Article
Medicine, General & Internal
Ronald Peek, Lotte L. Eijkenboom, Didi D. M. Braat, Catharina C. M. Beerendonk
Summary: Short-term exposure to Everolimus has been shown to effectively eliminate Ewing's sarcoma tumor foci in ovarian tissue without causing harm to follicle morphology, survival, or early folliculogenesis. This suggests that pharmacological ex vivo purging of ovarian cortex tissue from contaminating ES tumor foci before autotransplantation may reduce the risk of reintroducing malignancy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Matthew T. T. Houdek, Mark J. J. Heidenreich, Safia K. K. Ahmed, Wendy Allen-Rhoades, Brittany L. L. Siontis, Steven I. I. Robinson, Ivy A. A. Petersen, Peter S. S. Rose
Summary: The study evaluated the treatment experience of EES patients and found that chemotherapy and surgery can achieve excellent local control.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
J. H. Kim, S. H. Kim, M. K. Jeon, J. E. Kim, K. H. Kim, K. -H. Yun, H. -C. Jeung, S. Y. Rha, J. -H. Ahn, H. S. Kim
Summary: Combination therapy with pemetrexed and cisplatin showed clinically meaningful and sustained responses among patients with advanced and refractory soft tissue sarcomas, meeting its predefined primary study endpoint.
Article
Obstetrics & Gynecology
Stine Gry Kristensen, Yu Wakimoto, Lotte Berdiin Colmorn, Margit Dueholm, Susanne Elisabeth Pors, Kirsten Tryde Macklon, Linn Salto Mamsen, Dmitry Nikiforov, Jesus Cadenas, Vinnie Hornshoj Greve, Anne-Mette Bay Bjorn, Mikkel Rosendahl, Anette Tonnes Pedersen, Anders Nyboe Andersen, Jens Fedder, Erik Ernst, Claus Yding Andersen
Summary: This study evaluated the use of cryopreserved ovarian tissue in the Danish fertility preservation cohort, revealing that OTT rates depended on diagnosis, age at OTC, and follow-up time. Longer follow-up is needed, especially for younger girls.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
Xin Sun, Jie Xu, Lu Xie, Wei Guo
Summary: This study aimed to investigate the effectiveness and tolerability of anlotinib plus PD-1 inhibitors for previously treated metastatic soft tissue sarcoma patients. The results showed that this combination therapy demonstrated durable and promising efficacy and tolerable safety in real-world settings.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Marie-Madeleine Dolmans, Michael von Wolff, Catherine Poirot, Cesar Diaz-Garcia, Luciana Cacciottola, Nicolas Boissel, Jana Liebenthron, Antonio Pellicer, Jacques Donnez, Claus Yding Andersen
Summary: The feasibility of freezing and thawing ovarian tissue is well-documented, but ovarian tissue transplantation is progressing at a slower pace with limited clinical experience. Results from five European centers show a low risk of relapse with ovarian tissue reimplantation and successful recovery of endocrine function in most patients, although in vitro fertilization efficacy needs improvement. Chemotherapy before ovarian tissue cryopreservation does not significantly affect success rates. Further research is needed to optimize the approach for ovarian tissue transplantation.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Debra Gook, Lyndon Hale, Alex Polyakov, Tom Manley, Genia Rozen, Kate Stern
Summary: The study found that transplanting cryopreserved ovarian tissue to a sub-peritoneal abdominal site resulted in similar outcomes compared to transplantation to the ovary and pelvic area. This suggests that the sub-peritoneal abdominal site may be a suitable alternative for ovarian tissue transplantation when pelvic sites are contraindicated. The ease of oocyte retrieval at the sub-peritoneal abdominal site also has positive implications for clinical practice.
HUMAN REPRODUCTION
(2021)
Review
Oncology
Antonia Digklia, Ana Dolcan, Monika A. Kucharczyk, Robin L. Jones, Andrea Napolitano
Summary: Ewing sarcoma is a rare and highly malignant sarcoma that primarily affects young individuals but can occur at any age. It most commonly occurs in the long bones of the extremities and pelvis, but can also occur in soft tissues in older patients. There is currently no standard surveillance schedule for adult patients with Ewing sarcoma after initial treatment, leading to challenges in detecting recurrence and managing long-term side effects. This review aims to summarize available data on treatment-associated complications in long-term survivors and provide recommendations for optimizing follow-up and managing sequelae.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Oncology
Erik Stricker, Damon R. Reed, Matthew B. Schabath, Pagna Sok, Michael E. Scheurer, Philip J. Lupo
Summary: This study analyzed data from 2570 patients treated at the Moffitt Cancer Center between 1986 and 2014 to evaluate the impact of various factors on the overall survival of individuals with soft tissue or bone sarcomas. The study found poorer survival rates in older adults, current smokers, patients with cancer metastasis, and patients not receiving first-line surgery treatment. There was an overall improvement in survival over time, with gastrointestinal stromal tumors experiencing the most significant improvement. The study provides important findings for sarcoma research and emphasizes the need for further research on survivorship barriers.
