The developmental genetics of biological robustness

Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness

(2015) C. R. Bauer et al.   Molecular Systems Biology

Selection on noise constrains variation in a eukaryotic promoter

(2015) Brian P. H. Metzger et al.   NATURE

Over-expression of Arabidopsis AtCHR23 chromatin remodeling ATPase results in increased variability of growth and gene expression

(2014) Adam Folta et al.   BMC PLANT BIOLOGY

MicroRNAs and their roles in developmental canalization

(2014) Diana M Posadas et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Preservation of genetic and regulatory robustness in ancient gene duplicates ofSaccharomyces cerevisiae

(2014) Orla M. Keane et al.   GENOME RESEARCH

Cryptic genetic variation: evolution's hidden substrate

(2014) Annalise B. Paaby et al.   NATURE REVIEWS GENETICS

Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast

(2013) Gaël Yvert et al.   BMC Systems Biology

The details in the distributions: why and how to study phenotypic variability

(2013) KA Geiler-Samerotte et al.   CURRENT OPINION IN BIOTECHNOLOGY

Plant phenomics and high-throughput phenotyping: accelerating rice functional genomics using multidisciplinary technologies

(2013) Wanneng Yang et al.   CURRENT OPINION IN PLANT BIOLOGY

Lack of tailless leads to an increase in expression variability in Drosophila embryos

(2013) Hilde Janssens et al.   DEVELOPMENTAL BIOLOGY

Robustness and Epistasis in the C. elegans Vulval Signaling Network Revealed by Pathway Dosage Modulation

(2013) Michalis Barkoulas et al.   DEVELOPMENTAL CELL

Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability

(2013) S. Fehrmann et al.   Molecular Systems Biology

Phenoscope: an automated large-scale phenotyping platform offering high spatial homogeneity

(2013) Sébastien Tisné et al.   PLANT JOURNAL

Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish

(2013) N. Rohner et al.   SCIENCE

Stochastic gene expression in mammals: lessons from olfaction

(2013) Angeliki Magklara et al.   TRENDS IN CELL BIOLOGY

Spatiotemporal variation of leaf epidermal cell growth: a quantitative analysis of Arabidopsis thaliana wild-type and triple cyclinD3 mutant plants

(2012) Joanna Elsner et al.   ANNALS OF BOTANY

Mechanical Stress Acts via Katanin to Amplify Differences in Growth Rate between Adjacent Cells in Arabidopsis

(2012) Magalie Uyttewaal et al.   CELL

JAGGED Controls Growth Anisotropy and Coordination between Cell Size and Cell Cycle during Plant Organogenesis

(2012) Katharina Schiessl et al.   CURRENT BIOLOGY

Molecular mechanisms of robustness in plants

(2012) Janne Lempe et al.   CURRENT OPINION IN PLANT BIOLOGY

DEFICIENCY SCREENING FOR GENOMIC REGIONS WITH EFFECTS ON ENVIRONMENTAL SENSITIVITY OF THE SENSORY BRISTLES OF DROSOPHILA MELANOGASTER

(2012) Kazuo H. Takahashi et al.   EVOLUTION

Multiple capacitors for natural genetic variation inDrosophila melanogaster

(2012) Kazuo H. Takahashi   MOLECULAR ECOLOGY

Negative feedback confers mutational robustness in yeast transcription factor regulation

(2012) C. M. Denby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elastic Domains Regulate Growth and Organogenesis in the Plant Shoot Apical Meristem

(2012) D. Kierzkowski et al.   SCIENCE

Robustness and flexibility in nematode vulva development

(2012) Marie-Anne Félix et al.   TRENDS IN GENETICS

Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant

(2012) Sasha F. Levy et al.   PLOS BIOLOGY

Inheritance Beyond Plain Heritability: Variance-Controlling Genes in Arabidopsis thaliana

(2012) Xia Shen et al.   PLoS Genetics

Cellular Decision Making and Biological Noise: From Microbes to Mammals

(2011) Gábor Balázsi et al.   CELL

Quantitative Variation in Autocrine Signaling and Pathway Crosstalk in the Caenorhabditis Vulval Network

