Article
Biochemistry & Molecular Biology
Ines Drenjancevic, Jan Pitha
Summary: In addition to proven medications, omega-3 polyunsaturated fatty acids (n-3 PUFAs) are considered to have additive effects on cardiovascular health. They influence the cardiovascular system through various mechanisms, including effects on metabolism, inflammation, thrombosis, and direct effects on cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Manoj Kumar, Namrata Pal, Poonam Sharma, Manoj Kumawat, Devojit Kumar Sarma, Bilkees Nabi, Vinod Verma, Rajnarayan R. Tiwari, Swasti Shubham, Bahram Arjmandi, Ravinder Nagpal
Summary: This paper provides insights into the potential role of omega-3 fatty acids in the management of Type-2 diabetes mellitus (T2DM) by influencing gut dysbiosis. By reviewing and discussing the molecular mechanisms and signaling pathways, the paper explores the associations between omega-3 fatty acids, gut dysbiosis, and the pathophysiology of T2DM and its related comorbidities. Moreover, the significance of gut microbiota in T2DM prevention and treatment is highlighted along with the potential of omega-3 fatty acids to positively modulate gut microbiota, leading to the discovery of new targets and therapeutic strategies for T2DM.
Article
Public, Environmental & Occupational Health
Jae Eun Shim, Youngmi Lee, Sujin Song
Summary: This study examined the dietary intake and food sources of long-chain polyunsaturated fatty acids (LC-PUFAs) in Korean adults from 2007 to 2018. The findings showed an increase in the intake of alpha-linolenic acid (ALA) and linoleic acid (LA), while the intake of eicosapentaenoic acid (EPA) and EPA+DHA showed a decreasing trend. The study also highlighted the need to encourage the consumption of EPA and DHA from healthy food sources to improve cardiovascular health in the Korean population.
EPIDEMIOLOGY AND HEALTH
(2023)
Article
Fisheries
Michail I. Gladyshev, Alexander A. Makhrov, Nadezhda N. Sushchik, Olesia N. Makhutova, Anastasia E. Rudchenko, Dmitrii A. Balashov, Evgenii V. Vinogradov, Valentina S. Artamonova
Summary: This study examined the composition and contents of fatty acids (FA) in fillets of seven strains of rainbow trout. The results showed that the diet composition and genetics played a role in the FA composition of the fish. The Steelhead strain of rainbow trout demonstrated a higher ability to regulate its FA composition, particularly regarding the important acids EPA and DHA. Furthermore, FA markers were identified that can be used to differentiate between wild and farmed rainbow trout.
Article
Nutrition & Dietetics
Tomoaki Okada, Toru Miyoshi, Masayuki Doi, Kosuke Seiyama, Wataru Takagi, Masahiro Sogo, Kazumasa Nosaka, Masahiko Takahashi, Keisuke Okawa, Hiroshi Ito
Summary: This study aimed to retrospectively investigate the 10-year trend of changes in polyunsaturated fatty acids in patients with acute coronary syndrome, revealing a secular decreasing trend in EPA and DHA levels, but not in AA and DGLA levels. The decreasing trend in EPA and DHA levels was not age-dependent and remained significant only in men, highlighting the need for further research on the effects of n-3 PUFAs on secondary prevention of ACS.
Article
Pharmacology & Pharmacy
Charlotte Smith Bonde, Louis Bornancin, Yi Lu, Henrik Toft Simonsen, Maria Martinez-Valladares, Miguel Pena-Espinoza, Helena Mejer, Andrew R. Williams, Stig Milan Thamsborg
Summary: The study shows that seaweed can provide bioactive compounds with anti-parasitic activity, with Saccharina latissima and Laminaria digitata showing particularly high anti-parasitic activity. Fatty acids may play an important role in controlling intestinal helminth infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Richard L. Weinberg, Robert D. Brook, Melvyn Rubenfire, Kim A. Eagle
Summary: Omega-3 polyunsaturated fatty acids play a key role in heart-healthy diet, and can be obtained through fatty fish consumption or fish oil supplementation. They not only treat hypertriglyceridemia, but also prevent cardiovascular events, with additional benefits such as reducing inflammation and improving plaque stability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Environmental Sciences
Priyanshi Sikka, Tapan Behl, Sanchay Sharma, Aayush Sehgal, Saurabh Bhatia, Ahmed Al-Harrasi, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Ω-3 fatty acids are recognized for their benefits on physical and mental health, primarily obtained from fish and fish products. Adequate intake of Ω-3 fatty acids can improve brain function and neuronal function, reduce depressive symptoms, and have fewer side effects compared to antidepressants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Nutrition & Dietetics
Maja Tomczyk, Jeffery L. Heileson, Miroslaw Babiarz, Philip C. Calder
Summary: Fatty fish and certain species of algae are the only natural sources of EPA and DHA, which have various beneficial effects for athletes. Due to limited intake and fluctuating content, athletes may consider using supplements to ensure sufficient EPA and DHA levels.