Review
Oncology
Hanrui Wang, Jianwei Wang, Qiang Wang, Yujuan Yang, Jing Guo, Chao Ren, Yakui Mou, Chuanliang Jia, Xicheng Song
Summary: This article reports a case of laryngeal Ewing sarcoma, in which immunohistochemistry diagnosis method and DC-CTL immunotherapy were used. The patient showed no signs of recurrence or metastasis after seven years.
FRONTIERS IN ONCOLOGY
(2022)
Review
Obstetrics & Gynecology
Lotte Eijkenboom, Emma Saedt, Carlijn Zietse, Didi Braat, Catharina Beerendonk, Ronald Peek
Summary: This systematic review provides an overview of the experimental strategies for using cryopreserved human ovarian tissue to restore fertility after cancer, including in-vitro maturation of oocytes, constructing an artificial ovary, purging strategies, xenotransplantation for oocyte maturation, and stem cell-based oogenesis. Although these strategies are still under development and have not reached clinical trials, they may offer safe fertility restoration options for oncological patients in the future.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Oncology
Sarah Watson, Benjamin Verret, Stanislas Ropert, Julien Adam, Rastislav Bahleda, Sylvain Briand, Andrea Cavalcanti, Ali N. Chamseddine, Charles Court, Elie Fadel, Matthieu Faron, Leila Haddag-Miliani, Clemence Henon, Cecile Le Pechoux, Antonin Levy, Olaf Mercier, Carine Ngo, Charles Honore, Axel Le Cesne, Olivier Mir
Summary: The activity of single-agent gemcitabine in advanced angiosarcoma was evaluated in this study. The results showed that gemcitabine had clinically meaningful activity, especially in cardiac angiosarcoma and patients who had received prior treatments.
Article
Endocrinology & Metabolism
Linn Salto Mamsen, Stine Gry Kristensen, Susanne Elisabeth Pors, Jane Alro Botkjaer, Erik Ernst, Kirsten Tryde Macklon, Debra Gook, Ajay Kumar, Bhanu Kalra, Claus Yding Andersen
Summary: This study evaluated the ovarian tissue of girls with BT and SCD who underwent OTC before age 18, finding that their follicle numbers and health were similar to a reference group with normal ovaries. OTC should be considered as an option for fertility preservation in young girls and adolescents with BT and SCD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Ahmed Mohammed Morsy, Salah Abdel-Hadi, Khalid Mohammed Rezk, Gamal Amira, Badawy Mohammed Ahmed, Marwa Tammam Hussien, Mahmoud Gamal Ameen, Hosam Eldein Mostafa Kamel, Doaa Mohamed Fouad, Alia Mohamed Attia, Asmaa Salah, Osama Mostafa Abd Elbadee, Ayatallah Ali Yousseif, Marwa Ismail Abdelgawad, Asmaa Hussein Fathy, Yasmine Nagy Elwany, Islam Karam-Allah Ramadan, Khaled Hassan Mosallam, Ahmed Ibrahim Abd Elwahab, Khaled Hashim Mahmoud, Maged Abdel Fattah Amine, Ahmed Refaat Abd Elzaher, Hanan Ahmed Eltyb, Ahmed Mubarak Hefni
Summary: This study aimed to evaluate the survival outcomes of Ewing sarcoma in Upper Egypt and identify factors of prognostic significance, showing that metastatic disease, surgery used as a local modality, response to neoadjuvant chemotherapy, and primary tumor size were significantly associated with overall survival. While the 5-year overall survival rate was comparable to previous studies in Egypt, outcomes in Egypt still lag behind internationally published studies due to differences in study samples among research centers.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Yuhua Wang, Ram Naresh Pandey, Kaushik Roychoudhury, David Milewski, Tanya Kalin, Sara Szabo, Joseph G. Pressey, Rashmi S. Hegde
Summary: Loss of EYA3 or pharmacologic inhibition of the EYA3 tyrosine phosphatase activity inhibits tumor growth and angiogenesis in Ewing sarcoma. EYA3 regulates VEGFA levels in Ewing tumors, promotes DNA damage repair and survival of Ewing sarcoma tumor cells. Target engagement is demonstrated in tumor tissue through elevated levels of the EYA3 substrate H2AX-pY142 upon loss of EYA3 or with Benzarone treatment.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Genetics & Heredity
