Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Applied
Mereke Alimzhanova, Madina Mamedova, Kazhybek Ashimuly, Alham Alipuly, Yerlan Adilbekov
Summary: A simple and rapid method based on miniaturized solid-phase microextraction (mini-SPME) followed by gas chromatography-mass spectrometry was developed to identify eight endocrine disruptors in drinking water samples. The method showed high sensitivity and accuracy, and can be used for qualitative and quantitative analysis of analytes at extremely low concentrations.
Article
Public, Environmental & Occupational Health
Jessica M. Madrigal, Robert M. Sargis, Victoria Persky, Mary E. Turyk
Summary: The study suggests that certain organochlorine pesticides may alter male estradiol levels. The positive associations with estradiol may implicate sex hormones as a possible mechanism for disease risk among those with organochlorine pesticide exposure.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Review
Pharmacology & Pharmacy
Maria Popescu, Talia B. Feldman, Tanuja Chitnis
Summary: This study examines the impact of endocrine disruptors on gender bias in autoimmune diseases, highlighting how environmental factors may interfere with immune-related endocrine signaling and potentially lead to autoimmunity. It also emphasizes that the heterogeneity in research on endocrine disruptors may pose challenges in interpreting and translating results.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sheila I. Pena-Corona, Juan I. Chavez-Corona, Luis E. Perez-Caltzontzin, Dinorah Vargas-Estrada, C. Adriana Mendoza-Rodriguez, Edgar Ramos-Martinez, Jose L. Cerbon-Gutierrez, Jose A. Herrera-Barragan, David Quintanar-Guerrero, Gerardo Leyva-Gomez
Summary: Bisphenols are widely used plasticizers, but exposure to them is related to infertility and other pathologies. This study compared the protective effects of melatonin and vitamins against bisphenol-induced damage on reproductive variables. The results showed that melatonin improved sperm concentration and viability, while vitamins had negative effects on sperm concentration, testis weight, and testosterone levels. Molecular docking simulations suggested that vitamin E had the best binding affinity with androgen and estrogen receptors. These findings indicate that vitamins could act as endocrine disruptors, while melatonin is most effective in protecting against the toxic effects of bisphenols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tatiana S. Kalinina, Vladislav V. Kononchuk, Lyudmila F. Gulyaeva
Summary: Endocrine disruptors, such as organochlorine pesticides (OCPs), are a major concern due to their possible association with hormone-dependent carcinogenesis. Experimental results show that these pesticides can affect the expression of hormone receptors and target genes in breast cancer cells, with the effects varying based on the receptor status of the cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katelyn A. Bruno, Logan P. Macomb, A. Carolina Morales-Lara, Jessica E. Mathews, J. Augusto Frisancho, Alex L. Yang, Damian N. Di Florio, Brandy H. Edenfield, Emily R. Whelan, Gary R. Salomon, Anneliese R. Hill, Chathuranga C. Hewa-Rahinduwage, Ashley J. Scott, Henry D. Greyner, Frank A. Molina, Merci S. Greenaway, George M. Cooper, DeLisa Fairweather
Summary: The study found that housing mice in plastic cages increases the progression of viral myocarditis, with male mice being mainly affected by complement activation and increased macrophages, while female mice are mainly affected by mast cell activation and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Monica Kam Draskau, Anna Kjerstine Rosenmai, Martin Scholze, Mikael Pedersen, Julie Boberg, Sofie Christiansen, Terje Svingen
Summary: Clotrimazole is a widely used antifungal drug, but studies have shown that its use during pregnancy can significantly alter hormone levels, potentially affecting the reproductive system of the fetus.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rafael Moreno-Gomez-Toledano, Maria Delgado-Marin, Sandra Sanchez-Esteban, Alberto Cook-Calvete, Sara Ortiz, Ricardo J. Bosch, Marta Saura
Summary: Plastic production, disposal, and recycling systems pose significant challenges to the planet's health by releasing endocrine disruptors into the environment. The study focused on the mixture of bisphenols (BPmix) in a large human cohort and found a positive association between BPmix and heart disease. Further experiments demonstrated that BPmix had a higher effect on cell viability compared to BPA, and its combination induced apoptosis in endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Guelen Ayhan, Florence Rouget, Frank Giton, Nathalie Costet, Leah Michineau, Christine Monfort, Jean-Pierre Thome, Philippe Kadhel, Sylvaine Cordier, Alejandro Oliva, Luc Multigner