Article
Nutrition & Dietetics
Maria Dolores Mesa, Fernando Gil, Pablo Olmedo, Angel Gil
Summary: This study aims to estimate the amount of n-3 LC-PUFA provided by commonly consumed fishes, shrimps, and mollusks, to conduct a risk-benefit analysis of fish consumption. Consuming 2-3 servings of a variety of fishery products per week can help meet recommended n-3 LC-PUFA levels while maintaining a balance to avoid potential risks from contaminants.
Article
Nutrition & Dietetics
Roberta Dourado Cavalcante da Cunha de Sa, Jussara de Jesus Simao, Viviane Simoes da Silva, Talita Mendes de Farias, Maysa Mariana Cruz, Vitor Jaco Antraco, Lucia Armelin-Correa, Maria Isabel Alonso-Vale
Summary: This study found that different ratios of EPA and DHA have different impacts on adipose tissue metabolism, with fish oil rich in EPA instead of DHA effectively reversing changes induced by obesity.
Review
Nutrition & Dietetics
Thais Keiko Siroma, David Johane Machate, Veronica Assalin Zorgetto-Pinheiro, Priscila Silva Figueiredo, Gabriela Marcelino, Priscila Aiko Hiane, Danielle Bogo, Arnildo Pott, Elenir Rose Jardim Cury, Rita de Cassia Avellaneda Guimaraes, Marcelo Luiz Brandao Vilela, Rosangela dos Santos Ferreira, Valter Aragao do Nascimento
Summary: This review emphasizes the role of ingesting polyphenols and omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in reducing obesity and related metabolic diseases. Consumption of foods rich in polyphenols and omega-3 PUFAs, such as vegetables, fruits, fish, and their by-products, is associated with a decrease in obesity and its related diseases. Further research and the development of food education projects are needed to help reduce obesity and other metabolic diseases.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Linlin Huang, Fanjie Zhang, Ping Xu, Yijie Zhou, Yijun Liu, Hongdie Zhang, Xiaozhen Tan, Xinxu Ge, Yong Xu, Man Guo, Yang Long
Summary: Current guidelines recommend regular consumption of fat-rich fish to obtain sufficient omega-3 polyunsaturated fatty acids for preventing cardiovascular events. However, the cardiovascular benefits of omega-3 polyunsaturated fatty acids in patients with diabetes are uncertain. This meta-analysis of randomized controlled trials found that omega-3 fatty acid supplementation reduces cardiovascular disease risk in patients with diabetes, with eicosapentaenoic acid showing a significant effect. Further well-designed trials are needed to evaluate safety and effects on atrial fibrillation.
ADVANCES IN NUTRITION
(2023)
Article
Chemistry, Applied
Xiaofang Dao, Dawei Zhang, Linlin Wang, Lina Wang
Summary: This study evaluated the fatty acid (FA) composition in the milk of lactating Tibetan women and the consequences of dietary patterns. The milk was found to have high levels of total saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) compared to milk from other regions in China. However, total polyunsaturated fatty acids (PUFA) were slightly lower, and the concentration of docosahexaenoic acid (DHA) was significantly lower. The main n-3 FAs in human milk, including DHA and EPA, may be influenced by carbohydrate intake.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Review
Nutrition & Dietetics
Meghan Dempsey, Michelle S. Rockwell, Laurel M. Wentz
Summary: The majority of the population lack adequate omega-3 fatty acids (n-3 FA), leading to global deficiencies and poor omega-3 status. This study aimed to evaluate the effect of n-3 FA interventions on omega3-index (O3i) and estimate sufficient intake to meet recommendations.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Novita D. Naomi, Elske M. Brouwer-Brolsma, Marion E. C. Buso, Sabita S. Soedamah-Muthu, Joanne A. Harrold, Jason C. G. Halford, Anne Raben, Johanna M. Geleijnse, Edith J. M. Feskens
Summary: This study examined the associations between consumption of sugar-sweetened beverages (SSB), low/no-calorie beverages (LNCB), and fruit juice (FJ) and all-cause mortality in Dutch adults. The results showed adverse associations between SSB consumption and all-cause mortality, while replacing SSB with LNCB might be associated with lower mortality risk, particularly in women. Moderate intake of FJ was associated with lower all-cause mortality risk.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Medicine, General & Internal
