PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability

Embelin ameliorates cognitive dysfunction and progression of kindling in pentylenetetrazol-induced kindling in mice by attenuating brain inflammation

(2021) Ubedul Hoda et al.   EPILEPSY & BEHAVIOR

Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice

(2020) Neeraj Kumar Sharma et al.   EPILEPSY & BEHAVIOR

Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole

(2020) Azadeh Yazdi et al.   EPILEPSY & BEHAVIOR

Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling

(2020) Zartashia Kazmi et al.   NEUROTOXICOLOGY

Involvement of H 2 S, NO and BDNF‐TrkB signalling pathway in the protective effects of simvastatin against pentylenetetrazole‐induced kindling and cognitive impairments in mice

(2020) Marwa A. Ahmed et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Investigating Cardiac Morphological Alterations in a Pentylenetetrazol-Kindling Model of Epilepsy

(2020) Enes Akyuz et al.   Diagnostics

Neocortical injury–induced status epilepticus

(2020) Tanveer Singh et al.   EPILEPSIA

Cognition and memory impairment attenuation via reduction of oxidative stress in acute and chronic mice model of epilepsy using antiepileptogenic Nux vomica

(2020) Priya Mishra et al.   JOURNAL OF ETHNOPHARMACOLOGY

Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures

(2020) Priya Mishra et al.   EPILEPSY & BEHAVIOR

D-limonene Inhibits Pentylenetetrazole-Induced Seizure via Adenosine A2A Receptor Modulation on GABAergic Neuronal Activity

(2020) Sowoon Seo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PTZ-induced seizures in mice require a revised Racine scale

(2019) Jan Van Erum et al.   EPILEPSY & BEHAVIOR

Amentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome

(2019) Shikuo Rong et al.   Frontiers in Pharmacology

Neurobiology of organophosphate-induced seizures

(2019) John Williamson et al.   EPILEPSY & BEHAVIOR

Interaction of sigma-1 receptor modulators with seizure development in pentylenetetrazole-induced kindled mice

(2019) Masoumeh Emamghoreishi et al.   EPILEPSY RESEARCH

The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures

(2019) Benoit Girard et al.   NEUROBIOLOGY OF DISEASE

TRPM2 ion channel is involved in the aggravation of cognitive impairment and down regulation of epilepsy threshold in pentylenetetrazole-induced kindling mice

(2019) Qianqian Zheng et al.   BRAIN RESEARCH BULLETIN

A face‐to‐face comparison of the intra‐amygdala and intrahippocampal kainate mouse models of mesial temporal lobe epilepsy and their utility for testing novel therapies

(2019) Lisa Welzel et al.   EPILEPSIA

Lamotrigine-resistant corneal-kindled mice: A model of pharmacoresistant partial epilepsy for moderate-throughput drug discovery

(2018) Zachery Koneval et al.   EPILEPSIA

Long-term negative impact of an inappropriate first antiepileptic medication on the efficacy of a second antiepileptic medication in mice

(2018) Jodi L. Pawluski et al.   EPILEPSIA

Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors

(2018) Andrew Hooper et al.   EPILEPSY & BEHAVIOR

Animal models of status epilepticus and temporal lobe epilepsy: a narrative review

(2018) Nikita Nirwan et al.   REVIEWS IN THE NEUROSCIENCES

Pentylenetetrazole-Induced Kindling Mouse Model

(2018) Tadayuki Shimada et al.   Jove-Journal of Visualized Experiments

Neuroprotective Effect of Coumarin Nasal Formulation: Kindling Model Assessment of Epilepsy

(2018) Suraj Muke et al.   Frontiers in Pharmacology

Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties

(2018) Alana Gomes de Souza et al.   BIOMEDICINE & PHARMACOTHERAPY

Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam

(2018) Brenda Marrero-Rosado et al.   EPILEPSIA

Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy

(2018) Seyed Raheleh Ahmadian et al.   NEUROPHARMACOLOGY

Neurobehavioral comorbidities of epilepsy: Role of inflammation

(2017) Andrey M. Mazarati et al.   EPILEPSIA

Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine

(2017) M. Suhaib Azim et al.   EPILEPSY & BEHAVIOR

Neurochemical evidence based suggested therapy for safe management of epileptogenesis

(2017) Navjot Kaur et al.   EPILEPSY & BEHAVIOR

Managing epilepsy-associated depression: Serotonin enhancers or serotonin producers?

(2017) Tanveer Singh et al.   EPILEPSY & BEHAVIOR

Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy

(2017) Qing Zhou et al.   MOLECULAR NEUROBIOLOGY

Ferulic Acid Supplementation for Management of Depression in Epilepsy

(2017) Tanveer Singh et al.   NEUROCHEMICAL RESEARCH

Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression

(2017) Tanveer Singh et al.   NEUROCHEMISTRY INTERNATIONAL

Protective effect of spermine against pentylenetetrazole kindling epilepsy induced comorbidities in mice

(2017) Mandeep Kumar et al.   NEUROSCIENCE RESEARCH

Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression

(2017) Tanveer Singh et al.   Pharmacological Reports

Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy

(2017) Mona Hashemian et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Kainic Acid-Induced Post-Status Epilepticus Models of Temporal Lobe Epilepsy with Diverging Seizure Phenotype and Neuropathology

(2017) Daniele Bertoglio et al.   Frontiers in Neurology

Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation

(2016) Arindam Ghosh Mazumder et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression

(2016) Tanveer Singh et al.   EPILEPSY & BEHAVIOR

Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies

(2016) Wolfgang Löscher   EPILEPSY RESEARCH

Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression

(2016) Tanveer Singh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuritin Mediates Activity-Dependent Axonal Branch Formation in Part via FGF Signaling

