Article
Multidisciplinary Sciences
Aurore De Cauwer, Thomas Loustau, William Erne, Angelique Pichot, Anne Molitor, Tristan Stemmelen, Raphael Carapito, Gertraud Orend, Seiamak Bahram, Philippe Georgel
Summary: Age-related diseases are a major concern in developed countries, and suitable animal models are needed to better understand the aging process and evaluate the molecular impact on delaying the occurrence of these diseases. Current mouse models of aging do not fully mimic the diseases seen in elderly humans. The premature aging phenotypes in Dicer-deficient animals affect multiple organs and tissues, with the adipose tissue showing potential actionable pathways for reversal.
Article
Endocrinology & Metabolism
Maria da Luz Sousa Fialho, Ujang Purnama, Kaitlyn M. J. H. Dennis, Claudia N. Montes Aparicio, Marcos Castro-Guarda, Emmanuelle Massourides, Damian J. Tyler, Carolyn A. Carr, Lisa C. Heather
Summary: By stabilizing HIF1 alpha, molidustat promotes anaerobic glucose metabolism in the diabetic heart, providing a route to overcome the blunted hypoxic response induced by insulin resistance and improving metabolic function while enhancing cardioprotection.
Article
Pharmacology & Pharmacy
Md. Shahid Sarwar, David Cheng, Rebecca Mary Peter, Ahmad Shannar, Pochung Chou, Lujing Wang, Renyi Wu, Davit Sargsyan, Michael Goedken, Yujue Wang, Xiaoyang Su, Ronald P. Hart, Ah-Ng Kong
Summary: This study investigated the regulation of cellular metabolism, DNA methylation, and transcriptome status in the kidney of diabetic nephropathy mice under high glucose conditions. The results showed that high glucose regulated cellular metabolites, metabolic signaling pathways, gene expression, and DNA methylation, which may be involved in the progression of diabetic nephropathy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiong Shen, Yu-te Zhong, Xiang-xiang Liu, Jun-nan Hu, Si-min Qi, Ke Li, Zi Wang, Hong-yan Zhu, Xin-dian Li, Ying-ping Wang, Wei Li
Summary: In this study, the ameliorative effects of platycodin D (PD) on high-fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetes (T2D) mice were investigated. PD treatment improved body weight gain and maintained glucose homeostasis. PD also reduced liver tissue pathologies and abnormal liver function caused by T2D. Additionally, PD decreased hepatic glycogen decomposition and lipid levels, as well as hepatic fat accumulation. The results suggest that PD modulation of hepatic glycolipid metabolism abnormalities shows promise for T2D therapy in the future.
Article
Chemistry, Medicinal
Honglei Zhao, Hongyan Wu, Meitao Duan, Ruixuan Liu, Quanhong Zhu, Kai Zhang, Lili Wang
Summary: The study demonstrated the protective effects of cinnamaldehyde on type 1 diabetes mellitus in mice, potentially through modulating glycogen synthesis in the liver, gut microbiota, and serum metabolomics to lower blood glucose levels and reduce insulin resistance.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Dipak Sarnobat, R. Charlotte Moffett, Peter R. Flatt, Nigel Irwin, Andrei Tarasov
Summary: Diabetes is characterized by the loss of pancreatic islet beta-cells, resulting in a loss of important signals for islet alpha-cells. This study investigates the role of insulin and GABA signals in the development of alpha-cells and their potential for transdifferentiation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Plant Sciences
Dan Luo, Xiaokang Dong, Jie Huang, Chengcheng Huang, Guowei Fang, Yanqin Huang
Summary: The study found that Pueraria lobata root polysaccharide (PLP) has therapeutic effects on diabetic metabolic syndrome in db/db mice by activating the PI3K/AKT signaling pathway to improve insulin resistance, glucose, and lipid metabolism. PLP may be considered as a potential antidiabetic agent in clinical therapy.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andras Franko, Martin Irmler, Cornelia Prehn, Silke S. Heinzmann, Philippe Schmitt-Kopplin, Jerzy Adamski, Johannes Beckers, Juergen-Christoph von Kleist-Retzow, Rudolf Wiesner, Hans-Ulrich Haring, Martin Heni, Andreas L. Birkenfeld, Martin Hrabe de Angelis
Summary: The study found that bezafibrate improved glucose metabolism in diabetic mice by decreasing inflammatory pathways and increasing insulin signaling and lipid pathways. This resulted in ameliorated glucotoxicity and reduced insulin resistance in the mice.
