Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromes

p53/p21 Pathway Involved in Mediating Cellular Senescence of Bone Marrow-Derived Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients

(2013) Zhifeng Gu et al.   Clinical & Developmental Immunology

Mesenchymal stromal cells from patients with myelodyplastic syndrome display distinct functional alterations that are modulated by lenalidomide

(2013) R. A. Ferrer et al.   HAEMATOLOGICA

Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells

(2013) S Geyh et al.   LEUKEMIA

Evidences of Early Senescence in Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells

(2013) Thibaud André et al.   PLoS One

Bone Marrow Mesenchymal Stem Cells in Myelodysplastic Syndromes: Cytogenetic Characterization

(2012) Lu-Xi Song et al.   ACTA HAEMATOLOGICA

Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients

(2012) C. Santamaria et al.   HAEMATOLOGICA

Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis

(2012) Marc H. G. P. Raaijmakers   INTERNATIONAL JOURNAL OF HEMATOLOGY

Knockdown of p21Cip1/Waf1 enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells

(2011) Tu-Lai Yew et al.   AGING CELL

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

(2011) Moustapha Kassem et al.   AGING CELL

Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: implications for immunotherapy

(2011) Shikhar Aggarwal et al.   BRITISH JOURNAL OF HAEMATOLOGY

Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes

(2011) Zhi-Gang Zhao et al.   CANCER LETTERS

Disease progression mechanism in myelodysplastic syndromes: Insight into the role of the microenvironment

(2011) Mariko Ishibashi et al.   LEUKEMIA RESEARCH

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST

(2010) C.-C. Tsai et al.   BLOOD

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

The molecular signature of in vitro senescence in human mesenchymal stem cells

(2010) Hye Bin Noh et al.   Genes & Genomics

Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes

(2010) X. Feng et al.   HAEMATOLOGICA

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

IL-17-producing CD4+T cells, pro-inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome

(2009) Shahram Y. Kordasti et al.   BRITISH JOURNAL OF HAEMATOLOGY

Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q− syndrome

(2009) O Lopez-Villar et al.   LEUKEMIA

Accelerating Stem Cell Proliferation by Down-Regulation of Cell Cycle Regulator p21

(2009) Magdalena Plasilova et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Reserves, Functional, Immunoregulatory, and Cytogenetic Properties of Bone Marrow Mesenchymal Stem Cells in Patients with Myelodysplastic Syndromes

(2009) Mirjam Klaus et al.   STEM CELLS AND DEVELOPMENT

Correlation between proliferative activity and cellular thickness of human mesenchymal stem cells

(2008) Yoshihiro Katsube et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool

(2008) J. García-Castro et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells and unwitting host to molecular parasites

(2008) Y Shiozawa et al.   LEUKEMIA

Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cells

(2008) Eugenia Flores-Figueroa et al.   LEUKEMIA RESEARCH

Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation

(2008) D.C. Lacey et al.   OSTEOARTHRITIS AND CARTILAGE

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One