Atrial fibrillation: the role of common and rare genetic variants

A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

(2013) Morten Salling Olesen et al.   CARDIOVASCULAR RESEARCH

High prevalence of genetic variants previously associated with Brugada syndrome in new exome data

(2013) B Risgaard et al.   CLINICAL GENETICS

Novel genetic markers improve measures of atrial fibrillation risk prediction

(2013) Brendan M. Everett et al.   EUROPEAN HEART JOURNAL

New population-based exome data are questioning the pathogenicity of previously cardiomyopathy-associated genetic variants

(2013) Charlotte Andreasen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation

(2012) Morten S Olesen et al.   BMC Medical Genetics

Rare Variants in GJA5 Are Associated With Early-Onset Lone Atrial Fibrillation

(2012) Ingrid E. Christophersen et al.   CANADIAN JOURNAL OF CARDIOLOGY

Novel SCN3B Mutation Associated With Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.5

(2012) Taisuke Ishikawa et al.   CIRCULATION JOURNAL

High Prevalence of Long QT Syndrome–Associated SCN5A Variants in Patients With Early-Onset Lone Atrial Fibrillation

(2012) Morten S. Olesen et al.   Circulation-Cardiovascular Genetics

Autosomal Recessive Atrial Dilated Cardiomyopathy With Standstill Evolution Associated With Mutation of Natriuretic Peptide Precursor A

(2012) Marcello Disertori et al.   Circulation-Cardiovascular Genetics

Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm

(2012) I. I. Muller et al.   Disease Models & Mechanisms

A KCNJ8 mutation associated with early repolarization and atrial fibrillation

(2012) J. T. Delaney et al.   EUROPACE

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation

(2012) Ingrid E. Christophersen et al.   EUROPEAN HEART JOURNAL

High prevalence of genetic variants previously associated with LQT syndrome in new exome data

(2012) Lena Refsgaard et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

GATA6 loss-of-function mutation in atrial fibrillation

(2012) Yi-Qing Yang et al.   European Journal of Medical Genetics

Prevalence and spectrum of GATA6 mutations associated with familial atrial fibrillation

(2012) Yi-Qing Yang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

AKCNQ1Mutation Causes a High Penetrance for Familial Atrial Fibrillation

(2012) DANIEL C. BARTOS et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Chromosome 4q25 Variants Are Genetic Modifiers of Rare Ion Channel Mutations Associated With Familial Atrial Fibrillation

(2012) Marylyn D. Ritchie et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Epistatic Effects of Potassium Channel Variation on Cardiac Repolarization and Atrial Fibrillation Risk

(2012) Stefan A. Mann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Familial Aggregation of Lone Atrial Fibrillation in Young Persons

(2012) Nina Øyen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mutation spectrum of the GATA4 gene in patients with idiopathic atrial fibrillation

(2012) Jun Wang et al.   MOLECULAR BIOLOGY REPORTS

Variants of the Lamin A/C (LMNA) Gene in Non-Valvular Atrial Fibrillation Patients

(2012) Michal Saj et al.   Molecular Diagnosis & Therapy

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

(2012) Patrick T Ellinor et al.   NATURE GENETICS

Transgenic Insights Linking Pitx2 and Atrial Arrhythmias

(2012) Diego Franco et al.   Frontiers in Physiology

The Genetics of Atrial Fibrillation: From the Bench to the Bedside

(2011) Junjie Xiao et al.   Annual Review of Genomics and Human Genetics

KCNE5 ( KCNE1L ) Variants Are Novel Modulators of Brugada Syndrome and Idiopathic Ventricular Fibrillation

(2011) Seiko Ohno et al.   Circulation-Arrhythmia and Electrophysiology

PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression

(2011) Paulus Kirchhof et al.   Circulation-Cardiovascular Genetics

PITX2 Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to Arrhythmogenesis

(2011) Ana Chinchilla et al.   Circulation-Cardiovascular Genetics

GATA4 loss-of-function mutations in familial atrial fibrillation

(2011) Yi-Qing Yang et al.   CLINICA CHIMICA ACTA

Transient outward current (Ito) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome

(2011) John R. Giudicessi et al.   HEART RHYTHM

HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies

(2011) Michael J. Ackerman et al.   HEART RHYTHM

SCN1Bb R214Q found in 3 patients: 1 with Brugada syndrome and 2 with lone atrial fibrillation

(2011) Morten S. Olesen et al.   HEART RHYTHM

A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Nav1.5 and Kv4.3 channel currents

(2011) Dan Hu et al.   HEART RHYTHM

Common variants for atrial fibrillation: results from genome-wide association studies

(2011) Xinyuan Liu et al.   HUMAN GENETICS

Novel insights into the distribution of cardiac HCN channels: An expression study in the mouse heart

(2011) Stefan Herrmann et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation

(2011) Valentin Fuster et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Long-Term Follow-Up of Patients With Short QT Syndrome

(2011) Carla Giustetto et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

(2011) Hilma Holm et al.   NATURE GENETICS

Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population

(2010) Pengyun Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation

(2010) Morten S. Olesen et al.   CARDIOVASCULAR RESEARCH

Monogenic atrial fibrillation as pathophysiological paradigms

(2010) S. Mahida et al.   CARDIOVASCULAR RESEARCH

Paradigm of Genetic Mosaicism and Lone Atrial Fibrillation

(2010) Isabelle L. Thibodeau et al.   CIRCULATION

Executive Summary: Heart Disease and Stroke Statistics—2010 Update

(2010) et al.   CIRCULATION

Nesprins LINC the nucleus and cytoskeleton

(2010) Jason A Mellad et al.   CURRENT OPINION IN CELL BIOLOGY

Novel connexin40 missense mutations in patients with familial atrial fibrillation

(2010) Y.-Q. Yang et al.   EUROPACE

Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation

(2010) Maximilian G. Posch et al.   European Journal of Medical Genetics

Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation

(2010) Tao Yang et al.   HEART RHYTHM

Gain-of-function mutation S422L in the KCNJ8-encoded cardiac KATP channel Kir6.1 as a pathogenic substrate for J-wave syndromes

(2010) Argelia Medeiros-Domingo et al.   HEART RHYTHM

R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation

(2010) Daniel C. Bartos et al.   HEART RHYTHM

Laminopathy presenting as familial atrial fibrillation

(2010) Britt Maria Beckmann et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

(2010) A. Beqqali et al.   JOURNAL OF CELL SCIENCE

Common variants in KCNN3 are associated with lone atrial fibrillation

(2010) Patrick T Ellinor et al.   NATURE GENETICS

Genome-wide association study of PR interval

(2010) Arne Pfeufer et al.   NATURE GENETICS

Comprehensive Mutation Scanning of LMNA in 268 Patients With Lone Atrial Fibrillation

(2009) Katharine M. Brauch et al.   AMERICAN JOURNAL OF CARDIOLOGY

Gain-of-function mutation of Na v 1.5 in atrial fibrillation enhances cellular excitability and lowers the threshold for action potential firing

(2009) Qiuju Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Familial Aggregation of Atrial Fibrillation

(2009) Ingrid Elisabeth Christophersen et al.   Circulation-Arrhythmia and Electrophysiology

Mutations in Sodium Channel β1- and β2-Subunits Associated With Atrial Fibrillation

(2009) Hiroshi Watanabe et al.   Circulation-Arrhythmia and Electrophysiology

A Mutation in the β3 Subunit of the Cardiac Sodium Channel Associated With Brugada ECG Phenotype

(2009) Dan Hu et al.   Circulation-Cardiovascular Genetics

Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation

(2009) Saumya Das et al.   HEART RHYTHM

NovelKCNE3mutation reduces repolarizing potassium current and associated with long QT syndrome

(2009) Seiko Ohno et al.   HUMAN MUTATION

The genetic basis of Brugada syndrome: A mutation update

(2009) Paula L. Hedley et al.   HUMAN MUTATION

The genetic basis of long QT and short QT syndromes: A mutation update

(2009) Paula L. Hedley et al.   HUMAN MUTATION

Role of the R1135H KCNH2 mutation in Brugada syndrome

(2009) Ronald Wilders et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation

(2009) Yiqing Yang et al.   JOURNAL OF HUMAN GENETICS

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

(2009) Robert L. Abraham et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

(2009) Emelia J Benjamin et al.   NATURE GENETICS

Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death

(2008) Xianqin Zhang et al.   CELL

KCNE3 Mutation V17M Identified in a Patient with Lone Atrial Fibrillation

(2008) Alicia Lundby et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cardiac Sodium Channel ( SCN5A ) Variants Associated with Atrial Fibrillation

(2008) Dawood Darbar et al.   CIRCULATION

Emerin and the Nuclear Lamina in Muscle and Cardiac Disease

(2008) James M. Holaska   CIRCULATION RESEARCH

Functional Effects of KCNE3 Mutation and Its Role in the Development of Brugada Syndrome

(2008) Eva Delpón et al.   Circulation-Arrhythmia and Electrophysiology

Prevalence of early-onset atrial fibrillation in congenital long QT syndrome

(2008) Jonathan N. Johnson et al.   HEART RHYTHM

Gain of function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation

(2008) Lasse S. Ravn et al.   HEART RHYTHM

A Novel SCN5A Gain-of-Function Mutation M1875T Associated With Familial Atrial Fibrillation

(2008) Takeru Makiyama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation

(2008) Denice M. Hodgson-Zingman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiac sodium channel mutation in atrial fibrillation

(2007) Patrick T. Ellinor et al.   HEART RHYTHM