Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonio Bianchi, Antonella Giampietro, Alfredo Pontecorvi, Gerald Raverot, Laura De Marinis
Summary: This review provides an overview of the second-line therapies for acromegaly, summarizing the evidence on clinical, molecular, and morphological aspects that can predict the response to these treatments and advocating for a patient-tailored therapeutic approach in clinical practice.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Bai, Yu Shen, Rushi Chen, Xianchang Zhang, Mathias Nittka, Gregor Koerzdoerfer, Qiyong Gong, Meiyun Wang
Summary: Magnetic resonance fingerprinting (MRF) can effectively differentiate gonadotroph from non-gonadotroph pituitary macroadenomas, guiding treatment decisions.
EUROPEAN RADIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sofie Eline Tollefsen, Ole Solheim, Patricia Mjones, Sverre Helge Torp
Summary: Meningioma is a common brain tumor without approved specific drugs. This study aims to compile the current insights of somatostatin analogs for treating patients with meningioma. A systematic search was conducted, and 17 eligible studies were evaluated. Although the efficacy of somatostatin analogs remains unclear, some studies suggest that they may be a last-option treatment for severely ill-patients. However, a controlled study or randomized clinical trial is needed to establish their efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sebastian Gulde, Tobias Wiedemann, Mathias Schillmaier, Isabel Valenca, Amelie Lupp, Katja Steiger, Hsi-Yu Yen, Stephen Baeuerle, Johannes Notni, Raul Luque, Herbert Schmid, Stefan Schulz, Donna P. Ankerst, Franz Schilling, Natalia S. Pellegata
Summary: There is currently a lack of effective medical therapy for residual/recurrent nonfunctioning pituitary tumors (NFPTs). Pasireotide may be an effective treatment, especially for female NFPTs patients. Female NFPTs patients have higher levels of Sstr3 expression, which may also be present in human NFPTs patients.
Article
Endocrinology & Metabolism
Antonella Giampietro, Sara Menotti, Sabrina Chiloiro, Alfredo Pontecorvi, Laura De Marinis, Antonio Bianchi
Summary: This study reports three cases of resistant acromegaly treated with a de-escalation approach using pasireotide LAR. The results showed that de-escalation treatment with pasireotide LAR may allow a greater proportion of patients to achieve control of acromegaly, especially in clinically aggressive cases. Although there may be a risk of hyperglycemia, it can be controlled with oral antidiabetic medications.
Article
Oncology
Laura Streit, Sophie Moog, Sylvain Hugel, Marion Rame, Emeline Tanguy, Virginie Andry, Herbert A. Schmid, Laurent Brunaud, Florence Bihain, Claire Nomine-Criqui, Yannick Goumon, Stephanie Lacomme, Sandra Lomazzi, Michel Vix, Didier Mutter, Nicolas Vitale, Stephane Ory, Stephane Gasman
Summary: NETs like pheochromocytoma can cause severe symptoms and life-threatening conditions. Treatment with somatostatin analogues may help inhibit the secretion of catecholamines. The study found that SOM230 could effectively inhibit catecholamine secretion and be considered a potential anti-secretory treatment for patients with pheochromocytoma.
Article
Endocrinology & Metabolism
Richard A. Feelders, Maria Fleseriu, Pinar Kadioglu, Marie Bex, Deyanira Gonzalez-Devia, Cesar Luiz Boguszewski, Dilek Gogas Yavuz, Heather Patino, Alberto M. Pedroncelli, Ricardo Maamari, Arghya Chattopadhyay, Beverly M. K. Biller, Rosario Pivonello
Summary: The study evaluated the efficacy and safety of pasireotide alone or combined with cabergoline in patients with Cushing's disease. The addition of cabergoline in patients with persistently elevated cortisol levels on maximum tolerated doses of pasireotide was shown to be effective and well-tolerated in enhancing control of hypercortisolism in some CD patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Tomoko Mizuno, Naoko Inoshita, Noriaki Fukuhara, Keita Tatsushima, Akira Takeshita, Shozo Yamada, Hiroshi Nishioka, Yasuhiro Takeuchi
Summary: Pasireotide, a drug with high affinity for SSTR5, has potential as a new treatment for refractory Cushing's disease. This article reports a case of ineffective treatment with pasireotide in refractory Cushing's disease and suggests that the analysis of SSTR5 expression may help predict the efficacy of pasireotide.
