Review
Chemistry, Applied
Hai-Yang Li, Yan-Ling Yi, Sheng Guo, Fang Zhang, Hui Yan, Zhi-Lai Zhan, Yue Zhu, Jin-Ao Duan
Summary: This review provides a comprehensive summary of the extraction, purification, structural characterization, and biological activities of Laminaria japonica polysaccharides, offering valuable insights for further research, production, and application in functional foods and therapeutic agents.
Article
Biochemistry & Molecular Biology
Tingting Li, Haiqiong Ma, Hong Li, Hao Tang, Jinwen Huang, Shiying Wei, Qingxia Yuan, Xiaohuo Shi, Chenghai Gao, Shunli Mi, Longyan Zhao, Shengping Zhong, Yonghong Liu
Summary: In this study, the physicochemical properties and anticoagulant activities of Laminaria japonica polysaccharides were investigated. The results showed that LJP06 and LJP08 exhibited strong anticoagulant activity by inhibiting intrinsic factor Xase. These findings provide insights for the application of Laminaria japonica polysaccharides as anticoagulants.
Article
Chemistry, Applied
Jianjun Zhou, Ziyang Jia, Min Wang, Qi Wang, Francisco J. Barba, Liuyu Wan, Xuedong Wang, Yang Fu
Summary: This study found that the addition of LJP can decrease the hardness of WS gel, improve its structure, and inhibit gel retrogradation. These results provide a new theoretical insight for the production of WS-based food.
FOOD HYDROCOLLOIDS
(2022)
Review
Biochemistry & Molecular Biology
Fei Luan, Junbo Zou, Zhili Rao, Yafei Ji, Ziqin Lei, Lixia Peng, Yan Yang, Xirui He, Nan Zeng
Summary: This review comprehensively summarizes the extraction, purification, structural characteristics, biological activities, clinical applications, and toxicities of Laminaria japonica polysaccharides. The relationship between structural characteristics and biological activities is highlighted, with an outline of the underlying molecular mechanisms. The study also proposes research perspectives and challenges in the field of Laminaria japonica polysaccharides.
Article
Biochemistry & Molecular Biology
Qianni Chen, Jiaqi Fan, Lianzhu Lin, Mouming Zhao
Summary: The optimal combination of Lycium barbarum L. polysaccharide (LBP) and Laminaria japonica polysaccharide (LJP) showed the strongest prebiotic effect, regulating gut probiotics and their metabolites. This study provides theoretical and methodological guidance for optimal screening of compound polysaccharides as new prebiotics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Tung-Yi Lin, Hung-Chih Lo, Wei-Lun Qiu, Chi-Hsein Chao, Mei-Kuang Lu, Hsien-Yeh Hsu
Summary: In this study, the anticancer activity of LJPS was optimized using the TFF system. The crude LJPS was divided into two fractions, 10K-R and 10K-F, with molecular masses of approximately 985 and 3 kDa, respectively. The biological functions showed that 10K-R inhibited the viability and mobility of cancer cells, while 10K-F did not. This study provides the first evidence of purifying polysaccharide using the TFF system and reveals the potential mechanism of 10K-R in cancer cell inhibition.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Dafang Yin, Xiaojie Sun, Na Li, Yingying Guo, Yu Tian, Lianzhu Wang
Summary: Polysaccharides in brown algae, particularly from kelp Laminaria japonica, are important economically for food and pharmaceutical industries. This study compared four extraction methods for L. japonica polysaccharides, finding that ultrasound-assisted extraction showed the highest yield and sulfate content, while enzyme-assisted extraction had the highest total carbohydrate content. The method of extraction significantly influenced the characteristics and antioxidant activities of the polysaccharides.
PROCESS BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xueqian Zhang, Ying You, LiLong Wang, Chunqing Ai, Linjuan Huang, Songtao Wang, Zhongfu Wang, Shuang Song, Beiwei Zhu
Summary: Previous studies have shown that fucoidan can resist high-fat-diet-induced obesity by modulating the composition of gut microbiota. In this study, the anti-obesity effects of fucoidan were compared between mice with different gut microbiota communities. The results demonstrated that mice with different initial gut microbiota responded differently to fucoidan supplementation, and certain gut bacteria were required for the anti-obesity effects.
Article
Biochemistry & Molecular Biology
Zhen Jin, Zhifeng Fang, Zhangming Pei, Hongchao Wang, Jinlin Zhu, Yuan-kun Lee, Hao Zhang, Jianxin Zhao, Wenwei Lu, Wei Chen
Summary: This study compared the effects of LJNP and 2'FL on gut microbiota and host regulation through oral administration in mice. LJNP was found to be more effective in protecting the intestinal barrier and promoting weight loss compared to 2'FL. The study also demonstrated that LJNP can modulate gut microbiota, maintain blood glucose level, and regulate body weight and antioxidant function.