Summary: In utero exposure to chlordecone was associated with elevated levels of selected thyroid (TSH) and sex-steroid (DHEA, TT, and DHT) hormones at seven years in a non-monotonic dose response (inverted U) relationship, suggesting potential implications for future health and reproductive function in adolescence and adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Gisele Giannocco, Marina Malta Letro Kizys, Rui Monteiro Maciel, Janaina Sena de Souza
Summary: Thyroid hormones, T3 and T4, are crucial for regulating gene expression in tissues from fetal to adult stages, with particular importance in the central nervous system. Environmental substances can interfere with the functioning of the thyroid gland, leading to neurological disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Environmental
Tianxin Zhao, Xiangliang Tang, Dian Li, Jinglu Zhao, Rui Zhou, Fangpeng Shu, Wei Jia, Wen Fu, Huimin Xia, Guochang Liu
Summary: This study found that prenatal exposure to environmentally relevant levels of PBDE-99 can lead to damage in testicular function and structure, inducing steroidogenesis disorders and ultimately causing testicular dysgenesis.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Pan Yang, Bi-Gui Lin, Bin Zhou, Wen-Cheng Cao, Pan-Pan Chen, Yan-Ling Deng, Jian Hou, Sheng-Zhi Sun, Tong-Zhang Zheng, Wen-Qing Lu, Li-Ming Cheng, Wan-Jiang Zeng, Qiang Zeng
Summary: The study found that prenatal exposure to BPA, BPF, and BPS can have detrimental effects on fetal growth, with stronger effects noted in female infants. Associations were observed with birth length, ponderal index, and gestational age, showing different relationships with fetal growth parameters.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Merve Buke Sahin, Murat Cagan, Anil Yirun, Aylin Balci Ozyurt, Selinay Basak Erdemli Kose, Irem Iyigun, Melda Celik, Ozgur Ozyuncu, Pinar Erkekoglu, Cavit Isik Yavuz
Summary: This study assessed fetal exposure to Bisphenol derivatives and found a positive correlation between birth weight and cord blood Bisphenol A concentration. Further research on maternal exposure during the fetal and neonatal period is critical for public health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Klaudia Szymczak, Margery G. H. Pelletier, James M. Mackay, DeAnne Reid, Peter C. W. Gaines
Summary: Neutrophils are important regulators of innate immunity, and a small molecule antagonist called RIST4721 can effectively inhibit their chemotaxis in ex vivo-cultured mouse bone marrow cells stimulated by KC. RIST4721-treated neutrophils exhibited enhanced phagocytosis and reactive oxygen species production, confirming the specificity of the drug. These findings suggest that RIST4721 could be a potential treatment for various inflammatory conditions mediated by neutrophils.
Article
Environmental Sciences
Mahaut Beghin, Melodie Schmitz, Stephane Betoulle, Olivier Palluel, Sebastien Baekelandt, Syaghalirwa N. M. Mandiki, Erin Gillet, Katherine Nott, Jean-Marc Porcher, Christelle Robert, Sebastien Ronkart, Patrick Kestemont
Summary: This study found that subchronic waterborne exposure to a common pharmaceutical mixture in freshwater ecosystems may affect the neuroendocrine and immune systems of juvenile rainbow trout.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Audrey Catteau, Jean-Marc Porcher, Anne Bado-Nilles, Isabelle Bonnard, Marc Bonnard, Arnaud Chaumot, Elise David, Odile Dedourge-Geffard, Laurence Delahaut, Nicolas Delorme, Adeline Francois, Laura Garnero, Christelle Lopes, Katherine Nott, Patrice Noury, Olivier Palluel, Melissa Palos-Ladeiro, Herve Queau, Sebastien Ronkart, Khadija Sossey-Alaoui, Cyril Turies, Bernard Tychon, Olivier Geffard, Alain Geffard
Summary: The study demonstrated that a multispecies active biomonitoring approach can improve the diagnostic of aquatic systems, and the use of a multispecies Integrated Biomarker Response (IBR) value can assess the quality of water. By studying different species, the study highlighted the importance of a multispecies approach in evaluating biological impacts and contaminant toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Marine & Freshwater Biology
Corentin Mit, Anne Bado-Nilles, Gaelle Daniele, Barbara Giroud, Emmanuelle Vulliet, Remy Beaudouin
Summary: Bisphenol A (BPA) is a concerning chemical due to its endocrine disrupting function, high production volume, and persistence in aquatic environment. A physiologically-based toxicokinetic (PBTK) model was modified to accurately simulate the fate of BPA in fish. The experiments showed that BPA metabolism in fish is not only limited to the liver, but plasma and gills may also play a role.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Amelie Cant, Marc Bonnard, Jean-Marc Porcher, Jean Prygiel, Audrey Catteau, Laurence Delahaut, Olivier Palluel, Cyril Turies, Alain Geffard, Anne Bado-Nilles
Summary: This study conducted biological monitoring of genotoxicity and erythrocyte necrosis in six stations in northern France using a multi-biomarker approach. The results showed that this method can improve the existing biomarker approach and expand the understanding of the potential effects of contaminants.
