Article
Cell Biology
Guanlin Wu, Weidong Weng, Pengfei Xia, Shixian Yan, Cheng Zhong, Lei Xie, Yu Xie, Gang Fan
Summary: This review aims to summarize previous studies related to bladder cancer and the Wnt signaling pathway, with a focus on exploring the participating substances and their mechanisms in the regulation of the Wnt signaling pathway to better determine how to promote new chemotherapeutic drugs, potential therapeutic targets, and diagnostic biomarkers.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Ziva Ledinek, Monika Sobocan, Damjan Sisinger, Marko Hojnik, Tomaz Budefeld, Uros Potocnik, Jure Knez
Summary: Endometrial cancer, the most common gynecologic malignancy in the developed world, is undergoing changes in risk stratification and treatment approaches due to better understanding of tumor biology. Upregulated Wnt signaling, which contributes to cancer initiation and progression, shows potential for developing specific inhibitor therapy. This study analyzed the expression of Wnt signaling and epithelial-to-mesenchymal transition (EMT) markers in endometrial cancer, finding significant correlations with hormone receptor status but not with other clinico-pathological characteristics. Additionally, the study observed significant differences in expression of the Wnt antagonist, Dkk1, among patient risk assessment categories using integrated molecular risk assessment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Iram Fatima, Susmita Barman, Rajani Rai, Kristina W. Thiel, Vishal Chandra
Summary: The role of Wnt signaling in endometrial carcinoma, including its activation mechanisms and links to cell cycle regulation, hormonal pathways, and other signaling cascades, remains a significant research focus. Therapeutic interference with Wnt signaling poses a challenge, and further advancements in drug discovery are needed.
Review
Oncology
Mayumi Kobayashi Kato, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato
Summary: This study investigated the clinical characteristics, diagnosis, treatment, and prognosis of brain metastases from uterine cervical carcinoma and uterine endometrial carcinoma. The findings highlight factors influencing treatment selection and prognosis, with specific high-risk factors and poor prognostic indicators identified for each type of carcinoma. Despite limited evidence, further research is needed to better understand brain metastases from uterine cancer.
Article
Cell Biology
Hyun-Yi Kim, Shujin Li, Dong-Joon Lee, Jin Hoo Park, Takashi Muramatsu, Hidemitsu Harada, Young-Soo Jung, Han-Sung Jung
Summary: A potential cancer stem cell population was identified in ameloblastoma cells, and the activation of Wnt signaling pathway was found to be a promising therapeutic approach to decrease this population.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
Summary: The study revealed that BCL9L and Wnt/beta-catenin signaling play an oncogenic role in bladder cancer cells, and may be associated with the progression of bladder cancer. Mutations in UTRs of BCL9L can affect its activity, thereby influencing cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Molly L. Parrish, Russell R. Broaddus, Andrew B. Gladden
Summary: Endometrial carcinoma is the most diagnosed gynecological malignancy in Western countries, with rising incidence and mortality rates. Mutations in exon 3 of the CTNNB1 gene may lead to decreased progression-free survival in a subset of patients with endometrioid EC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Yaoyao Zhu, Xia Li
Summary: Colorectal cancer is a common and deadly cancer worldwide, with a close association to genetic mutations, chronic inflammatory disorders, and poor dietary habits. The Wnt signaling pathway plays a crucial role in various physiological processes of colorectal cancer. This review summarizes the recent advances in understanding the mechanisms and potential regulators of the three branches of the Wnt signaling pathway in colorectal cancer.
Article
Obstetrics & Gynecology
Pablo Padilla-Iserte, Victor Lago, Carmen Tauste, Berta Diaz-Feijoo, Antonio Gil-Moreno, Reyes Oliver, Pluvio Coronado, Maria Belen Martin-Salamanca, Manuel Pantoja-Garrido, Josefina Marcos-Sanmartin, Juan Gilabert-Estelles, Cristina Lorenzo, Eduardo Cazorla, Fernando Roldan-Rivas, Jose Ramon Rodriguez-Hernandez, Lourdes Sanchez, Juan Carlos Muruzabal, David Hervas, Santiago Domingo
Summary: This study indicates that the use of a uterine manipulator in patients with early-stage endometrial cancer may lead to worse oncological outcomes, including a higher risk of recurrence and lower disease-free survival. Prospective trials are needed to confirm these results.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Milosz Pietrus, Kazimierz Pitynski, Marcin Waligora, Katarzyna Milian-Ciesielska, Artur Ludwin, Maciej W. W. Socha, Klaudia Skrzypek
Summary: Endometrial cancer, a common cancer in females, requires more efficient methods to determine malignancy and optimize treatment. The study aimed to evaluate the impact of subcellular WNT-1 and mTOR levels on the clinical course of endometrial cancer. The levels of WNT-1 and mTOR in different cellular compartments were assessed in 64 patients with endometrial cancer of varying grades and stages. The results showed associations between WNT-1 and mTOR expression levels and tumor grade and staging, with membranous WNT-1 being negatively associated and cytoplasmic WNT-1 and nuclear mTOR being positively associated with higher grades of endometrial cancer, especially nuclear mTOR with FIGO stages IB-IV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marisa R. Moroney, Elizabeth Woodruff, Lubna Qamar, Andrew P. Bradford, Rebecca Wolsky, Benjamin G. Bitler, Bradley R. Corr
Summary: The study investigated the impact of Wnt/beta-catenin inhibition on endometrial cancer recurrence, with PRI724 and SM04690 showing significant inhibitory effects on CTNNB1-mutant cell lines. Targeting the Wnt/beta-catenin pathway effectively inhibited proliferation and beta-catenin/TCF transcriptional activity in CTNNB1-mutant EC, suggesting a potential therapeutic vulnerability for treatment of CTNNB1-mutant EC.
