Article
Clinical Neurology
Haiyu Liu, Liang Zhang
Summary: Seizure clusters are common in epileptic patients and are associated with an increased risk of developing status epilepticus and higher morbidity and mortality rates. Through an experiment involving hippocampal kindling in mice, it was found that seizure clustering represents a prominent feature of spontaneous recurrent seizures, showing variable patterns between individual mice. Despite limitations, systemic homeostatic mechanisms may play a crucial role in governing the occurrence and termination of seizure clusters.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Peter J. West, Kyle Thomson, Peggy Billingsley, Timothy Pruess, Carlos Rueda, Gerald W. Saunders, Misty D. Smith, Cameron S. Metcalf, Karen S. Wilcox
Summary: The study demonstrates that in this MTLE IAK model, pharmacoresistant seizures are resistant to two representative sodium channel-inhibiting ASDs (phenytoin and carbamazepine) and partially sensitive to GABA receptor modulating ASDs (diazepam and phenobarbital) or a mixed-mechanism ASD (valproate). This model is being incorporated into the NINDS-funded ETSP testing platform for treatment resistant epilepsy.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Claudia Tonini, Marco Segatto, Francesca Martino, Luisa Cigliano, Martina Nazzaro, Laura Barberio, Maurizio Mandala, Valentina Pallottini
Summary: The study suggests that caloric restriction in late life can partially reverse some age-related changes studied here, but not all impacts can be completely altered.
Article
Biochemistry & Molecular Biology
Ilia G. Komoltsev, Stepan O. Frankevich, Natalia I. Shirobokova, Aleksandra A. Volkova, Mikhail V. Onufriev, Julia V. Moiseeva, Margarita R. Novikova, Natalia V. Gulyaeva
Summary: This study using a rat TBI model found that immediate post-traumatic seizures and changes in corticosterone levels may be associated with neuroinflammation-mediated distant hippocampal damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Anya Zahra, Yuqing Sun, Nancy Aloysius, Liang Zhang
Summary: In the extended hippocampal kindling mouse model, seizures mainly manifest as generalized motor seizures, are not significantly influenced by light cycles, and are preceded by inactive behaviors. These findings suggest that ambient cage behaviors play a significant role in influencing spontaneous recurrent seizures in rodent models of temporal lobe epilepsy.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Efrat Shavit-Stein, Shani Berkowitz, Tal Davidy, Uri Fennig, Shani Guly Gofrit, Amir Dori, Nicola Maggio
Summary: This study evaluated the effects of thrombin pathway inhibition in a mice model of SE and found that thrombin is involved in memory impairment and cognitive dysfunction. Inhibiting the thrombin pathway can prevent cognitive impairment and reduce neuronal damage.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Hemant Kumar, Jatinder Katyal, Dinesh Joshi, Yogendra Kumar Gupta
Summary: In this study, the role of morphine administration in the development of epilepsy was investigated using a status epilepticus (SE) model in rats. The results showed that low doses of morphine increased the frequency of spontaneous convulsive seizures (SS), while high doses had no significant effect. However, morphine may alter the susceptibility and frequency of seizures. Further evaluation and research are needed to confirm these findings.
EPILEPSY & BEHAVIOR
(2022)
Article
Clinical Neurology
Kevin D. Chen, Alicia M. Hall, Megan M. Garcia-Curran, Gissell A. Sanchez, Jennifer Daglian, Renhao Luo, Tallie Z. Baram
Summary: The study successfully induced eFSE in mice and found that eFSE increased susceptibility to the epileptic agent KA in adult mice, leading to shortened latency to seizure onset and increased severity. 16.5% of the mice developed epilepsy after experiencing eFSE, suggesting that eFSE promotes pro-epileptogenic network changes in some mice, resembling temporal lobe epilepsy.
Article
Clinical Neurology
Aurelie Hanin, Jorge Cespedes, Karim Dorgham, Yashwanth Pulluru, Margaret Gopaul, Guy Gorochov, David A. Hafler, Vincent Navarro, Nicolas Gaspard, Lawrence J. Hirsch
Summary: The study aims to investigate inflammation in patients with new-onset refractory status epilepticus (NORSE) by analyzing cytokines/chemokines in cerebrospinal fluid (CSF) and serum. Significant increase of pro-inflammatory cytokines/chemokines was observed in patients with SE compared to those without, and in patients with cNORSE compared to non-cryptogenic RSE. Elevated innate immunity cytokine/chemokine levels were associated with worse short- and long-term outcomes in patients with NORSE.
