Article
Multidisciplinary Sciences
Monica Campos, Jody Phelan, Anton Spadar, Emma Collins, Aderitow Goncalves, Bethanie Pelloquin, Natasha Marcella Vaselli, Anne Meiwald, Emma Clark, Caleb Stica, James Orsborne, Moussa Sylla, Constant Edi, Denka Camara, Abdul Rahim Mohammed, Yaw Asare Afrane, Mojca Kristan, Thomas Walker, Lara Ferrero Gomez, Louisa A. Messenger, Taane G. Clark, Susana Campino
Summary: Surveillance of malaria vector species and monitoring of insecticide resistance are crucial for informing malaria control strategies. This study developed a high-throughput panel using genetic barcoding, PCR, and next-generation sequencing to monitor Anopheles mosquitoes in malaria endemic regions. The panel successfully detected Plasmodium infection and insecticide resistance mutations in four Anapheles species, providing a reliable and cost-effective approach for surveillance.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Mahendra Pratap Kashyap, Rajesh Sinha, M. Shahid Mukhtar, Mohammad Athar
Summary: Advancements in cutting-edge technological tools and bioinformatics have revolutionized the understanding and research of cancer. This review focuses on the epigenetic regulation of non-melanoma skin cancer, emphasizing the roles of genetic mutations, epigenetic regulation, and novel therapeutic interventions in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mareike Herzog, Elisa Alonso-Perez, Israel Salguero, Jonas Warringer, David J. Adams, Stephen P. Jackson, Fabio Puddu
Summary: The study shows that yeast cells carrying a range of cancer-associated mutations in the Pol ε exonuclease domain exhibit ultra-mutagenesis, with similarities to mutations observed in cells lacking the exonuclease domain. This suggests a shared mechanism of mutagenesis leading to mutation patterns similar to cancer Signature 14.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Public, Environmental & Occupational Health
Nathan L. DeBono, Robert D. Daniels, Laura E. Beane Freeman, Judith M. Graber, Johnni Hansen, Lauren R. Teras, Tim Driscoll, Kristina Kjaerheim, Paul A. Demers, Deborah C. Glass, David Kriebel, Tracy L. Kirkham, Roland Wedekind, Adalberto M. Filho, Leslie Stayner, Mary K. Schubauer-Berigan
Summary: This study is a meta-analysis of the association between occupational exposure as a firefighter and cancer. The results show that there is epidemiological evidence supporting a causal relationship between being a firefighter and certain cancers, but challenges remain in exposure assessment, confounding, and medical surveillance bias.
SAFETY AND HEALTH AT WORK
(2023)
Article
Cell Biology
Ning Zhao, Maozu Guo, Chunlong Zhang, Chunyu Wang, Kuanquan Wang
Summary: In this study, pan-cancer analysis was conducted to uncover specific and common patterns of long non-coding RNA (lncRNA) methylation in 23 cancer types. Several lncRNAs were identified as diagnostic biomarkers for specific cancer types, and two lncRNAs were identified as pan-cancer biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Ammad Ahmad Farooqi, Sundas Fayyaz, Palmiro Poltronieri, George Calin, Massimo Mallardo
Summary: Cutting-edge research has revealed that deregulated epigenetic marks play a critical role in cancer development. This research provides valuable insights into the mechanisms that control cellular functions, including changes in chromatin accessibility, transcription and translation, and post-translational modifications. The study discusses DNA and RNA modifications, chromatin modifying proteins, and histone deacetylases. It also explores the role of non-coding RNAs and the impact of mitochondrial dysfunction on epitranscriptome marks. Overall, this research has the potential to lead to the development of novel drugs and personalized medicine for cancer patients.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Acoustics
Hongyu Ge, Yujiao Guo, Tianyu Luo, Manzhi Yang, Chuanwei Zhang
Summary: This study proposes a fault identification method based on continuous wavelet transform (CWT) and two-dimensional convolutional neural network (2DCNN) to address the low recognition rate and human intervention issues in traditional mechanical equipment fault diagnosis. By collecting and preprocessing vibration signals of different fault states of a worm rotation unit, a 2DCNN fault identification model is established and optimized with the addition of a hybrid domain attention module CBAM. The results show that this method can effectively recognize different states of mechanical element action unit faults.
