Article
Cardiac & Cardiovascular Systems
Di Liu, Hui Wu, Yun Zhao Li, Jun Yang, Jian Yang, Jia Wang Ding, Gang Zhou, Jing Zhang, Xin'an Wang, Zhi Xing Fan
Summary: This study demonstrated that overexpression of cFLIP can significantly alleviate myocardial ischemia/reperfusion injury-induced apoptosis and autophagy. The protective effects were achieved by downregulating the activity of the NF-κB pathway and upregulating the expression of Bcl-2.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Oncology
Hardeep Singh Tuli, Prangya Rath, Abhishek Chauhan, Katrin Sak, Diwakar Aggarwal, Renuka Choudhary, Ujjawal Sharma, Kanupriya Vashishth, Sheetu Sharma, Manoj Kumar, Vikas Yadav, Tejveer Singh, Mukerrem Betul Yerer, Shafiul Haque
Summary: Luteolin, a common flavonoid, has shown promising anticancer properties by targeting various cellular processes to inhibit tumor growth and reverse medication resistance in cancer cells.
Article
Biochemistry & Molecular Biology
Syed Moasfar Ali, Faisal Nabi, Malik Hisamuddin, Irum Rizvi, Azeem Ahmad, Md Nadir Hassan, Pradipta Paul, Ali Chaari, Rizwan H. Khan
Summary: Protein misfolding in amyloidosis is linked to various pathophysiological conditions. Inhibition of toxic aggregates or disaggregation of preformed fibrils is an important strategy in preventing these diseases. Natural compounds, such as luteolin, have been shown to prevent amyloid fibril formation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Chaitrali Saha, Jingyu Li, Xuerong Sun, Xinguang Liu, Gonghua Huang
Summary: Fas-mediated apoptosis plays a significant role in various cellular processes. The immune regulation controlled by Fas can have both beneficial and harmful effects on immune disorders. The role of apoptosis in the ageing process is still unclear, but this study shows that Fas signaling can induce premature senescence in mouse embryonic fibroblasts, while Fas deficiency leads to senescence through increased SA-beta-galactosidase activity, p53 phosphorylation, and the expression of p16, p21, and IL-6.
Article
Chemistry, Medicinal
Tiantian Qin, Jinzhu Zhao, Xiaojie Liu, Leilei Li, Xueyan Zhang, Xiaoli Shi, Yu Ke, Weihua Liu, Junfeng Huo, Yalong Dong, Yiwei Shen, Yanyu Li, Mingjing He, Shuhua Han, Linlin Li, Chengxue Pan, Cong Wang
Summary: The combination of natural flavonoid compound luteolin with low-dose paclitaxel synergistically regulated the proliferation, migration, EMT, and apoptosis of esophageal cancer cells in vitro, and synergistically inhibited tumor growth in vivo without obvious toxicity. The molecular mechanisms involve the inhibition of SIRT1 for cell migration and EMT, and the activation of the mitochondrial apoptotic pathway through the ROS/JNK pathway for apoptosis induction.
PHYTOTHERAPY RESEARCH
(2021)
Article
Food Science & Technology
Zhipeng Li, Qingchen Wang, Zhonghong Zhang, Xiao Zhang, Xintong Wu, Li Li, Yi Zhang, Yihua Yu
Summary: Luteolin inhibits neuroinflammation and alleviates depression-like behavior by upregulating A20 and Nrf2.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Jingru Huangfu, Caili Hao, Zongbo Wei, I. Michael Wormstone, Hong Yan, Xingjun Fan
Summary: The study reveals that cFLIP is a critical gene regulating lens epithelial cell survival, with an important impact on the response to TNF alpha stimulation.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Applied
Risheng Li, Chuanfen Pu, Yue Sun, Qingjie Sun, Wenting Tang
Summary: This study proposed a new method of using soybean oleosome-associated protein (SOP) decorated liposomes (SOP-Lips) to improve the stability of phospholipid bilayer membranes. The results showed that after the interaction between SOP and liposomes, membrane fluidity decreased and the arrangement of lipid fatty acyl chains improved, leading to enhanced membrane stability and digestion resistance. This work provides a viable strategy for using SOP-Lips as a delivery system for nutraceuticals in functional food, dietary supplements, and pharmaceuticals.
FOOD HYDROCOLLOIDS
(2022)
Article
Neurosciences
Hiroaki Kaku, Alexander V. Ludlow, Michael F. Gutknecht, Thomas L. Rothstein
Summary: Research has revealed that the mammalian protein FAIM plays a crucial role in preventing and dissolving A beta fibrils in Alzheimer's disease, offering a promising new approach for treating neurodegenerative diseases.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Oncology
Ho Soo Yoo, Sae Bom Won, Young Hye Kwon
Summary: The study suggests that luteolin inhibits the growth of colon cancer cells through enhancing p53 activity to induce apoptosis and cell cycle arrest in a p53-dependent manner, regardless of the induction of autophagy.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Shifeng Xiao, Qiuping Wu, Xuanbao Yao, Jiahao Zhang, Weicong Zhong, Junyi Zhao, Qiong Liu, Mohan Zhang
Summary: Isobavachalcone is a promising compound for potential preventive and therapeutic medicine for Alzheimer's disease, as it can inhibit tau protein aggregation and disaggregation, as well as regulate tau phosphorylation.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Chorpaka Thepthanee, Chan-Chiung Liu, Hsu-Sheng Yu, Ho-Shin Huang, Chia-Hung Yen, Yen-Hsien Li, Maw-Rong Lee, Ean-Tun Liaw
Summary: Black rice leaves, known as agricultural waste, contain antioxidants that have multiple benefits for human health. The ethyl acetate fraction obtained from black rice leaves, particularly Sub5, showed the highest levels of phenolic and flavonoid compounds and exhibited superior antioxidant and anticancer activities. Sub5 inhibited the proliferation of liver, breast, and colorectal cancer cells, induced cell cycle arrest and apoptosis, and suppressed signaling pathways involved in cancer development. The bioactive constituents in Sub5 were characterized using HPLC-DAD-MS/MS. Overall, Sub5 has high potential as a functional dietary supplement to inhibit liver cancer development.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Ming-Chang Tsai, Ching-Chun Chen, Tsui-Hwa Tseng, Yun-Ching Chang, Yi-Jie Lin, I-Ning Tsai, Chi-Chih Wang, Chau-Jong Wang
Summary: Anthocyanins from Hibiscus sabdariffa can induce apoptosis in colorectal cancer cells through the activation of AMPK signaling pathways. This study elucidates the regulatory role of HAs in apoptosis-related proteins in colorectal cancer cells.
Review
Medicine, General & Internal
David N. Zacks, Andrew J. Kocab, Joanne J. Choi, Meredith S. Gregory-Ksander, Marisol Cano, James T. Handa
Summary: This review summarizes the relationship between cell death pathways and the death of retinal pigment epithelial (RPE) and retinal cells in AMD, and discusses a novel approach of targeting the Fas receptor to preserve these structures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Alastair C. Keen, Maria Hauge Pedersen, Laura Lemel, Daniel J. Scott, Meritxell Canals, Dene R. Littler, Travis Beddoe, Yuki Ono, Lei Shi, Asuka Inoue, Jonathan A. Javitch, J. Robert Lane
Summary: Understanding the signaling of heterotrimeric G proteins is crucial for understanding physiological responses. Pertussis toxin has been widely used to inhibit G alpha(i/o) G proteins, but its effectiveness against G alpha(z) has been limited. A recently discovered toxin, OZITX, has been found to specifically inhibit both G alpha(i/o) and G alpha(z) G proteins, providing a new tool to study their signaling.
COMMUNICATIONS BIOLOGY
(2022)
