Saroglitazar, a novel dual PPAR-α/γ agonist, reverses high fat-low protein diet-induced metabolic and cognitive aberrations in C57BL/6J male mice

Differential effects of alprazolam against methylphenidate-induced neurobehavioral alterations

(2020) Meenu Dutt et al.   PHYSIOLOGY & BEHAVIOR

High fat-low protein diet induces metabolic alterations and cognitive dysfunction in female rats

(2019) Ravinder Naik Dharavath et al.   METABOLIC BRAIN DISEASE

High fat diet feeding induced insulin resistance exacerbates 6-OHDA mediated neurotoxicity and behavioral abnormalities in rats

(2018) Sorabh Sharma et al.   BEHAVIOURAL BRAIN RESEARCH

Time-response studies on development of cognitive deficits in an experimental model of insulin resistance

(2018) Anand Kamal Sachdeva et al.   CLINICAL NUTRITION

Sustained high-fat diet modulates inflammation, insulin signalling and cognition in mice and a modified xenin peptide ameliorates neuropathology in a chronic high-fat model

(2018) Paul Denver et al.   DIABETES OBESITY & METABOLISM

Saroglitazar treatment prevents NASH, eliminates hepatocyte ballooning, and significantly improves serum LFTs, lipids and insulin resistance in DIAMOND(tm) mice compared to pioglitazone benchmark

(2018) R. Caffrey et al.   JOURNAL OF HEPATOLOGY

Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression

(2018) Yashika Bansal et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Characterization of Peripheral Activity States and Cortical Local Field Potentials of Mice in an Elevated Plus Maze Test

(2018) Toya Okonogi et al.   Frontiers in Behavioral Neuroscience

Vitamin D administration, cognitive function, BBB permeability and neuroinflammatory factors in high-fat diet-induced obese rats

(2017) G Hajiluian et al.   INTERNATIONAL JOURNAL OF OBESITY

Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models

(2017) Mukul R. Jain et al.   LIVER INTERNATIONAL

Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation

(2017) Sisi Yang et al.   Molecular Medicine Reports

Blocking FSH induces thermogenic adipose tissue and reduces body fat

(2017) Peng Liu et al.   NATURE

Preclinical evaluation of saroglitazar magnesium, a dual PPAR-α/γ agonist for treatment of dyslipidemia and metabolic disorders

(2017) Harilal Patel et al.   XENOBIOTICA

Neuroprotective potential of sesamol and its loaded solid lipid nanoparticles in ICV-STZ-induced cognitive deficits: Behavioral and biochemical evidence

(2015) Anand Kamal Sachdeva et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lycopene abrogates Aβ(1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s disease

(2015) Anand Kamal Sachdeva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cerebral Cortical Microvascular Rarefaction in Metabolic Syndrome is Dependent on Insulin Resistance and Loss of Nitric Oxide Bioavailability

(2015) Paul D. Chantler et al.   MICROCIRCULATION

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Effects of high-fat diet exposure on learning & memory

(2015) Zachary A. Cordner et al.   PHYSIOLOGY & BEHAVIOR

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

(2015) Auriel A. Willette et al.   JAMA Neurology

Insulin, Aging, and the Brain: Mechanisms and Implications

(2015) Abimbola A. Akintola et al.   Frontiers in Endocrinology

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

A novel animal model of metabolic syndrome with non-alcoholic fatty liver disease and skin inflammation

(2014) Nagaraj M. Kulkarni et al.   PHARMACEUTICAL BIOLOGY

The longer-term impacts of Western diet on human cognition and the brain

(2013) Heather Francis et al.   APPETITE

Pharmacokinetics, Safety, and Tolerability of Saroglitazar (ZYH1), a Predominantly PPARα Agonist with Moderate PPARγ Agonist Activity in Healthy Human Subjects

(2013) Rajendra H. Jani et al.   CLINICAL DRUG INVESTIGATION

Insulin, cognition, and dementia

(2013) Brenna Cholerton et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hippocampal damage impairs recognition memory broadly, affecting both parameters in two prominent models of memory

(2013) A. J. O. Dede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγ Agonist Pioglitazone Reverses Memory Impairment and Biochemical Changes in a Mouse Model of Type 2 Diabetes Mellitus

(2012) Li-Ying Jiang et al.   CNS Neuroscience & Therapeutics

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats

(2012) Terry L. Davidson et al.   PHYSIOLOGY & BEHAVIOR

A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects

(2011) Cameron J Holloway et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High-carbohydrate, High-fat Diet–induced Metabolic Syndrome and Cardiovascular Remodeling in Rats

(2010) Sunil K. Panchal et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Sesamol Suppresses Neuro-Inflammatory Cascade in Experimental Model of Diabetic Neuropathy

(2010) Kanwaljit Chopra et al.   JOURNAL OF PAIN

Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity

(2010) Scott E. Kanoski et al.   PHYSIOLOGY & BEHAVIOR

Cognitive impairment following high fat diet consumption is associated with brain inflammation

(2009) Paul J. Pistell et al.   JOURNAL OF NEUROIMMUNOLOGY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Bezafibrate, a Peroxisome Proliferator-Activated Receptors Agonist, Decreases Body Temperature and Enhances Electroencephalogram Delta-Oscillation during Sleep in Mice

(2008) Sachiko Chikahisa et al.   ENDOCRINOLOGY

Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats

(2008) Asif R. Pathan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

The hippocampus and memory: insights from spatial processing

(2008) Chris M. Bird et al.   NATURE REVIEWS NEUROSCIENCE