Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function
Authors
Keywords
-
Journal
MOLECULAR PSYCHIATRY
Volume 18, Issue 3, Pages 273-287
Publisher
Springer Nature
Online
2012-05-08
DOI
10.1038/mp.2012.42
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Pharmacokinetics of Venlafaxine Extended Release 75 mg and Desvenlafaxine 50 mg in Healthy CYP2D6 Extensive and Poor Metabolizers
- (2011) Alice I. Nichols et al. CLINICAL DRUG INVESTIGATION
- CYP2D6 in the Brain: Impact on Suicidality
- (2011) J C Stingl (formerly Kirchheiner) et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Pharmacogenetics: From Bench to Byte— An Update of Guidelines
- (2011) J J Swen et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network
- (2011) M V Relling et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Anandamide Oxidation by Wild-Type and Polymorphically Expressed CYP2B6 and CYP2D6
- (2011) C. Sridar et al. DRUG METABOLISM AND DISPOSITION
- The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy
- (2011) Medine Idrizoglu Gulcebi et al. EPILEPSY RESEARCH
- Cytochrome P450 mediates dopamine formation in the brain in vivo
- (2011) Ewa Bromek et al. JOURNAL OF NEUROCHEMISTRY
- Potentials and Challenges for Arterial Spin Labeling in Pharmacological Magnetic Resonance Imaging
- (2011) D. J. J. Wang et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- CYP2C19 genotype predicts steady state escitalopram concentration in GENDEP
- (2011) Patricia Huezo-Diaz et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice
- (2011) J.C. Winter et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011
- (2011) C. Hiemke et al. PHARMACOPSYCHIATRY
- Antidepressant medication prevents suicide in depression
- (2010) G. Isacsson et al. ACTA PSYCHIATRICA SCANDINAVICA
- CYP2D6, serotonin, and suicide—a relationship?
- (2010) L Bertilsson CLINICAL PHARMACOLOGY & THERAPEUTICS
- Enrichment of Clinical Study Populations
- (2010) R Temple CLINICAL PHARMACOLOGY & THERAPEUTICS
- What Is Clinical Utility and Why Should We Care?
- (2010) L J Lesko et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Differential outcomes from metabolic ratios in the identification of CYP2D6 phenotypes–focus on venlafaxine and O-desmethylvenlafaxine
- (2010) Mani Kandasamy et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- The role of CYP2D6 and ABCB1 pharmacogenetics in drug-naïve patients with first-episode schizophrenia treated with risperidone
- (2010) Nikolina Jovanović et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure—an impact similar to male gender or smoking in schizophrenic patients
- (2010) Roza Ghotbi et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- A population pharmacokinetic evaluation of the influence of CYP2D6 genotype on risperidone metabolism in patients with acute episode of schizophrenia
- (2010) Igor Locatelli et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Cytochrome P450 2D6 Phenotype Predicts Antidepressant Efficacy of Venlafaxine
- (2010) Kasia W. Lobello et al. JOURNAL OF CLINICAL PSYCHIATRY
- CYP2D6 in the brain: genotype effects on resting brain perfusion
- (2010) J Kirchheiner et al. MOLECULAR PSYCHIATRY
- Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling
- (2010) Jennie L Conroy et al. NATURE NEUROSCIENCE
- Drug Metabolism within the Brain Changes Drug Response: Selective Manipulation of Brain CYP2B Alters Propofol Effects
- (2010) Jibran Y Khokhar et al. NEUROPSYCHOPHARMACOLOGY
- CYP2C19 variation and citalopram response
- (2010) David A. Mrazek et al. Pharmacogenetics and Genomics
- Xenobiotic metabolizing and transporter genes: gene–gene interactions in schizophrenia and related disorders
- (2010) Patricia Gassó et al. PHARMACOGENOMICS
- Genetic polymorphisms of cytochrome P450 enzymes influence metabolism of the antidepressant escitalopram and treatment response
- (2010) Ming-Hsien Tsai et al. PHARMACOGENOMICS
- Association between CYP2C19*17 and metabolism of amitriptyline, citalopram and clomipramine in Dutch hospitalized patients
- (2010) A de Vos et al. PHARMACOGENOMICS JOURNAL
- Effect of Cytochrome P450 Enzyme Polymorphisms on Pharmacokinetics of Venlafaxine
- (2010) Donald E McAlpine et al. THERAPEUTIC DRUG MONITORING
- Baseline Brain Perfusion and the Serotonin Transporter Promoter Polymorphism
- (2009) Roberto Viviani et al. BIOLOGICAL PSYCHIATRY
- Evidence for oxazepam as anin vivoprobe of UGT2B15: oxazepam clearance is reduced byUGT2B15D85Y polymorphism but unaffected byUGT2B17deletion
- (2009) Xi He et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- High Frequency of Occurrence of CYP2D6 Gene Duplication/Multiduplication Indicating Ultrarapid Metabolism Among Suicide Cases
- (2009) A L Zackrisson et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
- (2009) F. Dutheil et al. DRUG METABOLISM AND DISPOSITION
- Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
- (2009) A. Mazur et al. DRUG METABOLISM AND DISPOSITION
