Article
Health Care Sciences & Services
Sarah Bonar, Harold L. Schneider III, Katherine Cook, Renato V. Samala, Michelle F. F. Poole
Summary: This retrospective study demonstrated the safety and efficacy of olanzapine for the treatment of nausea and emesis in palliative care patients. It reduced the need for antiemetic medications, improved appetite, and had a cost-saving effect. QTc prolongation and liver function abnormalities were observed in a small percentage of patients.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Oncology
Gudrun Kreye, Manuela Wasl, Andrea Dietz, Daniela Klaffel, Andrea Groselji-Strele, Katharina Eberhard, Anna Glechner
Summary: This study found that using lemon oil pads can effectively alleviate nausea and vomiting in patients with advanced cancer receiving palliative care. Aromatherapy is a well-accepted complementary therapy in this field, and it was feasible for the majority of patients.
Review
Nutrition & Dietetics
Devanshi Gala, Hattie H. Wright, Bekhinkosi Zigori, Skye Marshall, Megan Crichton
Summary: The study suggests that CINV-specific nutrition education and support from health professionals can improve CINV. Non-restrictive dietary patterns, particularly those including adequate energy and macronutrient intakes, ginger, and Mediterranean diet concepts, may benefit CINV.
CLINICAL NUTRITION
(2022)
Article
Medicine, Research & Experimental
Tomoki Tamura, Keita Kawakado, G. O. Makimoto, Masamoto Nakanishi, Shoichi Kuyama
Summary: The study suggests that prophylactic administration of antiemetics at the initiation of opioid analgesics may help reduce gastrointestinal toxicity, as shown by a lower likelihood of requiring additional antiemetic medication in patients who received prophylaxis.
Article
Clinical Neurology
Vera Dufner, Almuth Friederike Kessler, Larissa Just, Peter Hau, Elisabeth Bumes, Hendrik Johannes Pels, Oliver Martin Grauer, Bettina Wiese, Mario Loehr, Karin Jordan, Herwig Strik
Summary: This pilot study investigated the impact of chemotherapy-induced nausea and vomiting (CINV) on glioma patients' levels of depression and quality of life. It was found that higher levels of depression were associated with more severe effects of CINV and lower quality of life. Further research is needed to address the delayed nausea and the use of long acting antiemetics for temozolomide-induced nausea.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Isseki Maeda, Eriko Satomi, Daisuke Kiuchi, Kaoru Nishijima, Yoshinobu Matsuda, Akihiro Tokoro, Keita Tagami, Yoshihisa Matsumoto, Akemi Naito, Tatsuya Morita, Satoru Iwase, Hiroyuki Otani, Takuya Odagiri, Hiroaki Watanabe, Masanori Mori, Yosuke Matsuda, Hiroka Nagaoka, Meiko Mayuzumi, Yoshiaki Kanai, Nobuhiro Sakamoto, Keisuke Ariyoshi
Summary: The study aimed to evaluate the safety, effectiveness, and patient-perceived benefit of olanzapine treatment for nausea and vomiting in advanced cancer patients. Results showed that short-term, low-dose olanzapine treatment was effective in managing multifactorial nausea and vomiting, with a correlation between perceived treatment benefit and level of nausea reduction. More confirmatory studies with longer follow-up are needed to determine the duration of effect and adverse events.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Winnie Yeo, Frankie K. F. Mo, Christopher C. H. Yip, Victoria A. Yeo, Leung Li, Thomas K. H. Lau, Kwai T. Lai, Vicky T. C. Chan, Kwan H. Wong, Elizabeth Pang, Maggie Cheung, Vivian Chan, Carol C. H. Kwok, Joyce J. S. Suen, Alex Molassiotis
Summary: This study examined the impact of CINV on QoL in breast cancer patients treated with AC, finding that CINV significantly affected patients' QoL, with a correlation between QoL in earlier cycles and subsequent cycles. New antiemetic regimens showed improvement in QoL outcomes.