SHOCK AND VIBRATION
(2022)
Article
Oncology
Tian He, Gary Wildey, Karen McColl, Alyssa Savadelis, Kyle Spainhower, Cassidy McColl, Adam Kresak, Aik Choon Tan, Michael Yang, Ata Abbas, Afshin Dowlati
Summary: RUNX1T1 gene amplification was specific to small cell tumors of c-SCLC patients but rare in 'pure' SCLC patients. Higher expression of RUNX1T1 was observed in SCLC compared to other cancers, including NSCLC. Additionally, stable RUNX1T1 overexpression led to significant changes in E2F targets and decreased CDKN1A (p21) expression in multiple lung cancer cell lines.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Richard Heery, Martin H. Schaefer
Summary: While large-scale studies have identified hundreds of mutated driver genes in various cancer types, the contribution of epigenetic changes to cancer remains unclear. A novel method correcting for epigenetic covariates reveals a concise set of potential epigenetic driver events, indicating higher convergence on common tumor suppressor pathways and higher tolerance of other aberrations in prostate cancer.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Medicine, Research & Experimental
Ajinath Kale, Himanshu Sankrityayan, Hans-Joachim Anders, Anil Bhanudas Gaikwad
Summary: Klotho is a novel anti-aging protein expressed at highest levels in the kidney, with its regulation contributing to kidney disease progression. Levels of Klotho decrease during kidney injury and other diseases, but supplementation or overexpression can attenuate kidney disease. Various epigenetic and non-epigenetic mechanisms regulate Klotho expression, with natural products showing potential in this regulation.
Article
Engineering, Environmental
John T. Sloop, Alex Chao, Jennifer Gundersen, Allison L. Phillips, Jon R. Sobus, Elin M. Ulrich, Antony J. Williams, Seth R. Newton
Summary: Several thousand chemical releases occur annually in the U.S., with almost 30% of them having unknown composition. Non-targeted analysis (NTA) methods can be used when targeted methods fail to identify the chemicals present. By utilizing new data processing workflows, confident chemical identifications can be achieved through NTA within a useful timescale for rapid response. A study was conducted to demonstrate the potential usefulness of NTA in rapid response scenarios, and three mock scenarios were designed with various challenges. The results show the effectiveness of NTA in timely and confident identification of unknown stressors.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Stefan Harsanyi, Zuzana Varchulova Novakova, Katarina Bevizova, Lubos Danisovic, Stanislav Ziaran
Summary: Bladder cancer is the 10th most common cancer worldwide, with a variety of diagnostic methods available, including standard cystoscopy and urine cytology. Liquid biopsy as a new trend is proving to be almost equally effective in detecting bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cell Biology
David Corujo, Marcus Buschbeck
Summary: The interaction between non-immune and immune cells in the tumor microenvironment plays a crucial role in the immune attack on cancer cells. A recent study on melanoma cells reveals that specific histone variants can suppress the expression of cytokine genes in cancer-associated fibroblasts, resulting in an immunosuppressive tumor microenvironment.
NATURE CELL BIOLOGY
(2023)
Article
Oncology
Reem Khaled M. E. Alsayed, Khalid Sultan A. M. Sheikhan, Majid Ali Alam, Jorg Buddenkotte, Martin Steinhoff, Shahab Uddin, Aamir Ahmad
Summary: Cancer 'stemness' is crucial for the existence and characteristics of cancer cells. Transcription factors such as NF-KB and STAT-3 play a significant role in cancer stemness and are potential targets for cancer therapy. The study of non-coding RNAs has revealed their interactions with these transcription factors, offering insights into the regulatory mechanisms of cancer stemness and potential therapeutic opportunities.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hiroaki Tachiwana, Noriko Saitoh
Summary: LncRNAs are a class of non-coding RNAs widely present in mammalian cells, involved in regulating cellular functions. Their dysregulation in cancer is closely related to disease development and they have diagnostic and therapeutic potential.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Environmental Sciences
Muqiu Hu, Xin Zhao, Jinghan Gu, Lulu Qian, Zhiqing Wang, Yuanyuan Nie, Xiaoyu Han, Long An, Haiqiang Jiang
Summary: Due to its simple process, environmental friendliness, and low operating costs, biometallurgy has become a popular technology for metals recovering from low-grade ores and tailings. An optimized agar was used to isolate and grow functional bacteria, resulting in the successful isolation of six functional stains. These strains were further tested for their ability to leach metals from polymetallic sulfide tailings, with significant improvements observed when the strains were mixed together. The selection of leaching process should be based on tailings composition and target metals.
