Article
Medicine, General & Internal
Emma Fransson, Unnur Gudnadottir, Luisa W. Hugerth, Eva Wiberg Itzel, Marica Hamsten, Fredrik Boulund, Alexandra Pennhag, Juan Du, Ina Schuppe-Koistinen, Nele Brusselaers, Lars Engstrand
Summary: The SweMaMi project aims to understand the dynamics of the microbiome during pregnancy through longitudinal sampling, metagenomics, questionnaires, and health registry linkage. With over 5000 pregnant participants, the project has collected a large number of microbiome samples and information. The next steps involve characterizing the microbial DNA and exploring the role of the microbiome in maternal and neonatal outcomes and early-childhood diseases.
Article
Medicine, General & Internal
Momina Anis Motiwala, Saqib Habib, Robia Ghafoor, Seema Irfan
Summary: This study compared the antimicrobial efficacy of Calcipex and Metapex in endodontic treatment of teeth with chronic apical periodontitis by assessing bacterial load reduction. The results will be disseminated through annual reports, peer-reviewed journals, and conferences.
Article
Medicine, General & Internal
Giorgia Caruana, Antonios Kritikos, Anthony Vocat, Amanda Luraschi, Eric Delarze, Alexander Sturm, Marta Pla Verge, Grzegorz Jozwiak, Samidha Kushwaha, Julie Delaloye, Danuta Cichocka, Gilbert Greub
Summary: This study aims to determine the agreement of the Resistell AST on Gram-negative bacteria isolated from blood cultures. It is a single-centre, prospective, cross-sectional, single-arm diagnostic accuracy study with ethical approval. The results will be widely disseminated through conference presentations and peer-reviewed publications.
Article
Medicine, General & Internal
Saima Sultana, Sadia Afrin, Mahamudul Hasan, Adnan Ansar, K. M. Saif-Ur-Rahman
Summary: This systematic review examined the diagnostic accuracy of stool specimens for diagnosing pulmonary tuberculosis in adults. Nine studies met the inclusion criteria, but the current data did not provide conclusive evidence on the accuracy of stool specimens for PTB diagnosis in adults.
Article
Medicine, General & Internal
Cleber Cremonese, Fabio Neves Souza, Fabiana Almerinda Goncalves Palma, Jonatas Fernandes Araujo Sodre, Ricardo Lustosa Brito, Priscyla dos Santos Ribeiro, Juliet Oliveira Santana, Rachel Helena Coelho, Juan P. Aguilar Ticona, Romero J. Nazare, Daiana de Oliveira, Caina Queiroz Silva, Max T. Eyre, Vinicius de Araujo Mendes, Jackie Knee, Paula Ristow, Christine E. Stauber, Yeimi Alexandra Alzate Lopez, Emanuele Giorgi, Peter J. Diggle, Mitermayer Galvao G. Reis, Oliver Cumming, Albert Ko, Federico Costa
Summary: This study aims to evaluate the effectiveness of a simplified sewerage intervention in reducing the risk of exposure to contaminated environments and Leptospira infection in low-income communities in Salvador, Brazil. The study design includes non-randomized intervention and control clusters, with a cohort of 1400 adult participants. The primary outcome is the incidence of Leptospira infection assessed through serological measurements.
Article
Medicine, General & Internal
Aminiel Shangali, Doreen Kamori, Willybroad Massawe, Salim Masoud, Upendo Kibwana, Anthony G. Mwingwa, Anselmo Manisha, Ambele M. Mwandigha, Mariam M. Mirambo, Stephen E. Mshana, Joel Manyahi, Mtebe Majigo
Summary: The study aimed to identify the causative pathogens and their antimicrobial susceptibility patterns in ear infections at a tertiary hospital in Dar es Salaam. Otitis externa was the predominant type of ear infection. The most frequently isolated bacteria were Staphylococcus aureus and Pseudomonas aeruginosa, and a significant proportion of the isolates showed multidrug resistance.
Article
Multidisciplinary Sciences
Alberto Signoroni, Alessandro Ferrari, Stefano Lombardi, Mattia Savardi, Stefania Fontana, Karissa Culbreath
Summary: Full Laboratory Automation is changing work habits in clinical microbiology, and deep learning architectures are revolutionizing visual interpretation tasks. DeepColony is a multi-network system that can effectively interpret diagnostic bacterial culture plates in clinical microbiology, achieving presumptive pathogen identification.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Christopher W. Towe, Sudershan Srinivasan, Vanessa P. Ho, Katelynn Bachmann, Stephanie G. Worrell, Yaron Perry, Luis M. Argote-Green, Philip A. Linden
Summary: The study demonstrates that microbiology and antibiotic resistance are associated with postoperative mortality after decortication for empyema. The presence of Candida in pleural culture, antibiotic resistance count, and emphysema were found to be associated with adverse outcomes.