Review
Biochemistry & Molecular Biology
Weixia Zhong, Omar Shahbaz, Garrett Teskey, Abrianna Beever, Nala Kachour, Vishwanath Venketaraman, Nissar A. Darmani
Summary: Nausea and vomiting are considered defense mechanisms triggered by threatening toxins/drugs/bacteria/viruses/fungi entering the body. Vomiting involves forceful removal of gastrointestinal contents, while nausea is a subjective sensation that is more difficult to study in nonhuman species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Rei Tanaka, Junya Sato, Hiroshi Ishikawa, Tetsu Sato, Michihiro Shino, Yasuhisa Ohde, Tetsumi Sato, Keita Mori, Akifumi Notsu, Sumiko Ohnami, Maki Mizuguchi, Takeshi Nagashima, Ken Yamaguchi
Summary: Despite significant advancements in cancer chemotherapy and immunotherapy, personalized opioid therapy research lags behind. This study found that OPRM1 and COMT gene variants influence the risk of somnolence as an adverse effect of opioid analgesic therapy.
Review
Anesthesiology
Polyxeni Theodosopoulou, Martina Rekatsina, Chryssoula Staikou
Summary: This review investigates the gene polymorphisms that influence the efficacy of 5-hydroxytryptamine (serotonin) type 3 receptor antagonists (5HT3RA) in postoperative nausea and vomiting (PONV). The study suggests that specific genetic profiles could contribute to the inefficacy of a certain drug, and patients might benefit from switching to a different drug.
MINERVA ANESTESIOLOGICA
(2023)
Article
Oncology
Lingping Kong, Jing Wang, Shasha Guan, Xiaochen Chen, Meiqing Li, Liming Gao, Diansheng Zhong, Linlin Zhang
Summary: In this study, a nomogram for predicting the occurrence of opioid-induced nausea and vomiting in cancer patients was developed using retrospective clinical data.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Tulay Kus, Gokmen Aktas, Melike Ozcelik, Merve Dirikoc, Teoman Sakalar, Abdulkerim Oyman, Ozgur Tanriverdi, Tugba Yavuzsen, Sinan Unal, Havva Yesil Cinkir, Aykut Bahceci, Ali Alkan, Serdar Turhal, Huseyin Abali
Summary: Chemotherapy-induced nausea and vomiting may be associated with cancer patients' illness perceptions, with positive perceptions negatively correlated and negative perceptions positively correlated with CINV.
Article
Medicine, General & Internal
Franziska Jahn, Bernhard Wormann, Juliane Brandt, Annette Freidank, Petra Feyer, Karin Jordan
Summary: Nausea and vomiting are common side effects of cancer therapy, affecting up to 50% of patients despite prophylactic measures. Risk-adjusted prevention and treatment based on individual and treatment-related factors is crucial, with commonly used antiemetics including 5-HT3 receptor antagonists, NK1 receptor antagonists, and dexamethasone. Olanzapine has shown to be beneficial as an additional or rescue drug, while benzodiazepines, dimenhydrinate, and cannabinoids can be used as backup antiemetics.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2022)
Review
Oncology
Marco Filetti, Pasquale Lombardi, Raffaele Giusti, Rosa Falcone, Florian Scotte, Diana Giannarelli, Antonella Carcagni, Valeria Altamura, Giovanni Scambia, Gennaro Daniele
Summary: This study provides an up-to-date estimate of the efficacy and safety of different combinations used for chemotherapy-induced nausea and vomiting. Overall, 3- or 4-drug regimens containing dexamethasone, 5-HT3 antagonists, mirtazapine or olanzapine showed the highest probability of being the most effective in terms of complete response. Regimens containing dexamethasone and 5-HT3 antagonist had the lowest probability of being the most effective in terms of complete, acute, and delayed response.
