Article
Multidisciplinary Sciences
Michael Rohr, Jordan Beardsley, Sai Preethi Nakkina, Xiang Zhu, Jihad Aljabban, Dexter Hadley, Deborah Altomare
Summary: The study developed a meta-dataset comprising healthy, adenoma, and CRC tissue samples from multiple independent studies, providing a robust platform for investigating colorectal adenoma formation and malignant transformation through integrated analysis and functional validation.
Article
Multidisciplinary Sciences
Zainab M. Almutairi
Summary: This study characterized the B12Dg gene in pearl millet and investigated its expression in response to abiotic stress and plant hormone treatment during germination. The results showed that PgB12Dg was upregulated in roots and downregulated in seeds, with significant expression changes under drought and cold stress. Additionally, plant hormone treatment revealed upregulation by gibberellic acid and downregulation by abscisic acid in germinated seeds.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Jessica Roelands, Manon Van der Ploeg, Marieke E. Ijsselsteijn, Hao Dang, Jurjen J. Boonstra, James C. H. Hardwick, Lukas J. A. C. Hawinkels, Hans Morreau, Noel F. C. C. de Miranda
Summary: Spatial profiling of pT1 CRC samples revealed the molecular and immunological landscape of early-stage colorectal cancer, identifying biomarkers associated with disease progression and targetable immune processes applicable in a clinical setting.
Review
Oncology
Farzana Y. Zaman, Suzanne G. Orchard, Andrew Haydon, John R. Zalcberg
Summary: Aspirin has been shown to play a beneficial role in preventing CRC, while non-aspirin NSAIDs have also been studied and found to potentially decrease CRC incidence in certain high-risk subgroups. However, the use of non-aspirin NSAIDs may come with increased risks of toxicity. Further studies are needed to establish the associations between concurrent aspirin and non-aspirin NSAID use, and CRC-related outcomes.
BRITISH JOURNAL OF CANCER
(2022)
Article
Engineering, Biomedical
Shraddha Chakraborty, Charlotte Luchena, Jonathan J. Elton, Marcel P. Schilling, Markus Reischl, Margaux Roux, Pavel A. Levkin, Anna A. Popova
Summary: In this study, a method called "Cells-to-cDNA on Chip" was developed to isolate mRNA from live cells and convert it to cDNA in individual droplets, enabling cell screening, phenotypic microscopy-based assessments, and gene expression analysis on an open DMA platform. This method provides a basis for obtaining detailed information about molecular dynamics in cultured cells.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Oncology
R. Charles Coombes, Holly Tovey, Lucy Kilburn, Janine Mansi, Carlo Palmieri, John Bartlett, Jonathan Hicks, Andreas Makris, Abigail Evans, Sibylle Loibl, Carsten Denkert, Elisabeth Murray, Robert Grieve, Robert Coleman, Annabel Borley, Marcus Schmidt, Beate Rautenberg, Catarina Alisa Kunze, Uwe Rhein, Keyur Mehta, Kelly Mousa, Tessa Dibble, Xiao Lou Lu, Gunter von Minckwitz, Judith M. Bliss
Summary: The Randomized European Celecoxib Trial (REACT) evaluated the role of Celecoxib as an addition to conventional therapy for women with ERBB2-negative primary breast cancer. The study did not find evidence of a disease-free survival benefit for patients receiving 2 years of Celecoxib treatment compared to placebo. Longer-term treatment or higher doses of Celecoxib may need to be explored in further studies to determine potential benefits.
Article
Biochemical Research Methods
Niels M. Leijten, Petra Bakker, Herman P. Spaink, Jeroen den Hertog, Simone Lemeer
Summary: Thermal proteome profiling (TPP) enables unbiased detection of drug-target protein engagements in vivo. By using whole zebrafish embryo lysate, this study identified potential protein targets of napabucasin, including oxidoreductase PORA, which may affect Stat3 signaling.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Review
Medicine, General & Internal
Vinutna Ganduri, Kruthiga Rajasekaran, Shrimahitha Duraiyarasan, Mayowa A. Adefuye, Nisha Manjunatha
Summary: Colorectal carcinoma is the most common gastrointestinal cancer, arising from benign precursor polyps and influenced by genetics, pathology, and COX enzymes. Inhibition of COX by NSAIDs is believed to be helpful in preventing colorectal carcinoma.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Biochemical Research Methods
Pontus Eriksson, Nour-al-dain Marzouka, Gottfrid Sjodahl, Carina Bernardo, Fredrik Liedberg, Mattias Hoglund
Summary: In this study, we evaluated the behavior of gene-pair-based single sample predictors (SSPs) in gene expression-based multiclass prediction tasks. We found that these methods showed excellent performance, with high accuracy and informative prediction scores, in many expression-based classification tasks. However, the compatibility of gene-pair-based predictors with new datasets still needs to be verified.
Article
Oncology
Jung Ho Kim, Mi-Kyoung Seo, Ji Ae Lee, Seung-Yeon Yoo, Hyeon Jeong Oh, Hyundeok Kang, Nam-Yun Cho, Jeong Mo Bae, Gyeong Hoon Kang, Sangwoo Kim
Summary: CRCs with MSI-H are immunologically heterogeneous and can be classified into immune-high, immune-intermediate, and immune-low subgroups. Immune-low MSI-H CRCs show similarities to specific subgroups of microsatellite-stable CRCs in terms of immune parameters, but exhibit distinct pathological features, genomic alterations, and activated signaling pathways, further dividing into different gene expression subtypes. These findings provide insights into precise immunotherapeutic strategies for different subtypes of MSI-H tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Wenpu Lai, Xiaofang Wang, Lian Liu, Ling Xu, Lipeng Mao, Jiaxiong Tan, Xianfeng Zha, Huien Zhan, Wen Lei, Yu Lan, Guobing Chen, Yangqiu Li, Oscar Junhong Luo
Summary: This study identified a subset of circulating CD103+ T cells in B-ALL patients, which showed different developmental potential into effector T cells or exhausted T cells, closely associated with patient prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Shizhe Yu, Haoren Wang, Lingpeng Yang, Yingxue Yan, Qiang Cai, Duo Ma, Long Jiang, Zehai Gao, Zhiyong Yu, Zongping Xia
Summary: The comprehensive study of the spatial-cellular anatomy of the human liver is crucial for understanding the cellular origins of liver disease. In this study, spatial transcriptomics were conducted on normal human liver tissue sections, providing detailed transcriptional information on liver zonation. A total of 6581 high-quality spots from normal livers were analyzed, mainly consisting of hepatocytes, which were classified into four sub-groups. These data serve as a reliable reference for studying the spatial heterogeneity of liver lobules.
Article
Medicine, Research & Experimental
Qi Lian, Lipeng Zhong, Kepu Fu, Yuxin Ji, Xiangyue Zhang, Chunju Liu, Chunhong Huang
Summary: Snake venom is a toxic arsenal that induces various symptoms in snakebite victims. This study reveals the presence of inhibitor cocktail in non-venomous snakes, which can neutralize snake venoms and mitigate venom-induced damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Genetics & Heredity
Yujie Fan, Jiyan Qi, Xiaohu Xiao, Heping Li, Jixian Lan, Yacheng Huang, Jianghua Yang, Yi Zhang, Shengmin Zhang, Jun Tao, Chaorong Tang
Summary: This study reveals extensive physiological and molecular changes in Hevea laticifers incurred by tapping treatment. The identification of a large number of differentially expressed genes and proteins contributes to unraveling the gene regulatory network of tapping-stimulated latex production.
FRONTIERS IN GENETICS
(2022)
Article
Biology
Leah M. Williams, Sainetra Sridhar, Jason Samaroo, Jada Peart, Ebubechi K. Adindu, Anvitha Addanki, Christopher J. DiRusso, Pablo J. Aguirre Carrion, Nahomie Rodriguez-Sastre, Trevor Siggers, Thomas D. Gilmore
Summary: Transcription factor NF-kappa B plays a key role in immunity in mammals. This study characterized and compared NF-kappa B in Capsaspora and choanoflagellates, revealing differences in structure and activity, which could provide insight into the evolutionary origins of this important protein.
COMMUNICATIONS BIOLOGY
(2021)
Article
Chemistry, Analytical
Jongwon Oh, Min-Seung Park, Mi-Ryung Chun, Jung Hye Hwang, Jin-Young Lee, Jae Hwan Jee, Soo-Youn Lee
Summary: Measuring nicotine metabolites using liquid chromatography--tandem mass spectrometry is an objective method for identifying smoke exposure. The developed method for simultaneous measurement of multiple metabolites proved to be sensitive and effective in screening smoking status in the general population.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2022)
Article
Gastroenterology & Hepatology
Eun Sil Kim, Sujin Choi, So Yoon Choi, Ji Hyung Park, Byung-Ho Choe, Soo-Youn Lee, Mi Jin Kim, Yon Ho Choe, Ben Kang
Summary: NUDT15 intermediate metabolisers are associated with lower loss of response in pediatric patients with CD treated with IFX and AZA combination therapy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Julia C. F. Quintanilha, Jin Wang, Alexander B. Sibley, Chen Jiang, Amy S. Etheridge, Fei Shen, Guanglong Jiang, Flora Mulkey, Jai N. Patel, Daniel L. Hertz, Elizabeth Claire Dees, Howard L. McLeod, Monica Bertagnolli, Hope Rugo, Hedy L. Kindler, William Kevin Kelly, Mark J. Ratain, Deanna L. Kroetz, Kouros Owzar, Bryan P. Schneider, Danyu Lin, Federico Innocenti
Summary: A genome-wide association study (GWAS) meta-analysis was conducted in European ancestry bevacizumab-treated patients, identifying significant SNPs associated with hypertension and proteinuria, providing new markers for predicting toxicities induced by bevacizumab.
BRITISH JOURNAL OF CANCER
(2022)
Correction
Oncology
Julia C. F. Quintanilha, Jin Wang, Alexander B. Sibley, Chen Jiang, Amy S. Etheridge, Fei Shen, Guanglong Jiang, Flora Mulkey, Jai N. Patel, Daniel L. Hertz, Elizabeth Claire Dees, Howard L. McLeod, Monica Bertagnolli, Hope Rugo, Hedy L. Kindler, William Kevin Kelly, Mark J. Ratain, Deanna L. Kroetz, Kouros Owzar, Bryan P. Schneider, Danyu Lin, Federico Innocenti
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Emma C. Hulshof, Mirjam de With, Femke M. de Man, Geert-Jan Creemers, Birgit A. L. M. Deiman, Jesse J. Swen, Saskia Houterman, Stijn L. W. Koolen, Sander Bins, Anna M. J. Thijs, Marjan M. J. Laven, Anke M. Hovels, Saskia A. C. Luelmo, Danny Houtsma, Katerina Shulman, Howard L. McLeod, Ron H. N. van Schaik, Henk-Jan Guchelaar, Ron H. J. Mathijssen, Hans Gelderblom, Maarten J. Deenen
Summary: This study aimed to determine the safety, feasibility, pharmacokinetics, and cost of UGT1A1 genotype-guided dosing of irinotecan. The results showed that UGT1A1 genotype-guided dosing significantly reduces the incidence of febrile neutropenia in UGT1A1 PM patients treated with irinotecan, results in a therapeutically effective systemic drug exposure, and is cost-saving.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Daryl Pritchard, Jai N. Patel, Lindsay E. Stephens, Howard L. McLeod
Summary: This report compares PGx information in the FDA Table of Pharmacogenetic Associations with CPIC guidelines and finds significant differences between the two sources, including the drugs listed and gene-drug associations. FDA and CPIC have different perspectives and criteria when evaluating PGx associations and clinical validity, leading to divergent information in their respective sources.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2022)
Editorial Material
Medical Laboratory Technology
Young Jin Kim, Soo-Youn Lee, Mina Hur
ANNALS OF LABORATORY MEDICINE
(2022)
Article
Genetics & Heredity
Wei Li, Jielin Wan, Cuiyu Chen, Chengfang Zhou, Ping Liao, Qian Hu, Jiali Hu, Yang Wang, Yu Zhang, Cong Peng, Yuanfei Huang, Weihua Huang, Wei Zhang, Howard L. Mcleod, Yijing He
