Evaluation of Generic Methods to Predict Human Pharmacokinetics Using Physiologically Based Pharmacokinetic Model for Early Drug Discovery of Tyrosine Kinase Inhibitors

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

(2017) Adam S. Darwich et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of the GastroPlus™ Advanced Compartmental and Transit (ACAT) Model in Early Discovery

(2016) N. Gobeau et al.   PHARMACEUTICAL RESEARCH

Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set

(2016) Tetsuo Yamagata et al.   XENOBIOTICA

Application of physiologically based pharmacokinetic modeling in the prediction of pharmacokinetics of bicyclol controlled-release formulation in human

(2015) Baolian Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In vitro dissolution methodology, mini-Gastrointestinal Simulator (mGIS), predicts better in vivo dissolution of a weak base drug, dasatinib

(2015) Yasuhiro Tsume et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of preclinicalin vitroandin vivoADME properties and prediction of human PK using a physiologically based pharmacokinetic model for YQA-14, a new dopamine D3receptor antagonist candidate for treatment of drug addiction

(2014) Fei Liu et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Prediction of Human Pharmacokinetics from Preclinical Information of Rhein, an Antidiabetic Nephropathy Drug, Using a Physiologically Based Pharmacokinetic Model

(2013) Kun Hao et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation

(2012) Peng Zou et al.   AAPS Journal

In silico Prediction of Total Human Plasma Clearance

(2012) Giuliano Berellini et al.   Journal of Chemical Information and Modeling

Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling

(2011) Hannah M. Jones et al.   CLINICAL PHARMACOKINETICS

Toward an integrated human clearance prediction strategy that minimizes animal use

(2011) Kevin Beaumont et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds

(2010) A.-K. Sohlenius-Sternbeck et al.   XENOBIOTICA

Modelling and PBPK Simulation in Drug Discovery

(2009) Hannah M. Jones et al.   AAPS Journal

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

(2009) Natilie A. Hosea et al.   JOURNAL OF CLINICAL PHARMACOLOGY