Review
Immunology
Ashton Harper, Vineetha Vijayakumar, Arthur C. Ouwehand, Jessica ter Haar, David Obis, Jordi Espadaler, Sylvie Binda, Shrilakshmi Desiraju, Richard Day
Summary: Viral infections continue to pose significant global morbidity and mortality, with factors such as climate change, increased mobility of people and goods, and disruptions in the gastrointestinal microbiome all playing a role. Understanding the complex relationship between the microbiome, viral immunity, and host physiology is crucial for developing effective prevention and treatment strategies for viral diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Yunjian Wu, Shan Hu, Changyu Wu, Feng Gu, Ying Yang
Summary: The global infection rate of fungal diseases is increasing year by year, becoming one of the most serious infectious diseases threatening human health. The development of new alternatives to antifungal drugs is essential due to the increasing side effects and fungal resistance. Probiotics, as beneficial microorganisms, have shown inhibitory activity on a wide range of pathogenic fungi and could become a new method for the treatment of fungal diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Health Care Sciences & Services
Shadma Wahab, Dalia Almaghaslah, Syed Esam Mahmood, Md Faruque Ahmad, Abdulrahman A. Alsayegh, Yahya M. Abu Haddash, Mohammad Akhlaquer Rahman, Irfan Ahamd, Wasim Ahmad, Mohammad Khalid, Shazia Usmani, Md Parwez Ahmad, Umme Hani
Summary: Mortality and morbidity from influenza and other respiratory viruses are significant causes of concern worldwide. Probiotics, as a medication, have shown immunomodulating and antiviral properties in treating respiratory viral infections. However, the mechanisms of probiotics in fighting viral infections are sometimes unclear. This comprehensive review addresses probiotic strains, dosage regimens, production procedures, delivery systems, and pre-clinical and clinical research.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Immunology
Liu Cong, Chaoqun Chen, Shanshan Mao, Zibing Han, Zuobin Zhu, Ying Li
Summary: The morbidity and mortality of invasive fungal infections are increasing gradually, as fungi have developed stronger defense capabilities and resistance to antibiotics. Developing new drugs and strategies to combat these fungi is crucial. Recent research has shown that certain probiotics and intestinal bacteria can inhibit the invasion and colonization of fungi, providing new strategies for resisting invasive fungal infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Andrej Steyer, Dusanka Micetic-Turk, Sabina Fijan
Summary: This review summarizes the latest scientific evidence on the antiviral properties of probiotics against rotavirus gastroenteric infections in children. The study found that probiotics can shorten the duration of diarrhea by enhancing immune function and modulating intestinal microbiota. However, the effectiveness of probiotics may be influenced by factors such as dosage, duration of treatment, quality, and other factors.
Article
Biotechnology & Applied Microbiology
Tatielle Gomes Dias, Liliane dos Santos Rodrigues, Josivan Regis Farias, Ana Lucia Fernandes Pereira, Adriana Gomes Nogueira Ferreira, Marcelino Santos Neto, Richard Pereira Dutra, Aramys Silva Reis, Rosane Nassar Meireles Guerra, Valerio Monteiro-Neto, Marcia Cristina Goncalves Maciel
Summary: With the increasing resistance of bacteria to conventional antibiotics, researchers are turning to alternative strategies such as microbiota modulation to prevent and treat bacterial infections. This review examines the immunomodulatory effects of probiotics in bacterial infections based on an integrative analysis of scientific literature. The most commonly studied bacteria genera were Salmonella, Escherichia, Klebsiella, and Streptococcus, with Lactobacillus being the most frequently used probiotic genus, specifically Lactobacillus delbrueckii subsp. bulgaricus. Prophylactic treatment with probiotic concentrations equal to or greater than 8 log CFU/mL was commonly chosen, although there was heterogeneity in terms of effective treatment duration.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Food Science & Technology
Fabiana Helen Santos, Sandeep K. Panda, Danielle Cristine Mota Ferreira, Gargi Dey, Gustavo Molina, Franciele Maria Pelissari
Summary: Recently, there has been growing interest in nutraceutical compounds for the development of anti-infective and anti-inflammatory nutritional formulations. Various bio-based delivery vehicles, such as micro and nano particles, nano-emulsions, and liposome-based models, have shown potential in enhancing the bioaccessibility and bioavailability of these compounds. This review aims to provide recent information on effective nutraceuticals and suitable delivery vehicles for combating infections and inflammatory conditions.
