Article
Integrative & Complementary Medicine
Pawana Boonrueng, Peththa Wadu Dasuni Wasana, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat, Hasriadi
Summary: This study demonstrates strong antinociceptive synergism between curcumin and piperine in mouse models, with no potential CNS side effects, suggesting its possible use in clinical trials.
Article
Ophthalmology
Li-Fong Seet, Zhu Li Yap, Stephanie W. L. Chu, Li Zhen Toh, Farah Ilyana Ibrahim, Xiao Teng, Tina T. Wong
Summary: This study aimed to compare the effectiveness of combination therapy consisting of low-dose mitomycin C (MMC) and valproic acid (VPA) against high-dose MMC for improving the scar phenotype in minimally invasive glaucoma surgery (MIGS). The results showed that combination therapy was less toxic and potentially more effective in reducing scarring compared to high-dose MMC alone. Combination therapy maintained the vasculature without increased vascularization and altered collagen morphology, reducing encapsulation and regulating collagen content and organization. VPA may be combined with low-dose MMC as a safe and effective alternative to high-dose MMC for anti-scarring outcomes in MIGS.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Dhekra Hasan Khudhair, Ali I. Al-Gareeb, Hayder M. Al-kuraishy, Aya H. El-Kadem, Engy Elekhnawy, Walaa A. Negm, Sameh Saber, Simona Cavalu, Adrian Tirla, Saqer S. Alotaibi, Gaber El-Saber Batiha
Summary: Vitamin C and curcumin pretreatment, either alone or in combination, have significant hepatoprotective effects against MTX-induced liver toxicity, alleviating liver damage and exerting their effects through antioxidant and anti-inflammatory mechanisms.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
O. Uyanik, S. Gurbuz, O. Ciftci, H. Oguzturk, M. Aydin, A. Cetin, N. Basak, M. Gokhan Turtay, N. Yucel
Summary: The study confirmed the toxic effects of Irinotecan on rat testis tissue and found that Curcumin could mitigate these effects. Curcumin treatment significantly reduced histopathological damage and decreased oxidative stress induced by IR, while also improving antioxidant enzyme activity levels. Further studies are needed to validate these results.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Reyhaneh Rabiee, Saeedeh Hosseini Hooshiar, Amir Ghaderi, Sadegh Jafarnejad
Summary: Schizophrenia is a mental disorder characterized by psychosis, including hallucinations, delusions, and disorganized thinking. Recent theories suggest that abnormalities in interneurons, the immune system, myelin formation, and oxidative stress can lead to changes in brain structure and contribute to schizophrenia. Traditional antipsychotic drugs have significant side effects, while alternative therapies like curcumin can reduce symptoms without major side effects. Curcumin has therapeutic properties such as antioxidant, anti-mutagenic, anti-inflammatory, and antimicrobial functions, and it can protect the nervous system. Its ability to cross the blood-brain barrier offers potential for neuroprotection in schizophrenia. Curcumin improves and prevents potential neurological and behavioral disorders in schizophrenia patients, reduces neuroleptic side effects, and maintains lipid homeostasis. It also increases brain-derived neurotrophic factor levels and improves hyperkinetic movement disorders. Curcumin may act as an additional defense mechanism to maintain cell integrity and protect against free radical damage, showing therapeutic potential for schizophrenia improvement.
NEUROCHEMICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Yaseen Hussain, Lubna Islam, Haroon Khan, Rosanna Filosa, Michael Aschner, Saba Javed
Summary: Chemotherapy in cancer therapy has limited efficacy, prompting the exploration of combination therapies using natural products to overcome treatment barriers. The combination therapy of curcumin and cisplatin shows promise in reducing adverse effects and improving resistance, but further research is needed to fully understand its effectiveness.
PHYTOTHERAPY RESEARCH
(2021)
Article
Urology & Nephrology
Joshua M. Kuperus, Ross D. Busman, Susan K. Kuipers, Helen T. Broekhuizen, Sabrina L. Noyes, Christopher M. Brede, Conrad M. Tobert, Brian R. Lane
Summary: Significant differences in side effects and tolerability were demonstrated between full-dose BCG, reduced-dose BCG, and gemcitabine. Gemcitabine had the highest prevalence, severity, and duration of body aches, while BCG had higher prevalence and duration of hematuria. Reduced-dose BCG showed the lowest prevalence, severity, and duration of fatigue.