CANCER TREATMENT REVIEWS
(2023)
Article
Health Care Sciences & Services
Bhumik Patel, Jonathan Downie, Julie Bayliss, Andrea Stephenson, Myra Bluebond-Langner
Summary: This study reviewed the use of continuous daily aprepitant for refractory nausea and vomiting in children receiving care from a specialist palliative care team. The results showed resolution of symptoms and improved mobility and feeding in all patients with no adverse events reported.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Article
Health Care Sciences & Services
R. Norman, R. Viney, N. K. Aaronson, J. E. Brazier, D. Cella, D. S. J. Costa, P. M. Fayers, G. Kemmler, S. Peacock, A. S. Pickard, D. Rowen, D. J. Street, G. Velikova, T. A. Young, M. T. King
QUALITY OF LIFE RESEARCH
(2016)
Article
Urology & Nephrology
Athene Lane, Chris Metcalfe, Grace J. Young, Tim J. Peters, Jane Blazeby, Kerry N. L. Avery, Daniel Dedman, Liz Down, Malcolm D. Mason, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan
Editorial Material
Ophthalmology
T. Fayers, G. K. Loh, M. F. Cordeiro, V. Lee, R. Jain, P. M. Fayers
Article
Health Care Sciences & Services
Sally J. Wheelwright, Jane B. Hopkinson, Anne-Sophie Darlington, Deborah F. Fitzsimmons, Peter Fayers, Trude R. Balstad, Anne Bredart, Eva Hammerlid, Stein Kaasa, Ourania Nicolatou-Galitis, Monica Pinto, Heike Schmidt, Tora S. Solheim, Florian Strasser, Iwona M. Tomaszewska, Colin D. Johnson
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2017)
Correction
Genetics & Heredity
Yufei Wang, James D. Mckay, Thorunn Rafnar, Zhaoming Wang, Maria N. Timofeeva, Peter Broderick, Xuchen Zong, Marina Laplana, Yongyue Wei, Younghun Han, Amy Lloyd, Manon Delahaye-Sourdeix, Daniel Chubb, Valerie Gaborieau, William Wheeler, Nilanjan Chatterjee, Gudmar Thorleifsson, Patrick Sulem, Geoffrey Liu, Rudolf Kaaks, Marc Henrion, Ben Kinnersley, Maxime Vallee, Florence Le Calvez-Kelm, Victoria L. Stevens, Susan M. Gapstur, Wei V. Chen, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Hans E. Krokan, Maiken Elvestad Gabrielsen, Frank Skorpen, Lars Vatten, Inger Njolstad, Chu Chen, Gary Goodman, Simone Benhamou, Tonu Vooder, Kristjan Vaelk, Mari Nelis, Andres Metspalu, Marcin Lener, Jan Lubinski, Mattias Johansson, Paolo Vineis, Antonio Agudo, Francoise Clavel-Chapelon, H. Bas Bueno-De-Mesquita, Dimitrios Trichopoulos, Kay-Tee Khaw, Mikael Johansson, Elisabete Weiderpass, Anne Tjonneland, Elio Riboli, Mark Lathrop, Ghislaine Scelo, Demetrius Albanes, Neil E. Caporaso, Yuanqing Ye, Jian Gu, Xifeng Wu, Margaret R. Spitz, Hendrik Dienemann, Albert Rosenberger, Li Su, Athena Matakidou, Timothy Eisen, Kari Stefansson, Angela Risch, Stephen J. Chanock, David C. Christiani, Rayjean J. Hung, Paul Brennan, Maria Teresa Landi, Richard S. Houlston, Christopher I. Amos
Article
Orthopedics
M. B. Johnsen, G. A. Vie, B. S. Winsvold, J. H. Bjorngaard, B. O. Asvold, M. E. Gabrielsen, L. M. Pedersen, A. I. Hellevik, A. Langhammer, O. Furnes, G. B. Flugsrud, F. Skorpen, P. R. Romundstad, K. Storheim, L. Nordsletten, J. A. Zwart
OSTEOARTHRITIS AND CARTILAGE
(2017)
Article
Health Care Sciences & Services
Mogens Groenvold, Morten Aagaard Petersen, Anette Damkier, Mette Asbjoern Neergaard, Jan Bjoern Nielsen, Lise Pedersen, Per Sjogren, Annette Sand Stromgren, Tove Bahn Vejlgaard, Christian Gluud, Jane Lindschou, Peter Fayers, Irene J. Higginson, Anna Thit Johnsen