(2016) T. Shimada et al.   JOURNAL OF NEUROSCIENCE

Antiepileptogenic effects of borneol in pentylenetetrazole-induced kindling in mice

(2016) Rufi Tambe et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Protective Effect of Nerolidol Against Pentylenetetrazol-Induced Kindling, Oxidative Stress and Associated Behavioral Comorbidities in Mice

(2016) Dilpreet Kaur et al.   NEUROCHEMICAL RESEARCH

Effect of Liraglutide on Corneal Kindling Epilepsy Induced Depression and Cognitive Impairment in Mice

(2016) Prashant Koshal et al.   NEUROCHEMICAL RESEARCH

Chronic 5-HT3 receptor antagonism ameliorates seizures and associated memory deficit in pentylenetetrazole-kindled mice

(2016) Awanish Mishra et al.   NEUROSCIENCE

Resveratrol suppressed seizures by attenuating IL-1β, IL1-Ra, IL-6, and TNF-α in the hippocampus and cortex of kindled mice

(2016) Ubedul Hoda et al.   NUTRITIONAL NEUROSCIENCE

Neuroprotective mechanism of Coenzyme Q10 (CoQ10) against PTZ induced kindling and associated cognitive dysfunction: Possible role of microglia inhibition

(2016) Manveen Bhardwaj et al.   Pharmacological Reports

Fluvoxamine alleviates seizure activity and downregulates hippocampal GAP-43 expression in pentylenetetrazole-kindled mice

(2015) Momen W. Alhaj et al.   BEHAVIOURAL PHARMACOLOGY

Atorvastatin prevents development of kindling by modulating hippocampal levels of dopamine, glutamate, and GABA in mice

(2015) Nouroz Sehar et al.   EPILEPSY & BEHAVIOR

Effects of a lyophilized aqueous extract of Feretia apodanthera Del. (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress, and cognitive impairment in mice

(2015) G.S. Taiwe et al.   EPILEPSY & BEHAVIOR

Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: Search for add on therapy

(2015) Awanish Mishra et al.   METABOLIC BRAIN DISEASE

Reduced estradiol synthesis by letrozole, an aromatase inhibitor, is protective against development of pentylenetetrazole-induced kindling in mice

(2015) Davood Rashid et al.   NEUROCHEMISTRY INTERNATIONAL

Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats

(2015) Theresa A. Lusardi et al.   NEUROPHARMACOLOGY

Epileptogenesis

(2015) Asla Pitkänen et al.   Cold Spring Harbor Perspectives in Medicine

Characterization of a Lamotrigine-Resistant Kindled Model of Epilepsy in Mice: Evaluation of Drug Resistance Mechanisms

(2014) Ekta Singh et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Adjuvant Anticholinesterase Therapy for the Management of Epilepsy-Induced Memory Deficit: A Critical Pre-clinical Study

(2014) Awanish Mishra et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice

(2014) Ran-ran Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ficus religiosa L. figs — A potential herbal adjuvant to phenytoin for improved management of epilepsy and associated behavioral comorbidities

(2014) Paramdeep Singh et al.   EPILEPSY & BEHAVIOR

Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy

(2014) Wei Xie et al.   Journal of Neuroinflammation

Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model

(2014) Aakifa Ahmad et al.   NEUROLOGICAL SCIENCES

Effect of saponin fraction from Ficus religiosa on memory deficit, and behavioral and biochemical impairments in pentylenetetrazol kindled mice

(2013) Damanpreet Singh et al.   EPILEPSY & BEHAVIOR

Possible nitric oxide mechanism in the protective effect of hesperidin against pentylenetetrazole (PTZ)-induced kindling and associated cognitive dysfunction in mice

(2013) Anil Kumar et al.   EPILEPSY & BEHAVIOR

Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice

(2013) Kailash M. Choudhary et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Experimental Models of Status Epilepticus and Neuronal Injury for Evaluation of Therapeutic Interventions

(2013) Doodipala Reddy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of anticonvulsant and antiepileptogenic potential of thymol in various experimental models

(2013) Jayant Sancheti et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Psychoneurochemical Investigations to Reveal Neurobiology of Memory Deficit in Epilepsy

(2013) Awanish Mishra et al.   NEUROCHEMICAL RESEARCH

Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy

(2012) Paul S. Buckmaster et al.   EPILEPSY RESEARCH

Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats

(2012) Ajay K. Srivastava et al.   EPILEPSY RESEARCH

Neurogenesis is enhanced and mossy fiber sprouting arises in FGF7-deficient mice during development

(2012) Clara H. Lee et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Effect of Anacyclus pyrethrum on Pentylenetetrazole-Induced Kindling, Spatial Memory, Oxidative Stress and Rho-Kinase II Expression in Mice

(2012) Monika Pahuja et al.   NEUROCHEMICAL RESEARCH

Effect of medroxyprogesterone on development of pentylenetetrazole-induced kindling in mice

(2012) S.A. Nasir et al.   NEUROSCIENCE

Increased indoleamine 2,3-dioxygenase (IDO) activity in idiopathic generalized epilepsy

(2011) Suvi Liimatainen et al.   EPILEPSY RESEARCH

Age dependent learning and memory deficit in Pentylenetetrazol kindled mice

(2011) Awanish Mishra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus

(2011) H. Mizoguchi et al.   JOURNAL OF NEUROSCIENCE

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Effect of prenatal pentylenetetrazol-induced kindling on learning and memory of male offspring

(2010) A. Pourmotabbed et al.   NEUROSCIENCE

Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

(2010) W. Loscher et al.   PHARMACOLOGICAL REVIEWS

A revised Racine's scale for PTZ-induced seizures in rats

(2009) Annika Lüttjohann et al.   PHYSIOLOGY & BEHAVIOR