The osteoclast, bone remodelling and treatment of metabolic bone disease

Bone Modeling and Remodeling

(2012) Ego Seeman   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Osteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption

(2012) Brendan Boyce et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Inhibition of Cathepsin K for Treatment of Osteoporosis

(2012) Steven Boonen et al.   Current Osteoporosis Reports

Targeting sclerostin as potential treatment of osteoporosis

(2011) S. E. Papapoulos   ANNALS OF THE RHEUMATIC DISEASES

Effects of ONO-5334, a novel orally-active inhibitor of cathepsin K, on bone metabolism

(2011) Yasuo Ochi et al.   BONE

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

(2011) K. Henriksen et al.   ENDOCRINE REVIEWS

Lineage-committed osteoclast precursors circulate in blood and settle down into bone

(2011) Akinori Muto et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study

(2011) Richard Eastell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

(2011) Alexander David Barrow et al.   JOURNAL OF CLINICAL INVESTIGATION

The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorption

(2011) David J Mellis et al.   JOURNAL OF ENDOCRINOLOGY

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Suppression of bone formation by osteoclastic expression of semaphorin 4D

(2011) Takako Negishi-Koga et al.   NATURE MEDICINE

Regulation of bone by the adaptive immune system in arthritis

(2011) Kazuo Okamoto et al.   ARTHRITIS RESEARCH & THERAPY

Biochemical and molecular mechanisms of action of bisphosphonates

(2010) Michael J. Rogers et al.   BONE

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

(2010) David E. Hughes et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Parathyroid Hormone-Related Protein for the Treatment of Postmenopausal Osteoporosis: Defining the Maximal Tolerable Dose

(2010) Mara J. Horwitz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

(2010) Masaru Ishii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Strontium Ranelate Decreases Receptor Activator of Nuclear Factor- B Ligand-Induced Osteoclastic Differentiation In Vitro: Involvement of the Calcium-Sensing Receptor

(2010) A. Caudrillier et al.   MOLECULAR PHARMACOLOGY

How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis

(2010) P. J. Marie et al.   OSTEOPOROSIS INTERNATIONAL

Cellular mechanisms of bone remodeling

(2010) Erik Fink Eriksen   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis

(2010) Junichi Kikuta et al.   RHEUMATOLOGY INTERNATIONAL

T Lymphocytes Amplify the Anabolic Activity of Parathyroid Hormone through Wnt10b Signaling

(2009) Masakazu Terauchi et al.   Cell Metabolism

Intermittent PTH Administration Stimulates Pre-Osteoblastic Proliferation Without Leading to Enhanced Bone Formation in Osteoclast-Lessc-fos−/−Mice

(2009) Paulo Henrique Luiz de Freitas et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: A randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial

(2009) Rosemary A Hannon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

(2009) Masaru Ishii et al.   NATURE

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

(2009) Steven R. Cummings et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Osteoclasts secrete non-bone derived signals that induce bone formation

(2008) Morten A. Karsdal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bone density, strength, and formation in adult cathepsin K (−/−) mice

(2008) B. Pennypacker et al.   BONE

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL

Advances in osteoclast biology resulting from the study of osteopetrotic mutations

(2008) T. Segovia-Silvestre et al.   HUMAN GENETICS

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

(2008) L. Pederson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical properties and regulation of cathepsin K activity

(2007) Fabien Lecaille et al.   BIOCHIMIE

Genetics, pathogenesis and complications of osteopetrosis

(2007) Andrea Del Fattore et al.   BONE

Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts

(2007) Karen Fuller et al.   BONE