Article
Environmental Sciences
Emmanuelle Lebeau-Roche, Gaelle Daniele, Aurelie Fildier, Christelle Bonnefoy, Cyril Turies, Anne Bado-Nilles, Jean-Marc Porcher, Odile Dedourge-Geffard, Emmanuelle Vulliet, Alain Geffard
Summary: This study applied metabolomics-based approaches to identify toxicity pathways and potential biomarkers in the fish species three-spined stickleback exposed to diclofenac. The results showed significant impacts on the liver metabolome, with upregulation of energy metabolism in females and downregulation in males. The antioxidant system was impacted in males, while the immunity system was down-regulated in females. Several potential metabolic biomarkers were identified.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Mahaut Beghin, Severine Paris-Palacios, Syaghalirwa N. M. Mandiki, Melodie Schmitz, Olivier Palluel, Erin Gillet, Isabelle Bonnard, Katherine Nott, Christelle Robert, Jean-Marc Porcher, Sebastien Ronkart, Patrick Kestemont
Summary: This study assessed the environmental risk of wastewater treatment plant (WWTP) effluents on aquatic ecosystems by examining the health of juvenile rainbow trout. The results showed that the pollution levels upstream from the WWTP can have detrimental effects on fish health, which are exacerbated by exposure to WWTP effluents. The use of a multi-biomarker approach provided comprehensive information about the biological effects caused by both point source pollution and the constitutive pollution levels in the receiving environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Gaelle Daniele, Florent Lafay, Carine Arnaudguilhem, Sandra Mounicou, Alain Geffard, Isabelle Bonnard, Odile Dedourge-Geffard, Christelle Bonnefoy, Emmanuelle Vulliet
Summary: Mollusks are sensitive to environmental changes in water and are thus used as bio-indicators to monitor water contamination. Iodinated X-ray contrast media (ICMs) are widely present in aquatic environments due to their high consumption, low biodegradability, and low removal rates. Although assumed to have low toxicity, continuous exposure to ICMs can lead to adverse effects, making the evaluation of their environmental risk important.
Article
Environmental Sciences
Mamadou Diop, Jerome Couteau, Anne Bado-Nilles, Eric Tavernier, Baghdad Ouddane, Jeremy Denis, Gwendoline Duong, Francois Gevaert, Sebastien Monchy, Jean Laroche, Rachid Amara
Summary: This study examines the impact of fish density and exposure duration on the bioaccumulation of trace metal elements (TME) and biomarker responses. The results show that fish density has no effect on TME accumulation in the muscle, but exposure duration significantly affects TME levels. We suggest that a 15-day exposure period with low fish density is sufficient for assessing TME pollution in the field.
MARINE POLLUTION BULLETIN
(2022)
Article
Environmental Sciences
Audrey Catteau, Antoine Le Guernic, Melissa Palos Ladeiroa, Odile Dedourge-Geffard, Marc Bonnard, Isabelle Bonnard, Laurence Delahaut, Anne Bado-Nilles, Jean -Marc Porcher, Christelle Lopes, Olivier Geffard, Alain Geffard
Summary: The Integrated Biomarker Response (IBR) is commonly used in biomonitoring, but it has limitations for routine and large-scale use. To overcome these limitations, a new index called IBR-T was proposed, which considers the threshold values of biomarkers and calculates the IBR value only for significantly modulated biomarkers. The comparison between IBR-T and IBRv2 showed that IBR-T has a better correlation with the percentage of significantly modulated biomarkers and provides a more ecologically relevant ranking of sites. IBR-T is important for biomonitoring as it simplifies data interpretation, directly indicates the contamination status of a site, aids in decision-making, and facilitates communication of results to the general public.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Biochemistry & Molecular Biology
Emilie Lance, Lucas Sartor, Pierre Foucault, Alain Geffard, Benjamin Marie
Summary: This study revealed the sexual molecular dimorphism in different tissues of the zebra mussel, especially in the gonads. The findings emphasize the importance of considering inter-sex differences to avoid confounding factors in the analysis and interpretation of data.
Article
Environmental Sciences
Stephane Pesce, Laure Mamy, Wilfried Sanchez, Marcel Amichot, Joan Artigas, Stephanie Aviron, Carole Barthelemy, Remy Beaudouin, Carole Bedos, Annette Berard, Philippe Berny, Cedric Bertrand, Colette Bertrand, Stephane Betoulle, Eve Bureau-Point, Sandrine Charles, Arnaud Chaumot, Bruno Chauvel, Michael Coeurdassier, Marie-France Corio-Costet, Marie-Agnes Coutellec, Olivier Crouzet, Isabelle Doussan, Juliette Fabure, Clementine Fritsch, Nicola Gallai, Patrice Gonzalez, Veronique Gouy, Mickael Hedde, Alexandra Langlais, Fabrice Le Bellec, Christophe Leboulanger, Christelle Margoum, Fabrice Martin-Laurent, Remi Mongruel, Soizic Morin, Christian Mougin, Dominique Munaron, Sylvie Nelieu, Celine Pelosi, Magali Rault, Sergi Sabater, Sabine Stachowski-Haberkorn, Elliott Sucre, Marielle Thomas, Julien Tournebize, Sophie Leenhardt
Summary: Preserving biodiversity and ecosystem services is crucial for sustainable development and human well-being. However, the use of plant protection products (PPP) has led to an alarming decline in biodiversity. A scientific assessment was conducted by a panel of experts, exploring the impacts of PPP on biodiversity and ecosystem services. The assessment revealed that PPP contaminates various environmental matrices and has clear ecotoxicological effects, causing the decline of certain biological groups and altering ecosystem functions and services. The study suggests local actions and regulatory improvements to mitigate PPP-driven pollution, but highlights the need for further research to understand its full impact.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
