Review
Endocrinology & Metabolism
Lin Chen, Zirui Dong, Xiaoyan Chen
Summary: Survival rates for children and adolescents with malignancy have increased due to advances in oncology treatments, but these treatments can have toxic effects on the reproductive organs. Cryopreservation of oocytes and sperm is recognized as an effective strategy for preserving fertility in pubertal patients, while the use of hormonal agonists for ovarian protection is controversial. Ovarian tissue cryopreservation is the only option for prepubertal girls, but the outcomes after transplantation are varied. Immature testicular tissue cryopreservation is experimental for prepubertal boys. Guidelines for fertility preservation exist, but implementation in clinical practice is limited. This review aims to discuss indications, outcomes, and workflow for fertility preservation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Marcos Eiji Shiroma, Luciana Lamarao Damous, Fernanda Pereira Cotrim, Cristiane Lima Roa, Jose Cipolla-Neto, Russel Joseph Reiter, Edmund Chada Baracat, Jose Maria Soares Jr
Summary: Melatonin pretreatment improves the quality of rat ovarian grafts by promoting the restart of the estrous cycle, increasing the expression of various key proteins in the ovaries, and reducing apoptosis levels. Further studies on reproductive function enhancement are warranted based on these findings.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiangyan Ruan, Jiaojiao Cheng, Juan Du, Fengyu Jin, Muqing Gu, Rui Ju, Yurui Wu, Long Li, Yuejiao Wang, Lingling Jiang, Yu Yang, Yanqiu Li, Zecheng Wang, Jun Ma, Mingzhen Zhang, Alfred O. Mueck
Summary: This study retrospectively analyzed children with rare diseases who underwent ovarian tissue cryopreservation (OTC) in China's first and largest ovarian tissue cryobank. The results showed no significant difference in OTC outcomes between rare disease patients and age-matched children with non-rare diseases. The findings provide valuable information for counseling girls with rare diseases about fertility preservation and indicate the increasing demand for OTC in pediatrics.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiangyan Ruan, Jiaojiao Cheng, Juan Du, Fengyu Jin, Muqing Gu, Yanglu Li, Rui Ju, Yurui Wu, Huanmin Wang, Wei Yang, Haiyan Cheng, Long Li, Wenpei Bai, Weimin Kong, Xin Yang, Shulan Lv, Yuejiao Wang, Yu Yang, Xin Xu, Lingling Jiang, Yanqiu Li, Alfred O. Mueck
Summary: This study investigates the effectiveness and feasibility of ovarian tissue cryopreservation (OTC) in children facing gonadotoxicity treatment. The results suggest that OTC is a safe and effective method for preserving the fertility of prepubertal girls, and chemotherapy does not affect the effectiveness of OTC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Seido Takae, Yuriko Iwahata, Yodo Sugishita, Hideyuki Iwahata, Ryo Kanamori, Eriko Shiraishi, Kaoru Ito, Yuki Suzuki, Yoshiko Yamaya, Kunihide Tanaka, Kei Oyama, Dai Keino, Kentaro Nakamura, Kei Odawara, Yuki Horage, Lingbo Meng, Arby Igualada, Ahmad Mohd Faizal, Ludmilla Ogouma Aworet, Shigeyuki Furuta, Miki Sakamoto, Tetsuya Mori, Hiroaki Kitagawa, Nao Suzuki
Summary: A questionnaire survey was conducted to investigate the understanding and awareness of fertility preservation (FP) in pediatric patients. The results showed that most children understood that the treatment would affect their fertility, and 88.9% expressed understanding for FP and wished to receive it. Concerns about FP mainly focused on fear, pain, and costs. Children expressed satisfaction and happiness after being provided with information about FP treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Alla Vash-Margita, Katarzyna Szymanska-Vandendriessche, Kathryn Gunther, David F. Rodriguez-Buritica, Emily Christison-Lagay, Saurabh Saluja, Kutluk H. Oktay
Summary: This article describes an approach to fertility preservation through ovarian tissue harvesting and cryopreservation for a toddler with galactosemia. The authors highlight the importance of intervention for early preservation of fertility in patients with progressive primary ovarian insufficiency associated with galactosemia. A multidisciplinary team is involved in the procedure, including reproductive endocrinology and infertility specialists, pediatric gynecologists and surgeons, and genetics experts.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Marine Grellet-Grun, Beatrice Delepine, Pauline Le Van Quyen, Gerlinde Averous, Anne Durlach, Cecile Greze, Laetitia Ladureau-Fritsch, Isabelle Lichtblau, Anne-Sophie Canepa, Antoine Line, Catherine Paillard, Claire Pluchart, Olivier Pirrello, Catherine Rongieres, Ghassan Harika, Francois Becmeur, Marius Teletin