ANNALS OF THORACIC SURGERY
(2021)
Book Review
Multidisciplinary Sciences
Heidi Ledford
Summary: Government responsibility for public health has influenced the nation's concept of freedom.
Article
Medicine, General & Internal
Arie H. Havelaar, Mussie Brhane, Ibsa Abdusemed Ahmed, Jafer Kedir, Dehao Chen, Loic Deblais, Nigel French, Wondwossen A. Gebreyes, Jemal Yousuf Hassen, Xiaolong Li, Mark J. Manary, Zelealem Mekuria, Abdulmuen Mohammed Ibrahim, Bahar Mummed, Amanda Ojeda, Gireesh Rajashekara, Kedir Teji Roba, Cyrus Saleem, Nitya Singh, Ibsa Aliyi Usmane, Yang Yang, Getnet Yimer, Sarah McKune
Summary: This study aims to identify reservoirs of Campylobacter infection in infants in rural Eastern Ethiopia and evaluate the interactions with child health. The research collects data through questionnaires and sample collection to analyze the genetic structure of Campylobacter in different reservoirs.
Review
Medicine, General & Internal
Changcheng Shi, Jian Ye, Renjie Xu, Weizhong Jin, Shuang Xu, Fei Teng, Nengming Lin
Summary: The study found that MSSA isolates with high vancomycin MICs were associated with higher mortality and a greater likelihood of septic thrombophlebitis compared to isolates with low MICs. Similar results were obtained in Etest detection, but no significant differences were found in broth microdilution detection.
Review
Medicine, General & Internal
Yunchun Zhou, Wei Mu, Jihua Zhang, Shi Wu Wen, Smita Pakhale
Summary: A systematic review and meta-analysis estimated the global prevalence of non-tuberculous mycobacteria (NTM) in adults with non-cystic fibrosis bronchiectasis from 2006 to 2021. The study found that the prevalence of NTM varied greatly depending on geographical location, with Mycobacterium avium complex being the most common subspecies. The study highlights the rising prevalence of NTM in this population and the need for further cohort studies.
Article
Medicine, General & Internal
Kathryn R. Koller, Annette Wilson, Daniel P. Normolle, Jeremy K. Nicholson, Jia Li, James Kinross, Flora R. Lee, Christie A. Flanagan, Zoe T. Merculieff, Priya Iyer, Daniela L. Lammers, Timothy K. Thomas, Stephen J. D. O'Keefe
Summary: The study discusses the impact of dietary fibre supplementation on colorectal cancer risk among Alaska Native people. Methods include baseline assessments, colonoscopy, randomization to fibre supplement or placebo, and evaluation of biomarkers. The research aims to inform on the effects of fibre supplements on mucosal inflammation, proliferative markers, and microbiome diversity.
Review
Medicine, General & Internal
Dora Yesenia Valencia, Magdiel Habila, D. Jean McClelland, Abraham Degarege, Purnima Madhivanan, Karl Krupp
Summary: This systematic review protocol aims to investigate the impact of statins on biofilm-associated infections. The study will cover six databases, assess the quality of the studies, and conduct a meta-analysis to comprehensively evaluate this association.
Article
Public, Environmental & Occupational Health
Guillermo A. Zabala, Khonsavath Bellingham, Vayouly Vidhamaly, Phonepasith Boupha, Kem Boutsamay, Paul N. Newton, Celine Caillet
Summary: Substandard and falsified antibiotics are widely prevalent in low- and middle-income countries (LMICs) with poor quality of evidence. However, available evidence suggests the need for interventions to strengthen regulatory, purchasing, and financial mechanisms to improve global antibiotic supply.