ANNALS OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Deniz Dilan Setel, Merve Beker, Sule Terzioglu-Usak, Birsen Elibol
Summary: The study demonstrates that a combination of astragalus membranaceus with caloric restriction can improve learning performance and increase telomerase activity in rats, while reducing apoptosis rate and increasing anti-aging protein klotho. This combination could become a promising strategy for healthy cognitive aging.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Clinical Neurology
Diogo Vila Verde, Till Zimmer, Alessandro Cattalini, Marlene F. Pereira, Erwin van Vliet, Giuseppe Testa, Vadym Gnatkovsky, Eleonora Aronica, Marco de Curtis
Summary: The study found that seizures during FncSE may worsen brain tissue damage, while glial cells are only transiently activated in regions far from the lesion, suggesting that seizure activity during FncSE without local pathogenic factors does not lead to long-lasting detrimental changes.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Chang, Yi Chang, Su-Jane Wang
Summary: This study investigated the potential antiseizure mechanisms of rutin in rats using the kainic acid (KA) seizure model. The results indicate that rutin attenuated seizure severity and neuronal loss by decreasing glutamatergic hyperactivity and suppressing the neuroinflammatory cascade.
Article
Neurosciences
Meinrad Drexel, Sadegh Rahimi, Guenther Sperk
Summary: This study reveals the crucial role of somatostatin-containing interneurons in hippocampal epilepsy, suggesting that their malfunctioning is causatively involved in the development of temporal lobe epilepsy (TLE).
Article
Biochemistry & Molecular Biology
Olga E. Zubareva, Denis S. Sinyak, Alisa D. Kalita, Alexandra V. Griflyuk, Georgy P. Diespirov, Tatiana Y. Postnikova, Aleksey V. Zaitsev
Summary: This study evaluated the effects of anakinra, lamotrigine, and their combination on epileptogenesis using a rat model. The treatment showed significant reductions in the severity of seizures and neuronal loss in the CA1 hippocampus. However, the combination treatment was less effective in preventing neuron loss in the hippocampal CA3 field compared to monotherapy. The findings suggest that anakinra and lamotrigine, either alone or in combination, may be clinically useful in preventing histopathological and behavioral abnormalities associated with epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Pilar Bosque Varela, Lukas Machegger, Andreas Oellerer, Juergen Steinbacher, Mark McCoy, Johannes Pfaff, Eugen Trinka, Giorgi Kuchukhidze
Summary: This study aimed to characterize the spectrum of peri-ictal MRI abnormalities in patients with status epilepticus. The results showed that almost half of the patients had peri-ictal MRI abnormalities, with ictal hyperperfusion being the most prevalent followed by diffusion restriction and FLAIR abnormalities. The neocortex, especially the frontal lobes, was most frequently affected, and the majority of abnormalities were unilateral.
EPILEPSY & BEHAVIOR
(2023)
Article
Biophysics
Hamid Tebyanian, Mohammad Hadi Norahan, Hossein Eyni, Mansoureh Movahedin, S. M. Javad Mortazavi, Ali Karami, Mohammad Reza Nourani, Nafiseh Baheiraei
JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS
(2019)
Article
Biotechnology & Applied Microbiology
Forouzan Rahmani, Mansoureh Movahedin, Zohreh Mazaheri, Masoud Soleimani
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2019)
Article
Dermatology
Mohadese Estaji, Manijhe Mokhtari-Dizaji, Mansoureh Movahedin, Arash Padash, Sahar Ghaffari Khaligh
Summary: Fullerene nanoemulsion significantly reduced epidermis and dermis thickness, Young modulus, and shear modulus, leading to decreased skin stiffness and effective wrinkle repair. Histological studies confirmed the therapeutic effect of fullerene nanoemulsion on skin wrinkles.
SKIN RESEARCH AND TECHNOLOGY
(2021)
Article
Andrology
Payam Mohammadi, Seyed Alireza Mesbah-Namin, Mansoureh Movahedin
Summary: This study found that lower expression of AQP3 and higher expression of CASP3 were associated with decreased sperm motility in asthenozoospermic individuals. Additionally, higher CASP3 activity may indicate active apoptosis in individuals with asthenozoospermia. The DNA-damaged sperm count was higher in asthenozoospermic individuals and showed a negative correlation with AQP3 and CASP3 activity.