(2011) Erika Hoyos et al.   CURRENT BIOLOGY

A Polycomb-based switch underlying quantitative epigenetic memory

(2011) Andrew Angel et al.   NATURE

Predicting mutation outcome from early stochastic variation in genetic interaction partners

(2011) Alejandro Burga et al.   NATURE

LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 Form a Positive Feedback Regulatory Loop in theArabidopsisCircadian Clock

(2011) Ying Wang et al.   PLANT CELL

A Gene's Ability to Buffer Variation Is Predicted by Its Fitness Contribution and Genetic Interactions

(2011) Guang-Zhong Wang et al.   PLoS One

Exploring transcription regulation through cell-to-cell variability

(2011) R. Rinott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model for the regulation of Arabidopsis thaliana leaf margin development

(2011) G. D. Bilsborough et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA networks and developmental plasticity in plants

(2011) Ignacio Rubio-Somoza et al.   TRENDS IN PLANT SCIENCE

Transcriptome Analysis of the Arabidopsis Megaspore Mother Cell Uncovers the Importance of RNA Helicases for Plant Germline Development

(2011) Anja Schmidt et al.   PLOS BIOLOGY

Genomic Analysis of QTLs and Genes Altering Natural Variation in Stochastic Noise

(2011) Jose M. Jimenez-Gomez et al.   PLoS Genetics

Stochastic Mechanisms of Cell Fate Specification that Yield Random or Robust Outcomes

(2010) Robert J. Johnston et al.   Annual Review of Cell and Developmental Biology

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Shadow Enhancers Foster Robustness of Drosophila Gastrulation

(2010) Michael W. Perry et al.   CURRENT BIOLOGY

Variability in gene expression underlies incomplete penetrance

(2010) Arjun Raj et al.   NATURE

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

(2010) Nicolás Frankel et al.   NATURE

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

A General Mechanism for Network-Dosage Compensation in Gene Circuits

(2010) M. Acar et al.   SCIENCE

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Bias and Evolution of the Mutationally Accessible Phenotypic Space in a Developmental System

(2010) Christian Braendle et al.   PLoS Genetics

Single-Molecule Approaches to Stochastic Gene Expression

(2009) Arjun Raj et al.   Annual Review of Biophysics

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Time for circadian rhythms: plants get synchronized

(2009) Paloma Más et al.   CURRENT OPINION IN PLANT BIOLOGY

Evolution under canalization and the dual roles of microRNAs--A hypothesis

(2009) C.-I Wu et al.   GENOME RESEARCH

Partial penetrance facilitates developmental evolution in bacteria

(2009) Avigdor Eldar et al.   NATURE

System-wide molecular evidence for phenotypic buffering in Arabidopsis

(2009) Jingyuan Fu et al.   NATURE GENETICS

Evolution of colour vision in mammals

(2009) G. H. Jacobs   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Robustness: mechanisms and consequences

(2009) Joanna Masel et al.   TRENDS IN GENETICS

The many functions of ERECTA

(2009) Martijn van Zanten et al.   TRENDS IN PLANT SCIENCE

Plasticity and Errors of a Robust Developmental System in Different Environments

(2008) Christian Braendle et al.   DEVELOPMENTAL CELL

Intraspecific evolution of the intercellular signaling network underlying a robust developmental system

(2008) J. Milloz et al.   GENES & DEVELOPMENT

Genetic variation and quantitative trait loci associated with developmental stability and the environmental correlation between traits in maize

(2008) BERNARDO ORDAS et al.   Genetics Research

HSP90-buffered genetic variation is common in Arabidopsis thaliana

(2008) T. A. Sangster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE

Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae

(2008) Sasha F Levy et al.   PLOS BIOLOGY

Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait

(2008) Juliet Ansel et al.   PLoS Genetics

Role of Duplicate Genes in Robustness against Deleterious Human Mutations

(2008) Tzu-Lin Hsiao et al.   PLoS Genetics