Review
Biochemistry & Molecular Biology
Gioacchino Natoli, Francesco Pileri, Francesco Gualdrini, Serena Ghisletti
Summary: Macrophages respond to microbial and endogenous danger signals by activating various effector and homeostatic responses. This involves rapid changes in gene expression programs and metabolic rewiring, with chromatin modifications integrating transcriptional and metabolic regulation. The mutual influences between signal-induced metabolic changes and gene expression are not fully understood yet, and further research is needed to explore these interactions.
Review
Biochemistry & Molecular Biology
Bibo Li
Summary: Telomere maintenance is crucial for genome stability and regulation of antigenic variation in microbial pathogens. Trypanosomes, such as T. brucei, use a unique DNA polymerase, PolIE, to coordinate the synthesis of telomere G- and C-strands, in contrast to mammalian cells that rely on telomere proteins. Understanding these mechanisms can aid in the development of treatments for diseases caused by these pathogens.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Parasitology
David Horn
Summary: Genome-scale genetic screens have played a crucial role in African trypanosomes by uncovering mechanisms related to drug resistance, metabolism, and gene expression control. They have also been effective in identifying potential antitrypanosomal drug targets.
TRENDS IN PARASITOLOGY
(2022)
Article
Multidisciplinary Sciences
Nicola M. Moloney, Konstantin Barylyuk, Eelco Tromer, Oliver M. Crook, Lisa M. Breckels, Kathryn S. Lilley, Ross F. Waller, Paula MacGregor
Summary: This study maps the spatial proteomes of two African trypanosome species, Trypanosoma brucei and Trypanosoma congolense, providing insights into the molecular basis for diversity within and between these pathogen species. Comparative analysis reveals key routes of parasitic adaptation to different biological niches.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Fabien Guegan, K. Shanmugha Rajan, Fabio Bento, Daniel Pinto-Neves, Mariana Sequeira, Natalia Guminska, Seweryn Mroczek, Andrzej Dziembowski, Smadar Cohen-Chalamish, Tirza Doniger, Beathrice Galili, Antonio M. Estevez, Cedric Notredame, Shulamit Michaeli, Luisa M. Figueiredo
Summary: This study identified 1428 previously uncharacterized lncRNA genes in the T. brucei genome. The key regulator, grumpy lncRNA, was found to promote parasite differentiation into the quiescent stumpy form, with this function being promoted by the encoded small nucleolar RNA. Overexpression of grumpy reduced parasitemia in infected mice.
Article
Immunology
Man Ni, Yuting Chen, Xiaoya Sun, Yujie Deng, Xinqi Wang, Tao Zhang, Ye Wu, Lingxiang Yu, Shenqian Xu, Haiyang Yu, Zongwen Shuai, Faming Pan
Summary: The methylation patterns of IRF5 promoter are associated with susceptibility to AS, and may play a role in the pathological process and identification of AS patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Ethan C. Ashby, Jennifer L. Havens, Lindsey M. Rollosson, Johanna Hardin, Danae Schulz
Summary: African trypanosomiasis is a burdensome disease in sub-Saharan Africa, transmitted by a parasite through the tsetse fly. Chemical inhibition of bromodomain proteins causes significant changes in the transcriptome of both insect-stage and bloodstream-stage parasites. Understanding the gene-regulatory processes in these highly diverged eukaryotes may provide insights into the evolution of gene-regulatory mechanisms.
MICROBIOLOGY SPECTRUM
(2023)
Review
Biochemistry & Molecular Biology
Olga Nosova, Igor Bazov, Victor Karpyak, Mathias Hallberg, Georgy Bakalkin
Summary: Neuropeptides act as important regulators in controlling neural network functions, with their expression tightly restricted and regulated through transcriptional and epigenetic mechanisms. Dynorphins, a type of opioid peptide, play critical roles in neurological disorders and pain processing, with studies on prodynorphin gene providing insights into regulation mechanisms of neuropeptide genes in normal and pathological human brain.
Article
Neurosciences
Anna Welle, Carmen Kasakow, Annemarie M. Jungmann, Davide Gobbo, Laura Stopper, Karl Nordstroem, Abdulrahman Salhab, Gilles Gasparoni, Anja Scheller, Frank Kirchhoff, Joern Walter
Summary: This study reveals significant differences in gene expression and DNA methylation between astrocytes from the cerebral cortex and cerebellum, linked to region-specific transcription factor networks. The epigenetic variations suggest complex combinatorial regulation of regional astrocyte transcriptomes.
