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Cell Biology
Jelena Ostojic, Young-Sil Yoon, Tim Sonntag, Billy Nguyen, Joan M. Vaughan, Maxim Shokhirev, Marc Montminy
Summary: The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and CRTC1-3. In melanoma cells, CRTC3 deficiency leads to impaired differentiation and melanosome maturation. CRTC3 interacts with CREB to stimulate OCA2 expression, affecting pigmentation and melanoma risk, and is activated by ERK1/2 signaling.
Article
Biochemistry & Molecular Biology
Vinay Kumar Sharma, Xuyu Yang, Soo-Kyung Kim, Amirhossein Mafi, Daniel Saiz-Sanchez, Patricia Villanueva-Anguita, Lan Xiao, Asuka Inoue, William A. Goddard, Y. Peng Loh
Summary: Interaction between NF-alpha 1/CPE and 5-HTR1E activates the beta-arrestin/ERK/CREB/BCL2 pathway to protect neurons from oxidative stress and neuroexcitotoxicity, preventing cognitive dysfunction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Xiang-Yu Meng, Hui-Zhi Zhang, Yi-Yue Ren, Ke-Jie Wang, Jun-Feng Chen, Rui Su, Jun-Hui Jiang, Ping Wang, Qi Ma
Summary: PNN was found to be upregulated in prostate cancer tissues and play a crucial role in promoting cell growth, invasion, and migration through the activation of CREB. The effects of PNN on prostate cancer cells were mediated by the PI3K/AKT and ERK/MAPK pathways, indicating that PNN could be a potential therapeutic target for prostate cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ling Zhu, Yan-Yu Zhou, Zhi Zhang, Su-Qing Yin, Dong-Dong Lv, Yu-Ling Wu, Bao-Shan Wang, Meng-Han Mao, Ying-Fu Jiao, Wei-Feng Yu, Po Gao, Li-Qun Yang
Summary: Remifentanil enhances liver regeneration by promoting hepatocyte proliferation rather than anti-inflammatory effects. This effect was confirmed both in vitro and in vivo, and the underlying mechanism may involve the beta-arrestin 2/ERK/cyclin D1 axis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xiaoqin Zhang, Wenqian Zhou, Yangyang Niu, Saiya Zhu, Yingying Zhang, Xiaogang Li, Chen Yu
Summary: Lysyl oxidase (LOX) plays an essential role in renal fibrosis by catalyzing collagen over cross-linking. Increased LOX expression leads to deposition and cross-linking of collagen. LOX is regulated by the beta-arrestin-ERK-STAT3 pathway. Inhibition of LOX improves renal fibrosis.
Review
Biochemistry & Molecular Biology
Kiae Kim, Yeonjin Han, Longhan Duan, Ka Young Chung
Summary: Beta-arrestins are proteins initially identified for desensitizing and internalizing G-protein-coupled receptors (GPCRs). By scaffolding MAPK signaling components, beta-arrestins initiate a second wave of signaling, promoting the activation of ERK1/2 or JNK3. Understanding the molecular and structural mechanisms of beta-arrestin-mediated MAPK scaffolding assembly is crucial for understanding GPCR-mediated MAPK activation and selectively regulating the MAPK signaling cascade for therapeutic purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Changxiu Qu, Ji Young Park, Min Woo Yun, Qing-Tao He, Fan Yang, Kiae Kim, Donghee Ham, Rui-Rui Li, T. M. Iverson, Vsevolod V. Gurevich, Jin-Peng Sun, Ka Young Chung
Summary: Arrestins play a role in homologous desensitization and internalization of G protein-coupled receptors, and can also initiate signaling by interacting with other proteins. They scaffold MAPK signaling cascades and facilitate the activation of specific proteins through this scaffolding mechanism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Elisavet Lioulia, Panagiotis Mokos, Emmanuel Panteris, Dimitra Dafou
Summary: This study demonstrates the UBE2T/MAPK-ERK/beta-catenin axis as a critical regulator of cell state transition and EMT in HCC.
