☆ 4.5 Article

Can NK cells be a therapeutic target in human diseases? Can NK cells be a therapeutic target in human type 1 diabetes?

EUROPEAN JOURNAL OF IMMUNOLOGY (2008)

Journal

EUROPEAN JOURNAL OF IMMUNOLOGY

Volume 38, Issue 11, Pages 2961-2963

Publisher

WILEY-BLACKWELL

DOI: 10.1002/eji.200838851

Keywords

Immunotherapy; Islet inflammation; NK cells; Type 1 diabetes

Categories

Immunology

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Abstract

Type 1 diabetes is caused by the autoimmune destruction of insulin-producing cells with consequent hyperglycemia and serious chronic complications. Both innate and adaptive immune responses participate in disease pathogenesis. Studies in animal models and in man have shown that NK cells are involved both in disease progression and in disease protection, thus suggesting that NK cells can represent a potential therapeutic target in type 1 diabetes, once the contribution of these cells to islet autoimmunity has been fully elucidated.

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