Review
Biochemistry & Molecular Biology
Pawel Serek, Monika Oleksy-Wawrzyniak
Summary: The intestinal barrier, composed of cells, mucus, and microbiota, plays a crucial role in maintaining immune homeostasis. Disturbances in its tightness can lead to a range of issues, including systemic infections and autoimmune diseases. Zonulin, a protein found in epithelial cells, plays a key regulatory role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Monika Kumherova, Kristina Vesela, Michaela Kosova, Jaromir Masata, Sarka Horackova, Jan Smidrkal
Summary: This study focused on isolating vaginal lactobacilli from pregnant women and testing their functional properties. The results showed that L. fermentum and L. rhamnosus exhibited high antibacterial activity, while L. crispatus, L. fermentum, and L. rhamnosus showed strong anti-Candida activity. These findings suggest that these lactobacillus strains may be used in probiotic products for the treatment and prevention of vulvovaginal infections in women.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Review
Immunology
Abdul Raheem, Lin Liang, Guangzhi Zhang, Shangjin Cui
Summary: The widespread use of antibiotics can lead to a range of adverse effects, prompting the search for probiotics as alternatives. Probiotics play an important role in regulating host immune responses, with a focus on their application in infectious disease treatments garnering significant research interest.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Jose Antonio Pico-Monllor, Beatriz Ruzafa-Costas, Eva Nunez-Delegido, Pedro Sanchez-Pellicer, Javier Peris-Berraco, Vicente Navarro-Lopez
Summary: Studies have shown that certain probiotic strains can be used to prevent and improve respiratory tract infections. A combination of various probiotics can effectively strengthen the immune system of the healthy working population and reduce symptoms of upper respiratory tract infections.
Article
Infectious Diseases
Richard A. Watson
Summary: The potential role of probiotics in preventing and treating recurrent urinary tract infections has been extensively studied. However, a successful strategy has been difficult to achieve. A new targeted approach, involving the instillation of specific lactobacilli directly into the bladder, shows promise but may require a long-term campaign for clinically proven success.
Article
Microbiology
Ashraf Khalifa, Hairul-Islam Mohamed Ibrahim, Abdullah Sheikh
Summary: This study isolated potential probiotics from camel milk samples and tested them against Salmonella infection and host immune development. Three isolates (PM1, PM5, and PM6) showed significant antimicrobial activities and probiotic traits. PM5, identified as Bacillus subtilis, exhibited substantial effects in reducing Salmonella infection in a chicken model. Supplementation with probiotics can improve the growth performance of broilers and the quality of broiler chickens against enteric pathogens.
Article
Agriculture, Dairy & Animal Science
Ashraf Khalifa, Hairul Islam Mohamed Ibrahim
Summary: In this study, beneficial probiotics, specifically Enterococcus faecium, were isolated from broiler chicken carcasses and found to improve chicken health against Salmonella infections. Chickens fed with E. faecium showed improved body weight, reduced mortality, and lower levels of S. enterica. The presence of E. faecium also led to increased levels of short-chain fatty acids and reduced levels of pro-inflammatory markers. These findings highlight the potential of E. faecium as a preventive measure against bacterial infections in broiler chickens.
JOURNAL OF ANIMAL SCIENCE
(2023)
Review
Virology
Faizan Ahmed Sadiq
Summary: The prevalence of infectious diseases caused by viruses and bacteria is a global concern, impacting both health and economy. Manipulating human gut microbiota has been shown to play a significant role in immune development, homeostasis, and body metabolism, offering potential new therapeutic strategies for viral infections. Identifying and overcoming challenges in this area of research is crucial for advancing clinical practices in managing viral infections.