MOLECULAR CARCINOGENESIS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fumitaka Ejima, Yoshihiko Fukukura, Kiyohisa Kamimura, Masatoyo Nakajo, Takuro Ayukawa, Fumiko Kanzaki, Shintaro Yanazume, Hiroaki Kobayashi, Ikumi Kitazono, Hiroshi Imai, Thorsten Feiweier, Takashi Yoshiura
Summary: The study found that the ADC ratio obtained via oscillating gradient and pulsed gradient DWIs may serve as useful imaging biomarkers for risk stratification in patients with endometrial cancer. Compared to conventional DWI methods, the ADC ratio showed stronger correlations with histological grade, FIGO stage, and prognostic risk classification. The results suggest that ADC ratio could potentially improve risk assessment in patients with endometrial cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Oncology
Yun Li, Chenying Liu, Xin Zhang, Xiaodi Huang, Shujun Liang, Feiyue Xing, Han Tian
Summary: CCT5 is upregulated in gastric cancer with lymph node metastasis and is associated with poor prognosis. CCT5 promotes cell proliferation, invasion, and lymphatic tube formation in gastric cancer. It also enhances tumor growth and lymph node metastasis in vivo. By disrupting the interaction between E-cadherin and beta-catenin, CCT5 enhances Wnt/beta-catenin signaling activity and epithelial-mesenchymal transition. These findings suggest that CCT5 may serve as a potential biomarker for the diagnosis and treatment of gastric cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Fabio Da Silva, Kaiqing Zhang, Anneline Pinson, Edoardo Fatti, Michaela Wilsch-Braeuninger, Jessica Herbst, Valerie Vidal, Andreas Schedl, Wieland B. Huttner, Christof Niehrs
Summary: This study reveals the critical role of WNT/STOP signaling in mouse neocortex development, promoting neurogenesis by stabilizing neurogenic transcription factors Sox4 and Sox11 in basal progenitors during mitosis. The findings suggest that mitosis is a key phase for neural progenitor fate.
Article
Obstetrics & Gynecology
Anais Alonso, Nicole Laurencia Yuwono, Sahar Houshdaran, Jason Abbott, Rachael Rodgers, Caroline Elizabeth Ford, Kristina Warton
Summary: This study aimed to investigate whether women with laparoscopically confirmed endometriosis have higher plasma concentrations of circulating cell-free DNA (cirDNA) than those without endometriosis. The results showed no significant differences in any of the cirDNA parameters between the two groups.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Medical Laboratory Technology
Nicole Laurencia Yuwono, Mollie Ailie Acheson Boyd, Claire Elizabeth Henry, Bonnita Werner, Caroline Elizabeth Ford, Kristina Warton
Summary: The objective of this study was to determine the effect of long-term storage on the yield and fragmentation of cirDNA in plasma. The results showed that storage for up to two years caused a decline in cirDNA yield, with short fragments being lost more rapidly than long fragments. CirDNA yield was influenced by plasma input and elution volumes, but not by hemolysis.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Oncology
Bonnita Werner, Kristina Warton, Caroline E. Ford
Summary: Cell-free DNA (cfDNA) is a valuable molecular biomarker in oncology research and treatment, and while its properties in blood have been extensively studied, there is still much to be discovered about cfDNA in other body fluids. Saliva, sputum, cerebrospinal fluid, urine, faeces, pleural effusions, and ascites have unique advantages over blood in terms of cfDNA, making them potential alternatives for liquid biopsies. This review provides an overview of the current knowledge and identifies areas where further research is needed to accelerate the clinical implementation of non-blood liquid biopsies.
Article
Pharmacology & Pharmacy
Dongli Liu, Gunnar F. Kaufmann, James B. Breitmeyer, Kristie-Ann Dickson, Deborah J. Marsh, Caroline E. Ford
Summary: This study investigated the potential of Zilovertamab, a ROR1-targeting therapy, in treating high-grade serous ovarian cancer and endometrial cancer. The results showed that Zilovertamab alone could inhibit tumor cell proliferation, but its combination with commonly used chemotherapy drugs did not enhance the anti-proliferative activity.