Article
Multidisciplinary Sciences
Hiroya Kadokawa, Miyako Kotaniguchi, Onalenna Kereilwe, Shinichi Kitamura
Summary: The study suggests that ethanolamine plasmalogens (EPls) in the brains of old cows may be associated with age-related infertility, unlike those in young cows. Old-brain EPl fails to stimulate FSH secretion from gonadotrophs, possibly due to changes in the ratio of EPl molecular species and increased FAR1 levels.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Naomi Even-Zohar, Yona Greenman
Summary: Gonadotroph cell adenoma is the most common clinically nonfunctioning pituitary adenoma, usually discovered incidentally due to local mass effects. Treatment options include surgical resection, radiation therapy, and medical treatment, with dopamine agonists showing the best evidence.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Kensaku Fukunaga, Hitomi Imachi, Seisuke Sato, Toshihiro Kobayashi, Yuki Yoshioka, Takanobu Saheki, Natsuki Ban, Kurumi Urushihara, Jingya Lyu, Tao Dong, Ryou Ishikawa, Kyuichi Kadota, Reiji Haba, Naoko Inoshita, Koji Murao
Summary: In this case, a 21-year-old woman with recurrent Cushing's disease and acromegaly showed a significant response to treatment initiation with pasireotide-long-acting release (LAR), indicating the efficacy of pasireotide-LAR in controlling both conditions. It is rare for Cushing's disease to present with acromegaly, and pharmacotherapy for this combination has not been widely discussed.
Article
Surgery
Kaisa Ahopelto, Akseli Bonsdorff, Juulia Grasberger, Marko Lempinen, Arno Nordin, Ilkka Helanterae, Ville Sallinen
Summary: This study compared the use of pasireotide and octreotide in reducing complications after simultaneous pancreas-kidney transplantation (SPK). The results showed that pasireotide was associated with lower postoperative morbidity within 90 days compared to octreotide. This suggests that pasireotide may be a better choice in pancreas transplantation surgery.
TRANSPLANT INTERNATIONAL
(2023)
Article
Oncology
Adriana Albani, Luis Gustavo Perez-Rivas, Sicheng Tang, Julia Simon, Kristin Elisabeth Lucia, Paula Colon-Bolea, Jochen Schopohl, Sigrun Roeber, Michael Buchfelder, Roman Rotermund, Joerg Flitsch, Jun Thorsteinsdottir, Jochen Herms, Guenter Stalla, Martin Reincke, Marily Theodoropoulou
Summary: Cushing's disease is a rare and difficult to manage condition. The effectiveness of pasireotide, the only approved pharmaceutical for treatment, varies among patients. Research has found that USP8 gene mutations may be linked to pasireotide response, and overexpressing USP8 mutants may regulate SSTR5 gene expression through stimulating AP-1 transcriptional activity.
ENDOCRINE-RELATED CANCER
(2022)
Article
Oncology
Jessica Amaru, Federica Barbieri, Marica Arvigo, Agnese Solari, Adriana Bajetto, Federica Nista, Claudia Campana, Gabriele Gaggero, Alessandro Prior, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Tullio Florio, Federico Gatto
Summary: The first-generation somatostatin receptor ligands (fg-SRLs), like octreotide, and the second-generation ligand, pasireotide, act mainly through SST2 in somatotroph tumor cells, and their combination does not show any additional benefits.