Summary: Ovarian tissue cryopreservation (OTC) is an effective fertility preservation option for pediatric patients undergoing gonadotoxic therapies. A retrospective study in France showed that the most common indication for OTC in children was stem cell transplantation. The number of ovarian tissue fragments collected during surgery was correlated with patient age, and the long-term follow-up revealed a high survival rate but a significant proportion of patients with premature ovarian insufficiency (POI).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ashley A. Diaz, Hana Kubo, Nicole Handa, Maria Hanna, Monica M. Laronda
Summary: Ovarian tissue cryopreservation is the only option for preserving fertility in prepubescent girls and patients who cannot undergo ovarian stimulation. Despite the lack of standardized processing methods, ovarian tissue transplantation can restore ovarian hormone activity regardless of processing size.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Raffaella Fabbri, Rossella Vicenti, Valentina Magnani, Roberto Paradisi, Mario Lima, Lucia De Meis, Stefania Rossi, Diego Raimondo, Paolo Casadio, Stefano Venturoli, Michela Maffi, Renato Seracchioli
Summary: This study reports the 20-year experience of the Bologna clinical center in ovarian tissue cryopreservation and transplantation. The results show that ovarian tissue cryopreservation is an effective technique for preserving ovarian function in pediatric and adult patients, and it can help restore menstruation and achieve pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Marie Nelson, Jennifer Levine
Summary: Although fertility preservation is not fully integrated into comprehensive cancer care for pediatric and adolescent patients, recent advances and trends have been summarized in this review to guide healthcare professionals. Standardized infertility risk assessment guidelines provide consistency in clinical care and serve as a baseline for future research. Dissemination of information is critical for fertility preservation to become an integral part of comprehensive cancer care.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Obstetrics & Gynecology
Brid Ni Dhonnabhain, Nagla Elfaki, Kyra Fraser, Aviva Petrie, Benjamin P. Jones, Srdjan Saso, Paul J. Hardiman, Natalie Getreu
Summary: This study compares obstetric outcomes in cancer patients who undergo cryopreservation of reproductive cells or tissues before gonadotoxic therapy. The results indicate that cryopreservation of oocytes, embryos, and ovarian tissue has similar effectiveness in terms of clinical pregnancy and live birth rates. However, ovarian tissue cryopreservation is associated with a significantly lower miscarriage rate compared to embryo cryopreservation.
FERTILITY AND STERILITY
(2022)
Article
Oncology
Sophia M. Schermerhorn, Mitchell P. Rosen, Erin M. Blevins, Kevin A. Byrd, Joseph T. Rabban, Philip Marsh, Donald J. Lucas
Summary: Ovarian tissue cryopreservation is the only option for fertility preservation in prepubescent females receiving gonadotoxic therapy, but it has limited availability. Establishing networks between centers can increase access to fertility preservation services, especially in children.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Obstetrics & Gynecology
Lorraine S. Kasaven, Srdjan Saso, Natalie Getreu, Helen O'Neill, Timothy Bracewell-Milnes, Fevzi Shakir, Joseph Yazbek, Meen-Yau Thum, James Nicopoullos, Jara Ben Nagi, Paul Hardiman, Cesar Diaz-Garcia, Benjamin P. Jones
Summary: Age-related fertility decline is a prevalent concern in western cultures due to the increasing age of first-time motherhood. Elective oocyte and embryo cryopreservation are established methods of fertility preservation, but the alternative option of elective ovarian cortex cryopreservation has not been considered in this context.