Article
Food Science & Technology
Yanan Gao, Mingkun Guo, Peng Zheng, Ruoyi Liu, Dandan Wang, Daqing Zhao, Mingxing Wang
Summary: Laminaria japonica polysaccharides (LJP) may alleviate obesity and related gut microbiota dysbiosis and intestinal inflammatory disorders through reducing weight, liver fat accumulation, improving serum indicators, and decreasing inflammation.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yifan Chen, Weixuan Huang, Yang Chen, Minqian Wu, Ruohan Jia, Lijun You
Summary: By degrading LJP with UV/H2O2, hydrogels with different molecular weights were produced for wound dressings with excellent anti-inflammatory activity and swelling property. Low Mw LJP-based hydrogels showed great potential for wound dressing application.
Article
Food Science & Technology
Huiting Lin, Jiawen Zhang, Shiyang Li, Baodong Zheng, Jiamiao Hu
Summary: The study showed that polysaccharides from Laminaria japonica have beneficial effects on gestational diabetes mellitus mice, potentially through altering gut microbiota, with the up-regulation of short-chain fatty acids-producing bacterium Turicibacter being a key factor. This indicates the potential of LP to serve as a prebiotic and food supplementation for GDM patients.
Article
Biochemistry & Molecular Biology
Jiayu Gao, Dongyi Hu, Yang Shen, Yiying Zheng, Ying Liang
Summary: This study investigated the extraction methods, structure and characteristics, and antioxidant activities of Hyperici Perforati Herba polysaccharide (HPHP). An ultrasonic-assisted extraction method was developed by response surface analysis, with optimum conditions determined. Three HPHPs were obtained and their structures and characteristics were elucidated. HPHPs exhibited strong antioxidant activities and protective effects against oxidative damage in human cells. These findings contribute to the understanding and further research of HPHPs as potential antioxidants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Ecology
Orsolya Vincze, Csongor Vagasi, Janka Penzes, Krisztian Szabo, Nora M. Magonyi, Gabor A. Czirjak, Peter L. Pap
Summary: Sex-specific physiology in wild birds was investigated in this study. Results showed that higher female immune indices were most common, while oxidative physiology showed no general sex bias and packed cell volume was generally male-biased. Contrary to predictions based on sexual selection, male-biased sexual size dimorphism was associated with male-biased immune measures. Factors such as sexual dichromatism, mating system and parental roles had no effect on sex-specificity in physiology. Importantly, female-biased immunity remained after accounting for sexual selection indices, suggesting alternative explanations should be explored for cross-species differences in physiological sex bias.
Article
Biotechnology & Applied Microbiology
Xiaodan Fu, Yuming Zhan, Nannan Li, Dongxing Yu, Wei Gao, Ziqiang Gu, Lin Zhu, Rong Li, Changliang Zhu
Summary: Recent studies have shown that seaweed polysaccharides can improve metabolic syndromes induced by high-fat diets and are associated with the regulation of gut microbiota. A new study has developed a method of preparing low-molecular-weight seaweed polysaccharides using high-pressure pretreatment and composite enzymatic degradation. The study also evaluated the effectiveness of these polysaccharides in preventing obesity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Mechanical
Yajun Cao, Wei Wang, Wanqing Shen, Xiaoyan Cui, Jianfu Shao
Summary: This study proposes a new hybrid phase-field fracture method for investigating the cracking behavior of anisotropic plastic materials. By introducing a unified decomposition method and a new damage field evolution criterion, as well as considering the contribution of plastic strain energy, the model exhibits different types of cracking patterns and is validated against experimental results.
INTERNATIONAL JOURNAL OF PLASTICITY
(2022)
Article
Toxicology
Xiaoyan Cui, Jinglei Sun, Congxin Li, Suhua Qiu, Chenxia Shi, Jingtao Ma, Yanfang Xu
Summary: Both nilotinib and vandetanib decrease the abundance of hERG channels, leading to arrhythmias.
TOXICOLOGY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Hui Xiong, Na Li, Lanqingqing Zhao, Zhe Li, Yongzhou Yu, Xiaoyan Cui, Qi Liu, Chunying Zhao
Summary: This study aimed to reveal the material basis and mechanism of Danggui Shaoyao San (DSS) in treating primary dysmenorrhea (PD) through an integrative approach of serum pharmacochemistry, metabolomics, and network pharmacology. The results showed that DSS significantly improved the symptoms of PD by modulating arachidonic acid metabolism, pentose and glucuronate interconversions, and phenylalanine metabolism. Network pharmacology analysis revealed that active components of DSS were closely related to steroid hormone biosynthesis, arachidonic acid metabolism, and sphingolipid signaling pathway. This study provides a solid basis for the application of DSS.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Xiao-Yan Cui, Xiao Wu, Dan Lu, Dan Wang
Summary: Using network pharmacology, this study explored the potential mechanism of Sanqi and Huangjing for the treatment of diabetes mellitus. The results showed that the intervention effects of Sanqi and Huangjing in diabetes may involve several active components and targets, and participate in multiple pathways.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Geochemistry & Geophysics
Yan Zhuang, Kangyu Wang, Shunlei Hu, Xidong Zhang, Xiaoyan Cui
Summary: This study numerically investigates the tensile membrane effect in a geogrid reinforced piled embankment under dynamic loading. The results show that the maximum sag of the geogrid is at the center of two adjacent piles, with tensile force localized at the corners of the pile caps. Under dynamic loading, an increase in sag and strain of the geogrid is mainly due to the degradation of soil arching effect. The tensile force in the geogrid increases with embankment height, pile spacing, and geogrid stiffness, but decreases with friction angle of the embankment fill.