Review
Medicine, General & Internal
Maria Celeste Cantone, Alessandra Dicitore, Giovanni Vitale
Summary: Neuroendocrine neoplasms (NENs) are a diverse family of tumors arising from neuroendocrine cells throughout the body. Despite being relatively rare, their incidence and prevalence are increasing due to improved diagnosis and patient management. Medical options, including somatostatin analogues, are available when surgery is not curative, especially for patients with metastatic disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Oliver Cousins, Angela Hodges, Julia Schubert, Mattia Veronese, Federico Turkheimer, Jaleel Miyan, Britta Engelhardt, Federico Roncaroli
Summary: The brain is protected by the blood-brain barrier, but the commonly accepted model of disease spread across a disrupted barrier cannot explain the focal distribution of lesions seen in neurological diseases. This article critically reviews the possible role of a blood-CSF-brain route as a disease entry pathway into the brain parenchyma, summarizing the evidence supporting this pathway and its relevance to various neurological diseases.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ninelia Minaskan Karabid, Tobias Wiedemann, Sebastian Gulde, Hermine Mohr, Renu Chandra Segaran, Julia Geppert, Maria Rohm, Giovanni Vitale, Germano Gaudenzi, Alessandra Dicitore, Donna Pauler Ankerst, Yiyao Chen, Rickmer Braren, Georg Kaissis, Franz Schilling, Mathias Schillmaier, Graeme Eisenhofer, Stephan Herzig, Federico Roncaroli, Juergen B. Honegger, Natalia S. Pellegata
Summary: Invasive nonfunctioning pituitary neuroendocrine tumors (PitNETs) are difficult to remove and current therapies often fail. This study investigated the ANGPT2/TIE2 axis in NF-PitNETs and found that PitNET cells express functional TIE2 receptors and secrete bioactive ANGPT2, which promotes tumor cell growth. Inhibition of this signaling pathway showed promise in inhibiting PitNET growth in various models. Therefore, the ANGPT2/TIE2 axis could be a potential therapeutic target for NF-PitNETs.
EMBO MOLECULAR MEDICINE
(2022)
Article
Clinical Neurology
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schuller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
Summary: Pediatric central nervous system (CNS) tumors are the leading cause of cancer-related death in children aged 0-14 years. A newly identified CNS tumor type characterized by PLAGL1/2 amplification and a lack of recurrent genetic alterations has been described. These tumors are composed of primitive embryonal-like cells and are associated with intermediate survival, but the cell of origin and optimal treatment strategies are yet to be determined.
ACTA NEUROPATHOLOGICA
(2023)
Article
Biochemistry & Molecular Biology
Naila Naz, Syeda F. Naqvi, Nadine Hohn, Kiara Whelan, Phoebe Littler, Federico Roncaroli, Andrew C. Robinson, Jaleel A. Miyan
Summary: We examined the cerebral folate system in AD and normal brains. Our findings demonstrate a significant reduction in FDH, FR alpha, and folate in the CSF of AD patients. Additionally, we observed a switch in the folate supply pathway in AD cortex, correlating with a metabolic direction towards neuronal hypermethylation. These findings provide insights into the cognitive decline in AD and suggest a potential treatment target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Clinical Neurology
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schueller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Duncan Street, Edwin Jabbari, Alyssa Costantini, P. Simon Jones, Negin Holland, Timothy Rittman, Marte T. Jensen, Viorica Chelban, Yen Y. Goh, Tong Guo, Amanda J. Heslegrave, Federico Roncaroli, Johannes C. Klein, Olaf Ansorge, Kieren S. J. Allinson, Zane Jaunmuktane, Tamas Revesz, Thomas T. Warner, Andrew J. Lees, Henrik Zetterberg, Lucy L. Russell, Martina Bocchetta, Jonathan D. Rohrer, David J. Burn, Nicola Pavese, Alexander Gerhard, Christopher Kobylecki, P. Nigel Leigh, Alistair Church, Michele T. M. Hu, Henry Houlden, Huw Morris, James B. Rowe
Summary: The study compares candidate clinical trial end points in progressive supranuclear palsy, multiple system atrophy, corticobasal syndrome and related disorders. Neuroimaging metrics generally require smaller sample sizes than cognitive and functional measures, but the optimal outcome measures differ by disease type.
Article
Biochemistry & Molecular Biology
Benjamin Wende, Anna-Sophia Liselott Beyer, Niklas Ruhnke, Daniel Kaemmerer, Joerg Saenger, Stefan Schulz, Amelie Lupp
Summary: A rabbit monoclonal antibody, 8H9L8, was developed for studying the protein expression of CALCRL. The antibody was confirmed to be specific and used for immunohistochemical analyses of normal and neoplastic tissues. CALCRL was found to be expressed in various tissues and showed strong expression in certain tumors, potentially serving as a useful target for future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Claudia Garcia-Diaz, Anni Poysti, Elisabetta Mereu, Melanie P. Clements, Lucy J. Brooks, Felipe Galvez-Cancino, Simon P. Castillo, Wenhao Tang, Gordon Beattie, Lilas Courtot, Sara Ruiz, Federico Roncaroli, Yinyin Yuan, Samuel Marguerat, Sergio A. Quezada, Holger Heyn, Simona Parrinello
Summary: The recurrence of Glioblastoma (GBM) is caused by invasive margin cells that escape surgery, but the extent to which these cells resemble their bulk counterparts is unclear. In this study, we generated three immuno-competent somatic GBM mouse models to compare matched bulk and margin cells. We found that tumors converge on common neural-like cellular states regardless of mutations, but bulk and margin cells have distinct biology.