MOLECULAR ONCOLOGY
(2022)
Article
Toxicology
Jinping Shao, Wenli Yu, Wei Wei, Suifeng Wang, Zhenli Zheng, Lei Li, Yanyan Sun, Jingjing Zhang, Zhihua Li, Xiuhua Ren, Weidong Zang, Jing Cao
Summary: This study used multiple experimental methods to prove the involvement of the MAPK-ERK-CREB signaling pathway in the regulation of Nav1.6 and revealed its mechanism in oxaliplatin-induced neuropathic pain.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Berna Guven, Arzu Onay-Besikci
Summary: This review focuses on the role of beta arrestins in mediating metabolic modulation, particularly in relation to insulin signaling. It is suggested that beta arrestins play a regulatory role in insulin secretion and action, making them potential targets for therapeutic intervention in metabolic disorders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Hyungyeong Choi, Jeong-Hyun Yoon, Kumju Youn, Mira Jun
Summary: This study investigated the anti-melanogenic effects of decursin and its underlying mechanism. Decursin was found to inhibit melanin synthesis and exert its effects through the regulation of MITF and multiple signaling pathways. The anti-melanogenic effects of decursin were confirmed in ex vivo 3D human skin models, suggesting its potential as a protective agent against hyperpigmentation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Sabyasachi Maity, Raman Abbaspour, David Nahabedian, Steven A. Connor
Summary: The noradrenergic system plays a crucial role in memory formation and synaptic plasticity. Norepinephrine stimulates beta-ARs to regulate memory formation and affects neural circuit function through epigenetic modifications. Understanding these mechanisms is essential for studying brain disorders and developing neurotherapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xin Wen, Geng Hu, Xue Xiao, Xinzhi Zhang, Qiang Zhang, Hengjun Guo, Xianyao Li, Qingxin Liu, Haifang Li
Summary: FGF2 inhibits mineralization of bone marrow stromal cells by up-regulating osteoclastogenesis gene expression, while enhancing osteoclast development through the ERK-CREB pathway. This highlights the potential of FGF2/ERK/CREB inhibitors in treating bone-related disorders like osteoporosis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Neurosciences
Jeniffer Sanguino-Gomez, Jacobus C. Buurstede, Oihane Abiega, Carlos P. Fitzsimons, Paul J. Lucassen, Bart J. L. Eggen, Sylvie L. Lesuis, Onno C. Meijer, Harm J. Krugers
Summary: Stressful experiences can lead to increased levels of noradrenaline and glucocorticoid hormones in the brain, affecting the interaction between microglia and neurons, impairing neuronal function and learning memory, and triggering immune response-related effects that impair memory and synaptic plasticity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Dae-Kyum Kim, Jin-Won Huh, Hyeonseung Yu, Yeji Lee, Yongxin Jin, Un-Hwan Ha
Summary: This study investigated the impact of DnaJ on IL-1 beta expression in macrophages and found that DnaJ modulates macrophages to secrete IL-1 beta by activating NF-kappa B and MAPK signaling pathways. ERK was identified as a positive mediator for IL-1 beta expression, while p38 acted as a negative mediator. Furthermore, the reciprocal actions of MAPKs were found to regulate the activation of inflammasome-related molecules. The study also explored the involvement of CD91/CD40 in ERK signaling-mediated IL-1 beta production from DnaJ-treated macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Bavat Bornstein, Eitan Erez Zahavi, Sivan Gelley, Maayan Zoosman, Shiri Penina Yaniv, Ora Fuchs, Ziv Porat, Eran Perlson, Oren Schuldiner
Article
Biochemistry & Molecular Biology
Dana Rabinovich, Shiri P. Yaniv, Idan Alyagor, Oren Schuldiner
Article
Developmental Biology
Shiri P. Yaniv, Oren Schuldiner
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Shiri P. Yaniv, Noa Issman-Zecharya, Meital Oren-Suissa, Benjamin Podbilewicz, Oren Schuldiner
Article
Clinical Neurology
Alexandra Kavushansky, Milli Kritman, Mouna Maroun, Ehud Klein, Gal Richter-Levin, Koon-Sea Hui, Dorit Ben-Shachar
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Clinical Neurology
Bella Smolin, Rachel Karry, Shunit Gal-Ben-Ari, Dorit Ben-Shachar
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2012)
Article
Clinical Neurology
Hanoch Kaphzan, Dorit Ben-Shachar, Ehud Klein
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Eli Shulman, Valery Belakhov, Gao Wei, Ann Kendall, Esther G. Meyron-Holtz, Dorit Ben-Shachar, Jochen Schacht, Timor Baasov
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Clinical Neurology
Anat Lucki, Ehud Klein, Rachel Karry, Dorit Ben-Shachar
JOURNAL OF NEURAL TRANSMISSION
(2014)
Article
Biochemistry & Molecular Biology
O. Robicsek, R. Karry, I. Petit, N. Salman-Kesner, F-J Mueller, E. Klein, D. Aberdam, D. Ben-Shachar
MOLECULAR PSYCHIATRY
(2013)
Article
Multidisciplinary Sciences
Yaniv Hakim, Shiri P. Yaniv, Oren Schuldiner
Article
Endocrinology & Metabolism
Eyal Asor, Hila Belhanes, Alexandra Kavushansky, Salman Zubedat, Ehud Klein, Avi Avital, Dorit Ben-Shachar
PSYCHONEUROENDOCRINOLOGY
(2013)
Article
Cell & Tissue Engineering
I. Petit, N. Salman Kesner, R. Karry, O. Robicsek, E. Aberdam, F. J. Mueller, D. Aberdam, D. Ben-Shachar
STEM CELL RESEARCH
(2012)
Article
Cell Biology
Shiri P. Yaniv, Hagar Meltzer, Idan Alyagor, Oren Schuldiner
JOURNAL OF CELL BIOLOGY
(2020)
Article
Psychiatry
Eyal Asor, Dorit Ben-Shachar
WORLD JOURNAL OF PSYCHIATRY
(2012)
Article
Cell Biology
Mohamed Kodiha, Nabila Azad, Siwei Chu, Noah Crampton, Ursula Stochaj
Summary: This study reveals that oxidative stress induces the nuclear accumulation of RanBP1 and the signaling pathways mediated by EGFR and PKA play a role in regulating RanBP1 localization during stress. RanBP1 acts as a downstream effector of these signaling routes, positioning it at the intersection of important cellular signaling circuits.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2024)