- Impact of CYP2C19 phenotypes on escitalopram metabolism and an evaluation of pupillometry as a serotonergic biomarker
- (2009) L. Noehr-Jensen et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Evaluation of the influence of sex and CYP2C19 and CYP2D6 polymorphisms in the disposition of citalopram
- (2009) Salvador Fudio et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes
- (2009) Santi Álvarez et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- Response to serotonin reuptake inhibitors in OCD is not influenced by common CYP2D6 polymorphisms
- (2009) Filip C.W. Van Nieuwerburgh et al. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
- Impact of CYP2D6 Genotype on Steady-State Serum Concentrations of Risperidone and 9-Hydroxyrisperidone in Patients Using Long-Acting Injectable Risperidone
- (2009) Magnhild Hendset et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Venlafaxine Metabolism as a Marker of Cytochrome P450 Enzyme 2D6 Metabolizer Status
- (2009) Alice I. Nichols et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- ABCB1 and Cytochrome P450 Polymorphisms
- (2009) Eveline Jaquenoud Sirot et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Components of variance in brain perfusion and the design of studies of individual differences: The baseline study
- (2009) Roberto Viviani et al. NEUROIMAGE
- CYP2D6 Genotype Predicts Antipsychotic Side Effects in Schizophrenia Inpatients: A Retrospective Matched Case-Control Study
- (2009) Camilla J. Kobylecki et al. NEUROPSYCHOBIOLOGY
- Pharmacogenetic variation at CYP2C9, CYP2C19, and CYP2D6 at global and microgeographic scales
- (2009) Johanna Sistonen et al. Pharmacogenetics and Genomics
- Relation betweenCYP2D6genotype, personality, neurocognition and overall psychopathology in healthy volunteers
- (2009) Eva M Peñas-LLedó et al. PHARMACOGENOMICS
- Molecular diversity at theCYP2D6locus in healthy and schizophrenic southern Brazilians
- (2009) Fabiana B Kohlrausch et al. PHARMACOGENOMICS
- Association between theCYP2D6*4polymorphism and depression or anxiety in the elderly
- (2009) Monique J Bijl et al. PHARMACOGENOMICS
- The CYP2C19*17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients
- (2009) P W Schenk et al. PHARMACOGENOMICS JOURNAL
- Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants
- (2008) Monique J. Bijl et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Steady-State Concentrations of Mirtazapine, N-Desmethylmirtazapine, 8-Hydroxymirtazapine and their Enantiomers in Relation to Cytochrome P450 2D6 Genotype, Age and Smoking Behaviour
- (2008) Anna-Britta Lind et al. CLINICAL PHARMACOKINETICS
- Generation of Mice Transgenic for Human CYP2C18 and CYP2C19: Characterization of the Sexually Dimorphic Gene and Enzyme Expression
- (2008) S. Lofgren et al. DRUG METABOLISM AND DISPOSITION
- From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions
- (2008) Daniel W. Nebert et al. DRUG METABOLISM REVIEWS
- Serum concentrations of sertraline and N-desmethyl sertraline in relation to CYP2C19 genotype in psychiatric patients
- (2008) I. Rudberg et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Kinetics of omeprazole and escitalopram in relation to the CYP2C19*17 allele in healthy subjects
- (2008) Staffan Ohlsson Rosenborg et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions
- (2008) Bruno P. Guiard et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- PhRMA White Paper on ADME Pharmacogenomics
- (2008) J. Andrew Williams et al. JOURNAL OF CLINICAL PHARMACOLOGY
- ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier
- (2008) Sandrine Dauchy et al. JOURNAL OF NEUROCHEMISTRY
- The Endocannabinoid Anandamide Is a Substrate for the Human Polymorphic Cytochrome P450 2D6
- (2008) N. T. Snider et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Chronic imipramine but not bupropion increases arachidonic acid signaling in rat brain: is this related to ‘switching’ in bipolar disorder?
- (2008) H-J Lee et al. MOLECULAR PSYCHIATRY
- Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression
- (2008) Manfred Uhr et al. NEURON
- Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment
- (2008) Amandeep Mann et al. NEUROPHARMACOLOGY
- Brain Drug-Metabolizing Cytochrome P450 Enzymes are Active In Vivo, Demonstrated by Mechanism-Based Enzyme Inhibition
- (2008) Sharon Miksys et al. NEUROPSYCHOPHARMACOLOGY
- Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers
- (2008) Idilio González et al. PHARMACOGENOMICS
- Pharmacokinetic Genes Do Not Influence Response or Tolerance to Citalopram in the STAR*D Sample
- (2008) Eric J. Peters et al. PLoS One
- Dose-Dependent Effect of the CYP2D6 Genotype on the Steady-state Fluvoxamine Concentration
- (2008) Junzo Watanabe et al. THERAPEUTIC DRUG MONITORING
- Vascular Cytochrome P450 Enzymes: Physiology and Pathophysiology
- (2008) Ingrid Fleming TRENDS IN CARDIOVASCULAR MEDICINE
- Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain
- (2007) Fabien Dutheil et al. BIOCHIMIE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More