Letter
Medical Laboratory Technology
Teagan Fisher, Caroline E. Ford, Kristina Warton
CLINICAL CHEMISTRY
(2022)
Correction
Multidisciplinary Sciences
Dongli Liu, Kate Gunther, Luis A. Enriquez, Benjamin Daniels, Tracy A. O'Mara, Katrina Tang, Amanda B. Spurdle, Caroline E. Ford
SCIENTIFIC REPORTS
(2022)
Correction
Oncology
C. E. Henry, E. Llamosas, A. Djordjevic, N. F. Hacker, C. E. Ford
Article
Oncology
Ashley Weir, Eun-Young Kang, Nicola S. Meagher, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S. Anglesio, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H. Brand, James D. Brenton, Angela Brooks-Wilson, Michael E. Carney, Julie M. Cunningham, Kara L. Cushing-Haugen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Luis Paz-Ares, Javier Gayarre, Blake C. Gilks, Marcel Grube, Paul R. Harnett, Holly R. Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y. Hernandez, Sabine Heublein, Yajue Huang, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J. Kennedy, Felix K. F. Kommoss, Jennifer M. Koziak, Bernhard Kraemer, Nhu D. Le, Jaime Lesnock, Jenny Lester, Jan Lubinski, Janusz Menkiszak, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Robles-Diaz, Matthias Ruebner, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Helen Steed, Aline Talhouk, Sarah E. Taylor, Nadia Traficante, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Javier Benitez, Andrew Berchuck, David D. Bowtell, Francisco J. Candido dos Reis, Linda S. Cook, Anna DeFazio, Jennifer A. Doherty, Peter A. Fasching, Maria J. Garcia, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, David G. Huntsman, Beth Y. Karlan, Stefan Kommoss, Francesmary Modugno, Joellen M. Schildkraut, Hans-Peter Sinn, Annette Staebler, Linda E. Kelemen, Caroline E. Ford, Usha Menon, Paul D. P. Pharoah, Martin Koebel, Susan J. Ramus, D. Bowtell, A. DeFazio, N. Traficante, S. Fereday, A. Brand, P. Harnett, R. Sharma
Summary: Recently, a study found a positive correlation between protein expression of FOXJ1 and the 5-year survival rate of patients with tubo-ovarian high-grade serous carcinoma (HGSC). However, protein expression of GMNN was not significantly associated with patient survival. This study provides preliminary evidence for the prognostic value of FOXJ1 in HGSC and validates the prior mRNA-based prognostic association through immunohistochemistry.
BRITISH JOURNAL OF CANCER
(2023)
Article
Obstetrics & Gynecology
N. L. Yuwono, A. Alonso, J. Abbott, S. Houshdaran, C. E. Henry, R. Rodgers, C. E. Ford, K. Warton
Summary: The study found that circulating cell-free DNA from the endometrium does not increase during menstruation and is not elevated in endometriosis. The research did not identify cirDNA as a potential diagnostic biomarker for endometriosis.
HUMAN REPRODUCTION
(2022)
Review
Oncology
Tao Xie, Kristie-Ann Dickson, Christine Yee, Yue Ma, Caroline E. Ford, Nikola A. Bowden, Deborah J. Marsh
Summary: Synthetic lethality approaches involving the combination of events have shown significant advances in the treatment of women with ovarian cancer who have defects in the HRR pathway. PARP inhibitors have been approved for the clinical management of ovarian cancer, but challenges remain in overcoming acquired resistance, extending benefits to more patients, combining with other drugs, and developing new therapies.
Article
Biochemistry & Molecular Biology
Miya John, Caroline E. Ford
Summary: This study systematically examined the expression of transcript variants of ROR1/2 genes and found their expression in non-diseased tissues. The results suggest that the expression of ROR1/2 in healthy human tissues should be carefully considered for safety assessment of targeted therapy.
Article
Biochemical Research Methods
Bonnita Werner, Kristina Warton, Caroline E. Ford
Summary: Endogenous cfDNA in fetal bovine serum (FBS) may influence in vitro cfDNA measurements. Future studies should consider the presence of bovine cfDNA in FBS-supplemented media.
Article
Multidisciplinary Sciences
Marilisa Cortesi, Dongli Liu, Christine Yee, Deborah J. Marsh, Caroline E. Ford
Summary: Computational models are increasingly important in biomedical research, but their accuracy and effectiveness rely on suitable parameter identification and validation. This study calibrated an in-silico model of ovarian cancer using datasets from different experimental models, and compared the parameters and simulated behaviors. It provides a framework for studying the effect of experimental models on computational systems and offers guidelines for comparative testing and selection of experimental models and protocols for parameter optimization.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Oncology
Xing Xu, Yao Wang, Nicole Bryce, Katrina Tang, Nicola S. Meagher, Eun Young Kang, Linda E. Kelemen, Martin Kobel, Susan J. Ramus, Michael Friedlander, Caroline E. Ford, Edna C. Hardeman, Peter W. Gunning
Meeting Abstract
Oncology
Dongli Liu, Gunnar F. Kaufmann, James B. Breitmeyer, Kristie-Ann Dickson, Deborah J. Marsh, Caroline E. Ford
