Evaluation of the GastroPlus™ Advanced Compartmental and Transit (ACAT) Model in Early Discovery

Prediction of Oral Absorption of Low-Solubility Drugs by Using Rat Simulated Gastrointestinal Fluids: The Importance of Regional Differences in Membrane Permeability and Solubility

(2016) Yusuke Tanaka et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

(2015) HM Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Benefit of Retraining pKa Models Studied Using Internally Measured Data

(2015) Peter Gedeck et al.   Journal of Chemical Information and Modeling

Species Differences in the Dissolution and Absorption of Griseofulvin and Albendazole, Biopharmaceutics Classification System Class II Drugs, in the Gastrointestinal Tract

(2013) Yusuke Tanaka et al.   Drug Metabolism and Pharmacokinetics

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

(2013) Erik Sjögren et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

PBPK models for the prediction of in vivo performance of oral dosage forms

(2013) Edmund S. Kostewicz et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Animal versus human oral drug bioavailability: Do they correlate?

(2013) Helen Musther et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver

(2013) Aki T. Heikkinen et al.   MOLECULAR PHARMACEUTICS

The right compound in the right assay at the right time: an integrated discovery DMPK strategy

(2012) Peter Ballard et al.   DRUG METABOLISM REVIEWS

Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™

(2012) Aki T. Heikkinen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Advancing Prediction of Tissue Distribution and Volume of Distribution of Highly Lipophilic Compounds from a Simplified Tissue-Composition-Based Model as a Mechanistic Animal Alternative Method

(2012) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evolution of the physicochemical properties of marketed drugs: can history foretell the future?

(2011) Bernard Faller et al.   DRUG DISCOVERY TODAY

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the Wajima approach

(2011) Ragini Vuppugalla et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

(2011) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

(2010) Noha M. Zaki et al.   MOLECULAR PHARMACEUTICS

A pH-Dilution Method for Estimation of Biorelevant Drug Solubility along the Gastrointestinal Tract: Application to Physiologically Based Pharmacokinetic Modeling

(2010) Yi Gao et al.   MOLECULAR PHARMACEUTICS

Modelling and PBPK Simulation in Drug Discovery

(2009) Hannah M. Jones et al.   AAPS Journal

Evaluation of a Generic Physiologically Based Pharmacokinetic Model for Lineshape Analysis

(2008) Sheila Annie Peters   CLINICAL PHARMACOKINETICS

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

(2008) Ekarat Jantratid et al.   PHARMACEUTICAL RESEARCH