Article
Biochemistry & Molecular Biology
Tatyana Strekalova, Ekaterina Veniaminova, Evgeniy Svirin, Ekaterina Kopeikina, Tatyana Veremeyko, Amanda W. Y. Yung, Andrey Proshin, Shawn Zheng Kai Tan, Sharafuddin Khairuddin, Lee Wei Lim, Klaus-Peter Lesch, Susanne Walitza, Daniel C. Anthony, Eugene D. Ponomarev
Summary: Deficiency in GM3-derived gangliosides due to lack of ST3GAL5 enzyme can lead to severe neuropathology, including epilepsy and metabolic abnormalities. Knock-out mice lacking ST3Gal5 exhibit ADHD-like behaviors, altered metabolic measures, and EEG abnormalities, providing a useful platform for understanding the contribution of brain gangliosides to ADHD and associated comorbidities.
Article
Cell Biology
Peter C. Reifsnyder, Kevin Flurkey, Rosalinda Doty, Nigel A. Calcutt, Robert A. Koza, David E. Harrison
Summary: Rapamycin treatment has both positive and negative effects on the progression of type 2 diabetes (T2D) in a mouse model, but combination treatment with metformin can mitigate the negative effects while maintaining the benefits.
Article
Medicine, Research & Experimental
Ravinder Naik Dharavath, Shiyana Arora, Kanthi Kiran Kondepudi, Mahendra Bishnoi, Kanwaljit Chopra
Summary: SGZ treatment significantly reversed metabolic and cognitive alterations induced by a high fat-low protein diet, improving peripheral glucose and lipid profiles, as well as enhancing cerebral glucose homeostasis, BBB integrity, and reducing oxidative stress and neuroinflammation.
Article
Cell Biology
Istvan Tamas, Evelin Major, Daniel Horvath, Ilka Keller, Adam Ungvari, Timothy A. Haystead, Justin A. MacDonald, Beata Lontay
Summary: This study provides evidence for the insulin-sensitizing role of SMTNL1 in skeletal muscle. SMTNL1 regulates the phosphorylation of IRS1 and the insulin-signaling cascade, contributing to improved insulin sensitivity and glucose disposal.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guihua Wang, Jialin Xu, Hang Ma, Yu Mu, Wen Xu, Na Yan, Wei Liu, Dan Zheng, Xueshi Huang, Liya Li
Summary: In this study, the anti-diabetic effects of jambone E (JE), a phenolipid from Syzygium cumini, were investigated. The results showed that JE improved insulin resistance, reduced blood glucose and lipid levels, and activated the insulin signaling pathway through the activation of AKT.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biology
Laura Pajed, Ulrike Taschler, Anna Tilp, Peter Hofer, Petra Kotzbeck, Stephanie Kolleritsch, Franz P. W. Radner, Isabella Pototschnig, Carina Wagner, Margarita Schratter, Sandra Eder, Sabrina Huetter, Renate Schreiber, Guenter Haemmerle, Thomas O. Eichmann, Martina Schweiger, Gerald Hoefler, Erin E. Kershaw, Achim Lass, Gabriele Schoiswohl
Summary: The study examines the role of adipocyte hormone-sensitive lipase (HSL) in regulating whole body energy homeostasis, showing that adipocyte-specific HSL knockout (AHKO) mice fed a high-fat diet develop fatty liver but may reverse with age. The reversal is possibly linked to diminished lipolytic activity in adipose tissue and pronounced lipodystrophy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kongphop Parunyakul, Krittika Srisuksai, Sawanya Charoenlappanit, Narumon Phaonakrop, Sittiruk Roytrakul, Wirasak Fungfuang
Summary: Cordycepin may help prevent hepatic metabolism in T1DM by regulating the expression of energy-related proteins and UPS to maintain cell survival, as observed in the study on streptozotocin-induced T1DM mice. The improvement in liver function with cordycepin treatment was related to changes in metabolic pathways and protein expression. Further research is needed to explore the therapeutic potential of cordycepin in metabolic mechanisms.