Article
Agriculture, Dairy & Animal Science
Sara Lomonaco, Emily J. Furumoto, Joseph R. Loquasto, Patrizia Morra, Ausilia Grassi, Robert F. Roberts
JOURNAL OF DAIRY SCIENCE
(2015)
Article
Agriculture, Dairy & Animal Science
M. Laura Rolon, Alyssa J. Bakke, John N. Coupland, John E. Hayes, Robert F. Roberts
JOURNAL OF DAIRY SCIENCE
(2017)
Article
Gastroenterology & Hepatology
Tina P. Tan, Zhaoyong Ba, Mary E. Sanders, Frank J. D'Amico, Robert F. Roberts, Keisha H. Smith, Daniel J. Merenstein
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2017)
Article
Agriculture, Dairy & Animal Science
M. Tran, R. Roberts, T. L. Felix, F. M. Harte
JOURNAL OF DAIRY SCIENCE
(2018)
Article
Biotechnology & Applied Microbiology
Joseph R. Loquasto, Rodolphe Barrangou, Edward G. Dudley, Buffy Stahl, Chun Chen, Robert F. Roberts
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2013)
Article
Nutrition & Dietetics
Daniel J. Merenstein, Frank D'Amico, Caren Palese, Alexander Hahn, Jessy Sparenborg, Tina Tan, Hillary Scott, Kayla Polzin, Lore Kolberg, Robert Roberts
BRITISH JOURNAL OF NUTRITION
(2014)
Article
Agriculture, Dairy & Animal Science
Meriel L. Harwood, Joseph R. Loquasto, Robert F. Roberts, Gregory R. Ziegler, John E. Hayes
JOURNAL OF DAIRY SCIENCE
(2013)
Article
Agriculture, Dairy & Animal Science
Grace L. Voronin, Robert Roberts, Tara L. Felix, John N. Coupland, Federico M. Harte
JOURNAL OF DAIRY SCIENCE
(2020)
Article
Biochemical Research Methods
Dennis L. Welker, Bailey L. Crowley, Justin B. Evans, Martin H. Welker, Jeff R. Broadbent, Robert F. Roberts, David A. Mills
JOURNAL OF MICROBIOLOGICAL METHODS
(2020)
Article
Agriculture, Dairy & Animal Science
G. L. Voronin, G. Ning, J. N. Coupland, R. Roberts, F. M. Harte
Summary: High-pressure-jet processing can alter the physiochemical properties of low-fat ice cream by changing the density, particle size, rheological behavior, hardness, and melting rate. This treatment disrupts casein micelles and fat droplets, leading to unique microstructures and potentially enhanced properties of the ice cream.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
M. Tran, G. Lewis Voronin, R. F. Roberts, J. N. Coupland, G. R. Ziegler, F. M. Harte
Summary: Thermally treated fat-free chocolate milk formulations were processed using high-pressure jet (HPJ) technology, resulting in increased stability and viscosity, as well as shear-thinning behavior. The addition of micellar casein together with HPJ processing at 500 MPa showed the highest stability and viscosity, providing a processing alternative for clean-label, stable chocolate milk.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Nutrition & Dietetics
Daniel Merenstein, Claire M. Fraser, Robert F. Roberts, Tian Liu, Silvia Grant-Beurmann, Tina P. Tan, Keisha Herbin Smith, Tom Cronin, Olivia A. Martin, Mary Ellen Sanders, Sean C. Lucan, Maureen A. Kane
Summary: Probiotic Bifidobacterium animalis subsp. lactis BB-12 demonstrates protection against antibiotic-induced disruptions in gut microbiota and short-chain fatty acids, enhancing microbial recovery. Compared to the control group, the BB-12 group showed smaller changes in fecal acetate levels and less loss in gut microbiota diversity after antibiotic treatment.
Article
Food Science & Technology
Helene Hopfer, Alden C. Riak, Robert F. Roberts, John E. Hayes, Gregory R. Ziegler
Summary: This study investigates the synergistic and antagonistic interactions between sucrose, vanillin, and cocoa powder in chocolate milk. The results show that these ingredients can work together to enhance sweetness and suppress bitterness. This finding provides a potential strategy for reducing added sugar content in chocolate milk while maintaining consumer acceptability.
JOURNAL OF SENSORY STUDIES
(2022)
Review
Education, Scientific Disciplines
Alexandra O. Santau, Ruth S. MacDonald, Robert R. Roberts
JOURNAL OF FOOD SCIENCE EDUCATION
(2020)
Article
Food Science & Technology
Gloria Wang, John E. Hayes, Gregory R. Ziegler, Robert E. Roberts, Helene Hopfer