Kwok Leung Ong, Matti Marklund, Liping Huang, Kerry-Anne Rye, Nicholas Hui, Xiong-Fei Pan, Casey M. Rebholz, Hyunju Kim, Lyn M. Steffen, Anniek C. van Westing, Johanna M. Geleijnse, Ellen K. Hoogeveen, Yun-Yu Chen, Kuo-Liong Chien, Amanda M. Fretts, Rozenn N. Lemaitre, Fumiaki Imamura, Nita G. Forouhi, Nicholas J. Wareham, Anna Birukov, Susanne Jaeger, Olga Kuxhaus, Matthias B. Schulze, Vanessa Derenji de Mello, Jaakko Tuomilehto, Matti Uusitupa, Jaana Lindstroem, Nathan Tintle, William S. Harris, Keisuke Yamasaki, Yoichiro Hirakawa, Toshiharu Ninomiya, Toshiko Tanaka, Luigi Ferrucci, Stefania Bandinelli, Jyrki KVirtanen, Ari Voutilainen, Tharusha Jayasena, Anbupalam Thalamuthu, Anne Poljak, Sonia Bustamante, Perminder S. Sachdev, Mackenzie KSennII, Stephen S. Rich, Michael Y. Tsai, Alexis C. Wood, Markku Laakso, Maria Lankinen, Xiaowei Yang, Liang Sun, Huaixing Li, Xu Lin, Christoph Nowak, Johan aernloev, Ulf Riserus, Lars Lind, Melanie Le Goff, Cecilia Samieri, Catherine Helmer, Frank Qian, Renata Micha, Adrienne Tin, Anna Koettgen, Ian H. de Boer, David S. Siscovick, Dariush Mozaffarian, Jason H. Y. Wu
Summary: This study conducted a pooled analysis of 19 studies and found that higher levels of seafood-derived omega 3 polyunsaturated fatty acids (n-3 PUFAs) were associated with a lower risk of incident chronic kidney disease (CKD). However, no association was found for plant-derived n-3 PUFAs. These results highlight the beneficial role of seafood-derived n-3 PUFAs in preventing CKD.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Esther Cruijsen, Kamalita Pertiwi, Johanna M. Geleijnse
Article
Endocrinology & Metabolism
Novita D. Naomi, Joy Ngo, Elske M. Brouwer-Brolsma, Marion E. C. Buso, Sabita S. Soedamah-Muthu, Carmen Perez-Rodrigo, Joanne A. Harrold, Jason C. G. Halford, Anne Raben, Johanna M. Geleijnse, Lluis Serra-Majem, Edith J. M. Feskens
Summary: This study examined the associations between different types of beverage intake and non-alcoholic fatty liver disease (NAFLD). The results showed that higher intake of sugar-sweetened beverages (SSB) and low/no-calorie beverages (LNCB) were positively associated with NAFLD prevalence, while moderate intake of fruit juice (FJ) was inversely associated with NAFLD prevalence. The substitution of SSB with LNCB was associated with a higher NAFLD prevalence.
NUTRITION & DIABETES
(2023)
Article
Psychiatry
Hilde de Kluiver, Rick Jansen, Brenda W. J. H. Penninx, Erik J. J. Giltay, Robert A. A. Schoevers, Yuri Milaneschi
Summary: Depression overlaps with cardiometabolic conditions in terms of metabolomic signature. The metabolomic signature is linked to atypical depression profiles characterized by energy alterations. This specific clustering of metabolomic signature with clinical profile identifies a subgroup of depressed patients at higher cardiometabolic risk, potentially serving as a valuable target for interventions to reduce the detrimental impact of depression on health.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Kristel C. M. M. Polhuis, Lenneke Vaandrager, Maria A. Koelen, Johanna M. Geleijnse, Sabita S. Soedamah-Muthu
Summary: This study aims to examine the quantitative and qualitative effects of the SALUD program on healthy eating and well-being in people with type 2 diabetes mellitus. The SALUD program provides valuable information on salutogenic interventions and serves as a concrete, web-based tool. The combination of quantitative and qualitative measures allows for a comprehensive evaluation of effects, which can be used to optimize interventions for type 2 diabetes mellitus.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Food Science & Technology
Victoria Miller, Patrick Webb, Frederick Cudhea, Jianyi Zhang, Julia Reedy, Peilin Shi, Josh Erndt-Marino, Jennifer Coates, Renata Micha, Dariush Mozaffarian
Summary: An analysis based on data from the Global Dietary Database shows that mean animal-sourced food (ASF) intakes among children and adolescents increased modestly from 1990 to two portions per day in 2018, but remain low in sub-Saharan Africa, India, and Bangladesh. The intake of ASF varied by age group, with urban children with educated parents having higher consumption. These findings highlight the importance of targeted ASF consumption programs to address malnutrition.
