Challenges in pharmacogenetics

Association of udp-glucuronosyltransferase 1A9 (UGT1A9) gene polymorphism with kidney allograft function

(2015) Joanna Pazik et al.   Annals of Transplantation

TheCYP3A4*22allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations

(2012) Laure Elens et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A Randomized and Clinical Effectiveness Trial Comparing Two Pharmacogenetic Algorithms and Standard Care for Individualizing Warfarin Dosing (CoumaGen-II)

(2012) Jeffrey L. Anderson et al.   CIRCULATION

Effect of the P450 oxidoreductase *28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers

(2012) Jing-Jing Zhang et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Tamoxifen Use in Postmenopausal Breast Cancer: CYP2D6 Matters

(2012) Hiltrud Brauch et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function

(2012) J C Stingl et al.   MOLECULAR PSYCHIATRY

Association of sirolimus adverse effects with m-TOR, p70S6K or Raptor polymorphisms in kidney transplant recipients

(2012) Jean-Baptiste Woillard et al.   Pharmacogenetics and Genomics

NR1I2 Polymorphisms Are Related to Tacrolimus Dose-Adjusted Exposure and BK Viremia in Adult Kidney Transplantation

(2012) Katherine A. Barraclough et al.   TRANSPLANTATION

miRNAs as mediators of drug resistance

(2012) Sierk Haenisch et al.   Epigenomics

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Paraoxonase-1 Q192R Polymorphism and Antiplatelet Effects of Clopidogrel in Patients Undergoing Elective Coronary Stent Placement

(2011) Dietmar Trenk et al.   Circulation-Cardiovascular Genetics

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype

(2011) K R Crews et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events

(2011) Michael V. Holmes et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Predictive biomarkers: a paradigm shift towards personalized cancer medicine

(2011) Nicholas B. La Thangue et al.   Nature Reviews Clinical Oncology

Harnessing Our Opportunity to Make Primary Care Sustainable

(2011) Jim McDermott   NEW ENGLAND JOURNAL OF MEDICINE

Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients

(2011) Andreas Binder et al.   PLoS One

Warfarin Genotyping Reduces Hospitalization Rates

(2010) Robert S. Epstein et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Multiple personal genomes await

(2010) J. Craig Venter   NATURE

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

High Frequency of Occurrence of CYP2D6 Gene Duplication/Multiduplication Indicating Ultrarapid Metabolism Among Suicide Cases

(2009) A L Zackrisson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome

(2009) P. Michael Ho   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Intermediate metabolizer: increased side effects in psychoactive drug therapy. The key to cost-effectiveness of pretreatment CYP2D6 screening?

(2009) B Laika et al.   PHARMACOGENOMICS JOURNAL

Genetic modulation of the pharmacological treatment of pain

(2009) Jörn Lötsch et al.   PHARMACOLOGY & THERAPEUTICS

The Effect of CYP2C19 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Clopidogrel: A Possible Mechanism for Clopidogrel Resistance

(2008) KA Kim et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Common genetic, clinical, demographic and psychosocial predictors of response to pharmacotherapy in mood and anxiety disorders

(2008) Alessandro Serretti et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

A Common Human μ-Opioid Receptor Genetic Variant Diminishes the Receptor Signaling Efficacy in Brain Regions Processing the Sensory Information of Pain

(2008) Bruno Georg Oertel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

(2008) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE