Letter
Gastroenterology & Hepatology
Peng Chen, Fuchao Chen
Summary: This article is related to Ikegami et al's papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Review
Gastroenterology & Hepatology
Ole Haagen Nielsen, John Mark Gubatan, Carsten Bogh Juhl, Sarah Elizabeth Streett, Cynthia Maxwell
Summary: Adverse pregnancy outcomes among pregnant IBD women using biologics are comparable with that of the general population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yakup Kilic, Shahed Kamal, Farah Jaffar, Danujan Sriranganathan, Mohammed Nabil Quraishi, Jonathan P. Segal
Summary: Inflammatory bowel disease (IBD) is a multisystem disease that affects various body systems. The extraintestinal manifestations of IBD are frequent and impact the morbidity and mortality of patients with UC and CD.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Immunology
Mobina Jalalvand, Samaneh Enayati, Maryam Akhtari, Elham Madreseh, Ahmadreza Jamshidi, Elham Farhadi, Mahdi Mahmoudi, Aliakbar Amirzargar
Summary: This meta-analysis aimed to determine the frequency of peripheral blood regulatory T cells (Tregs) in inflammatory bowel disease (IBD) patients. The results showed no significant difference in the frequency of PB Tregs between IBD cases and control subjects. However, the frequency of CD4+CD25+CD127- and CD4+CD25+FoxP3+ Tregs were significantly lower in IBD cases. Additionally, UC cases and active IBD cases showed a significantly lower frequency of Treg cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Ugo Grossi, Gaetano Gallo, Gian Luca Di Tanna, Umberto Bracale, Mattia Ballo, Elisa Galasso, Andrea Kazemi Nava, Martino Zucchella, Francesco Cinetto, Marcello Rattazzi, Carla Felice, Giacomo Zanus
Summary: The safety and effectiveness of surgical treatment for hemorrhoidal disease in patients with inflammatory bowel disease (IBD) is currently poorly supported by evidence. However, cautious surgical management of non-responsive CD patients with inactive disease is still recommended, though further studies are needed to assess the potential benefits of non-excisional techniques in this population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Can Lu, Josefine Schardey, Tao Zhang, Alexander Crispin, Ulrich Wirth, Konrad W. Karcz, Alexandr Bazhin, Joachim Andrassy, Jens Werner, Florian Kuehn
Summary: This study conducted a systematic review and meta-analysis to compare the survival outcomes of IBD-associated and non-IBD-associated CRC. The results showed that IBD-CRC patients had a significantly worse overall survival than those without IBD. This may be attributed to more aggressive histological characteristics and a lower rate of R0 resections at the primary tumor site.
Review
Chemistry, Medicinal
Jose Israel Rodrigues Jr, Joice Kelly Gomes de Vasconcelos, Lylian Ellen Militao dos Santos Xavier, Amanda da Silva Gomes, Juliana Celia de Farias Santos, Samara Bomfim Gomes Campos, Amylly Sanuelly da Paz Martins, Marilia Oliveira Fonseca Goulart, Fabiana Andrea Moura
Summary: The objective of this study was to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review and meta-analysis were conducted, and it was found that antioxidant capacity and lipid peroxidation levels were not significantly modulated, while superoxide dismutase levels showed significant modulation. However, there is still limited research on oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment. The results highlight the potential of antioxidant supplementation in IBD management and emphasize the need for further investigations into its effects on oxidative stress biomarkers and cytokines.
Review
Gastroenterology & Hepatology
Shomron Ben-Horin, Lena Novack, Ren Mao, Jing Guo, Yue Zhao, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshifumi Hibi, Yehuda Chowers, Laurent Peyrin-Biroulet, Jean Frederic Colombel, Gilaad G. Kaplan, Min-hu Chen
Summary: Initiating biologic treatment early in the course of Crohn's disease may yield better treatment outcomes, while disease duration does not significantly impact results in ulcerative colitis.
Review
Gastroenterology & Hepatology
Laura Arp, Sabine Jansson, Vibeke Wewer, Johan Burisch
Summary: The prevalence of psychiatric comorbidities is high in patients with inflammatory bowel diseases (IBD) and higher than in the general population. Addressing mental health problems in these patients can improve treatment adherence, disease course, and reduce morbidity and mortality.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Marie Vibeke Vestergaard, Kristine H. Allin, Carsten Eriksen, Oliwia Zakerska-Banaszak, Ramesh P. Arasaradnam, Mohammad T. Alam, Karsten Kristiansen, Susanne Brix, Tine Jess
Summary: This study re-analyzed fecal microbiota data from 45 cohorts of inflammatory bowel disease (IBD) patients. The analysis identified a large number of genera associated with IBD, providing potential new treatment targets.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Anouk M. Wijnands, Michiel E. de Jong, Maurice W. M. D. Lutgens, Frank Hoentjen, Sjoerd G. Elias, Bas Oldenburg
Summary: A systematic review and meta-analysis identified 13 risk factors and 5 protective factors for advanced colorectal neoplasia in IBD patients. These findings could contribute to an improved surveillance based on CRC risk stratification in IBD.