M. McLaughlin, T. W. Kelsey, W. H. B. Wallace, R. A. Anderson, E. E. Telfer
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2015)
Editorial Material
Oncology
W. Hamish Wallace
Review
Oncology
Saro H. Armenian, Melissa M. Hudson, Renee L. Mulder, Ming Hui Chen, Louis S. Constine, Mary Dwyer, Paul C. Nathan, Wim J. E. Tissing, Sadhna Shankar, Elske Sieswerda, Rod Skinner, Julia Steinberger, Elvira C. van Dalen, Helena van der Pal, W. Hamish Wallace, Gill Levitt, Leontien C. M. Kremer
Article
Endocrinology & Metabolism
Emily S. Tonorezos, Melissa M. Hudson, Angela B. Edgar, Leontien C. Kremer, Charles A. Sklar, W. Hamish B. Wallace, Kevin C. Oeffinger
LANCET DIABETES & ENDOCRINOLOGY
(2015)
Article
Endocrinology & Metabolism
Richard A. Anderson, Rod T. Mitchell, Thomas W. Kelsey, Norah Spears, Evelyn E. Telfer, W. Hamish B. Wallace
LANCET DIABETES & ENDOCRINOLOGY
(2015)
Article
Medicine, General & Internal
Matteo Lambertini, Lucia Del Mastro, Maria C. Pescio, Claus Y. Andersen, Hatem A. Azim, Fedro A. Peccatori, Mauro Costa, Alberto Revelli, Francesca Salvagno, Alessandra Gennari, Filippo M. Ubaldi, Giovanni B. La Sala, Cristofaro De Stefano, W. Hamish Wallace, Ann H. Partridge, Paola Anserini
Article
Obstetrics & Gynecology
W. Hamish B. Wallace, Thomas W. Kelsey, Richard A. Anderson
FERTILITY AND STERILITY
(2016)
Article
Oncology
D. H. Brewster, D. Clark, L. Hopkins, J. Bauer, S. H. Wild, A. B. Edgar, W. H. Wallace
BRITISH JOURNAL OF CANCER
(2014)
Review
Oncology
Stine D. Sorensen, Tine Greve, Vera Timmermans Wielenga, W. Hamish B. Wallace, Claus Yding Andersen
Article
Obstetrics & Gynecology
R. A. Anderson, M. McLaughlin, W. H. B. Wallace, D. F. Albertini, E. E. Telfer
HUMAN REPRODUCTION
(2014)
Article
Multidisciplinary Sciences
Thomas W. Kelsey, Lucy Q. Li, Rod T. Mitchell, Ashley Whelan, Richard A. Anderson, W. Hamish B. Wallaces
Article
Medicine, General & Internal
Marsida Hutka, Lee B. Smith, Ellen Goossens, W. Hamish B. Wallace, Jan-Bernd Stukenborg, Rod T. Mitchell
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Renee L. Mulder, Melissa M. Hudson, Smita Bhatia, Wendy Landier, Gill Levitt, Louis S. Constine, W. Hamish Wallace, Flora E. van Leeuwen, Cecile M. Ronckers, Tara O. Henderson, Chaya S. Moskowitz, Danielle N. Friedman, Andrea K. Ng, Helen C. Jenkinson, Charlotte Demoor-Goldschmidt, Roderick Skinner, Leontien C. M. Kremer, Kevin C. Oeffinger
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Obstetrics & Gynecology
Kathleen Duffin, Ruth Howie, Tom W. Kelsey, Hamish B. Wallace, Richard A. Anderson
Summary: The Edinburgh Selection Criteria accurately identify female cancer patients under the age of 18 who are at risk of premature ovarian insufficiency (POI) and can be candidates for ovarian tissue cryopreservation (OTC). Long-term follow-up is necessary to ensure the appropriate use of OTC, as it is not without risk.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Katja C. E. Drechsel, Maxime C. F. Pilon, Francis Stoutjesdijk, Salena Meivis, Linda J. Schoonmade, William Hamish B. Wallace, Eline van Dulmen-den Broeder, Auke Beishuizen, Gertjan J. L. Kaspers, Simone L. Broer, Margreet A. Veening
Summary: This narrative review summarized existing literature on reproductive function in young Hodgkin lymphoma survivors. The results showed that female survivors had a high incidence of premature ovarian insufficiency, while male survivors often experienced post-treatment azoospermia. Higher doses of chemotherapeutic agents and pelvic radiotherapy were associated with impaired reproductive ability.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)