Article
Environmental Studies
Pan Liu, Xiaoyan Cui, Ye Li
Summary: This study explores subsidy strategies for blockchain-based traceability service providers and proposes three subsidy models. The findings suggest that varying subsidies can lower prices and increase the revenues of the entire supply chain members.
SCIENCE AND PUBLIC POLICY
(2023)
Article
Chemistry, Applied
Yujiao Wang, Xiaoyan Cui, Runhua Lu, Haixiang Gao, Huafen Li, Wenfeng Zhou
Summary: In this study, a fluorescent organic nanoparticle-based sensor was developed for the detection of fluorine-containing pesticides using ratio-metric fluorescence assay and Tyndall Effect assay. The sensor showed advantages such as being economical, simple, and portable, and achieved good results in detecting analytes in teas.
Article
Oncology
Ashley Patton, Amy Speeckaert, Micayla Zeltman, Xiaoyan Cui, Steve Oghumu, O. Hans Iwenofu
Summary: Soft tissue myoepitheliomas (STM) are benign neoplasms that usually occur in the subcutaneous and deep soft tissues. In this case report, a rare intravascular location of STM in the right index finger was observed. The novel IRF2BP2::CDX2 fusion was identified and confirmed. The overall features were considered diagnostic of STM, with no evidence of tumor elsewhere.
GENES CHROMOSOMES & CANCER
(2023)
Article
Construction & Building Technology
Yan Zhuang, Xiaoyan Cui, Shunlei Hu
Summary: This paper aims to investigate the displacement of adjacent tunnels caused by excavation by using finite element models. The results show that the displacement of the tunnel mainly occurs during excavation and pouring of floor slabs, and becomes stable after the construction of inclined steel struts. Factors such as excavation width, depth, distance between excavation and tunnel, and distance between tunnel centerline and excavation significantly affect the displacement of the adjacent tunnel. The maximum vertical displacement ranges from 2.0 mm to 12.6 mm, and the maximum lateral displacement ranges from 2.6 mm to 19.2 mm. A simplified analytical method is proposed and validated by three field cases for rapid prediction of maximum vertical displacement of existing adjacent tunnels caused by excavation.
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY
(2023)
Article
Oncology
Matthew C. Hiemenz, Jaspreet Kaur, Zheng Kuang, Richard S. P. Huang, Lukas Harries, Dana Metzger, Kelsie Schiavone, Sherri Z. Millis, Douglas I. Lin, Mirna Lechpammer, Brennan Decker, Douglas A. Mata, Abhinav Reddy, Matthew Parke, Eun Y. Lee, Xiaoyan Cui, O. Hans Iwenofu, Darya Buehler, Les Henderson, Erin M. Baldwin, Sosipatros A. Boikos, Shakti H. Ramkissoon, Steven C. Smith
Summary: This study characterizes six tumors with EWSR1 or FUS gene fusion with POU2AF3 and describes their histopathology and genomics. The tumors exhibit morphologic features similar to synovial sarcoma and aggressive behavior with local spread and/or distant metastases. Further studies are needed to confirm the functional significance of POU2AF3 fusions to EWSR1 or FUS.
GENES CHROMOSOMES & CANCER
(2023)
Meeting Abstract
Medicine, Research & Experimental
Bethany Burns, Raza Hoda, Gloria Lewis, Xiaoyan Cui, Sara Abbott, Miglena Komforti, J. Jordi Rowe, Gary Procop, Erinn Downs-Kelly, Patrick McIntire
LABORATORY INVESTIGATION
(2022)
Meeting Abstract
Medicine, Research & Experimental
Bethany Burns, Raza Hoda, Gloria Lewis, Xiaoyan Cui, Sara Abbott, Miglena Komforti, J. Jordi Rowe, Gary Procop, Erinn Downs-Kelly, Patrick McIntire
LABORATORY INVESTIGATION
(2022)
Meeting Abstract
Medicine, Research & Experimental
Lauren Duckworth, Raza Hoda, Miglena Komforti, Gloria Lewis, Xiaoyan Cui, J. Jordi Rowe, Erinn Downs-Kelly, Patrick McIntire
LABORATORY INVESTIGATION
(2022)
Meeting Abstract
Medicine, Research & Experimental
Lauren Duckworth, Raza Hoda, Miglena Komforti, Gloria Lewis, Xiaoyan Cui, J. Jordi Rowe, Erinn Downs-Kelly, Patrick McIntire
LABORATORY INVESTIGATION
(2022)
Meeting Abstract
Medicine, Research & Experimental
Lauren Duckworth, Raza Hoda, Miglena Komforti, Gloria Lewis, Xiaoyan Cui, Daniel Silbiger, J. Jordi Rowe, Erinn Downs-Kelly, Patrick McIntire
LABORATORY INVESTIGATION
(2022)