HUMAN REPRODUCTION
(2022)
Review
Biochemistry & Molecular Biology
Jeong Min Kim, Seongmin Kim, Sanghoon Lee
Summary: Although cancer treatments can impact fertility in women, preserving fertility is crucial for quality of life. Fertility experts should propose personalized preservation methods, with ovarian tissue cryopreservation and transplantation emerging as a potential solution. Using stem cells in this process can improve fertilization techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Andreas Schallmoser, Rebekka Einenkel, Cara Faerber, Vanessa Hueren, Anna Pougin, Norah Emrich, Julia John, Nicole Saenger
Summary: This study aims to explore the parameters of age, indications, storage characteristics, and reasons for tissue disposal in a large cohort of individuals undertaking cryopreservation. The majority of patients ended their storage due to pregnancy, a lack of desire to have children, expensive storage fees, and cancer recurrence. Interdisciplinary counseling is recommended before fertility preservation and when intending to end storage.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Ali Abbara, Maya Al-Memar, Maria Phylactou, Christopher Kyriacou, Pei Chia Eng, Rans Nadir, Chioma Izzi-Engbeaya, Sophie A. Clarke, Edouard G. Mills, Elisabeth Daniels, Lechun Huo, Ewa Pacuszka, Lisa Yang, Bijal Patel, Tricia An, Paul Bech, Alexander N. Comninos, Hanine Fourie, Tom W. Kelsey, Tom Bourne, Waljit S. Dhillo
Summary: This study compared the performance of Kisspeptin and beta hCG as biomarkers for miscarriage in the first trimester, finding that Kisspeptin showed better performance, especially in later gestational weeks. The conclusion suggests that Kisspeptin is a promising biomarker for miscarriage, and combining it with beta hCG improves prediction accuracy.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Ali Abbara, Maya Al-Memar, Maria Phylactou, Elisabeth Daniels, Bijal Patel, Pei C. Eng, Rans Nadir, Chioma Izzi-Engbeaya, Sophie A. Clarke, Edouard G. Mills, Tia Hunjan, Ewa Pacuszka, Lisa Yang, Paul Bech, Tricia Tan, Alexander N. Comninos, Tom W. Kelsey, Christopher Kyriacou, Hanine Fourie, Tom Bourne, Waljit S. Dhillo
Summary: Our study aimed to evaluate the changes in circulating kisspeptin levels in women with antenatal complications. The results showed that third-trimester kisspeptin levels were higher in women with hypertensive disorders of pregnancy (HDP) but lower in those with fetal growth restriction (FGR). We found that the odds of HDP increased by 30% and the odds of FGR decreased by 28% for every 1 nmol/L increase in plasma kisspeptin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Meeting Abstract
Oncology
Florian Clatot, Kelsey Thomas, Matteo Lambertini, Nathalie Olympios, Orianne Duhamel, Anne Perdrix, Richard Anderson
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Richard A. Anderson, Tom W. Kelsey, Anne Perdrix, Nathalie Olympios, Orianne Duhamel, Matteo Lambertini, Florian Clatot
Summary: This study investigated the value of anti-mullerian hormone (AMH) as a serum biomarker for predicting loss of ovarian function after chemotherapy in premenopausal women with early breast cancer (eBC). The results showed that AMH can accurately diagnose ovarian dysfunction after chemotherapy, and early analysis of AMH can accurately identify women who will not recover ovarian function.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Obstetrics & Gynecology
Richard A. Anderson, Tom W. Kelsey, David S. Morrison, W. Hamish B. Wallace
Summary: This study assessed family size and timescale for achieving pregnancy in women who remain fertile after cancer. The data showed a reduced chance of live birth after cancer, and women who subsequently conceived had a higher mean age at live birth and a smaller family size. However, the period of time after cancer diagnosis across which pregnancies occurred was similar or increased.