ENVIRONMENTAL RESEARCH
(2024)
Review
Environmental Sciences
Saqib Hassan, Aswin Thacharodi, Anshu Priya, R. Meenatchi, Thanushree A. Hegde, R. Thangamani, Ht Nguyen, Arivalagan Pugazhendhi
Summary: An Endocrine Disrupting Chemical (EDC) is a compound that disrupts the function of the endocrine system and is found in the environment. EDCs, such as Bisphenol A and pesticides, have been shown to have negative effects on the female reproductive system. Understanding the relationship between EDCs and women's health is crucial for developing strategies to protect reproductive health and informing public policy decisions.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Lichang Zhou, Zhaoling Li, Boyi Cheng, Jinqi Jiang, Xinqi Bi, Zongping Wang, Guanghao Chen, Gang Guo
Summary: Thiosulfate can promote sulfur-mediated bacterial activity, inhibit glycogen accumulating organisms, and enhance denitrification efficiency. After the carbon source is reduced, the competitive ability of glycogen accumulating organisms increases, resulting in reduced sulfate reduction.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Claire E. Campbell, Devyn L. Cotter, Katherine L. Bottenhorn, Elisabeth Burnor, Hedyeh Ahmadi, W. James Gauderman, Carlos Cardenas-Iniguez, Daniel Hackman, Rob McConnell, Kiros Berhane, Joel Schwartz, Jiu-Chiuan Chen, Megan M. Herting
Summary: Recent studies have found a connection between air pollution and increased risk for behavioral problems during development. However, more longitudinal studies are needed to investigate how exposure during the transition to adolescence may affect emotional behaviors.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Jing-hong Liang, Ru-yu Yang, Mei-ling Liu, Ying-qi Pu, Wen-wen Bao, Yu Zhao, Li-xin Hu, Yu-shan Zhang, Shan Huang, Nan Jiang, Xue-ya Pu, Shao-yi Huang, Guang-hui Dong, Ya-jun Chen
Summary: This study examines the association between urban Green and blue spaces (GBS) exposure and Emotion and behavior problems (EBP) in youth populations. The findings suggest that higher exposure to GBS, particularly green spaces (GS) and blue spaces (BS), is associated with a decrease in the risk of developing total difficulties in young individuals. The joint effect of GS and BS may also contribute to the decrease in EBPs.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Diego Ruiz-Sobremazas, Mario Ruiz Coca, Miguel Morales-Navas, Rocio Rodulfo-Cardenas, Caridad Lopez-Granero, Maria Teresa Colomina, Cristian Perez-Fernandez, Fernando Sanchez-Santed
Summary: Air pollution is associated with a range of health issues and gestational exposure to environmental pollutants may be linked to neurodevelopmental disorders. This study investigated the effects of oral gestational exposure to particulate matter (PM) on ultrasonic vocalizations (USV). The findings suggest that this exposure may lead to social deficits and abnormal gene expression related to neurotransmitter systems. Further research is needed to better understand the effects of air pollution on neurodevelopmental disorders and the neurotransmission systems involved.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Yagmur Kabakci, Sadiye Kosar, Ozgur Dogan, Fehmi Gorkem Uctug, Osman Atilla Arikan
Summary: This study investigated the effect of electrohydrolysis pretreatment on municipal solid waste. The results showed that applying electrohydrolysis pretreatment increased methane production and reduced the time required for hydrolysis, suggesting it is a promising method to improve anaerobic digestion efficiency.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Chuanwu Zhao, Yaozhong Pan, Hanyi Wu, Yu Zhu
Summary: This study analyzed the impact of industrial zones on urban heat islands using remote sensing images and a novel spectral index. The research found that the contraction or expansion of industrial zones has a significant effect on land surface temperature. The results are valuable for environmental assessment and fine management of industrial cities.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Bang Du, Zhongzhong Wang, Piet N. L. Lens, Xinmin Zhan, Guangxue Wu
Summary: This study investigated the performance, syntrophic relationships, microbial communities, and metabolic pathways of ethanol-fed reactors with different operational modes and solids retention times. The results showed that different microorganisms were enriched under different SRT conditions, and syntrophic bacteria related to methane production could be enriched under low SRT conditions.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Gokulan Ravindiran, Sivarethinamohan Rajamanickam, Muralikrishnan Ramalingam, Gasim Hayder, Balamurugan Karupaiya Sathaiah, Madhava Krishna Reddy Gaddam, Senthil Kumar Muniasamy, Priya Arunkumar
Summary: The present study investigated the sustainable approach for wastewater treatment using waste algal blooms. The biochar produced by the marine algae Ulva reticulata was used to remove chromium, nickel, and zinc from aqueous solutions. The study examined the adsorbents' properties and stability using SEM/EDX, FTIR, and XRD. The results showed that the biochar had high removal efficiency for the toxic metals, and the packed bed column effectively removed the heavy metal ions. The Thomas and Adams-Bohart models were found to best fit the regression values, and desorption studies were conducted to understand the sorption and elution processes.