Article
Obstetrics & Gynecology
J. Shakerzadeh, M. Movahedin, A. Eidi, N. Hayati Roodbari, K. Parivar
Summary: Forced suppression of mmu-let-7a-5p through successful transfection of Anti-miR leads to upregulation of downstream genes, Igf1, Itgb3 and Tgfb1, which directly involved in the trophoblast-endometrium attachment and improve the implantation rate.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemical Research Methods
Adam L. Tyson, Charly V. Rousseau, Christian J. Niedworok, Sepiedeh Keshavarzi, Chryssanthi Tsitoura, Lee Cossell, Molly Strom, Troy W. Margrie
Summary: Mapping the spatial distributions of nervous system cells is crucial for understanding its function. Manual mapping is biased and time-consuming, but a new automated algorithm has been developed to detect neuronal somata in 3D brain images. This algorithm allows for rapid and unbiased mapping of cellular distributions throughout the mouse brain.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Neurosciences
Sepiedeh Keshavarzi, Edward F. Bracey, Richard A. Faville, Dario Campagner, Adam L. Tyson, Stephen C. Lenzi, Tiago Branco, Troy W. Margrie
Summary: Animals rely on continuously tracking their heading direction and speed to navigate their environment. This study found that vestibular inputs dominate the coding of angular head velocity in the cortical region called retrosplenial cortex (RSP) in mice. Additionally, the integration of visual inputs onto these neurons enhances their tuning during active exploration, resulting in increased perceptual accuracy of angular self-motion and fidelity of its representation by RSP ensembles.
Article
Endocrinology & Metabolism
Maryam Daneshvar, Mansoureh Movahedin, Mohammad Salehi, Mehrdad Noruzinia
Summary: The study evaluated the impact of re-vitrification on the expression of miR-16, miR-let7a, and target genes in human blastocysts. The results showed that re-vitrification did not affect the ability of blastocysts to re-expand in culture, but led to a significant decrease in the expression of miR-16 and miR-let7a, along with a significant upregulation of the target genes ITG beta 3 and BCL-2 in re-vitrified and vitrified embryos.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Andrology
Mohammad Reza Deemeh, Seyed Alireza Mesbah-Namin, Mansoureh Movahedin
Summary: The newly improved MACS-Up method uses magnetic field to separate non-apoptotic spermatozoa directly from neat semen, making it a potential effective selection procedure for functional sperm in assisted reproductive technologies.
Article
Biochemistry & Molecular Biology
Mehrafarin Kiani, Mansoureh Movahedin, Iman Halvaei, Masoud Soleimani
Summary: This study explores a new protocol for differentiating human induced pluripotent stem cells (hiPSCs) into primordial germ cell-like cells (PGCLCs). The results show that exposure to bone morphogenetic protein 4 (BMP4) and retinoic acid (RA) leads to significant changes in cell differentiation and gene expression. Immunofluorescence and RT-PCR analysis further confirm the formation of PGCLCs. The study suggests that EB formation and continuous exposure to BMP4 and RA can induce the differentiation of hiPSCs into PGCLCs.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Multidisciplinary Sciences
Dario Campagner, Ruben Vale, Yu Lin Tan, Panagiota Iordanidou, Oriol Pavon Arocas, Federico Claudi, A. Vanessa Stempel, Sepiedeh Keshavarzi, Rasmus S. Petersen, Troy W. Margrie, Tiago Branco
Summary: This study reveals that the mouse retrosplenial cortex (RSP) and superior colliculus (SC) form a circuit that encodes the shelter-direction vector and is crucial for accurately orienting to shelter during escape. The circuit incorporates spatial information to execute rapid flights along the most efficient route to shelter.
Article
Pharmacology & Pharmacy
Shirin Barati, Mansoureh Movahedin
Summary: The study evaluated the antioxidant effects of Calligonum extract on the proliferation and colonization rate of spermatogonial cells, demonstrating its ability to reduce ROS levels and apoptosis, and increase cell proliferation and total antioxidant capacity.
PHARMACEUTICAL SCIENCES
(2021)
Article
Obstetrics & Gynecology
Nasrin Majidi Gharenaz, Mansoureh Movahedin, Zohreh Mazaheri
Summary: This study compared two methods for prolong storage of testicular scaffolds. The results demonstrated the superiority of the slow freezing method in extending the storage time of testicular scaffolds. Additionally, the scaffolds showed biocompatibility and did not have a harmful effect on cell proliferation.
INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE
(2021)
Article
Cell Biology
Nasrin Majidi Gharenaz, Mansoureh Movahedin, Zohreh Mazaheri
Article
Cell Biology
Mahdi Mohaqiq, Mansoureh Movahedin, Zohreh Mazaheri, Naser Amirjannati