene M. H. Wijnen, Edmond H. H. M. Rings, Barbara A. E. de Koning, Jessie M. Hulst
Summary: The study aimed to assess the growth and body composition changes in infants receiving parenteral nutrition (PN) after intestinal surgery and found compromised anthropometric parameters, decreased fat mass, and adequate fat-free mass in the first 6 months due to intestinal failure. Male and female infants responded differently to PN in terms of fat mass index.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Lotte E. Vlug, Merel W. Verloop, Bram Dierckx, Lotte Bosman, Jurgen C. de Graaff, Edmond H. H. M. Rings, Rene M. H. Wijnen, Barbara A. E. de Koning, Jeroen S. Legerstee
Summary: Adverse developmental outcomes are common in children with intestinal failure and surgical necrotizing enterocolitis, and to a much lesser extent in children with abdominal wall defects and midgut malformations. Lower gestational age, longer hospital stay, and higher number of surgeries are associated with lower cognitive development.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Lotte E. Vlug, Patric J. D. Delhanty, Esther G. Neelis, Martin Huisman, Jenny A. Visser, Edmond H. H. M. Rings, Rene M. H. Wijnen, Sjoerd C. J. Nagelkerke, Merit M. Tabbers, Jessie M. Hulst, Barbara A. E. de Koning
Summary: Children with intestinal failure have elevated levels of ghrelin, which may be related to gut starvation. The dose of parenteral nutrition is positively correlated with ghrelin levels.
FRONTIERS IN NUTRITION
(2022)
Article
Health Care Sciences & Services
Fabienne G. Ropers, Sophie Rietveld, Edmond H. H. M. Rings, Patrick M. M. Bossuyt, Leti van Bodegom-Vos, Marij A. Hillen
Summary: Studies have shown that pediatricians consider the patient's clinical condition, local practice, and patient expectations when making diagnostic test decisions. They perceive test-related burden in children as higher compared to adults and are more restrictive in test ordering to avoid unjustified burden. However, they may feel conflicted when parents desire testing or when guidelines recommend unnecessary tests, sometimes performing tests to appease parents or comply with guidelines due to feared personal consequences.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2023)
Article
Cell Biology
Justin Jacobse, Rachel E. Brown, Jing Li, Jennifer M. Pilat, Ly Pham, Sarah P. Short, Christopher T. Peek, Andrea Rolong, M. Kay Washington, Ruben Martinez-Barricarte, Mariana X. Byndloss, Catherine Shelton, Janet G. Markle, Yvonne L. Latour, Margaret M. Allaman, James E. Cassat, Keith T. Wilson, Yash A. Choksi, Christopher S. Williams, Ken S. Lau, Charles R. Flynn, Jean-Laurent Casanova, Edmond H. H. M. Rings, Janneke N. Samsom, Jeremy A. Goettel
Summary: The cytokine IL-23 plays a role in the development of inflammatory bowel disease (IBD). IL-23R is highly expressed in intestinal Tregs, but its effect on Tregs remains unknown. This study shows that IL-23 reduces the frequency and suppressive function of colonic Tregs and that mice lacking IL-23R in Tregs have increased Treg frequency and advantages during inflammation. Furthermore, IL-23 antagonizes the liver X receptor pathway, cellular cholesterol transporter Abca1, and increases Treg apoptosis. These findings suggest that IL-23 negatively regulates intestinal Tregs, potentially promoting chronic inflammation in patients with IBD.
Article
Endocrinology & Metabolism
Demi J. Timmermans, Lionne N. Grootjen, Alicia F. Juriaans, Eva F. Mahabier, Gerthe F. Kerkhof, Edmond H. H. M. Rings, Anita C. S. Hokken-Koelega
Summary: This study investigated the effects of growth hormone treatment on cognitive functioning and behavior in young adults with Prader-Willi syndrome (PWS), and found that three years of treatment can maintain their IQ levels and that emotional and behavioral disturbances are similar to peers with other intellectual disabilities.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Justin Jacobse, Rachel E. Brown, Jing Li, Mary K. Washington, Edmond H. H. M. Rings, Janneke N. Samsom, Christopher S. Williams, Jeremy A. Goettel
Meeting Abstract
Immunology
L. Vlug, E. Neelis, W. Kastelijn, J. Olieman, M. Vermeulen, J. Roelants, D. Rizopoulos, J. Wells, M. Fewtrell, R. Wijnen, E. Rings, B. de Koning, J. Hulst
Meeting Abstract
Immunology
L. Vlug, E. Neelis, P. Delhanty, J. Visser, M. Huisman, E. Rings, R. Wijnen, M. Tabbers, B. de Koning
Article
Pediatrics
Caroline R. Meijer, M. Elske van den Akker, Leti van Bodegom, Johanna C. Escher, Nan van Geloven, Floris van Overveld, Edmond H. H. M. Rings, Lucy Smit, Martine de Vries, M. Luisa Mearin
Summary: The study aims to detect coeliac disease children by active case finding at Youth Health Care Centres in a well-described region in the Netherlands to evaluate feasibility, cost-effectiveness, and acceptability.
BMJ PAEDIATRICS OPEN
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Justin Jacobse, Jing Li, Mary K. Washington, Edmond H. H. M. Rings, Janneke N. Samsom, Jeremy A. Goettel