Article
Biochemistry & Molecular Biology
Yueyue Lou, Ting Xu, Huaqiang Cao, Qiuyue Zhao, Pengpai Zhang, Penghua Shu
Summary: This research investigated the bioactive constituents of C. glabra leaves and discovered two new phenolic compounds, ceroffesters A-B (1-2), as well as thirteen known compounds. These compounds exhibited antioxidant activities and inhibitory activities against mushroom tyrosinase and acetylcholinesterase. Compounds 3-6, 10, and 13 showed significant antioxidant activities, while compounds 5, 10, and 13 exhibited the most potent tyrosinase inhibitory activities. Compounds 3, 5, and 6 demonstrated moderate inhibitory activities against acetylcholinesterase.
Review
Biochemistry & Molecular Biology
Panagiota D. Pantiora, Alexandros I. Balaouras, Ioanna K. Mina, Christoforos I. Freris, Athanasios C. Pappas, Georgios P. Danezis, Evangelos Zoidis, Constantinos A. Georgiou
Summary: Pomegranate, known for its medicinal properties, contains phenolic acids, tannins, and flavonoids. The potential health benefits of pomegranate juice and by-products have attracted scientific interest, particularly in their role as potential protective agents against diseases like cancer. This review provides an update on current research on pomegranate's potential against different human diseases, with a focus on cancer. Additionally, it discusses the potential applications of pomegranate as a natural additive to improve the quality of animal products.
Article
Biochemistry & Molecular Biology
Alicja Skrzypek, Monika Karpinska, Malgorzata Juszczak, Aneta Grabarska, Joanna Wietrzyk, Elzbieta Krajewska-Kulak, Marek Studzinski, Tadeusz Paszko, Joanna Matysiak
Summary: Benzoxazole and naphthoxazole fused systems, functionalized by the 2,4-dihydroxyphenyl moiety, showed potential activity in inhibiting AChE, anticancer effects, and antioxidant properties. Naphtho[1,2-d][1,3]oxazoles exhibited higher antiproliferative activity against human cancer cell lines compared to benzoxazoles, with one analog showing no toxicity to normal cells.
Article
Chemistry, Inorganic & Nuclear
Shahan Zeb Khan, Zaibunisa Khan, Iftikhar Ahmad, Sajid Khan, Salman Khan, Mushtaq Ahmed, Muhammad Inam, Francine Belanger-Gariepy, Zia ur Rehman
Summary: Four new complexes [(DTCs)(PAr3)PdCl] were synthesized and characterized, with complex 3 showing the most potent anticancer activity and antioxidant activity against various human cancer cell lines and DPPH, respectively. All complexes exhibited a mixed type of inhibition against acetylcholinesterase, indicating their potential therapeutic use for Alzheimer's disease.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Plant Sciences
Aminu Shehu Abubakar, Xiaoyu Huang, Ziggiju Mesenbet Birhanie, Gang Gao, Xinkang Feng, Chunming Yu, Ping Chen, Jikang Chen, Kunmei Chen, Xiaofei Wang, Aiguo Zhu
Summary: Apocynum hendersonii is a medicinal plant with potential health benefits due to its rich bioactive components. This study evaluated the reactivity and composition of different solvent extracts of A. hendersonii leaves. The extracts were found to contain important bioactive constituents such as phenols, flavonoids, and polysaccharides. Methanol extract showed the highest flavonoid content and antioxidant capacity, while ethanol extract exhibited the strongest antibacterial activity and inhibition of enzymes. Principal component analysis indicated a positive correlation between constituents, bioactivities, and extracts. These findings suggest that A. hendersonii can be a valuable natural source of antimicrobial and antioxidant compounds with potential applications in pharmaceutical and food industries.
Article
Biochemistry & Molecular Biology
Sultan Alshehri, Syed Sarim Imam
Summary: The study evaluated the beneficial effects of rosinidin in lipopolysaccharide (LPS)-induced learning and memory impairment in rats. Results showed that rosinidin significantly reduced LPS-induced neurobehavioral impairments, oxidative stress, neuroinflammatory markers, and reversed the Ach enzyme activities and BDNF levels towards normal.
Article
Biochemistry & Molecular Biology
Christian Bailly
Summary: Flavonoids are a diverse and well-researched class of natural compounds. 2'-hydroxyflavonoids, particularly 2'-HF and 2'-HFa, show potential anti-cancer activities, with 2D08 as a synthetic derivative enhancing these effects by regulating protein SUMOylation. The 2'-hydroxyl group in flavonoids plays a crucial role in determining their biological properties.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jakub W. Strawa, Katarzyna Jakimiuk, Zuzanna Kita, Michal Tomczyk
Summary: Hottonia palustris, a plant from the genus Hottonia, was studied for its phytochemical and pharmacological properties. Eleven compounds, including three new flavonoids, were isolated and characterized. The active compound, dibenzoylmethane, showed potential antioxidant and acetylcholinesterase inhibitory activities. H. palustris may serve as a valuable source of substances for the prevention and treatment of neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Tahira Foyzun, Abdullah Al Mahmud, Md. Salim Ahammed, Md. Imran Nur Manik, Md. Kamrul Hasan, K. M. Monirul Islam, Simin Sobnom Lopa, Md. Yusuf Al-Amin, Kushal Biswas, Mst. Rejina Afrin, A. H. M. Khurshid Alam, Golam Sadik
Summary: This study found that polyphenolics from Acacia nilotica exhibited strong antioxidant activity and protected against arsenic-induced neurotoxicity and oxidative stress. The polyphenolics could reverse the decrease in acetylcholinesterase activity, elevation in lipid peroxidation, and depletion of glutathione caused by arsenic exposure. The major active compounds in the polyphenolics were identified as gallic acid methyl ester, catechin, and catechin-7-gallate.
Article
Agronomy
Tabasum Ara, Sabeeha Shafi, Mohammed Ghazwani, Javid Iqbal Mir, Abdul Haseeb Shah, Raies A. Qadri, Abdulrahim R. Hakami, Mohammad Khalid, Umme Hani, Shadma Wahab
Summary: Walnut leaves are rich in nutrients, minerals, and antioxidants, and have high antioxidant, anticancer, and antifungal activities.
Article
Pharmacology & Pharmacy
Sami I. Alzarea, Abdullah F. Alasmari, Abdullah S. Alanazi, Abdulaziz I. Alzarea, Metab Alharbi, Abdulrahman Alshammari, Imran Kazmi, Fakhria A. Aljoufi, Nadeem Sayyed, Muhammad Afzal
Summary: The present study demonstrates that butin possesses anti-inflammatory and anti-arthritic properties in rats with complete Freund's adjuvant-induced arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Chen Zhao, Zhongjian Wang, Rongzong Cui, Le Su, Xin Sun, Orlando Borras-Hidalgo, Kunlun Li, Jianlin Wei, Qiulin Yue, Lin Zhao
Summary: This study found that nitrogen fertilizer significantly affects the phytochemical constituents, antioxidant, and anticancer properties of Allium fistulosum. High nitrogen levels enhanced the antioxidant capacity and anticancer activity of A. fistulosum, suggesting potential health benefits.
Article
Chemistry, Applied
Qian-Nan Xu, Dan Zhu, Guang-Hui Wang, Ting Lin, Cui-Ling Sun, Rong Ding, Wen-Jing Tian, Hai-Feng Chen
Summary: A new phenolic glycoside, Descaudatine A, was isolated from Desmodium caudatum, showing potent antioxidant activity. Other compounds in the plant also exhibited antioxidant and anticancer activities, some of which could inhibit proliferation of cancer cells by inducing apoptosis.
NATURAL PRODUCT RESEARCH
(2021)
Article
Polymer Science
Nikoleta Stoyanova, Mariya Spasova, Nevena Manolova, Iliya Rashkov, Ani Georgieva, Reneta Toshkova
Summary: Innovative fibrous materials loaded with natural biologically active compounds have been successfully fabricated using blend electrospinning and dual electrospinning methods. The materials, made from cellulose acetate and water-soluble polyethylene glycol, exhibit nanometer-scale fiber diameters. The inclusion of the compounds quercetin and rutin in the fibrous mats enhances their hydrophilicity and wettability, leading to improved in vitro release. Rutin-containing mats demonstrate the highest antioxidative activity and exhibit higher cytotoxicity against cancer cells compared to non-cancer cells. These fibrous materials hold promise for pharmaceutical, cosmetic, and biomedical applications.