Review
Microbiology
Cheshta Sharma, David Kadosh
Summary: Global estimates suggest that millions of people are affected by serious fungal infections annually, resulting in a significant number of deaths. The limited treatment options and the emergence of antifungal resistant strains further complicate the clinical management of these infections. This review highlights recently discovered post-transcriptional mechanisms that control antifungal resistance, providing new insights and potential strategies for more effective treatment.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sebastian Shaw, Sebastian Knuesel, Daniel Abbuehl, Arunasalam Naguleswaran, Ruth Etzensperger, Mattias Benninger, Isabel Roditi
Summary: African trypanosomes exhibit social motility on semi-solid surfaces. The authors found that procyclic forms acidify their environment due to glucose metabolism, generating pH gradients that are sensed via cyclic AMP signaling. Parasite mutants defective in cAMP signaling are inhibited in fly infection.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Jurandir Cruz, Bernardo Lemos
Summary: In this study, the authors discuss the regulatory mechanisms of post-transcriptional and post-translational modifications on ribosomal function, as well as their impact on cellular metabolism, replication control, and senescence. The research findings suggest that disruptions in these modifications can impair ribosome biogenesis and function, thus affecting protein synthesis related to carcinogenesis and senescence.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Immunology
Mariame Camara, Alseny M'mah Soumah, Hamidou Ilboudo, Christelle Travaille, Caroline Clucas, Anneli Cooper, Nono-Raymond Kuispond Swar, Oumou Camara, Ibrahim Sadissou, Estefania Calvo Alvarez, Aline Crouzols, Jean-Mathieu Bart, Vincent Jamonneau, Mamadou Camara, Annette MacLeod, Bruno Bucheton, Brice Rotureau
Summary: In the study of gambiense human African trypanosomiasis, it was found that live parasites may remain undetected in the blood of some seropositive individuals but are present in their skin. The skin may serve as a potential reservoir for African trypanosomes.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Plant Sciences
Madhushree Dutta, Surbhi Mali, Vidhi Raturi, Gaurav Zinta
Summary: The transition from juvenile to adult stage is an important switch in the plant's life cycle. Potato tuberization is influenced by various environmental factors and regulated by a complex signaling network involving hormones, sugars, phloem mobile signals, and transcriptional/post-transcriptional regulators. This review provides mechanistic insights into the signaling networks that coordinate potato tuberization under different conditions and highlights the importance of genetic and epigenetic regulation.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Multidisciplinary Sciences
Dorien Mabille, Laura Dirkx, Sofie Thys, Marjorie Vermeersch, Daniel Montenye, Matthias Govaerts, Sarah Hendrickx, Peter Takac, Johan Van Weyenbergh, Isabel Pintelon, Peter Delputte, Louis Maes, David Perez-Morga, Jean-Pierre Timmermans, Guy Caljon
Summary: Trypanosoma brucei, the parasite responsible for sleeping sickness, rapidly and permanently colonizes the lungs and affects the immune response, potentially making individuals more susceptible to opportunistic infections.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Tara Stanne, Mani Shankar Narayanan, Sophie Ridewood, Alexandra Ling, Kathrin Witmer, Manish Kushwaha, Simone Wiesler, Bill Wickstead, Jennifer Wood, Gloria Rudenko
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Microbiology
Jackie L. Y. Cheung, Nadina V. Wand, Cher-Pheng Ooi, Sophie Ridewood, Richard J. Wheeler, Gloria Rudenko
Article
Biochemistry & Molecular Biology
Sophie Ridewood, Cher-Pheng Ooi, Belinda Hall, Anna Trenaman, Nadina Vasileva Wand, Georgios Sioutas, Iris Scherwitzl, Gloria Rudenko
MOLECULAR MICROBIOLOGY
(2017)
Article
Infectious Diseases
Louise E. Kerry, Elaine E. Pegg, Donald P. Cameron, James Budzak, Gretchen Poortinga, Katherine M. Hannan, Ross D. Hannan, Gloria Rudenko
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Cell Biology
Cher-Pheng Ooi, Terry K. Smith, Eva Gluenz, Nadina Vasileva Wand, Sue Vaughan, Gloria Rudenko
Review
Biochemistry & Molecular Biology
Gloria Rudenko
ESSAYS IN BIOCHEMISTRY: MOLECULAR PARASITOLOGY
(2011)
Article
Microbiology
Tara M. Stanne, Manish Kushwaha, Matthew Wand, Jesse E. Taylor, Gloria Rudenko
Article
Biochemistry & Molecular Biology
Viola Denninger, Alexander Fullbrook, Mohamed Bessat, Klaus Ersfeld, Gloria Rudenko
MOLECULAR MICROBIOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Viola Denninger, Gloria Rudenko
MOLECULAR MICROBIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Mani Shankar Narayanan, Manish Kushwaha, Klaus Ersfeld, Alexander Fullbrook, Tara M. Stanne, Gloria Rudenko
NUCLEIC ACIDS RESEARCH
(2011)
Article
Biochemistry & Molecular Biology
Mani Shankar Narayanan, Gloria Rudenko
NUCLEIC ACIDS RESEARCH
(2013)
Editorial Material
Public, Environmental & Occupational Health
Gloria Rudenko
PATHOGENS AND GLOBAL HEALTH
(2012)
Article
Microbiology
Megan L. Povelones, Eva Gluenz, Marcin Dembek, Keith Gull, Gloria Rudenko
Editorial Material
Biology
Cher-Pheng Ooi, Gloria Rudenko
Review
Microbiology
Cornelis Vink, Gloria Rudenko, H. Steven Seifert
FEMS MICROBIOLOGY REVIEWS
(2012)