Article
Neurosciences
Cecilia Zavala-Tecuapetla, Joaquin Manjarrez-Marmolejo, Josue Orlando Ramirez-Jarquin, Claudia Veronica Rivera-Cerecedo
Summary: This study investigated the anticonvulsant efficacy of different sodium channel blockers on carbamazepine (CBZ)-resistant seizures. The results showed that eslicarbazepine has an anticonvulsant effect on CBZ-resistant seizures, while lamotrigine shows drug resistance and ranolazine worsens the seizures.
Article
Food Science & Technology
Xueyan Wang, Aiai Xiao, Yueqi Yang, Yingcai Zhao, Cheng Cheng Wang, Yuming Wang, Jun Han, Zhengping Wang, Min Wen
Summary: This study investigates the effects of EPA and DHA on PTZ-induced seizures and depression, and finds that they can alleviate these symptoms but with different efficiency and molecular mechanisms.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ewelina Koziol, Krzysztof Jozwiak, Barbara Budzynska, Peter A. M. de Witte, Danielle Copmans, Krystyna Skalicka-Wozniak
Summary: The study screened 18 different coumarin derivatives for behavioral and physiological antiseizure activity, confirming seven compounds with antiseizure activity; further substantiated in zebrafish the ability of these active compounds to reduce PTZ-induced antiepileptiform activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Mozhdeh Radpour, Samira Choopani, Hamid Gholami Pourbadie, Mohammad Sayyah
Summary: Toll-like receptor 4 (TLR4) signaling has a detrimental role in traumatic brain injury (TBI) pathology. However, TLR4 priming can alleviate TBI inflammation and seizure susceptibility. In this study, we found that postconditioning with TLR4 agonist monophosphoryl lipid A (MPL) reduces TBI neuroinflammation and epileptogenesis by decreasing neural death and inflammation, while upregulating anti-inflammatory cytokines.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Endocrinology & Metabolism
Tanveer Singh, Awanish Mishra, Rajesh Kumar Goel
Summary: PTZ-induced seizure in mice is a valuable model for evaluating novel anticonvulsants and studying epilepsy mechanisms, treatment methods, and associated comorbidities.
METABOLIC BRAIN DISEASE
(2021)
Article
Behavioral Sciences
Kanandra Taisa Bertoncello, Rodrigo Zanandrea, Carla Denise Bonan
Summary: Epilepsy affects patients' quality of life, and our study on zebrafish shows that PTZ exposure can lead to cognitive deficits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Emilia Rodrigues Almeida, Cassia Alves Lima-Rezende, Sabrina Ester Schneider, Cristiane Garbinato, Jefferson Pedroso, Laura Decui, Gean Pablo S. Aguiar, Liz Girardi Muller, J. Vladimir Oliveira, Anna Maria Siebel
Summary: The study utilized supercritical fluid micronization technology to produce micronized resveratrol, which showed anticonvulsant effects in a PTZ-induced seizure model in adult zebrafish similar to diazepam. Unlike diazepam, micronized resveratrol did not induce behavioral adverse events, indicating its potential as a safe and effective therapeutic alternative for epilepsy.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Pepin Marshall, Daniel R. Garton, Tomi Taira, Vootele Voikar, Carolina Vilenius, Natalia Kulesskaya, Claudio Rivera, Jaan-Olle Andressoo
Summary: This study revealed the important role of GDNF in regulating PV+ neurons in the brain, impacting memory and learning, and potentially having similar effects in the hippocampus. Gdnf(wt/hyper) mice showed impaired long-term memory performance and increased inhibitory tone in the hippocampus, as well as changes in PV+ cell numbers and seizure threshold.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ahmet Sevki Taskiran, Mustafa Ergul
Summary: Thiamine has a preventative effect on PTZ-induced seizures in rats and PTZ-induced neurotoxicity in SH-SY5Y neuroblastoma cells, reducing oxidative stress and apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Clinical Neurology
Michael Dietrich, Hans-Peter Hartung, Philipp Albrecht
Summary: 4-aminopyridine is used as a symptomatic therapy in various neurological disorders, with potential neuroprotective features beyond its symptomatic action, particularly in patients with multiple sclerosis.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Jenny Stritzelberger, Johannes D. Lang, Tamara M. Mueller, Caroline Reindl, Vivien Westermayer, Karel Kostev, Hajo M. Hamer
Summary: The debate over whether anti-seizure medication increases the risk for cancer has been ongoing for decades. However, a study using anonymous patient data collected by neurologists in Germany from 2009 to 2018 suggests that there is no increase in cancer risk for epilepsy patients using anti-seizure medication.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paola Imbrici, Elena Conte, Rikard Blunck, Fabrizia Stregapede, Antonella Liantonio, Michele Tosi, Maria Cristina D'Adamo, Annamaria De Luca, Vesna Brankovic, Ginevra Zanni