Article
Biochemistry & Molecular Biology
Shahenda Mahgoub, Nashwa Hashad, Sahar Ali, Reham Ibrahim, Ahmed M. Said, Fatma A. Moharram, Mohamed Mady
Summary: Five new compounds were isolated from C. viminalis, showing excellent antioxidant and cytotoxic activities. In silico analysis revealed that these compounds had higher binding affinity to 5-LOX compared to ascorbic acid and quercetin.
Review
Food Science & Technology
Hui Teng, Yimei Zheng, Hui Cao, Qun Huang, Jianbo Xiao, Lei Chen
Summary: Flavonoids, a class of widely existing polyphenols in food and medicine, have various pharmacological effects such as anti-oxidative, anticancer, and anti-inflammatory effects. However, their low bioavailability limits their clinical application, which is related to their intestinal absorption and metabolism. This review aims to establish the structural requirements of flavonoids for notable anticancer, anti-inflammatory, and antioxidant effects, and discuss the use of nanotechnology for safe delivery of flavonoids in food matrices.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Paz Otero, M. Carpena, P. Garcia-Oliveira, J. Echave, A. Soria-Lopez, P. Garcia-Perez, M. Fraga-Corral, Hui Cao, Shaoping Nie, Jianbo Xiao, J. Simal-Gandara, M. A. Prieto
Summary: Consumers nowadays are increasingly aware of the relationship between diet and health, leading to a preference for natural products. Seaweeds have emerged as a potential source of bioactive carbohydrates, with numerous polysaccharides arousing the interest of the scientific community due to their biological activities. Environmentally friendly extraction technologies and chemical modification methods have been developed to improve the yield, quality, and applications of seaweed polysaccharides. This review aims to compile current information about seaweed polysaccharides, including extraction and modification methods, biological activities, and future trends for their industrial applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Yong Chen, Jing Wang, Liang Zou, Hui Cao, Xiaoling Ni, Jianbo Xiao
Summary: This review discusses the beneficial effects of dietary proanthocyanidins (PAC) on gastrointestinal functions. The findings suggest that PAC can directly act on the gastrointestinal tract through its antioxidant, antibacterial, anti-inflammatory, and anti-proliferative properties. PAC can also interact with carbohydrates, proteins, and lipids, reducing their digestion and absorption. Additionally, PAC has a prebiotic-like effect on the intestinal microbiota, which may contribute to the potential health benefits.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Zebin Weng, Yuanrong Chen, Tingting Liang, Yajuan Lin, Hui Cao, Haizhao Song, Ling Xiong, Fang Wang, Xinchun Shen, Jianbo Xiao
Summary: Wheat germ protein is a promising source of bioactive peptides with various biological functions. However, there are still scientific issues that need further exploration in the basic research and industrialization process of WGBPs.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Medicine, Research & Experimental
Nermeen Yosri, Sultan M. Alsharif, Jianbo Xiao, Syed G. Musharraf, Chao Zhao, Aamer Saeed, Ruichang Gao, Noha S. Said, Alessandro Di Minno, Maria Daglia, Zhiming Guo, Shaden A. M. Khalifa, Hesham R. El-Seedi
Summary: Arctium lappa, also known as burdock, is a medicinal edible plant that has been used in traditional Chinese medicine for centuries. It has demonstrated various pharmacological effects and has potential applications in nanomedicine.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Yan Geng, Jing Liu, Zichuan Wang, Tianzi Liu, Xintong Peng, Yan Huang
Summary: FAM83D is overexpressed in various cancers and may be associated with mutated TP53 and promoter DNA methylation. It is involved in progesterone-mediated oocyte maturation pathway, cell cycle regulation, and other signaling pathways. Therefore, differential expression of FAM83D could serve as a diagnostic and prognostic biomarker for various cancers.
Article
Clinical Neurology
Fan Zhang, Chuanyi Fu, Yidong Deng, Mao Zhang, Hao Peng, Wenan Li, Jian Zhong, Qing Zhou, Li Huang, Shuli Xiao, Jiannong Zhao
Summary: This study aimed to explore the association between CYP1B1 genetic variants and the risk of ischemic stroke (IS) in the Chinese Han population. The results showed that the genetic variants CYP1B1-rs10916 and CYP1B1-rs2855658 can increase the risk of IS in Chinese Han individuals aged 60 and above, smoking, or drinking alcohol.
CEREBROVASCULAR DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Hidayat Hussain, Jianbo Xiao, Akbar Ali, Ivan R. Green, Bernhard Westermann
Summary: This review categorizes and discusses 180 new unusual cyclized triterpenoids, along with their demonstrated biogenetic pathways, syntheses, and biological effects, published between 2009 and 2021. The research showcases significant advances in the field of triterpenes, with a notable increase in the discovery of cyclized triterpenoids and significant progress in their synthesis and biological activities.
NATURAL PRODUCT REPORTS
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Review
Food Science & Technology
Yongbing Xu, Guilin Chen, Felix Wambua Muema, Jianbo Xiao, Mingquan Guo
Summary: Moringa oleifera Lam. (M. oleifera) is a fast-growing plant with high nutritional and medicinal values. It has been traditionally used to treat various health conditions. Phytochemical studies have revealed the presence of over 300 components in different parts of M. oleifera. Additionally, M. oleifera exhibits numerous pharmacological activities. This work aims to comprehensively review its nutritional components, chemical constituents, pharmacological activities, and applications in functional food products and medicines, providing valuable insights for future research.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Plant Sciences
Rosa Tundis, Jianbo Xiao, Ana Sanches Silva, Filipa Carreiro, Monica Rosa Loizzo
Summary: Citrus is a significant genus in the Rutaceae family, known for its medicinal and economic value, and including crops such as lemons, oranges, grapefruits, and limes. Citrus species are rich in carbohydrates, vitamins, dietary fiber, and phytochemicals, with various health-promoting properties. Citrus essential oils, mainly composed of monoterpenes and sesquiterpenes, have antimicrobial, antioxidant, anti-inflammatory, and anti-cancer properties. These oils are widely used in food, cosmetics, and pharmaceutical products.
Review
Food Science & Technology
Huanqi Wu, Shangyuan Sang, Peifang Weng, Daodong Pan, Zufang Wu, Junsi Yang, Lingyi Liu, Mohamed A. Farag, Jianbo Xiao, Lianliang Liu
Summary: Starch-based materials have suitable structural characteristics for 3D food printing inks and possess viscoelasticity, viscous film-forming, dough pseudoplasticity, and rheological properties. 3D food printing technology has significant advantages in customizing personalized and precise nutrition, expanding the range of ingredients, designing unique food appearances, and simplifying the food supply chain.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Review
Food Science & Technology
Fan Zhang, Shengxiong Chen, Jianguo Zhang, Kiran Thakur, Maurizio Battino, Hui Cao, Mohamed A. Farag, Jianbo Xiao, Zhaojun Wei
Summary: Asparagus is a perennial herb with valuable functional ingredients, which has been used as medicine and food since ancient times. Among its main chemical constituents, saponins play a crucial role in various health benefits and biological activities. This review focuses on the preparation methods, structure, classification, biological functions, food and non-food applications of asparagus saponins, with a special emphasis on their anti-cancer effects. It also highlights the challenges and limitations in current research and serves as a bridge between bioactive components and human health, aiding research on functional and health-promoting foods and medicinal applications of asparagus saponins.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Yaqian Geng, Yingfeng Xie, Wei Li, Yao Mou, Fang Chen, Jianbo Xiao, Xiaojun Liao, Xiaosong Hu, Junfu Ji, Lingjun Ma
Summary: Myricitrin, a flavonol compound extracted from plant resources, has shown great potential for various biological activities such as anti-inflammatory and anti-cancer effects. However, its practical application is constrained by low production, high cost, and environmental damage caused by extraction. Fortunately, innovative and sustainable extraction techniques as well as biosynthesis based on synthetic biology are emerging as alternatives to conventional techniques, providing new perspectives for large-scale production of myricitrin.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Lu Li, Kexin Ji, Fengqi Du, Nini Jin, Christine Boesch, Mohamed A. Farag, He Li, Xinqi Liu, Jianbo Xiao
Summary: This systematic review suggests that flavonoid supplementation has beneficial effects on liver function, lipid profile, and inflammation in NAFLD patients, making it a promising drug regimen for the management of NAFLD and its associated complications.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
