Article
Biochemistry & Molecular Biology
Junjie Li, Qi Li, Wentao Wang, Xinran Zhang, Chen Chu, Xintian Tang, Bo Zhu, Lizhong Xiong, Yu Zhao, Dao-Xiu Zhou
Summary: DELLA proteins are important regulators of gibberellic acid signaling and have contributed to grain yield increases in rice and wheat varieties during the green revolution. This study identifies a complex involving the rice DELLA protein SLENDER RICE1 (SLR1), Polycomb-repressive complex 2 (PRC2), and histone deacetylase HDA702, which represses downstream genes through silent chromatin state formation. Disruption of this complex impairs SLR1-dependent histone modification and gene repression, highlighting the importance of chromatin regulators in DELLA-mediated gene regulation.
Article
Agronomy
Shuo Liu, Yu Bao, Hui Deng, Guanqing Liu, Yangshuo Han, Yuechao Wu, Tao Zhang, Chen Chen
Summary: DNA methylation is a crucial epigenetic modification that regulates gene expression and genome stability. The methylation inhibitor, AzaD, can effectively reduce genome-wide hypomethylation and cause a series of epigenetic variations.
Review
Medicine, Research & Experimental
Yingqing Chen, Xiaomin Shao, Xiangge Zhao, Yuan Ji, Xiaorong Liu, Peixuan Li, Mingyu Zhang, Qianqian Wang
Summary: PRMT5 functions as a crucial player in various cancers and has emerged as a promising target in cancer epigenetic therapy. There are existing PRMT5 inhibitors with different molecular mechanisms, but current issues need to be addressed to facilitate the future discovery of PRMT5 targeted drugs for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Yuqi Jiang, Jie Xu, Kairui Yue, Chao Huang, Mengting Qin, Dongyu Chi, Qixin Yu, Yue Zhu, Xiaohan Hou, Tongqiang Xu, Min Li, C. James Chou, Xiaoyang Li
Summary: The study focused on modifying HDAC inhibitors to deactivate the Michael reaction in order to improve their potency. Compound 11h showed significant improvements in both HDAC inhibitory activity and cell-based antitumor assay, demonstrating potential for clinical application and efficacy against AML.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Melanie A. Whitmore, Hong Li, Wentao Lyu, Sharmily Khanam, Guolong Zhang
Summary: The combination of HDACi and DNMTi/HMTi showed a strong synergy in inducing HDP gene expression, and also regulated the expression of tight junction proteins.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yang-Jie Zhang, Ran Xie, Jie Jiang, Li Zhai, Cong-Hui Yang, Jing Zhang, Xi Wang, Dong-Xue Chen, Hua-Tao Niu, Long Chen
Summary: The study demonstrates the methylation modification of GAS5 in melanoma and the reversible effect of 5-Aza-dC on this modification. Treatment with 5-Aza-dC inhibits cell proliferation, increases apoptosis, and reduces migration and invasion in melanoma cells. The antitumor effect of 5-Aza-dC in melanoma is related to the methylation modification of GAS5.
Article
Biochemistry & Molecular Biology
Karolina Luczkowska, Piotr Kulig, Klaudia Rusinska, Bartlomiej Baumert, Boguslaw Machalinski
Summary: This study investigates the effects of a methylation inhibitor on the proliferation of multiple myeloma cells and the development of resistance to treatment, finding that alterations in DNA methylation are associated with drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Md Sahab Uddin, Abdullah Al Mamun, Badrah S. Alghamdi, Devesh Tewari, Philippe Jeandet, Md Shahid Sarwar, Ghulam Md Ashraf
Summary: Research has shown that glioma progression is closely linked to different types of epigenetic phenomena, such as chromatin modifications, DNA methylation, chromatin remodeling, and aberrant microRNA. Targeting the genes and proteins that control these alterations can be an effective way to treat GBM. Treatment approaches include histone deacetylase inhibitors and DNA methyltransferase inhibitors.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jin-Ling Huo, Lemin Jiao, Qi An, Xiuying Chen, Yuruo Qi, Bingfei Wei, Yichao Zheng, Xiaojing Shi, Erhe Gao, Hong-Min Liu, Dong Chen, Cong Wang, Wen Zhao
Summary: This study evaluates the roles of myofibroblast- or cardiomyocyte-specific LSD1 deficiency in pressure overload-induced cardiac remodeling. The findings suggest that myofibroblast-specific LSD1 deletion attenuates transverse aortic constriction-induced cardiac remodeling and improves heart function, highlighting LSD1 as a potential therapeutic target for late-stage heart failure.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Wanlin Jiang, Megan E. Block, Chandra S. Boosani
Summary: This study investigates the role of TNF-alpha and IGF-1 in regulating the epigenetic mechanisms that promote VSMCs proliferation, and identifies a novel molecular mechanism involving DNMT1, HDAC10, and HDAC2. Results reveal the inter-dependence of epigenetic mediators in VSMCs proliferation.
Review
Pharmacology & Pharmacy
Meran Keshawa Ediriweera
Summary: Histone acetylation is a crucial epigenetic event and continues to be an area of great interest in biochemical research. The balance between histone acetyltransferases (HATs) and histone deacetylases (HDACs) is disrupted in various human cancers. Histone deacetylase inhibitors (HDACi) have shown promising results in restoring dysregulated histone acetylation profiles and are considered as potential anti-cancer therapeutics. Recent studies have identified odd-chain fatty acids as novel HDACi, further expanding the understanding of fatty acids in cancer therapy.
