Agonist stimulation at human μ opioid receptors in a [35S]GTPγS incorporation assay: observation of “bell-shaped” concentration–response relationships under conditions of strong receptor G protein coupling

Colloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves

(2014) Shawn C. Owen et al.   ACS Chemical Biology

Disruption of the Na+ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor

(2014) Kathryn E. Livingston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours

(2014) Eamonn Kelly et al.   PSYCHOPHARMACOLOGY

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Efficacy and ligand bias at the μ-opioid receptor

(2013) E Kelly   BRITISH JOURNAL OF PHARMACOLOGY

Tools for GPCR drug discovery

(2012) Ru Zhang et al.   ACTA PHARMACOLOGICA SINICA

Noninvasive quantification of intracellular sodium in human brain using ultrahigh-field MRI

(2012) Lazar Fleysher et al.   NMR IN BIOMEDICINE

The clozapine metabolite N-desmethylclozapine displays variable activity in diverse functional assays at human dopamine D2 and serotonin 5-HT1A receptors

(2011) Peter Heusler et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Relationship between Homo-oligomerization of a Mammalian Olfactory Receptor and Its Activation State Demonstrated by Bioluminescence Resonance Energy Transfer

(2011) Fallou Wade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of the GTPγS ([35S]GTPγS and Eu-GTPγS) binding assay for analysis of ligand potency and efficacy at G protein-coupled receptors

(2010) Philip G. Strange   BRITISH JOURNAL OF PHARMACOLOGY

Competitive interaction of 5-HT1A receptors with G-protein subtypes in CHO cells demonstrated by RNA interference

(2010) Isabelle Rauly-Lestienne et al.   CELLULAR SIGNALLING

G Proteins in Reverse Mode

(2010) Leif G. Hommers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

(2010) J. McPherson et al.   MOLECULAR PHARMACOLOGY

Cell-based assays in GPCR drug discovery

(2008) Sandra Siehler   Biotechnology Journal

Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptors

(2008) P G Strange   BRITISH JOURNAL OF PHARMACOLOGY

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY