Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Review
Gastroenterology & Hepatology
Yakup Kilic, Shahed Kamal, Farah Jaffar, Danujan Sriranganathan, Mohammed Nabil Quraishi, Jonathan P. Segal
Summary: Inflammatory bowel disease (IBD) is a multisystem disease that affects various body systems. The extraintestinal manifestations of IBD are frequent and impact the morbidity and mortality of patients with UC and CD.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Ole Haagen Nielsen, John Mark Gubatan, Carsten Bogh Juhl, Sarah Elizabeth Streett, Cynthia Maxwell
Summary: Adverse pregnancy outcomes among pregnant IBD women using biologics are comparable with that of the general population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Ugo Grossi, Gaetano Gallo, Gian Luca Di Tanna, Umberto Bracale, Mattia Ballo, Elisa Galasso, Andrea Kazemi Nava, Martino Zucchella, Francesco Cinetto, Marcello Rattazzi, Carla Felice, Giacomo Zanus
Summary: The safety and effectiveness of surgical treatment for hemorrhoidal disease in patients with inflammatory bowel disease (IBD) is currently poorly supported by evidence. However, cautious surgical management of non-responsive CD patients with inactive disease is still recommended, though further studies are needed to assess the potential benefits of non-excisional techniques in this population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshifumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean Frederic Colombel, Gilaad G. Kaplan, Min-hu Chen
Summary: Initiating biologic treatment early in the course of Crohn's disease may yield better treatment outcomes, while disease duration does not significantly impact results in ulcerative colitis.
Article
Surgery
Can Lu, Josefine Schardey, Tao Zhang, Alexander Crispin, Ulrich Wirth, Konrad W. Karcz, Alexandr Bazhin, Joachim Andrassy, Jens Werner, Florian Kuehn
Summary: This study conducted a systematic review and meta-analysis to compare the survival outcomes of IBD-associated and non-IBD-associated CRC. The results showed that IBD-CRC patients had a significantly worse overall survival than those without IBD. This may be attributed to more aggressive histological characteristics and a lower rate of R0 resections at the primary tumor site.
Review
Chemistry, Medicinal
Jose Israel Rodrigues Jr, Joice Kelly Gomes de Vasconcelos, Lylian Ellen Militao dos Santos Xavier, Amanda da Silva Gomes, Juliana Celia de Farias Santos, Samara Bomfim Gomes Campos, Amylly Sanuelly da Paz Martins, Marilia Oliveira Fonseca Goulart, Fabiana Andrea Moura
Summary: The objective of this study was to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review and meta-analysis were conducted, and it was found that antioxidant capacity and lipid peroxidation levels were not significantly modulated, while superoxide dismutase levels showed significant modulation. However, there is still limited research on oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment. The results highlight the potential of antioxidant supplementation in IBD management and emphasize the need for further investigations into its effects on oxidative stress biomarkers and cytokines.
Review
Immunology
Mobina Jalalvand, Samaneh Enayati, Maryam Akhtari, Elham Madreseh, Ahmadreza Jamshidi, Elham Farhadi, Mahdi Mahmoudi, Aliakbar Amirzargar
Summary: This meta-analysis aimed to determine the frequency of peripheral blood regulatory T cells (Tregs) in inflammatory bowel disease (IBD) patients. The results showed no significant difference in the frequency of PB Tregs between IBD cases and control subjects. However, the frequency of CD4+CD25+CD127- and CD4+CD25+FoxP3+ Tregs were significantly lower in IBD cases. Additionally, UC cases and active IBD cases showed a significantly lower frequency of Treg cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Isidora Simovic, Ida Hilmi, Ruey Terng Ng, Kee Seang Chew, Shin Yee Wong, Way Seah Lee, Stephen Riordan, Natalia Castano-Rodriguez
Summary: ATG16L1 rs2241880 is significantly associated with susceptibility to Crohn's disease (CD) and influences clinical outcomes, especially in Caucasian populations.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Laura Arp, Sabine Jansson, Vibeke Wewer, Johan Burisch
Summary: The prevalence of psychiatric comorbidities is high in patients with inflammatory bowel diseases (IBD) and higher than in the general population. Addressing mental health problems in these patients can improve treatment adherence, disease course, and reduce morbidity and mortality.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lili He, Yinghua Sun, Xihong Hu, Qiong Yao
Summary: The meta-analysis indicates that MRE performs well in detecting IBD in pediatric patients. Only two studies used US, suggesting that additional research is needed to confirm the diagnostic performance of US for IBD in children.