FERTILITY AND STERILITY
(2022)
Article
Oncology
Richard A. Anderson, Matteo Lambertini, Peter S. Hall, W. Hamish Wallace, David S. Morrison, Tom W. Kelsey
Summary: This study found that having a live birth after breast cancer does not have a negative impact on overall survival, especially for younger women who have not been pregnant before. The interaction between subsequent childbirth and survival increases with decreasing age. Women with different ER statuses and those who have received chemotherapy have similar survival rates after subsequent childbirth.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Obstetrics & Gynecology
Johanne Grosbois, Emily C. Bailie, Tom W. Kelsey, Richard A. Anderson, Evelyn E. Telfer
Summary: In vitro culture alters the composition and architecture of the human ovarian cortical extracellular matrix (ECM). The ECM varies in different layers of the ovarian cortex and undergoes remodeling during culture. Mechanical loosening during tissue preparation for culture leads to undefined modifications in the ECM network and alters cell-cell contact, resulting in spontaneous follicle activation.
HUMAN REPRODUCTION
(2023)
Article
Multidisciplinary Sciences
Thomas W. Kelsey, Chia-Ho Hua, Amber Wyatt, Danny Indelicato, W. Hamish Wallace
Summary: Radiation to the female pelvis as part of cancer treatment can lead to Premature Ovarian Insufficiency (POI) in young women. A model that predicts the age at which POI occurs for a known dose at a known age can aid in counseling patients about their fertility risk. The authors developed an algorithm that combines an updated model of ovarian reserve decline with the estimated median lethal dose for the human ovary to generate personalized predictions of premature ovarian insufficiency. The algorithm is available as an online calculator and can inform discussions about survivor fertility.
Article
Obstetrics & Gynecology
Kathleen Duffin, Ruth Howie, Tom W. Kelsey, Hamish B. Wallace, Richard A. Anderson
Summary: The Edinburgh Selection Criteria accurately identify female cancer patients under the age of 18 who are at risk of premature ovarian insufficiency (POI) and can be candidates for ovarian tissue cryopreservation (OTC). Long-term follow-up is necessary to ensure the appropriate use of OTC, as it is not without risk.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Katja C. E. Drechsel, Maxime C. F. Pilon, Francis Stoutjesdijk, Salena Meivis, Linda J. Schoonmade, William Hamish B. Wallace, Eline van Dulmen-den Broeder, Auke Beishuizen, Gertjan J. L. Kaspers, Simone L. Broer, Margreet A. Veening
Summary: This narrative review summarized existing literature on reproductive function in young Hodgkin lymphoma survivors. The results showed that female survivors had a high incidence of premature ovarian insufficiency, while male survivors often experienced post-treatment azoospermia. Higher doses of chemotherapeutic agents and pelvic radiotherapy were associated with impaired reproductive ability.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Oncology
Jennifer Geel, Anel van Zyl, Jan du Plessis, Marc Hendricks, Yasmin Goga, Amy Carr, Beverley Neethling, Artsiom Hramyka, Fareed Omar, Rema Mathew, Lizette Louw, Thanushree Naidoo, Thandeka Ngcana, Tanya Schickerling, Vutshilo Netshituni, Elelwani Madzhia, Liezl du Plessis, Tom Kelsey, Daynia E. Ballot, Monika L. Metzger
Summary: A risk stratification and response-adapted treatment protocol has been shown to improve the overall survival of children and adolescents with HL in South Africa.
PEDIATRIC BLOOD & CANCER
(2023)
Meeting Abstract
Obstetrics & Gynecology
R. Anderson, M. Lambertini, P. Hall, H. Wallace, D. Morrison, T. Kelsey
HUMAN REPRODUCTION
(2022)
Meeting Abstract
Oncology
J. Geel, T. Kelsey, A. Hramyka, M. Hendricks, K. Myezo, T. Ngcana, A. VanZyl, B. Neethling, E. Madzhia, R. Mathews, Y. Goga, V. Netshituni, F. Omar, D. Ballot, M. Metzger
PEDIATRIC BLOOD & CANCER
(2021)
Meeting Abstract
Obstetrics & Gynecology
R. Howie, K. Duffin, T. Kelsey, W. H. B. Wallace, R. A. Anderson
HUMAN REPRODUCTION
(2021)