ENVIRONMENTAL RESEARCH
(2024)
Review
Environmental Sciences
Vignesh Vinayagam, Kavitha Nagarasampatti Palani, Sudha Ganesh, Siddharth Rajesh, Vedha Varshini Akula, Ramapriyan Avoodaiappan, Omkar Singh Kushwaha, Arivalagan Pugazhendhi
Summary: The presence of pollutants in water contributes to global pollution and poses significant threats to humans and wildlife. Finding effective wastewater treatment techniques is crucial for reducing pollutant accumulation in the environment. This paper highlights recent advances in the electrochemical advanced oxidation method and other processes for treating pharmaceuticals, dyes, and pesticide-polluted effluents.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
M. M. M. Ahmed, Kai-Yue Chen, Fang-Yu Tsao, Yi-Cheng Hsieh, Yu-Ting Liu, Min Tzou
Summary: This study investigated the sorption of citric acid onto humic acid-iron hydr(o)xide coprecipitate (HAFHCP) and the reciprocal effects of citric acid and P sorption on HAFHCP. The results showed that citric acid could increase P availability and have an impact on P sorption.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Xibo Xu, Zeqiang Wang, Xiaoning Song, Wenjie Zhan, Shuting Yang
Summary: The selection of predictor variables is crucial in building a digital mapping model for potentially toxic elements (PTEs) in soil. Traditionally, spatial and spectral parameters have been used as predictor variables, but the temporal dimension is often overlooked. This study demonstrates the value of incorporating temporal indices in the model, leading to significant performance improvements. The temporal-spatial-spectral covariate combinations used in a random forest (RF) algorithm achieve satisfactory mapping accuracy and outperform other methods.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Yan Pei, Xun Liu, Mengbo Cao, Zijun Wang, Hongbing Yang
Summary: Heteroatom doping can reconfigure the electronic structure of heterogeneous catalysts, leading to the development of advanced oxidation water purification materials with superior performance and stability. In this study, a series of catalysts with different elemental doping were prepared using a simple and environmentally friendly method. The S-doped NiCo2O4 catalyst showed excellent catalytic performance for the removal of Tetracycline, with significantly increased kinetic constant and high oxidation and mineralization efficiency in a wide pH range. The degradation process was dominated by non-radical oxidation pathway after S doping, and the overall process moved towards low toxicity.
ENVIRONMENTAL RESEARCH
(2024)
Article
Environmental Sciences
Srivalli Thimmarayan, Harshavardhan Mohan, Gaddapara Manasa, Karthi Natesan, Shanmugam Mahendran, Pavithra Muthukumar Sathya, Byung-Taek Oh, R. Ravi Kumar, Rangasamy Sigamani Gandhimathi, Arul Jayaprakash, Kamala-Kannan Seralathan
Summary: This study investigated the bacterial degradation of naphthalene (NPT) isolated from crude oil-contaminated soil. Bacillus sp. GN 3.4, a potential bacteria for NPT biodegradation, was isolated and the optimal conditions for NPT degradation were determined. The study suggests that Bacillus sp. GN 3.4 could potentially aid in bioremediation by eliminating NPT from the soil.
ENVIRONMENTAL RESEARCH
(2024)