EUROPEAN RADIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Xiaoding Shen, Qianyi Wan, Rui Zhao, Yutao Wu, Yong Wang, Yaping Cui, Xiangnan Su, Xiaoting Wu
Summary: The umbrella review of 25 meta-analyses found that patients with inflammatory bowel diseases had a higher risk of adverse health outcomes in various aspects, but the quality of evidence was generally low. More research is needed to draw firmer conclusions.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Gastroenterology & Hepatology
Hailan Zhao, Haoming Xu, Shuzhen Chen, Jie He, Youlian Zhou, Yuqiang Nie
Summary: A systematic review and meta-analysis found a negative association between abundance of F. prausnitzii and IBD activity, but a cut-off level of F. prausnitzi for diagnosing and treating IBD has not been determined.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Irene Marafini, Edoardo Troncone, Irene Rocchetti, Giovanni Monteleone
Summary: The study found that patients with inflammatory bowel disease treated with vedolizumab had a higher risk of respiratory infections, especially for those with ulcerative colitis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Min Yuan, Lijun Xu, Xiaoping Yin
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
(2016)
Letter
Medicine, General & Internal
Min Yuan, Xu-Fang Xie, Wen-Feng Cao, Ying-Qiong Xiong, Ling-Feng Wu, Huang-Yan Zhou, Xiao-Mu Wu
MEDICAL PRINCIPLES AND PRACTICE
(2018)
Review
Medicine, General & Internal
Min Yuan, Wen-Feng Cao, Xu-Fang Xie, Huang-Yan Zhou, Xiao-Mu Wu
Review
Medicine, General & Internal
Huang-yan Zhou, Min Yuan
Article
Clinical Neurology
Qi Zhou, Min Yuan, Weiwen Qiu, Wenfeng Cao, Renshi Xu
Summary: The study assessed the quality of preclinical evidence for MSCs therapy of ALS, determined the effect size of MSCs treatment, and identified clinical parameters associated with differences in MSCs effects. The results showed that MSCs transplantation was beneficial for neurobehavioral improvement in ALS animal models, with animal gender and immunosuppressive drug CSA having a close correlation with disease progression deceleration effect size.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Min Yuan, Huang-Yan Zhou, Fan Hu, Shi-Ying Liu, Wei Rao, Ling-Feng Wu, Hong-Bing Nie, Wen-Feng Cao
Summary: This meta-analysis found that patients with kidney stones have a slightly increased risk of developing stroke, especially ischemic stroke. Larger-scale clinical trials are needed to further identify the relative impact of kidney stones on stroke outcomes.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Min Yuan, Zhi-Long Xiao, Huang-Yan Zhou, Wei Rao, Gang Huang, Hong-Bing Nie, Wen-Feng Cao, Ren-Shi Xu
Summary: This meta-analysis of 7 studies involving 13,305,007 participants found that individuals with BD have a significantly increased risk of both stroke incidence and mortality compared to those without BD. Further research should be conducted to determine if BD is a modifiable risk factor for stroke.
NEUROLOGICAL SCIENCES
(2022)
Review
Cell Biology
Yu Zhu, Min Yuan, Yue Liu, Fang Yang, Wen-Zhi Chen, Zhen-Zhen Xu, Zheng-Bing Xiang, Ren-Shi Xu
Summary: There is evidence suggesting a correlation between inflammatory bowel disease and Parkinson's disease, especially in older patients with IBD. Early anti-inflammatory treatment may reduce the risk of developing PD.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, General & Internal
Min Yuan, Xinhua Zhou, Xiaoqing Lu, Zhilong Xiao, Huangyan Zhou, Xiaohua Wang
Summary: This study found that statin use during hospitalization may be associated with a reduced risk-adjusted mortality in patients with intracerebral hemorrhage (ICH). Further randomized controlled trials are needed to clarify this association.
Article
Nutrition & Dietetics
Shaoyan Cai, Qinjia Wang, Chao Chen, Chunming Guo, Liangjie Zheng, Min Yuan
Summary: This study found a significant association between the blood urea nitrogen to serum albumin ratio (BAR) and in-hospital mortality in patients with sepsis. A higher BAR was associated with worse prognosis in the ICU.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Hui Wang, Binbin Hu, Juan Huang, Lin Chen, Min Yuan, Xingfu Tian, Ting Shi, Jiahao Zhao, Wei Huang
Summary: The study aimed to analyze the clinical features and gait characteristics of PD patients with fatigue and develop a model to identify fatigue in the early stages of PD. The results showed that PD patients with fatigue had more severe impairment of motor symptoms and fatigue became more pronounced as the disease progressed. Combining clinical characteristics and gait cycle parameters can identify PD patients at high risk of fatigue.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pathology
Min Yuan, Chengyu Li, Xiang Xiao, Dengfeng Wan, Bin Xi, Xingxing Jiang, Jianzhong Zhang
Summary: Lentinan effectively inhibits proliferation and promotes apoptosis of human astrocytoma U251 cells. When the concentration exceeds 100 μg/ml, cell activity gradually decreases, with the lowest activity at a concentration of 600 μg/ml. Low concentrations of Lentinan (25, 50, and 100 μg/ml) had no significant effect on apoptosis of human astrocytoma U251 cells. However, Lentinan above 200 μg/ml significantly promoted apoptosis and showed a concentration gradient effect, with the highest apoptosis rate at 600 μg/ml.
POLISH JOURNAL OF PATHOLOGY
(2023)
Letter
Medicine, General & Internal
Min Yuan, Huang-Yan Zhou, Ling-Feng Wu, Wen-Feng Cao, Ren-Shi Xu
CHINESE MEDICAL JOURNAL
(2021)
Review
Cell Biology
Ren-Shi Xu, Min Yuan
Summary: The concept, definition, and diagnosis of amyotrophic lateral sclerosis (ALS) pose some challenges, with a lack of unity and standardization in clinical practice. Future research should focus on identifying reliable biomarkers, particularly neuroimaging biomarkers, for the early and accurate diagnosis of ALS to benefit patients.
NEURAL REGENERATION RESEARCH
(2021)
Letter
Peripheral Vascular Disease
Min Yuan, Huang-Yan Zhou
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2020)
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
