Article
Biochemistry & Molecular Biology
Han-Lin Hsu, Bo-Jyun Lin, Yu-Chen Lin, Chih-Chieh Tu, Nham-Linh Nguyen, Ching-Chiung Wang, Mei-Chuan Chen, Chun-Han Chen
Summary: This study demonstrates that Cucurbitacin E has potential as a promising drug candidate for NSCLC by inhibiting cell viability and proliferation in EGFR and KRAS mutated NSCLC cells through modulation of cell cycle progression and protein phosphorylation levels.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Engineering, Environmental
Yang Xiang, Qian Ran, Chun Wu, Luping Zhou, Weiwei Zhang, Jiuxuan Li, Lixin Xiang, Yanni Xiao, Li Chen, Yan Chen, Xuelian Chen, Andres Stucky, Shengwen Calvin Li, Jiang F. Zhong, Zhongjun Li, Kaiyong Cai
Summary: This study utilized single-cell RNA sequencing to reveal the impact of different sized TiO2 NPs on the transcriptional profile of human bone marrow stromal cells, demonstrating that exposure to TiO2 NPs led to changes in gene expression and DNA damage signaling played a crucial role in cellular responses. Different sizes of TiO2 NPs had varying effects on gene expression levels.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Food Science & Technology
Hsin-Ling Yang, Sheng-Teng Huang, Zi-He Lyu, Asif Ali Bhat, Chithravel Vadivalagan, Yu-Lyu Yeh, You-Cheng Hseu
Summary: Coenzyme Q0 (CoQ0) from Antrodia camphorata exhibits therapeutic benefits in cancer treatment by activating apoptotic and autophagic cell death pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Jin Mo Ku, Min Jeong Kim, Yu-Jeong Choi, Seo Yeon Lee, Ji-Yeong Im, Yong-Kyu Jo, Sanghoon Yoon, Ji-Hyun Kim, Jie Won Cha, Yong Cheol Shin, Seong-Gyu Ko
Summary: Lung cancer is a common and deadly malignancy. This study tested the effectiveness of a natural drug, JI017, in lung cancer cells. The results showed that JI017 inhibited cell proliferation, induced apoptosis, regulated apoptotic molecules, and inhibited colony formation. JI017 also increased intracellular ROS generation and downregulated PI3K, AKT, and mTOR expression. In addition, JI017 promoted apoptosis through ROS-induced autophagy. In a mouse model, JI017 treatment reduced tumor size and increased markers of apoptosis and autophagy. Targeting JI017 and autophagy signaling could be a potential strategy for lung cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Lina Zhao, Wenjun Xia, Peng Jiang
Summary: The study reveals that CREB1 and ATF1 regulate GSH biosynthesis by suppressing the expression of GCLM and GSS, leading to increased susceptibility of cells to oxidative stress. Targeting GCLM or oxidative stress may offer potential therapeutic approaches for tumors with high expression of CREB1 family proteins.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tatiane Renata Fagundes, Bruna Taciane da Silva Bortoleti, Fernanda Tomiotto-Pellissier, Virginia Marcia Concato, Manoela Daiele Gonsalves, Nilton Syogo Arakawa, Milena Menegazzo Miranda-Sapla, Carolina Panis, Wander Rogerio Pavanelli
Summary: This study evaluated the anti-tumor activity of grandiflorenic acid (GFA) on breast, liver, and lung tumor cell lines. The treatment using GFA significantly inhibited cell proliferation and induced cell death. The mechanisms of cell death involved the production of reactive oxygen species, exposure of phosphatidylserine, depolarization of the mitochondrial membrane, and decrease in plasma membrane integrity. The study also found the formation of autophagy vacuoles.
Article
Biochemistry & Molecular Biology
Jing-Ru Weng, Balraj Gopula, Po-Chen Chu, Jing-Lan Hu, Chia-Hsien Feng
Summary: This study investigated the anti-tumor activity of a PKM2 inhibitor called MTP in oral squamous cell carcinoma cells. The results showed that MTP inhibited cell growth, induced apoptosis, and modulated the expression of PKM2 and oncogenic biomarkers. In addition, MTP increased reactive oxygen species generation and affected the expression of autophagic genes. These findings suggest that MTP has potential therapeutic use for oral squamous cell carcinoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Yuanyuan Yin, Hui Peng, Junbo Shao, Jing Zhang, Yujie Li, Jingbo Pi, Jiabin Guo
Summary: Zinc oxide nanoparticles (ZnO NPs) are commonly used in various industrial fields, but studies have shown they can harm human skin with mechanisms not fully understood. Research demonstrated that ZnO NPs induced cytotoxicity, ROS accumulation, and mitochondrial dysfunction in skin cells, with NRF2 playing a key role in protecting against these effects through regulation of antioxidants and autophagy.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Toxicology
Amlan Das, Subhendu Chakrabarty, Debasish Nag, Santanu Paul, Arnab Ganguli, Gopal Chakrabarti
Summary: D2O induces autophagy-dependent apoptosis in A549 cells via ROS generation upon microtubule depolymerization and inhibition of PI3K/Akt/mTOR signaling. It augments the efficacy of other microtubule-targeting anticancer drug taxol.
