Review
Cell Biology
Timoteo Marchini, Lucia Sol Mitre, Dennis Wolf
Summary: Atherosclerosis is a chronic inflammatory disease initiated and maintained by leukocytes, which can lead to myocardial infarction and stroke. Challenges in developing therapies for leukocyte accumulation include the lack of tissue-tropism of targeted factors and unspecific inhibition strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Stefan Frantz, Moritz Jens Hundertmark, Jeanette Schulz-Menger, Frank Michael Bengel, Johann Bauersachs
Summary: Most patients survive acute myocardial infarction, but the prevalence of heart failure is increasing, leading to economic strain on healthcare systems. Pathological changes in the heart significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, and female sex can distinctively shape the progression towards heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Engineering, Biomedical
Paolo Contessotto, Abhay Pandit
Summary: Myocardial infarction is a leading cause of global mortality, with different treatment approaches being evaluated through clinical trials. Current research focuses on therapeutic targets such as ischemia, inflammation, fibrosis, angiogenesis, and cellular stress. Novel biomaterial-based systems and unexplored translational studies offer promising avenues for future therapeutic strategies.
Article
Cardiac & Cardiovascular Systems
Xiaoqiong Wei, Song Zou, Zhonghui Xie, Zhen Wang, Nongyu Huang, Zhifu Cen, Yan Hao, Chengxin Zhang, Zhenyu Chen, Fulei Zhao, Zhonglan Hu, Xiu Teng, Yiyue Gui, Xiao Liu, Huaping Zheng, Hong Zhou, Shuwen Chen, Juan Cheng, Fanlian Zeng, Yifan Zhou, Wenling Wu, Jing Hu, Yuquan Wei, Kaijun Cui, Jiong Li
Summary: The study demonstrates the important role of EDIL3 in cardiac remodeling after myocardial infarction. EDIL3 deficiency improves adverse cardiac healing mainly through the mechanism of neutrophil extracellular trap-mediated pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2022)
Article
Immunology
Elena de Dios, Cesar Rios-Navarro, Nerea Perez-Sole, Jose Gavara, Victor Marcos-Garces, Maria J. Forteza, Ricardo Oltra, Jose M. Vila, Francisco J. Chorro, Vicente Bodi
Summary: Lymphopenia after ST-segment elevation myocardial infarction (STEMI) is associated with adverse cardiac consequences and poor prognosis. Increased expression of regulatory T cell and immune checkpoint genes CD25, CD69, PD-1, and CTLA-4 following STEMI correlates with better short- and long-term cardiac structure and function, with CD25 potentially predicting the extent of infarction size after one week.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Environmental
Junlang Li, Yongbo Lv, Dashuai Zhu, Xuan Mei, Ke Huang, Xianyun Wang, Zhenhua Li, Sichen Zhang, Shiqi Hu, Kristen D. Popowski, Ke Cheng, Juan Wang
Summary: A comparison between intramyocardial (IM) injection and intrapericardial cavity (IPC) injection of adult stem cells in hydrogel showed that IPC injection led to better retention and therapeutic benefits, resulting in significant improvement in cardiac function. Furthermore, IPC delivery demonstrated better cellular proliferation, less apoptosis, and improved vascular regeneration in the myocardium. Additionally, IPC injections led to higher rates of MSC-exosome absorption by heart cells, indicating more extensive paracrine activity and showing promise as a solution for the low retention issue of MSCs in the infarcted heart.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Medicine, Research & Experimental
Andrew R. Kompa, Fay L. Khong, Yuan Zhang, Cindy Nguyen, Amanda J. Edgley, Owen L. Woodman, Grant McLachlan, Darren J. Kelly
Summary: This study evaluated the efficacy of NP202, a synthetic flavonol, on cardiac remodelling in a chronic model of myocardial infarction (MI). Results showed that NP202 improved left ventricular function and structure, especially at a higher dose. NP202 also reduced hypertrophy and interstitial fibrosis in the non-infarct region of the myocardium.