PALLIATIVE MEDICINE
(2017)
Article
Economics
Madeleine T. King, Rosalie Viney, A. Simon Pickard, Donna Rowen, Neil K. Aaronson, John E. Brazier, David Cella, Daniel S. J. Costa, Peter M. Fayers, Georg Kemmler, Helen McTaggart-Cowen, Rebecca Mercieca-Bebber, Stuart Peacock, Deborah J. Street, Tracey A. Young, Richard Norman
Correction
Health Care Sciences & Services
R. Norman, R. Viney, N. K. Aaronson, J. E. Brazier, D. Cella, D. S. J. Costa, P. M. Fayers, G. Kemmler, S. Peacock, A. S. Pickard, D. Rowen, D. J. Street, G. Velikova, T. A. Young, M. T. King
QUALITY OF LIFE RESEARCH
(2017)
Article
Multidisciplinary Sciences
Tea Skaaby, Amy E. Taylor, Rikke K. Jacobsen, Lavinia Paternoster, Betina H. Thuesen, Tarunveer S. Ahluwalia, Sofus C. Larsen, Ang Zhou, Andrew Wong, Maiken E. Gabrielsen, Johan H. Bjorngaard, Claudia Flexeder, Satu Mannisto, Rebecca Hardy, Diana Kuh, Sarah J. Barry, Line Tang Mollehave, Charlotte Cerqueira, Nele Friedrich, Tobias N. Bonten, Raymond Noordam, Dennis O. Mook-Kanamori, Christian Taube, Leon E. Jessen, Alex McConnachie, Naveed Sattar, Mark N. Upton, Charles McSharry, Klaus Bonnelykke, Hans Bisgaard, Holger Schulz, Konstantin Strauch, Thomas Meitinger, Annette Peters, Harald Grallert, Ellen A. Nohr, Mika Kivimaki, Meena Kumari, Uwe Voelker, Matthias Nauck, Henry Voeizke, Chris Power, Elina Hypponen, Torben Hansen, Torben Jorgensen, Oluf Pedersen, Veikko Salomaa, Niels Grarup, Arnulf Langhammer, Pal R. Romundstad, Frank Skorpen, Jaakko Kaprio, Marcus R. Munafo, Allan Linneberg
SCIENTIFIC REPORTS
(2017)
Article
Geriatrics & Gerontology
Ola Magne Vagnildhaug, David Blum, Andrew Wilcock, Peter Fayers, Florian Strasser, Vickie E. Baracos, Marianne J. Hjermstad, Stein Kaasa, Barry Laird, Tora S. Solheim
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Article
Geriatrics & Gerontology
Tora S. Solheim, Barry J. A. Laird, Trude Rakel Balstad, Guro B. Stene, Asta Bye, Neil Johns, Caroline H. Pettersen, Marie Fallon, Peter Fayers, Kenneth Fearon, Stein Kaasa
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Article
Oncology
Morten Aa Petersen, Neil K. Aaronson, Juan Arraras, Wei-Chu Chie, Thierry Conroy, Anna Costantini, Linda Dirven, Peter Fayers, Eva-Maria Gamper, Johannes M. Giesinger, Esther J. J. Habets, Eva Hammerlid, Jorunn Helbostad, Marianne J. Hjermstad, Bernhard Holzner, Colin Johnson, Georg Kemmler, Madeleine T. King, Stein Kaasa, Jon H. Loge, Jaap C. Reijneveld, Susanne Singer, Martin J. B. Taphoorn, Lise H. Thamsborg, Krzysztof A. Tomaszewski, Galina Velikova, Irma M. Verdonck-de Leeuw, Teresa Young, Mogens Groenvold
EUROPEAN JOURNAL OF CANCER
(2018)
Article
Multidisciplinary Sciences
Ornulf Paulsen, Barry Laird, Nina Aass, Tor Lea, Peter Fayers, Stein Kaasa, Pal Klepstad
Article
Multidisciplinary Sciences
Kristine Pettersen, Sonja Andersen, Simone Degen, Valentina Tadini, Joel Grosjean, Shinji Hatakeyama, Almaz N. Tesfahun, Siver Moestue, Jana Kim, Unni Nonstad, Pal R. Romundstad, Frank Skorpen, Sveinung Sorhaug, Tore Amundsen, Bjorn H. Gronberg, Florian Strasser, Nathan Stephens, Dag Hoem, Anders Molven, Stein Kaasa, Kenneth Fearon, Carsten Jacobi, Geir Bjorkoy
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)