TOXICOLOGY IN VITRO
(2023)
Article
Biochemistry & Molecular Biology
Xuan Li, Zheng Li, Yu-Qi Meng, Hui Qiao, Ke-Rong Zhai, Zhen-Qing Li, Shi-Lin Wei, Bin Li
Summary: The study demonstrates that melittin targets mitochondria, causing mitochondrial damage, and inhibits the autophagy-lysosomal degradation pathway. This process triggers mitoROS burst and ultimately activates the mitochondria-associated Bax/Bcl-2 apoptotic signaling pathways in A549 cells.
Article
Biochemistry & Molecular Biology
Shiori Mori, Rina Fujiwara-Tani, Momoko Gyoten, Shota Nukaga, Rika Sasaki, Ayaka Ikemoto, Ruiko Ogata, Shingo Kishi, Kiyomu Fujii, Hiroki Kuniyasu
Summary: Berberine (BBR) inhibits the proliferation, invasion, and drug resistance of gastrointestinal cancer cells, and induces cell death by inhibiting mitochondrial complex I and enhancing complex II activities. These effects are associated with autophagy and reactive oxidative species production. BBR shows significant anti-tumor and anti-stemness effects, making it a potential new cell death-inducing agent for the treatment of gastrointestinal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Esra Cansever Mutlu, Fatemeh Bahadori, Muge Sennaroglu Bostan, Hande Kazak Sarilmiser, Ebru ToksoyOner, Mehmet Sayip Eroglu
Summary: A novel approach was developed to deliver PTX to human lung cancer cells using core-shell structured NPs coated with QHL, demonstrating prolonged drug release, enhanced internalization, and increased cytotoxicity.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Environmental Sciences
Yuan Meng, Yupeng Cui, Fanjia Peng, Lixue Guo, Ruifeng Cui, Nan Xu, Hui Huang, Mingge Han, Yapeng Fan, Menghao Zhang, Yupin Sun, Lidong Wang, Zhining Yang, Mengyue Liu, Wenhua Chen, Kesong Ni, Delong Wang, Lanjie Zhao, Xuke Lu, Xiugui Chen, Junjuan Wang, Shuai Wang, Wuwei Ye
Summary: In this study, CYS genes were identified from genome-wide analysis of Gossypium hirsutum, and GhCYS2 was found to be the pivotal gene responsible for Cd2+ response. Silencing GhCYS2 in plants resulted in decreased levels of cysteine and glutathione, accumulation of MDA and ROS, and impairment of photosynthesis. These effects led to leaf stomatal closure, distortion and deformation of epidermal cells, disruption of intercellular connections, and ultimately plant wilting and reduction in biomass. The association established between Cd2+ and cysteine in this investigation provides a valuable reference point for further inquiry into the functional and regulatory mechanisms of cysteine synthesis genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Qihui Luo, Lanlan Jia, Chao Huang, Qi Qi, Asad Jahangir, Yu Xia, Wentao Liu, Riyi Shi, Li Tang, Zhengli Chen
Summary: PPI exhibits a cytotoxic effect on colon cancer cells by inducing autophagy and apoptosis, and down-regulating the AKT/mTOR pathway. This study is the first to report the mechanism of PPI-induced ROS production and its potential as a therapeutic agent for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Chang-feng Song, Yu-heng Hu, Zhi-guo Mang, Zeng Ye, Hai-di Chen, De-sheng Jing, Gui-xiong Fan, Shun-rong Ji, Xian-jun Yu, Xiao-wu Xu, Yi Qin
Summary: In this study, the researchers investigated the role of autophagy in Her-induced cell death in human pancreatic cancer cell lines. They found that Her dose-dependently suppressed cell proliferation, promoted autophagy, and induced autophagic death in pancreatic ductal adenocarcinoma (PDAC) cell lines. Moreover, Her activated autophagy by increasing the phosphorylation of AMPK and decreasing the phosphorylation of mTOR/p70S6K. The study provides evidence for the development of Her as a therapeutic agent for the treatment of pancreatic cancer.
ACTA PHARMACOLOGICA SINICA
(2023)