Review
Cell Biology
Akihiko Kubota, Nikolaos G. Frangogiannis
Summary: Following myocardial infarction, macrophages play important roles in both injurious and reparative responses. They regulate the inflammatory response through phagocytosis and secretion of mediators, and contribute to the repair of the infarcted heart. However, the relationship between transcriptomic profiles and functional properties of macrophages in infarcted hearts is still unclear.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Masum M. Mia, Dasan Mary Cibi, Siti Aishah Binte Abdul Ghani, Anamika Singh, Nicole Tee, Viswanathan Sivakumar, Hanumakumar Bogireddi, Stuart A. Cook, Junhao Mao, Manvendra K. Singh
Summary: Yap/Taz play an important regulatory role in MI-induced cardiac fibrosis by controlling fibroblast proliferation, transdifferentiation into myofibroblasts, and fibroinflammatory program.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ana-Mishel Spiroski, Ian R. McCracken, Adrian Thomson, Marlene Magalhaes-Pinto, Mukesh K. Lalwani, Kathryn J. Newton, Eileen Miller, Cecile Benezech, Patrick Hadoke, Mairi Brittan, Joanne C. Mountford, Abdelaziz Beqqali, Gillian A. Gray, Andrew H. Baker
Summary: This study investigated the tissue remodeling effects of human embryonic stem cell-derived endothelial cell product (hESC-ECP) therapy on infarcted heart and found that it reduces infarct size and preserves functional myocardium. By examining the interactions between cells and immune regulation, this research provides new therapeutic avenues for improving cardiac outcomes following myocardial infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Bomee Chung, Yong Wang, Marleen Thiel, Fatemeh Rostami, Anika Rogoll, Valentin G. Hirsch, Zulaikha Malik, Anne Buehrke, Christian Baer, Michael Klintschar, Jan D. Schmitto, Carla Vogt, Christopher Werlein, Danny Jonigk, Johann Bauersachs, Kai C. Wollert, Tibor Kempf
Summary: This study aims to investigate the functional importance of cardiac iron status after myocardial infarction (MI) and the potential of pre-emptive iron supplementation in preventing cardiac iron deficiency (ID) and attenuating left ventricular (LV) remodelling. The results showed that cardiac iron status was dynamically regulated after MI, and iron supplementation could maintain cardiac iron content and attenuate adverse remodeling. These findings suggest that cardiac iron deficiency is a novel disease mechanism and therapeutic target in post-infarction LV remodeling and HF.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Holger Loerchner, Juan M. Adrian-Segarra, Christian Waechter, Roxanne Wagner, Maria Elisa Goes, Nathalie Brachmann, Krishnamoorthy Sreenivasan, Astrid Wietelmann, Stefan Guenther, Nicolas Doll, Thomas Braun, Jochen Poeling
Summary: This study discovered that simultaneous and rapid activation of OSMR and LIFR after myocardial infarction (MI) can protect the functional and structural integrity of the infarcted heart, and this can be achieved by using engineered human-like OSM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sarah-Lena Puhl, Michael Hilby, Michael Kohlhaas, Linus M. Keidel, Yvonne Jansen, Michael Hristov, Jakob Schindler, Christoph Maack, Sabine Steffens
Summary: Deficiency of GPR55 affects cardiac physiology and post-MI inflammation, leading to maladaptive cardiac remodeling.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Yibing Nong, Yiru Guo, Alex Tomlin, Xiaoping Zhu, Marcin Wysoczynski, Qianhong Li, Roberto Bolli
Summary: In the field of cell therapy for heart disease, a new paradigm of repeated dosing of cells has emerged. A method of echo-guided LV injection has been established for cell delivery in infarcted mice, with a high survival rate and improved cardiac function. This method provides a feasible, reproducible, less invasive, and effective delivery approach for cell therapy in murine heart disease models.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zhuo Li, Fangnan Wu, Lei Xi, Zhenjun Tian
Summary: Exercise training post-myocardial infarction activates the CHI3L1/PAR2 signaling pathway, improving myocardial function and enhancing cardiac angiogenesis in the infarcted heart.