Article
Medicine, General & Internal
Markus Kreuzthaler, Mathias Brochhausen, Cilia Zayas, Bernd Blobel, Stefan Schulz
Summary: This paper provides an overview of the linguistic and ontological challenges in transforming health ecosystems for precision medicine. It discusses the need for standardization and interoperability in clinical and research data representation, as well as smart support for content comprehension by humans and machines. The paper explores the current use of natural language processing in extracting information from healthcare texts and highlights the importance of biomedical ontologies in integrating heterogeneous data sources. It also addresses misconceptions and shortcomings in the field and suggests future steps for data interoperability.
FRONTIERS IN MEDICINE
(2023)
Article
Biology
Sebastian Fritzwanker, Falko Nagel, Andrea Kliewer, Viviane Stammer, Stefan Schulz
Summary: Phosphorylation of receptors is unstable during routine immunohistochemical procedures, requiring the use of phosphatase inhibitors for specific GPCR antibodies. We showed that phosphorylation of receptors is highly unstable during routine immunohistochemical procedures, and the use of phosphatase inhibitors is necessary for specific GPCR antibodies. Our findings were confirmed using phosphorylation state-specific MOP and CB1 antibodies.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Mueez Waqar, Federico Roncaroli, Ibrahim Djoukhadar, Leila Akkari, Claire O'Leary, Lauren Hewitt, Gabriella Forte, Richard Jackson, Eline Hessen, Lisa Withington, William Beasley, Jenny Richardson, Christopher Golby, Philip Whitehurst, Rovel Colaco, Matthew Bailey, Konstantina Karabatsou, Pietro I. D'Urso, Catherine McBain, David J. Coope, Gerben R. Borst
Summary: The POBIG trial aims to evaluate the safety and feasibility of single-fraction preoperative radiotherapy for newly diagnosed glioblastoma by assessing the maximum tolerated dose and maximum tolerated irradiation volume. The study includes delivering radiation ranging from 6 to 14 Gy in combination with standard care treatment. The objective is to establish the role of radiotherapy in preoperative modalities for glioblastoma.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Letter
Clinical Neurology
Christopher Kobylecki, Jennifer C. Thompson, Andrew C. Robinson, Federico Roncaroli, Julie S. Snowden, David M. Mann
Summary: A 70-year-old male patient presented with visual memory impairment and right-sided mesial temporal lobe atrophy. Neuropathological examination after his death 6 years later revealed progressive supranuclear palsy and Lewy body pathology. Although he did not meet the clinical criteria for either condition at the onset, the researchers propose that the interaction between the two pathologies in the mesial temporal regions could lead to this atypical clinical phenotype.
Letter
Clinical Neurology
Andrew C. Robinson, Yvonne S. Davidson, James Minshull, Imogen Lally, Liam Walker, David M. A. Mann, Federico Roncaroli
Article
Neurosciences
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stefano Patassini, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper
Summary: Vascular dementia (VaD) is a common type of dementia in the elderly, but its molecular basis is not well understood compared to other age-related dementias. This study used a novel technique to measure urea levels in post-mortem brain tissue and found elevated levels in multiple regions of the brain in VaD cases, suggesting a common urea-mediated disease mechanism present in several types of age-related dementias.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Christopher Holzmann-Littig, Nana Jedlicska, Marjo Wijnen-Meijer, Friederike Liesche-Starnecker, Karen Schmidt-Baese, Lutz Renders, Katja Weimann, Bjoern Konukiewitz, Juergen Schlegel
Summary: The COVID-19 pandemic has led to an increased demand for online learning resources in medical schools. This study examines the transition of a pathology course to an emergency remote education course and explores the effectiveness of a flipped classroom approach with research skills training.
EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION
(2023)