Article
Behavioral Sciences
Kyle C. Rossi, Jonathan M. Gursky, Trudy D. Pang, Mandip S. Dhamoon
Summary: The study found a significant association between epilepsy and status epilepticus events and increased odds of subsequent cardiac arrhythmia or cardiac arrest over multiple chronic timeframes. Enhanced cardiac surveillance may be necessary to reduce morbidity and mortality in patients with epilepsy.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Ming S. Soh, Richard D. Bagnall, Christopher Semsarian, Ingrid E. Scheffer, Samuel F. Berkovic, Christopher A. Reid
Summary: Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature death in epilepsy. This study found that SCN5A arrhythmogenic variants may confer increased risk of sudden death in individuals with epilepsy.
Article
Neurosciences
Ian C. Wenker, Elizabeth A. Blizzard, Pravin K. Wagley, Manoj K. Patel
Summary: Research has shown that patients with epilepsy experience significant heart rate changes during seizures, with bradycardia mediated by the activation of the parasympathetic nervous system and tachycardia mediated by the deactivation of the parasympathetic nervous system and activation of the sympathetic nervous system. Pharmacological interventions can influence these heart rate changes, but do not alter the sensitivity or severity of seizures.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Yasuo Nakai, Hiroki Nishibayashi, Tomohiro Donishi, Masaki Terada, Naoyuki Nakao, Yoshiki Kaneoke
Summary: In this study, regional functional connectivity alterations were observed in individuals with intractable focal epilepsy using resting-state functional MRI. The number of abnormal regions in each patient was associated with clinical parameters such as illness duration and seizure severity, and these abnormal regions were negatively related to quality of life. Additionally, abnormal regions in some patients were found to be distributed within the default mode network.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Supriya Sharma, Anil Kumar Rana, Shubham Nilkanth Rahmatkar, Vikram Patial, Damanpreet Singh
Summary: This study aimed to investigate the efficacy of Nardostachys jatamansi extract in the treatment of lithium-pilocarpine-induced seizures and associated cardiac irregularities. The results showed that the extract reduced seizure severity and cardiac abnormalities by inhibiting the mTOR signaling pathway. The chemical composition and interactions of Nardostachys jatamansi provide important insights for further research on this plant.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Behavioral Sciences
Marina Trivisano, Lorenzo Muccioli, Alessandro Ferretti, Hsiu-Fen Lee, Ching-Shiang Chi, Francesca Bisulli
Summary: The risk of sudden unexpected death in epilepsy (SUDEP) in children is influenced by various factors, including the severity and treatment of epilepsy. Factors such as seizure frequency, type, especially nocturnal generalized tonic-clonic seizures (GTCS), and resistance to anti-seizure medication can predispose patients to SUDEP. SUDEP may be caused by respiratory, cardiovascular, and central autonomic dysfunctions. Genetic mutations in cardiac channelopathy genes may increase the risk of seizure-induced arrhythmias. Night-time supervision can reduce the risk of SUDEP. Reconsidering safety protocols and using seizure detection devices can help reduce the risk of death in epilepsy patients.
EPILEPSY & BEHAVIOR
(2022)
Review
Clinical Neurology
Cheng Yu, Xue-jun Deng, Da Xu
Summary: Epilepsy and arrhythmia have a complex genetic relationship, and mutant genes can independently cause epilepsy and/or arrhythmia. Studying mutations in comorbidity of epilepsy and arrhythmia can improve treatment methods and provide new insights for assessing the risk of premature death.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Giacomo Evangelista, Fedele Dono, Stefano Consoli, Jacopo Lanzone, Clarissa Corniello, Mirella Russo, Francesca Anzellotti, Marco Onofrj, Catello Vollono, Stefano L. Sensi
Summary: HRV analysis is a valuable method for assessing cardiovascular risk and cardioautonomic impairment in SUDEP patients. The reduction of SDNN and RMSSD is common in SUDEP cases, while there are no significant differences in time and frequency domain parameters compared to controls. However, there is a trend towards increased LF/HF ratio in SUDEP patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Julie Bourgeois-Vionnet, Julien Jung, Romain Bouet, Mathilde Leclercq, Helene Catenoix, Laurent Bezin, Philippe Ryvlin, Sylvain Rheims
Summary: The study found that coffee consumption may be a protective factor for seizure-related respiratory dysfunction, with a dose-dependent effect.