Summary: Kv1.2 channels encoded by the KCNA2 gene regulate neuronal excitability and mutations in KCNA2 have been associated with a range of symptoms. A novel E236K variant in KCNA2 was identified in a patient with ataxia and epilepsy, showing altered biophysical properties compared to the wild-type channel. Functional studies suggest that variant-tailored therapeutic approaches, such as 4-AP treatment, may benefit patients with KCNA2 disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ahmet Sevki Taskiran, Mustafa Ergul, Handan Gunes, Aysegul Ozturk, Bilal Sahin, Ercan Ozdemir
Summary: Recent studies have shown that proton pump inhibitors, specifically pantoprazole, have positive effects on the nervous system regarding epileptic seizures and neurotoxicity. Pantoprazole treatment delayed seizure onset, protected memory, reduced oxidative damage markers, and increased neurotrophic factors in the brain. It also blocked neurotoxicity and apoptosis, while improving antioxidant status in neuronal cells.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Sana Javaid, Faleh Alqahtani, Waseem Ashraf, Syed Muhammad Muneeb Anjum, Muhammad Fawad Rasool, Tanveer Ahmad, Fawaz Alasmari, Abdullah F. Alasmari, Saleh Abdullah Alqarni, Imran Imran
Summary: This study investigated the effects of Tia, a new-generation antiseizure drug, on chronic epilepsy models with comorbid neurobehavioral and neuroinflammatory parameters. The results showed that Tia inhibited seizures and epileptic spike discharges, reduced anxiety and cognitive impairment, and decreased oxidative stress and neuroinflammation. These effects of Tia may be attributed to its modulation of BDNF/TrkB, reduction of oxidative stress, and mitigation of neuroinflammatory markers expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Behavioral Sciences
Hatice Aygun, Mustafa Ayyildiz
Summary: The study demonstrated that vortioxetine has anticonvulsant activity in experimental epilepsy models induced by penicillin and pentylenetetrazole, but exhibited proconvulsant activity in a specific genetic absence epilepsy model. Additionally, vortioxetine did not affect the amplitude of epileptiform activity in any of the experimental epilepsy models.
EPILEPSY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Jens V. Andersen, Sofie K. Christensen, Blanca I. Aldana, Jakob D. Nissen, Heikki Tanila, Helle S. Waagepetersen
NEUROCHEMICAL RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Laura F. McNair, Rasmus Kornfelt, Anne B. Walls, Jens V. Andersen, Blanca I. Aldana, Jakob D. Nissen, Arne Schousboe, Helle S. Waagepetersen
NEUROCHEMICAL RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Maria Sitges, Blanca Irene Aldana, Ronald Charles Reed
NEUROCHEMICAL RESEARCH
(2016)
Article
Endocrinology & Metabolism
Hans C. C. Helms, Blanca I. Aldana, Simon Groth, Morten M. Jensen, Helle S. Waagepetersen, Carsten U. Nielsen, Birger Brodin
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Neurosciences
Blanca I. Aldana, Helle S. Waagepetersen, Arne Schousboe, H. Steve White, Grzegorz Bulaj, Anne B. Walls
JOURNAL OF NEUROSCIENCE RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Blanca I. Aldana, Yu Zhang, Maria Fog Lihme, Lasse K. Bak, Jorgen E. Nielsen, Bjorn Hoist, Poul Hyttel, Kristine K. Freude, Helle S. Waagepetersen
NEUROCHEMISTRY INTERNATIONAL
(2017)
Article
Cell & Tissue Engineering
Yu Zhang, Benjamin Schmid, Nanett K. Nikolaisen, Mikkel A. Rasmussen, Blanca I. Aldana, Mikkel Agger, Kirstine Calloe, Tina C. Stummann, Hjalte M. Larsen, Troels T. Nielsen, Jinrong Huang, Fengping Xu, Xin Liu, Lars Bolund, Morten Meyer, Lasse K. Bak, Helle S. Waagepetersen, Yonglun Luo, Jorgen E. Nielsen, Bjorn Holst, Christian Clausen, Poul Hyttel, Kristine K. Freude
Article
Biochemistry & Molecular Biology
Carlos D. Gomez, Rudolf M. Buijs, Maria Sitges
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Neurosciences
Shaona Acharjee, Megan Verbeek, Carlos D. Gomez, Kanchan Bisht, Benjamin Lee, Lucas Benoit, Keith A. Sharkey, Adrienne Benediktsson, Marie-Eve Tremblay, Quentin J. Pittman
JOURNAL OF NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Maria Sitges, Carlos D. Gomez, Blanca I. Aldana
Article
Neurosciences
Carlos D. Gomez, Justin Read, Shaona Acharjee, Quentin J. Pittman
JOURNAL OF NEUROSCIENCE
(2019)
Review
Behavioral Sciences
Quentin J. Pittman, Carlos D. Gomez, Justin Read, Megan L. Lewis, Shaona Acharjee
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2019)
Article
Neurosciences
Carlos D. Gomez, Shaona Acharjee, Megan L. Lewis, Justin Read, Quentin J. Pittman
Summary: Early-life inflammatory stress increases seizure susceptibility later in life, leading to long-term increased hippocampal excitability in adult female and male mice associated with changes in glutamatergic synaptic transmission. These alterations may contribute to enhanced vulnerability of the brain to subsequent pathologic challenges such as epileptic seizures.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Mauricio E. Di Ianni, Andrea V. Enrique, Maria E. Del Valle, Blanca Aldana, Maria A. Rosella, Luisa Rocha, Eduardo A. Castro, Luis E. Bruno-Blanch, Alan Talevi
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2015)
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)