Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis

(2011) S. N. Zimmer et al.   BLOOD

High bone marrow angiopoietin-1 expression is an independent poor prognostic factor for survival in patients with myelodysplastic syndromes

(2011) C-L Cheng et al.   BRITISH JOURNAL OF CANCER

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Inflammation and mesenchymal stem cell aging

(2011) Günter Lepperdinger   CURRENT OPINION IN IMMUNOLOGY

Focal adhesion protein abnormalities in myelodysplastic mesenchymal stromal cells

(2011) Carmen Mariana Aanei et al.   EXPERIMENTAL CELL RESEARCH

Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system

(2011) M. H. G. P. Raaijmakers   HAEMATOLOGICA

Unraveling the Molecular Pathophysiology of Myelodysplastic Syndromes

(2011) Rafael Bejar et al.   JOURNAL OF CLINICAL ONCOLOGY

The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes

(2010) X. Li et al.   BLOOD

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

Establishment of a xenograft model of human myelodysplastic syndromes

(2010) Y. Muguruma et al.   HAEMATOLOGICA

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Advancements in the molecular pathogenesis of myelodysplastic syndrome

(2009) Pearlie K Epling-Burnette et al.   CURRENT OPINION IN HEMATOLOGY

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

(2009) Christa Maes et al.   EMBO JOURNAL

Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q− syndrome

(2009) O Lopez-Villar et al.   LEUKEMIA

The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes

(2009) Simone V. da Costa et al.   LEUKEMIA RESEARCH

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

Epithelial metaplasia: adult stem cell reprogramming and (pre)neoplastic transformation mediated by inflammation?

(2009) Michael Herfs et al.   TRENDS IN MOLECULAR MEDICINE

Defective Notch activation in microenvironment leads to myeloproliferative disease

(2008) Y.-W. Kim et al.   BLOOD

Inhibition of p38α MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment

(2008) Tony Navas et al.   LEUKEMIA & LYMPHOMA

Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function

(2008) A. M. Marcondes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell

(2008) Y. J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA