Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity

Chronic restraint stress promotes the mobilization and recruitment of myeloid‐derived suppressor cells through β‐adrenergic activated CXCL5‐CXCR2‐Erk signaling cascades

(2021) Mingyue Cao et al.   INTERNATIONAL JOURNAL OF CANCER

Clinical Use of Propranolol Reduces Biomarkers of Proliferation in Gastric Cancer

(2021) Qian Hu et al.   Frontiers in Oncology

Propranolol suppresses the growth of colorectal cancer through simultaneously activating autologous CD8 + T cells and inhibiting tumor AKT/MAPK pathway

(2020) Ping Liao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Prospective pilot trial with combination of propranolol with chemotherapy in patients with epithelial ovarian cancer and evaluation on circulating immune cell gene expression

(2019) Lois M. Ramondetta et al.   GYNECOLOGIC ONCOLOGY

The beta adrenergic receptor antagonist propranolol alters mitogenic and apoptotic signaling in late stage breast cancer

(2019) Alexa Montoya et al.   Biomedical Journal

Pre-operative β-blockade with propranolol reduces biomarkers of metastasis in breast cancer: a Phase II randomized trial

(2019) Jonathan G Hiller et al.   CLINICAL CANCER RESEARCH

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

(2019) Hemn Mohammadpour et al.   JOURNAL OF CLINICAL INVESTIGATION

Destress and do not suppress: targeting adrenergic signaling in tumor immunosuppression

(2019) Ignacio Iñigo-Marco et al.   JOURNAL OF CLINICAL INVESTIGATION

Bloqueadores beta: perspectiva histórica y mecanismos de acción

(2019) Eduardo Oliver et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2

(2019) Xuan Zhang et al.   Cell Death & Disease

Infantile hemangiomas

(2018) Rachael Hagen et al.   CURRENT OPINION IN PEDIATRICS

Propranolol for Off-label Treatment of Patients With Melanoma

(2018) Vincenzo De Giorgi et al.   JAMA Oncology

β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress

(2018) Guanxi Qiao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Skin cancer: Propranolol limits melanoma recurrence

(2017) David Killock   Nature Reviews Clinical Oncology

β-Adrenergic-stimulated macrophages: Comprehensive localization in the M1-M2 spectrum

(2016) Donald M. Lamkin et al.   BRAIN BEHAVIOR AND IMMUNITY

Sympathetic neural signaling via the β2-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8+ T-cell effector function

(2016) Leonardo D. Estrada et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The potential anticancer effect of beta-blockers and the genetic variations involved in the interindividual difference

(2016) Ruo-Hui He et al.   PHARMACOGENOMICS

Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway

(2016) Chengfang Zhou et al.   Oncotarget

Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response

(2015) Winnie Yeo et al.   BMC CANCER

Molecular Mechanisms Underlying β-Adrenergic Receptor-Mediated Cross-Talk between Sympathetic Neurons and Immune Cells

(2015) Dianne Lorton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective β2-AR Blockage Suppresses Colorectal Cancer Growth Through Regulation of EGFR-Akt/ERK1/2 Signaling, G1-Phase Arrest, and Apoptosis

(2015) Chih-Chien Chin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation

(2015) Naikhoba C.O. Munabi et al.   Stem Cells Translational Medicine

Beta-Blocker Drug Therapy Reduces Secondary Cancer Formation in Breast Cancer and Improves Cancer Specific Survival

(2015)   Oncotarget

Autonomic regulation of cellular immune function

(2014) Denise L. Bellinger et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

The MAPK pathway across different malignancies: A new perspective

(2014) Mauricio Burotto et al.   CANCER

β-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines

(2013) Silvia Moretti et al.   LABORATORY INVESTIGATION

Effect of β-Blockers and Other Antihypertensive Drugs On the Risk of Melanoma Recurrence and Death

(2013) Vincenzo De Giorgi et al.   MAYO CLINIC PROCEEDINGS

Propranolol inhibits endothelial progenitor cell homing: a possible treatment mechanism of infantile hemangioma

(2012) Hai-Xiao Zou et al.   CARDIOVASCULAR PATHOLOGY

β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway

(2011) Dong Zhang et al.   Molecular Cancer

Stimulation of β2-adrenergic receptors inhibits calcineurin activity in CD4+ T cells via PKA–AKAP interaction

(2010) Carsten Riether et al.   BRAIN BEHAVIOR AND IMMUNITY

Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: Implications for stress-related enhancement of tumor progression

(2008) Eric V. Yang et al.   BRAIN BEHAVIOR AND IMMUNITY