Article
Multidisciplinary Sciences
Guojun Tong, Hai Qian, Dongli Li, Jing Li, Jing Chen, Xiongfeng Li
Summary: This study aimed to establish and evaluate a rat model of inflammatory bowel disease (IBD) using antibiotics. The results showed that the antibiotic-induced IBD model was successfully established in SD rats and may serve as a useful model for clinical IBD research.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lili He, Yinghua Sun, Xihong Hu, Qiong Yao
Summary: The meta-analysis indicates that MRE performs well in detecting IBD in pediatric patients. Only two studies used US, suggesting that additional research is needed to confirm the diagnostic performance of US for IBD in children.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Isidora Simovic, Ida Hilmi, Ruey Terng Ng, Kee Seang Chew, Shin Yee Wong, Way Seah Lee, Stephen Riordan, Natalia Castano-Rodriguez
Summary: ATG16L1 rs2241880 is significantly associated with susceptibility to Crohn's disease (CD) and influences clinical outcomes, especially in Caucasian populations.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Youlian Zhou, Haoming Xu, Hongli Huang, Yingfei Li, Huiting Chen, Jie He, Yanlei Du, Ye Chen, Yongjian Zhou, Yuqiang Nie
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Biotechnology & Applied Microbiology
Kang Li, Wei Peng, Youlian Zhou, Yi Ren, Jianhua Zhao, Xiangsheng Fu, Yuqiang Nie
BIOMED RESEARCH INTERNATIONAL
(2020)
Review
Gastroenterology & Hepatology
Hao-Ming Xu, Hong-Li Huang, You-Lian Zhou, Hai-Lan Zhao, Jing Xu, Di-Wen Shou, Yan-Di Liu, Yong-Jian Zhou, Yu-Qiang Nie
Summary: Gut dysbacteriosis is closely linked to various diseases, and fecal microbiota transplantation is an effective method for reconstructing the gut microbiota. The gut microbiota plays a crucial role in neurological and psychiatric disorders through the microbiota-gut-brain axis, making it a promising new strategy for treating cerebral diseases.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2021)
Article
Biotechnology & Applied Microbiology
Hao-ming Xu, You-lian Zhou, Jing Xu, Ying-fei Li, Chong Zhao, Hong-li Huang, Yan-lei Du, Jie He, Yong-jian Zhou, Yu-qiang Nie
Summary: In this study, the relationship between PD-1 inhibition, gut microbiota, and IBD was investigated using a mouse model of experimental colitis. The results demonstrated that PD-1 inhibition attenuated colitis symptoms, improved the diversity of the enteric microbiome, and enriched the abundance of SCFA-producing bacteria.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Oncology
Fang Wei, Yuling Su, Yibo Quan, Xiaojia Li, Qi Zou, Liuxi Zhang, Shu Li, Mengmeng Jiang, Guohuan Lin, Ping Liang, Jie He, Keping Xie
Summary: This study investigates the therapeutic effects and mechanisms of anticoagulants on immunotherapy in pancreatic ductal adenocarcinoma (PDA). The combination of heparin and adoptive cell transfer (ACT) inhibits tumor growth and metastasis and promotes immune cell infiltration. Heparin also improves tumor vascular regression and increases anti-tumor T-cell responses.
CLINICAL CANCER RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Xin Nie, Chong Zhao, Yuan Zhang, Wenqi Huang, Youlian Zhou, Haiying Liu, Yuqiang Nie, Keping Xie, Lin Jia
Summary: This study found that TCOF1 is aberrantly increased in gastric cancer tissues and localizes to R-loops during S phase. TCOF1 interacts with DDX5 and suppresses R-loop levels. Knockdown of TCOF1 leads to increased nucleoplasmic R-loops during S phase, restraining DNA replication and cell proliferation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Zhang, Dan Ma, Baoqin Xuan, Debing Shi, Jie He, Minhao Yu, Hua Xiong, Yanru Ma, Chaoqin Shen, Fangfang Guo, Yingying Cao, Yuqing Yan, Ziyun Gao, Tianying Tong, Xiaoqiang Zhu, Jing-Yuan Fang, Haoyan Chen, Jie Hong
Summary: In this study, a novel upregulated long non-coding RNA (lncRNA) called CACClnc was identified, which was associated with chemoresistance and poor prognosis in colorectal cancer (CRC). The study revealed that CACClnc promoted CRC resistance to chemotherapy by enhancing DNA repair and homologous recombination. The expression of exosomal CACClnc in peripheral plasma of CRC patients was also found to effectively predict the chemotherapy effect prior to treatment. Therefore, targeting CACClnc and its associated pathway could provide valuable insight into clinical management and potentially improve outcomes for CRC patients.
Review
Cell Biology
Zhihong He, Jie He, Keping Xie
Summary: The Krüppel-like transcriptional factor is crucial for maintaining cellular functions and its deletion can lead to abnormal embryonic development and death. KLF4, a member of this family, not only plays a significant role in embryonic development but also in inflammation and malignancy. Its regulatory role in various cancers has been investigated, however, the complexity of its involvement in tumorigenesis may be attributed to its unique structure and the regulation of its upstream and downstream signaling molecules.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Sen Yu, Jie He, Keping Xie
Summary: Tight junction (TJ) is a barrier in epithelial and endothelial cells that maintains paracellular substrate transport and cell polarity. Zonula occludens (ZO) proteins, as cytoplasmic adaptor proteins adjacent to the cell membrane, connect transmembrane TJ proteins and cytoplasmic cytoskeleton to maintain barrier function. Besides their structural role, ZO proteins also play important roles in signal regulation, such as cell proliferation, motility, embryonic development, tissue homeostasis, inflammation, tumorigenesis, and cancer progression. This review focuses on the signal regulating function of ZO proteins in inflammation and tumorigenesis, and discusses the limitations and future challenges in ZO protein research.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)