Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial

SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS

(2020) Christian Mueller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

(2020) Timothy Miller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long‐Term Outcome

(2019) Letizia Mazzini et al.   Stem Cells Translational Medicine

NurOwn, phase 2, randomized, clinical trial in patients with ALS

(2019) James D. Berry et al.   NEUROLOGY

Bedeutung der Virchow-Robin-Räume

(2018) W. Reith et al.   RADIOLOGE

Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis

(2018) Gretchen M. Thomsen et al.   STEM CELLS

Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS

(2018) Stephen A. Goutman et al.   Annals of Clinical and Translational Neurology

GDNF-Secreting Human Neural Progenitor Cells Increase Tyrosine Hydroxylase and VMAT2 Expression in MPTP-Treated Cynomolgus Monkeys

(2018) Marina E. Emborg et al.   CELL TRANSPLANTATION

Stem cell transplantation for amyotrophic lateral sclerosis

(2018) Robert H. Baloh et al.   CURRENT OPINION IN NEUROLOGY

Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs

(2018) Manoj Kumar Jaiswal   MEDICINAL RESEARCH REVIEWS

Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1G93A ALS rat but has adverse side effects

(2017) G M Thomsen et al.   GENE THERAPY

Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

(2017) Patricia L. Andres et al.   MUSCLE & NERVE

Patients with ALS show highly correlated progression rates in left and right limb muscles

(2017) David J. Rushton et al.   NEUROLOGY

Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats

(2016) Melanie M. Das et al.   EXPERIMENTAL NEUROLOGY

Transplantation of spinal cord–derived neural stem cells for ALS

(2016) Jonathan D. Glass et al.   NEUROLOGY

Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord

(2015) Juanmarco Gutierrez et al.   NEUROSURGERY

Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells

(2015) Zhong-Wei Du et al.   Nature Communications

A cGMP-applicable Expansion Method for Aggregates of Human Neural Stem and Progenitor Cells Derived From Pluripotent Stem Cells or Fetal Brain Tissue

(2014) Brandon C. Shelley et al.   Jove-Journal of Visualized Experiments

Nerve injury induces glial cell line-derived neurotrophic factor (gdnf) expression in schwann cells through purinergic signaling and the pkc-pkd pathway

(2013) Pin Xu et al.   GLIA

Clinical Neurogenetics

(2013) Matthew B. Harms et al.   NEUROLOGIC CLINICS

Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats

(2013) Geneviève Gowing et al.   NEUROREPORT

Intermittent Hypoxia and Stem Cell Implants Preserve Breathing Capacity in a Rodent Model of Amyotrophic Lateral Sclerosis

(2012) Nicole L. Nichols et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain

(2011) Robert H. Andres et al.   BRAIN

Validation of a new strength measurement device for amyotrophic lateral sclerosis clinical trials

(2011) Patricia L. Andres et al.   MUSCLE & NERVE

Human Glial-Restricted Progenitor Transplantation into Cervical Spinal Cord of the SOD1G93A Mouse Model of ALS

(2011) Angelo C. Lepore et al.   PLoS One

Spinal Cord Mechanisms of Chronic Pain and Clinical Implications

(2010) Hsinlin Thomas Cheng   Current Pain and Headache Reports

Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial

(2009) L. Mazzini et al.   EXPERIMENTAL NEUROLOGY

Lesion-Induced Increase in Survival and Migration of Human Neural Progenitor Cells Releasing GDNF

(2008) Soshana Behrstock et al.   CELL TRANSPLANTATION

Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

(2008) Angelo C Lepore et al.   NATURE NEUROSCIENCE