Article
Psychiatry
N. J. de Bles, L. E. H. Puetz, N. Rius Ottenheim, A. M. van Hemert, B. M. Elzinga, B. W. J. H. Penninx, E. J. Giltay
Summary: Childhood trauma is associated with anger in adulthood, and all types of childhood trauma are related to borderline personality traits. It is important to focus on childhood traumatic experiences and adult anger to improve treatment outcomes for patients with depressive and anxiety disorders.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Nutrition & Dietetics
Nadia E. Bonekamp, Esther Cruijsen, Frank LJ. Visseren, Yvonne T. van der Schouw, Johanna M. Geleijnse, Charlotte Koopal
Summary: This study emulated a clinical trial to assess the relationship between compliance with the DASH diet and cardiovascular and all-cause mortality risk in patients with a history of myocardial infarction. The study found that there was no association between DASH diet compliance and risk of all-cause and cardiovascular mortality in this population.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Maria G. Jacobo G. Cejudo, Carolina Ochoa-Rosales, Fariba Ahmadizar, Maryam Kavousi, Johanna M. Geleijnse, Trudy Voortman
Summary: The study examined the association between beverage quality and insulin resistance, prediabetes, and type 2 diabetes risk. The results showed that the Healthy Beverage Index (HBI) score was not associated with insulin resistance, prediabetes, or type 2 diabetes risk.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Marion E. C. Buso, Elske M. Brouwer-Brolsma, Novita D. Naomi, Joy Ngo, Sabita S. Soedamah-Muthu, Christina Mavrogianni, Joanne A. Harrold, Jason C. G. Halford, Anne Raben, Johanna M. Geleijnse, Yannis Manios, Luis Serra-Majem, Edith J. M. Feskens
Summary: This analysis of five European studies found a weak positive association between sugar-sweetened beverage (SSB) consumption and weight and waist change, while low/no-calorie sweetened beverage (LNCB) consumption was only associated with weight change. Theoretical substitutions did not show any clear association.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Nadia E. Bonekamp, Frank L. J. Visseren, Maarten J. Cramer, Jannick A. N. Dorresteijn, Manon G. van der Meer, Ynte M. Ruigrok, Thomas T. van Sloten, Martin Teraa, Johanna M. Geleijnse, Charlotte Koopal, UCC-SMART Study Grp
Summary: This study aimed to quantify the relationship between self-reported, long-term lifestyle changes and clinical outcomes in patients with established cardiovascular disease (CVD). The results showed that maintaining or adopting a healthy lifestyle could significantly lower mortality and incident Type 2 diabetes risk in CVD patients. This emphasizes the importance of ongoing lifestyle optimization in CVD patients and suggests that it is never too late to improve one's lifestyle.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Luc Heerkens, Anniek C. van Westing, Trudy Voortman, Isabella Kardys, Eric Boersma, Johanna M. Geleijnse
Summary: NAFLD and CKD are strongly associated in patients with post-myocardial infarction (MI), which is reflected by higher serum uric acid (SUA) concentrations. SUA is a strong predictor of 12-year mortality risk after MI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Correction
Food Science & Technology
Victoria Miller, Patrick Webb, Frederick Cudhea, Peileinin Shi, Jianyi Zhang, Julia Reedy, Josh Erndt-Marino, Jennifer Coates, Dariush Mozaffarian, Global Dietary Database
Article
Psychology, Clinical
Maren C. G. Kopland, Karianne Vrabel, Margarita Slof-Op't Landt, Asle Hoffart, Sverre Urnes Johnson, Erik J. Giltay
Summary: The study utilized dynamic time warping analysis to investigate central change processes in therapy in a transdiagnostic sample, revealing the importance of targeting and monitoring feelings and cognitions related to shape for lasting symptom improvement. Furthermore, it highlighted the need for further investigation into the impact of childhood maltreatment on eating disorders to provide more insights for therapy.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)