Summary: Preclinical and early clinical studies have shown that propranolol, a beta-adrenergic receptor blocker, can exert antitumor activity through cell signaling and immune function pathways. The inhibition of beta(2)-AR signaling selectively suppresses cell viability and inhibits xenograft growth, while propranolol can activate CD8(+) T cells in the tumor microenvironment. However, selective beta(1) or beta(2)-AR blockers have no significant effect on the tumor immune microenvironment. Therefore, the antitumor activity of propranolol is predominantly dependent on cell signaling rather than the activation of CD8(+) T cells.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Cell Biology
Zhenwei Song, Brian Chen, Chi-Hao Tsai, Di Wu, Emily Liu, Isha Sharday Hawkins, Andrew Phan, James Todd Auman, Yazhong Tao, Hua Mei
Summary: This study identified two different types of putative limbal stem cells (LSCs) and several types of limbal progenitor cells (LPCs) using single-cell RNA sequencing. The findings contribute to a better understanding of corneal epithelial regeneration and wound healing.
Article
Pharmacology & Pharmacy
Roseann S. Gammal, Munir Pirmohamed, Andrew A. Somogyi, Sarah A. Morris, Christine M. Formea, Amanda L. Elchynski, Kazeem A. Oshikoya, Howard L. McLeod, Cyrine E. Haidar, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Mary Relling
Summary: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with the development of acute hemolytic anemia in the presence of oxidative stress. This guideline provides information on using G6PD genotype for diagnosing G6PD deficiency and categorizes medications based on their risk level in individuals with G6PD deficiency. High-risk medications should be avoided, medium-risk medications should be used with caution, and low-risk medications can be used without considering the G6PD phenotype.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medical Laboratory Technology
Beomki Lee, Won Young Heo, Jee Ah Kim, Hyun Seung Lee, Narae Hwang, Hyung-Doo Park, Se In Sung, Yun Sil Chang, Won Soon Park, Soo-Youn Lee
Summary: The NeoBase 2 assay was comprehensively evaluated and found to be able to distinguish between transient tyrosinemia of the newborn (TTN) and tyrosinemia type 1 (TYR 1) using succinylacetone (SUAC). Different cutoffs were established for analytes in preterm neonates. Simultaneous measurement of tyrosine (Tyr) and SUAC successfully differentiated between TYR 1 and TTN.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Young-Gon Kim, Jisook Park, Eun Young Park, Sang-Mi Kim, Soo-Youn Lee
Summary: This study investigated the response of normal pancreatic islet cells to pancreatic cancer-derived exosomes in order to identify potential biomarkers for pancreatic cancer-induced diabetes mellitus (PC-DM) and pancreatic cancer itself. Changes in microRNA expression were evaluated, and 24 candidate miRNA markers were proposed. These markers showed relevance to diabetes mellitus and/or insulin resistance, suggesting a potential association with PC-DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Beomki Lee, Soo-Youn Lee, Deok Hyun Han, Hyung-Doo Park
Summary: Cystinuria is a genetic disorder caused by defects in the b(0,+) transporter system. Variants in SLC3A1 and SLC7A9 follow different inheritance patterns and complicate variant interpretation. This study identified novel variants and used in silico analysis to predict functional loss and protein expression changes.
Review
Medicine, General & Internal
Joon-sik Choi, Seo Hee Yoon, Hyo Jung Park, Soo-Youn Lee, Yae-Jean Kim
Summary: There is insufficient evidence on teicoplanin trough levels in pediatric populations, but favorable clinical efficacy can be achieved in the majority of patients using recommended dosing regimens.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Correction
Pharmacology & Pharmacy
Daryl Pritchard, Jai N. Patel, Lindsay E. Stephens, Howard L. McLeod
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)