Review
Infectious Diseases
Simon A. Dingsdag, Neil Hunter
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Biochemistry & Molecular Biology
Marcus E. Graziotto, Mia C. Akerfeldt, Adam P. Gunn, Kylie Yang, Mark V. Somerville, Nicholas V. Coleman, Blaine R. Roberts, Trevor W. Hambley, Elizabeth J. New
JOURNAL OF INORGANIC BIOCHEMISTRY
(2017)
Article
Multidisciplinary Sciences
Chris L. Waring, Stuart I. Hankin, David W. T. Griffith, Michael A. Kertesz, Victoria Kobylski, Neil L. Wilson, Nicholas V. Coleman, Graham Kettlewell, Robert Zlot, Michael Bosse, Graham Bell
SCIENTIFIC REPORTS
(2017)
Article
Biotechnology & Applied Microbiology
Victoria McCarl, Mark V. Somerville, Mai-Anh Ly, Rebecca Henry, Elissa F. Liew, Neil L. Wilson, Andrew J. Holmes, Nicholas V. Coleman
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2018)
Article
Environmental Sciences
Fiona H. M. Tang, Thomas C. Jeffries, R. Willem Vervoort, Chris Conoley, Nicholas V. Coleman, Federico Maggi
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Biochemical Research Methods
Yanwei Ma, Dale D. McClure, Mark V. Somerville, Nicholas W. Proschogo, Fariba Dehghani, John M. Kavanagh, Nicholas V. Coleman
ACS SYNTHETIC BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Thomas Bourguignon, Yukihiro Kinjo, Paula Villa-Martin, Nicholas V. Coleman, Qian Tang, Daej A. Arab, Zongqing Wang, Gaku Tokuda, Yuichi Hongoh, Moriya Ohkuma, Simon Y. W. Ho, Simone Pigolotti, Nathan Lo
Review
Engineering, Environmental
Nicholas Coleman, Deborah J. Rich, Fiona H. M. Tang, R. Willem Vervoort, Federico Maggi
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Review
Microbiology
Scott Mitchell, Michelle Bull, Gary Muscatello, Belinda Chapman, Nicholas V. Coleman
Summary: Antibiotic resistance in bacterial pathogens is a growing concern, requiring a One Health approach. The equine hindgut may serve as a significant reservoir of ARGs and MGEs, warranting increased attention and strategies to minimize selection for resistance genes in horses to prevent their spread to the wider community.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Claudia F. Moratti, Colin Scott, Nicholas V. Coleman
Summary: Monooxygenases are enzymes that facilitate the degradation of alkanes and alkenes by bacteria. The regulatory components associated with these enzymes can be used to create efficient biosensors. However, there is still a wealth of unexplored genetic and functional diversity in the regulation of monooxygenases. Further research and development in this area can advance the commercialization and application of biosensors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Valentina Mendez, Sophie Holland, Shefali Bhardwaj, James McDonald, Stuart Khan, Denis O'Carroll, Russell Pickford, Sarah Richards, Casey O'Farrell, Nicholas Coleman, Matthew Lee, Michael J. Manefield
Summary: In this study, a bacterial strain capable of utilizing 6:2 FTS as a sulfur source was isolated and analyzed for its genomic and proteomic characteristics. The findings provide insights into the biodegradation of 6:2 FTS by the Actinobacterium D. aurantiaca J3, informing the fate of PFAS in the environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biotechnology & Applied Microbiology
Scott W. Mitchell, Robert A. Moran, Liam D. H. Elbourne, Belinda Chapman, Michelle Bull, Gary Muscatello, Nicholas V. Coleman
Summary: There is increasing recognition that addressing the problem of antimicrobial resistance requires a comprehensive one health approach. This means considering not only the perspectives of human medicine, but also the roles of antimicrobials in veterinary medicine and agriculture, as well as the importance of other ecological compartments in the dissemination of ARGs and mobile genetic elements like C1I. Antibiotic-resistant fecal bacteria were isolated from different types of horses, and their resistance profiles and genomes were analyzed to gain a better understanding of the impact of domestication and veterinary treatment on antimicrobial resistance.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Timothy M. Ghaly, Vaheesan Rajabal, Anahit Penesyan, Nicholas V. Coleman, Ian T. Paulsen, Michael R. Gillings, Sasha G. Tetu
Summary: Integrated genetic elements called integrons capture and rearrange gene cassettes to generate genetic diversity and contribute to microbial adaptation. This study explores the functional diversity of gene cassettes and finds that they encode various antimicrobial resistance determinants. Some of these functions are universally enriched across different environments, while others are sample-specific, suggesting local adaptation.
Article
Microbiology
Jacob E. Munro, Onder Kimyon, Deborah J. Rich, Joanna Koenig, Sihui Tang, Adrian Low, Matthew Lee, Mike Manefield, Nicholas V. Coleman
FEMS MICROBIOLOGY ECOLOGY
(2017)
Article
Microbiology
Nicholas V. Coleman
MICROBIOLOGY AUSTRALIA
(2016)