Journal
CELLULAR SIGNALLING
Volume 79, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2020.109886
Keywords
Wnt signalling pathway; Bladder cancer; Urothelial carcinoma
Categories
Funding
- Key Research Project of National Cancer Center [NCC201818A55]
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This review aims to summarize previous studies related to bladder cancer and the Wnt signaling pathway, with a focus on exploring the participating substances and their mechanisms in the regulation of the Wnt signaling pathway to better determine how to promote new chemotherapeutic drugs, potential therapeutic targets, and diagnostic biomarkers.
Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targeted anticancer drugs and new diagnostic markers can be discovered. It is known that the Wingless (Wnt) signalling pathway and its related genes, proteins and other substances are involved in multiple biological processes of various tumours. Clarifying the contribution of the Wnt signalling pathway in bladder tumours will help establish early diagnosis indicators, develop new therapeutic drugs and evaluate the prognosis for BC. This review aims to summarise previous studies related to BC and the Wnt signalling pathway, with a focus on exploring the participating substances and their mechanisms in the regulation of the Wnt signalling pathway to better determine how to promote new chemotherapeutic drugs, potential therapeutic targets and diagnostic biomarkers.
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