DRUG DISCOVERY TODAY
(2023)
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Asad Mohammad, Sudhakar Jha
Summary: Epigenetic modifications, such as DNA methylation and histone modification, play a crucial role in cancer progression and metastasis. Inhibitors targeting deregulated enzymes can reverse these modifications and show promising results in cancer therapeutics.
Article
Biochemistry & Molecular Biology
Sreepoorna Pramodh, Ritu Raina, Arif Hussain, Sali Abubaker Bagabir, Shafiul Haque, Syed Tasleem Raza, Mohammad Rehan Ajmal, Shalini Behl, Deepika Bhagavatula
Summary: This study analyzed the epigenetic modulatory behavior of luteolin on HeLa cells and found that luteolin can inhibit migration and colony formation in HeLa cells. It can also reactivate silenced tumor suppressor genes by modulating DNA methylation, enzyme activity, and global DNA methylation. Therefore, luteolin-targeted epigenetic alterations provide a potential approach for cancer prevention and intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Robert Jenke, Nina Ressing, Finn K. Hansen, Achim Aigner, Thomas Buch
Summary: Epigenetic changes can drive cancer malignancy, while histone deacetylase inhibitors (HDACis) hold promise as anticancer drugs due to their ability to target multiple pathways relevant to the disease.
Article
Multidisciplinary Sciences
Claire M. Robinson, Francois Lefebvre, Betty P. Poon, Aurelie Bousard, Xiaojun Fan, Mark Lathrop, Jorg Tost, William Y. Kim, Yasser Riazalhosseini, Michael Ohh
SCIENTIFIC REPORTS
(2018)
Review
Biochemistry & Molecular Biology
Claire M. Robinson, Michael Ohh
Article
Biochemistry & Molecular Biology
Chris J. Watson, Patrick Collier, Isaac Tea, Roisin Neary, Jenny A. Watson, Claire Robinson, Dermot Phelan, Mark T. Ledwidge, Kenneth M. McDonald, Amanda McCann, Osama Sharaf, John A. Baugh
HUMAN MOLECULAR GENETICS
(2014)
Article
Respiratory System
Claire M. Robinson, Roisin Neary, Ashleigh Levendale, Chris J. Watson, John A. Baugh
RESPIRATORY RESEARCH
(2012)
Article
Multidisciplinary Sciences
Daniel Tarade, Claire M. Robinson, Jeffrey E. Lee, Michael Ohh
NATURE COMMUNICATIONS
(2018)
Article
Oncology
Claire M. Robinson, Betty P. K. Poon, Yoshihito Kano, Fred G. Pluthero, Walter H. A. Kahr, Michael Ohh
MOLECULAR CANCER RESEARCH
(2019)
Article
Oncology
Ivette Valencia-Sama, Yagnesh Ladumor, Lynn Kee, Teresa Adderley, Gabriella Christopher, Claire M. Robinson, Yoshihito Kano, Michael Ohh, Meredith S. Irwin
Review
Oncology
Claire M. Robinson, Aaron Talty, Susan E. Logue, Katarzyna Mnich, Adrienne M. Gorman, Afshin Samali
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer with poor treatment outcomes. A major challenge in PDAC treatment strategies is the dense stroma surrounding tumor cells, shielding them from treatment. The unfolded protein response (UPR) may play a role in the progression and therapy resistance of PDAC.
Article
Biochemistry & Molecular Biology
Richard Huang, Jalna Meens, Scott Yuzwa, Laurie Ailles, Michael Ohh, Claire M. Robinson
Summary: Cancer stem cells play an important role in tumor biology. This study aimed to identify the existence of clear cell renal cell carcinoma (ccRCC) stem cells using the side population approach, but the results did not support the presence of cancer stem cells in ccRCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L. Udaskin, Ahmet Mentes, Richard Huang, Betty P. K. Poon, Wenguang He, Ivette Valencia-Sama, Claire M. Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S. Irwin, Jeffrey E. Lee, Ming-Sound Tsao, Brian Raught, Christopher B. Marshall, Michael Ohh, Mitsuhiko Ikura
Summary: This study demonstrates that KRAS Q61H mutation is not regulated by SHP2, leading to insensitivity to SHP2 inhibitors in pancreatic cancer cells. Furthermore, cancer cells with different KRAS mutations exhibit variable sensitivity to SHP2 inhibitors, potentially due to differences in regulation by GAP and GEF activities, as well as binding affinity to RAF.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman, Afshin Samali
Summary: The authors discovered that the active form of IRE1 alpha is involved in the reprogramming of lipid metabolism in cancer cells. IRE1 alpha plays a role in cancer progression and regulates lipid metabolism through cleaving mRNAs. The study showed that IRE1 alpha cleaves DGAT2 mRNA, leading to the accumulation of triacylglycerols, and inhibition of IRE1 alpha increases sensitivity to nutritional stress.
NATURE COMMUNICATIONS
(2022)
Letter
Cell Biology
Stuart Creedican, Claire M. Robinson, Katarzyna Mnich, Md Nahidul Islam, Eva Szegezdi, Ruth Clifford, Janusz Krawczyk, John B. Patterson, Stephen P. FitzGerald, Mark Summers, Ciaran Richardson, Kenneth Martin, Adrienne M. Gorman, Afshin Samali
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yew Hwang Chee, Afshin Samali, Claire M. Robinson
Summary: Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, with low long-term survival in patients diagnosed with advanced disease. The unfolded protein response (UPR) has been found to play a role in ccRCC and may offer potential therapeutic targets in the future.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)