Article
Ophthalmology
Neeru Amrita Vallabh, Fiona Mason, Jonathan T. S. Yu, Kenneth Yau, Cecilia H. Fenerty, Karl Mercieca, Anne Fiona Spencer, Leon Au
Summary: The study demonstrated that the PGI surgery significantly reduces intraocular pressure and the number of medications, with minimal complications.
Review
Chemistry, Medicinal
Asal Jalal Abadi, Sepideh Mirzaei, Mahmood Khaksary Mahabady, Farid Hashemi, Amirhossein Zabolian, Fardin Hashemi, Pourya Raee, Shahin Aghamiri, Milad Ashrafizadeh, Amir Reza Aref, Michael R. Hamblin, Kiavash Hushmandi, Ali Zarrabi, Gautam Sethi
Summary: Curcumin, isolated from Curcuma longa, has potent tumor-suppressor activity and can decrease the adverse impacts of cisplatin (CP) while enhancing its antitumor activity. Curcumin reduces ROS levels to prevent apoptosis in normal cells, inhibits inflammation, and reduces various toxicities caused by CP. Additionally, curcumin potentiates CP cytotoxicity and suppresses tumor-promoting pathways to prevent drug resistance.
PHYTOTHERAPY RESEARCH
(2022)
Article
Medicine, General & Internal
Bo Ram Seol, Sang Yoon Lee, Yu Jeong Kim, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Summary: The study found that trabeculectomy with 0.2 mg/mL and 0.4 mg/mL of MMC had similar IOP-control effects and low complication rates. There was no significant difference in efficacy or safety between the two concentrations of MMC used.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Pitchai Balakumar, Kumar Venkatesan, Noohu Abdulla Khan, N. M. Raghavendra, Vijayan Venugopal, D. R. Bharathi, Neeraj K. Fuloria
Summary: The prevalence of type 2 diabetes mellitus (T2DM) has rapidly increased in the past few decades. Current management strategies for insulin resistance are not effective enough and additional therapeutic options are needed. Curcumin has shown potential beneficial effects on insulin resistance and scientific evidence supports its potential applications against the disease. Curcumin combats insulin resistance through various mechanisms, such as increasing the levels of circulating irisin and adiponectin, activating PPARc, suppressing Notch1 signaling, and regulating SREBP target genes. This review provides a comprehensive understanding of the potential benefits of curcumin on insulin resistance, associated mechanistic insights, and new therapeutic possibilities.
DRUG DISCOVERY TODAY
(2023)
Article
Biology
Shuang Li, Tian-Jing Cai, Xue Lu, Mei Tian, Qing-Jie Liu
Summary: The potential influence of chemotherapeutic agents cyclophosphamide (CP) and mitomycin C (MMC) on radiation-induced transcriptional biomarkers was explored. The results showed that relatively low concentrations of CP and MMC had minimal impact on radiation-induced gene expression changes. The use of gene expression combinations could improve the applicability of transcriptional biodosimetry across diverse radiation exposures.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Editorial Material
Ophthalmology
Manju Pillai, Aniket A. Kalegore, Ann Mery Mathews, S. R. Krishnadas
Summary: The injection of MMC in trabeculectomy has advantages over the conventional sponge application method, including increased success rates, decreased complications, and less scarring and risk of retained sponges.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Zhen Mao, Xinxing Guo, Yimin Zhong, Xing Liu
Summary: The study demonstrates that Ahmed glaucoma valve implantation is a safe and effective treatment for uncontrolled glaucoma secondary to ICE syndrome, leading to a significant decrease in intraocular pressure with few complications.
Article
Chemistry, Medicinal
Ding Huang, Maojie Zhang, Haiyan Zhang, Zhiying Cui, Dong Luo, Tao Li, Xuemin Li, Yun He, Shao-Lin Zhang
Summary: In this study, the toxic effects of mitomycin C (MMC), an anticancer drug, were reduced by attaching triphenylphosphine groups (TPP+) to it. The resulting compound, 5, showed good anticancer activity and negligible toxicity to human normal cells. In mice, 5 had little effect on body weight and tissues, indicating reduced toxicity compared to MMC. These findings suggest that TPP+ can effectively reduce the toxicity of MMC.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)