Article
Clinical Neurology
Yoko Ikoma, Daichi Sasaki, Ko Matsui
Summary: This study investigated the plastic changes in astrocytic reactions in the lateral hypothalamus using fibre photometry in transgenic mice, and found their association with epileptogenesis. Changes in local brain environment and metabolism could be the cause and consequences of epilepsy. Controlling the pH and/or Ca2+ of astrocytes could be a new therapeutic target for treating epilepsy or preventing undesired plasticity associated with epileptogenesis.
Review
Neurosciences
Benjamin L. L. Kreitlow, William Li, Gordon F. F. Buchanan
Summary: Epilepsy is a neurological disease characterized by unprovoked seizures, and the influence of biological rhythms on epilepsy and seizure-associated death is underutilized. Understanding the physiological influence of rhythms and exploring their impact on epilepsy can lead to the development of seizure prediction technologies and time-dependent therapeutic strategies.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Zining Liu, Peravina Thergarajan, Ana Antonic-Baker, Zhibin Chen, Paul B. Sparks, Natasha A. Lannin, Patrick Kwan, Nigel C. Jones, Pablo M. Casillas-Espinosa, Piero Perucca, Terence J. O'Brien, Shobi Sivathamboo
Summary: This study examined the alterations in cardiac structure and function in patients with epilepsy through a systematic review and meta-analysis. The results showed that compared with healthy controls, patients with epilepsy had decreased left ventricular ejection fraction and increased A-wave velocity, E/e' ratio, and isovolumic relaxation time. Additionally, the prevalence of cardiac hypertrophy and fibrosis in sudden unexpected death in epilepsy (SUDEP) cases was not higher than in epilepsy controls. These findings suggest changes in diastolic and systolic echocardiogram parameters in epilepsy and highlight the importance of longitudinal studies to determine the prognostic significance of these changes. Echocardiography may be a useful noninvasive diagnostic test for the epilepsy population.
Article
Behavioral Sciences
Tahir Hakami, Mohammed Hakami
Summary: The study revealed that neurologists in Saudi Arabia do not frequently discuss Sudden Unexpected Death in Epilepsy (SUDEP) with their patients, and when they do, they emphasize a more individualized approach. However, the majority of neurologists have only a limited understanding of SUDEP risk factors.
EPILEPSY & BEHAVIOR
(2021)
Review
Clinical Neurology
Rosalie Marchal, Sylvain Rheims
Summary: The Autonomic Nervous System (ANS) plays a vital role in regulating many physiological functions. This review discusses the available data and objective tests on epilepsy-related autonomic dysfunction. Epilepsy is associated with an imbalance between the sympathetic and parasympathetic systems, and objective tests have shown alterations in heart rate, baroreflex function, cerebral autoregulation, sweat glands activity, thermoregulation, gastrointestinal and urinary function. Further research is needed to understand interictal ANS function and its potential association with clinically-relevant complications, such as Sudden Unexpected Death In Epilepsy (SUDEP).
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Ming S. Soh, Richard D. Bagnall, Mark F. Bennett, Lauren E. Bleakley, Erlina S. Mohamed Syazwan, A. Marie Phillips, Mathew D. F. Chiam, Chaseley E. McKenzie, Michael Hildebrand, Douglas Crompton, Melanie Bahlo, Christopher Semsarian, Ingrid E. Scheffer, Samuel F. Berkovic, Christopher A. Reid
Summary: The study compared the frequency and impact of KCNH2 variants in SUDEP patients and epilepsy controls, finding an enrichment of loss-of-function KCNH2 variants in SUDEP patients, suggesting a contribution of cardiac mechanisms to SUDEP risk. Genetic screening with functional analysis could identify predictive biomarkers of SUDEP risk based on KCNH2 loss-of-function variants.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Food Science & Technology
Karen M. VanderMolen, Jason G. Little, Vincent P. Sica, Tamam El-Elimat, Huzefa A. Raja, Nicholas H. Oberlies, Timothy R. Baker, Catherine Mahony
FOOD AND CHEMICAL TOXICOLOGY
(2017)
Article
Chemistry, Applied
Huzefa A. Raja, Timothy R. Baker, Jason G. Little, Nicholas H. Oberlies
Article
Cardiac & Cardiovascular Systems
Cameron S. Metcalf, Steven Poelzing, Jason G. Little, Steven L. Bealer
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2009)
Article
Clinical Neurology
Steven L. Bealer, Jason G. Little, Cameron S. Metcalf, Amy L. Brewster, Anne E. Anderson
Article
Clinical Neurology
Jason G. Little, Steven L. Bealer
Article
Multidisciplinary Sciences
Steven L. Bealer, Cameron S. Metcalf, Jason G. Little
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2011)
