Article
Cell Biology
Kristy D. Wendt, Jared Brown, Vlasta Lungova, Vidisha Mohad, Christina Kendziorski, Susan L. Thibeault
Summary: This study investigates the relationship and function of the larynx, trachea, and esophagus during embryonic development through transcriptional profiling. It identifies interrelated gene sets governing the organogenesis of this tripartite organ system and provides insights into disorders associated with cardiocraniofacial syndromes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Wei Yong, Haiying Ma, Man Na, Teng Gao, Ye Zhang, Liying Hao, Hang Yu, Huazhe Yang, Xin Deng
Summary: Melatonin is a multifunctional hormone regulated by the circadian rhythm, with roles in sleep-wake cycle rhythms, ageing retardation, antioxidant and anti-inflammatory functions, as well as significant impact on reproductive functions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Dan Li, Jun-Hua Pan, Xiao-Fang Huang, Yu-Qing Liao, Yong-Jin Ling, Jing-Ying Luo
Summary: This study performed a systematic review and meta-analysis to evaluate the antioxidant effect of melatonin in animal models of fibrosis. The results showed that melatonin supplementation significantly reduced oxidative indicators such as malondialdehyde, lipid peroxidation, and nitric oxide levels, and increased antioxidant indicators such as glutathione, glutathione peroxidase, and superoxide dismutase levels, in fibrotic diseases, suggesting a beneficial role of melatonin in correcting oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Francisca Felix, Catarina C. V. Oliveira, Elsa Cabrita
Summary: The study focuses on the effects of novel antioxidants in protecting fish cells, highlighting the importance of antioxidants in fish reproduction and their potential in improving gamete quality. The review discusses various types of antioxidants and their mechanisms of action, with a particular emphasis on the protective role of melatonin in preventing oxidative stress damage on fish spermatozoa.
Article
Environmental Sciences
Huan Wang, Xiangyin Zeng, Xinxin Zhang, Honggui Liu, Houjuan Xing
Summary: Exposure to NH3 can lead to oxidative stress and inflammation in pig trachea, disrupting the mucosal barrier and microtubule activity, and affecting the balance of SLC transporters. Transcriptome analysis provides new insights into the toxic mechanisms of NH3 and offers references for comparative medicine.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Sachin Gaun, Syed Afroz Ali, Pooja Singh, Jayant Patwa, Swaran Jeet Singh Flora, Ashok Kumar Datusalia
Summary: The study found that melatonin may have a protective effect against copper-induced lung damage by inhibiting oxidative stress and inflammation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Hanan A. Edres, Nabil M. Taha, Mohamed A. Lebda, Mohamed S. Elfeky
Summary: The study revealed that ACR exposure induced oxidative damage in the brain, leading to altered neurotransmitters and pathological brain lesions. Allicin and melatonin mitigated ACR-induced brain damage by restoring redox balance, enhancing neurotransmitters, reducing DNA damage, and providing anti-inflammatory effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Feifei Zhao, Sara Whiting, Sarah Lambourne, R. John Aitken, Ying-pu Sun
Summary: The study demonstrates that melatonin can protect human sperm from heat-induced oxidative stress by suppressing sperm mitochondrial ROS generation, increasing mitochondrial membrane potential, reducing lipid peroxidation product 4-HNE formation, and decreasing sperm DNA damage and apoptosis. This suggests melatonin as a potential treatment option for male infertility caused by heat-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Andrea Faggiano, Elisa Gherbesi, Ashot Avagimyan, Massimiliano Ruscica, Luca Donisi, Maria Antonia Fedele, Carlo Maria Cipolla, Marco Vicenzi, Stefano Carugo, Daniela Cardinale
Summary: Melatonin can mitigate the oxidative damage induced by anthracycline in a mouse model, demonstrating its potential as a preventive and therapeutic strategy for anthracycline-induced cardiotoxicity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Plant Sciences
Rukhsar Parwez, Umra Aqeel, Tariq Aftab, M. Masroor A. Khan, M. Naeem
Summary: A study found that foliar application of 75μM melatonin (MEL) can enhance the growth and productivity of fenugreek plants under nickel (Ni) stress. MEL supplementation restricts Ni accumulation, regulates oxidative stress, improves antioxidant enzyme activity, alleviates osmotic stress, and increases the concentration of compounds in the leaves.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Naseh Abdollahzade, Shirin Babri, Maryam Majidinia
Summary: Prenatal exposure to arsenic increases the risk of brain damage in the fetus, while melatonin shows neuroprotective effects by reducing oxidative stress and inflammation caused by arsenic, as well as suppressing DNA damage and apoptosis in the brain tissues of offspring rats.
