Article
Chemistry, Physical
Kyu-Woong Yeom, Do-Kyoung Lee, Nam-Gyu Park
Summary: The regulation of Lewis acid-base adduct intermediate plays a critical role in the preparation of high quality perovskite films with dual metal ions of Sn2+ and Pb2+. The interaction between metal ions and Lewis base additives, such as urea and thiourea, significantly affects the photovoltaic performance of Sn-Pb alloyed perovskite solar cells.
ADVANCED ENERGY MATERIALS
(2022)
Article
Chemistry, Organic
Roxana Postolache, Juana M. Perez, Marta Castineira Reis, Luo Ge, Esther G. Sinnema, Syuzanna R. Harutyunyan
Summary: In this study, catalytic asymmetric hydrophosphination of α,β-unsaturated carbonyl derivatives using a chiral Mn(I) complex as a catalyst is reported. Various phosphine-containing chiral products can be obtained through H-P bond activation via hydrophosphination of different ketone, ester, and carboxamide-based Michael acceptors.
Article
Chemistry, Organic
Xiaoqing Lv, Shengjun Liu, Yu Guo, Lijiu Gao, Liming Zhao, Jinpeng Zhang, Liangce Rong
Summary: A metal-free Meerwein arylation reaction was developed for the synthesis of 2-(aryl/alkyl arylmethylene)malononitrile derivatives from aryl(alkyl)idenemalononitriles and diazonium salts under mild conditions. Unlike traditional addition reactions, this study used a coupling reaction to form C(sp(2))-C(sp(2)) bond arylation products. The radical reaction mechanism was confirmed through control experiments. The method has broad substrate scope and good group tolerance, and the obtained products can be easily converted into valuable asymmetric ketones and undergo hydrogenation reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Kanak Kanti Das, Samir Manna, Santanu Panda
Summary: Asymmetric multicomponent reactions allow the stitching of multiple functional groups in an enantioselective and atom economical manner. The use of boron-based reagents in such reactions offers advantages such as non-toxicity, high stability, and easy conversion to other functional groups in a stereoselective manner. In the past decade, several transition metal catalyzed asymmetric multicomponent strategies using boron-based reagents have been developed.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Fangyuan Yu, Sen Yang, Zihao Xie, Dengfu Lu, Yuefa Gong
Summary: This article reports an iron-catalysed selective C-((sp3))-H alkylation method for glycine derivatives, which converts N-aryl glycinates into a series of pyrroline-containing amino esters using gamma,delta-unsaturated oxime esters as both the alkylation reagent and terminal oxidant. The ligand plays a key role in tuning the chemoselectivity, and a radical-polar crossover pathway is proposed according to the mechanistic studies. Additionally, the products obtained with this method can be transformed into various valuable building blocks.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Toshimichi Kobayashi, Soshi Nishino, Masahiro Miura, Koji Hirano
Summary: A copper-catalyzed silylamination reaction has been developed for the synthesis of β-silyl-α-amino acid derivatives, which are of great interest in medicinal and pharmaceutical chemistry. The use of a suitable chiral ligand enables asymmetric induction, leading to the formation of optically active compounds with high enantiomeric ratios.
Article
Chemistry, Multidisciplinary
Soshi Nishino, Yuji Nishii, Koji Hirano
Summary: A copper-catalyzed reaction has been developed for the regio- and diastereoselective borylamination of alpha,beta-unsaturated esters with B(2)pin(2) and hydroxylamines. The reaction delivers acyclic beta-boryl-alpha-amino acid derivatives with high anti-diastereoselectivity, which is difficult to achieve using established methods. Furthermore, the use of a chiral phosphoramidite ligand allows for the enantioselective synthesis of optically active beta-borylated alpha-amino acids. The resulting products can be further transformed into beta-functionalized alpha-amino acids, which are of great interest in medicinal chemistry.
Article
Chemistry, Organic
Xue Zhang, Dong-xue Qiu, Wen-ting Qiu, He-ran Wang, Zu-wei Zhao, Hai-feng Yu, Guang-bo Che
Summary: An efficient Ag2CO3 catalyzed aza-Michael addition of pyrazoles to α,β-unsaturated carbonyl compounds has been developed. Using 5 mol% of Ag2CO3 as catalyst, the reaction proceeds smoothly in DCE at 120 degrees C, giving a series of N-alkylated pyrazoles in good to excellent yields. Notably, N1-alkylated pyrazoles can be obtained with high regioselectivity (N1/N2 up to above 25:1) when asymmetrically substituted pyrazoles react with α,β-unsaturated carbonyl compounds. The method is also applicable on a gram scale.
Article
Chemistry, Organic
Hong Hu, Wen-Hua Xu, Wu-Xiang Kang, Wei Sun, Rui Sun, Xiao-Hong Wei, Meng Sun
Summary: An unprecedented Co(iii)-catalyzed stereoselective C-H homoallylation reaction has been developed for the synthesis of (E)-homoallylic alcohols from indole derivatives and 4-vinyl-1,3-dioxan-2-ones. This protocol offers mild reaction conditions, high efficiency, good yields, excellent stereoselectivity, and broad tolerance towards functional groups. It provides a powerful approach for the late-stage C-H homoallylation of bioactive and pharmaceutically relevant indole-based substrates.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Rahma A. Hassan, Ammar H. Al-Sabawi
Summary: A series of new alpha,beta-unsaturated carbonyl compounds, thiophene, imine, and coumarin derivatives were synthesized from the reaction of hydrazide-hydrazone derivative with various reagents using different conditions. The hydrazide-hydrazone derivative was prepared by reacting piperonal with 2-cyanoacetohydrazide. The structures of the newly synthesized chemical derivatives were determined based on their spectral information.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)