How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis

Strontium ranelate improves implant osseointegration

(2010) Laurent Maïmoun et al.   BONE

Essential Role of Nuclear Factor of Activated T Cells (NFAT)-mediated Wnt Signaling in Osteoblast Differentiation Induced by Strontium Ranelate

(2010) Olivia Fromigué et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration

(2010) Georges Boivin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats

(2010) Pierre J. Marie et al.   JOURNAL OF BONE AND MINERAL RESEARCH

In vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells

(2010) Songlin Peng et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis

(2010) René Rizzoli et al.   RHEUMATOLOGY INTERNATIONAL

Long-term treatment of postmenopausal osteoporosis with strontium ranelate: Results at 8 years

(2009) J.Y. Reginster et al.   BONE

Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age

(2009) Ego Seeman et al.   BONE

Osteoblasts play key roles in the mechanisms of action of strontium ranelate

(2009) TC Brennan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Strontium Ranelate Enhances Callus Strength More Than PTH 1-34 in an Osteoporotic Rat Model of Fracture Healing

(2009) Bjoern Habermann et al.   CALCIFIED TISSUE INTERNATIONAL

Comparative Effects of Teriparatide and Strontium Ranelate on Bone Biopsies and Biochemical Markers of Bone Turnover in Postmenopausal Women With Osteoporosis*

(2009) Robert R Recker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate

(2009) Olivia Fromigué et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Monitoring strontium ranelate therapy in patients with osteoporosis

(2009) D. L. Kendler et al.   OSTEOPOROSIS INTERNATIONAL

Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 years

(2009) O. Bruyère et al.   OSTEOPOROSIS INTERNATIONAL

Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis

(2009) P. J. Meunier et al.   OSTEOPOROSIS INTERNATIONAL

Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial

(2008) Jean-Yves Reginster et al.   ARTHRITIS AND RHEUMATISM

Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms

(2008) Joseph Caverzasio   BONE

The Calcium-sensing Receptor Is Involved in Strontium Ranelate-induced Osteoclast Apoptosis

(2008) Anne S. Hurtel-Lemaire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response

(2008) G. J. Atkins et al.   OSTEOPOROSIS INTERNATIONAL

Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants

(2008) S. D. Bain et al.   OSTEOPOROSIS INTERNATIONAL

Strontium ranelate does not stimulate bone formation in ovariectomized rats

(2008) R. K. Fuchs et al.   OSTEOPOROSIS INTERNATIONAL

Calculating clinically relevant drug doses to use in animal studies

(2008) R. K. Fuchs et al.   OSTEOPOROSIS INTERNATIONAL

New Insights in Bone Biology: Unmasking Skeletal Effects of the Extracellular Calcium-Sensing Receptor

(2008) E. M. Brown et al.   Science Signaling

The Extracellular Calcium-Sensing Receptor (CaSR) Is a Critical Modulator of Skeletal Development

(2008) W. Chang et al.   Science Signaling

Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro

(2007) Edith Bonnelye et al.   BONE