Review
Geriatrics & Gerontology
Junjie Wang, Shiqi Gao, Cameron Lenahan, Yichen Gu, Xiaoyu Wang, Yuanjian Fang, Weilin Xu, Haijian Wu, Yuanbo Pan, Anwen Shao, Jianmin Zhang
Summary: Stroke is a devastating disease with high mortality and disability worldwide. Oxidative stress plays a critical role in stroke-induced injury, and melatonin, as an antioxidant, shows promising potential in the treatment of stroke.
Article
Agriculture, Dairy & Animal Science
Marwa El-Sheikh, Ahmed Atef Mesalam, Seon-Min Kang, Myeong-Don Joo, Seham Samir Soliman, Atif Ali Khan Khalil, Mi-Jeong Ahn, Il-Keun Kong
Summary: A study demonstrated that melatonin (MT) plays a protective role during in vitro embryo production (IVP) by reducing the deleterious effects of juglone, a polyphenolic extract of walnut trees, on bovine oocyte development. The study observed that melatonin supplementation regulated oocyte development, apoptosis, autophagy, and mitochondrial function, thereby protecting oocytes from oxidative stress.
Article
Oncology
Ang Li, Fei Li, Wei Song, Zi-Li Lei, Qian-Qian Sha, Shao-Yuan Liu, Chang-Yin Zhou, Xue Zhang, Xiao-Zhen Li, Heide Schatten, Teng Zhang, Qing-Yuan Sun, Xiang-Hong Ou
Summary: This study investigated the relationship between gut microbiota and oocyte quality decline caused by circadian rhythm disruption. The results showed that the decreased absorption capacity of vitamin D in the intestine, as a result of reduced levels of bile acids such as lithocholic acid (LCA) and increased abundance of Turicibacter, led to decreased oocyte quality and embryonic development. The concentrations of anti-Mullerian hormone (AMH) hormone in blood and melatonin in follicular fluid were also reduced, contributing to the decline in oocyte quality and early embryonic development. Injection of vitamin D3 (VD3) or specific metabolites was able to rescue the oocyte quality and embryonic development. Overall, this study highlights the importance of gut microbiota regulation by microbial metabolites in improving ovary function.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Junqiang Zhang, Yuan Fang, Dongdong Tang, Xingyu Xu, Xiaoqian Zhu, Shusheng Wu, Hui Yu, Huiru Cheng, Ting Luo, Qunshan Shen, Yang Gao, Cong Ma, Yajing Liu, Zhaolian Wei, Xiaoyu Chen, Fangbiao Tao, Xiaojin He, Yunxia Cao
Summary: This study explores the protective effect and molecular mechanism of melatonin in cisplatin-induced oxidative stress in testicular tissue and Leydig cells. The results show that melatonin reduces oxidative stress and upregulates SIRT1/Nrf2 signaling, preventing the apoptosis of Leydig cells caused by cisplatin.
Article
Biochemistry & Molecular Biology
D. Duzgun Ergun, S. Dursun, N. Pastaci Ozsobaci, M. Naziroglu, D. Ozcelik
Summary: This study elucidated the relationship between hypercapnia and the TRPM2 channel, as well as the effects of zinc, selenium, and glutathione. Experimental results showed that hypercapnia increased oxidative stress, but zinc, selenium, and glutathione were found to protect cells from damage caused by oxidative stress.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yusuf Cagdas Kumbul, Mustafa Naziroglu
Summary: This study investigates the effects of paclitaxel (PAX) and melatonin (MLT) on human laryngeal squamous cancer cells (Hep2) and the underlying mechanisms. The results show that PAX and MLT can induce cell death and apoptosis in Hep2 cells by affecting intracellular Ca2+ and Zn2+ levels. Furthermore, MLT treatment enhances the anticancer effects of PAX and reduces resistance to PAX. The findings also suggest that TRPM2 plays a critical role in this process.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Correction
Biochemistry & Molecular Biology
Zine Kechrid, Malika Hamdiken, Mustafa Naziroglu, Manuel Flores-Arce
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Mustafa Naziroglu
Summary: Oxidative stress-induced activation of TRPM2 and TRPV4 channels can cause neuronal and cellular injury. This study discovered the potential antagonist properties of carvacrol (CARV) against TRPM2 and TRPV4 activations induced by oxidative stress, suggesting a protective role of CARV in neurodegenerative diseases associated with oxidative stress.
METABOLIC BRAIN DISEASE
(2022)
Article
Clinical Neurology
Kenan Yildizhan, Ramazan Cinar, Mustafa Naziroglu
Summary: Parkinson's disease (PD) is an age-related neurodegenerative disease. This study found that the activation of TRPM2 channel can cause apoptotic cell death in hippocampal neurons, and the use of resveratrol can protect neurons by reducing oxidative stress resources.
NEUROLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hatice Daldal, Mustafa Naziroglu
Summary: This study investigates the protective effects of selenium and resveratrol on optic nerve oxidative injury caused by excessive calcium influx and mitochondria reactive free oxygen radical (mitROS) generation-mediated activation of the TRPM2 channel. The findings suggest that these treatments can reduce injury and apoptosis by downregulating TRPM2 activity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ozgur Ocal, Mustafa Naziroglu
Summary: This study investigates the combined treatment of CiSP and EPA in DBTRG cells and finds that the activation of TRPM2 channel can enhance the anticancer, apoptotic, and oxidant actions of CiSP. Therefore, stimulating TRPM2 via EPA could be an effective approach in the treatment of glioblastoma tumors.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Neurosciences
Ozgur Ocal, Aymer Cosar, Mustafa Naziroglu
Summary: This study investigates the protective role of amantadine (AMN) against hypoxia-induced brain injury and apoptosis. The results suggest that AMN attenuates oxidative neurotoxicity, inflammation, and apoptosis by inhibiting the activation of TRPM2 and TRPV4 channels, thus reducing excessive calcium influx and mitochondrial free reactive oxygen species (mitROS) in neurons. These findings provide new insights into the neuroprotective effects of AMN against hypoxia and suggest its potential therapeutic application for neurodegenerative and cerebrovascular diseases associated with mitROS, calcium, and zinc dysregulation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Ophthalmology
Hatice Daldal, Mustafa Naziroglu
Summary: Rituximab (RTX) may have protective effects on LPS-induced adverse actions in retinal pigment epithelial cells by inhibiting TRPM2 channel.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Hatice Daldal, Mustafa Nazirogluz
Summary: This study investigated the modulatory effect of carvacrol on cell apoptosis and retinal oxidative damage induced by high blood glucose. The results showed that carvacrol alleviated cell death and oxidative stress caused by high blood glucose by inhibiting the activity of the TRPM2 channel.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yener Akyuva, Mustafa Nazirog
Summary: In this study, we investigated the effects of silver nanoparticles (AgNPs) and cisplatin (CiSP) exposure on glioblastoma cells through the activation of TRPM2 cation channels. We found that the cytotoxic and apoptotic actions of CiSP were enhanced by the treatment of AgNPs, which activated TRPM2. The oxidant actions of AgNPs were mediated by various cellular processes involving mitochondrial membrane depolarization, lipid peroxidation, and ROS generation. The combination of AgNPs and CiSP showed a synergistic action in the treatment of glioblastoma tumor cells through the stimulation of TRPM2.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Muge Mavioglu Kaya, Inan Kaya, Mustafa Naziroglu
Summary: The activation of TRPA1, TRPM2, and TRPV1 channels increases apoptotic and oxidant actions in colon cancer cells. Sambucus ebulus L (SEB) treatment inhibits the actions of these channels, thereby reducing colon tumor growth. Hence, TRPA1, TRPM2, and TRPV1 activations could be potential targets for colon tumor treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Pharmacology & Pharmacy
Kemal Ertilav, Mustafa Naziroglu
Summary: The study found that melittin (MLT) treatment can enhance the cytotoxic effects of cisplatin (CSP) on tumor cells by modulating Ca2+ channels. This enhancement is achieved through the activation of TRPM2 channels, which leads to the accumulation of mitochondrial reactive oxygen species (MitSOX) induced by mitochondrial Ca2+ and Zn2+. The study aimed to investigate the effects of CSP and MLT combination on DBTRG-05MG cells, including cell viability, cell death, apoptosis, and MitSOX levels.
Article
Neurosciences
Kenan Yildizhan, Mustafa Naziroglu
Summary: TRPM2 channel is activated by excessive generation of mitochondrial and cytosolic ROS and influx of intracellular free Ca2+. The inhibitions of NMDA receptor and TRPM2 channel decrease ROS and apoptosis in neurons. The modulator role of memantine and NMDA via modulation of TRPM2 on oxidative neurodegeneration and apoptosis in SH-SY5Y cells was investigated. Inhibition of NMDA receptor via memantine treatment modulated HYP-mediated ROS, apoptosis, and TRPM2-induced excessive Ca2+ and may provide a strategy for protecting HYP-mediated neurodegenerative diseases.
Article
Obstetrics & Gynecology
Yusuf Dal, Mustafa Naziroglu, Mehmet Okan Ozkaya
Summary: This study aimed to investigate the effects of low molecular weight heparin (LMWH) on calcium signaling, oxidative toxicity, and apoptosis in the thrombocytes of recurrent pregnancy loss (RPL) patients via modulation of TRPM2 and TRPV1 channels. The results showed that the concentrations of [Ca2+] (i), cytROS, mitochondrial membrane potential, apoptosis, caspase-3, and caspase-9 were high in the plasma and thrombocytes of RPL patients, but were diminished by the treatments of LMWH, TRPM2, and TRPV1 channel blockers.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)