Review
Cell Biology
Prachi Wele, Xian Wu, Haifei Shi
Summary: Colorectal cancer is the third most common cancer globally, with the second highest cancer-related mortality. Obesity has been identified as one of the contributing factors to the increase in colorectal cancer, but the mechanistic link between obesity, sex hormones, and colorectal cancer development is not well understood.
Article
Cardiac & Cardiovascular Systems
Brielle Hayward-Piatkovskyi, Cailin R. Gonyea, Sienna C. Pyle, Krithika Lingappan, Jason P. Gleghorn
Summary: Bronchopulmonary dysplasia (BPD) is a disease with sexual dimorphism, where males have a disadvantage. Sex differences in angiogenesis may explain the male disadvantage in BPD. In this study, male pulmonary microvascular endothelial cells (HPMECs) produce fewer but longer sprouts compared to females. Sex hormones modify the male phenotype by reducing sprout length and number. The sex-specific secretome of HPMECs influences angiogenesis in a sex-dependent manner, and this influence is sensitive to sex hormones.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Ophthalmology
Weihao Chen, Georgios Tsissios, Anthony Sallese, Byran Smucker, Anh-Thu Nguyen, Junfan Chen, Hui Wang, Katia Del Rio-Tsonis
Summary: The study established optical coherence tomography (OCT) as an effective in vivo imaging modality for tracking and analyzing the entire process of newt lens regeneration. OCT was able to accurately identify key features of the regeneration process, such as changes in lens volume, and establish dynamic spatial relationships between tissues. The findings demonstrate OCT's potential for studying tissue plasticity and developing therapies for blinding disorders in higher vertebrates.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Review
Plant Sciences
Yuan Zhang, Yuqing Lu, Hafez El Sayyed, Jiahui Bian, Jinxing Lin, Xiaojuan Li
Summary: This review discusses the recent advances in labeling and imaging techniques for studying the dynamic behaviors and regulation of transcription factors in plant cells, and the future prospects and challenges associated with applying these techniques to examine transcription factor behavior in living plants.
Article
Biology
Kepu Chen, Yuting Ye, Nikolaus F. Troje, Wen Zhou
Summary: The study provides evidence of the role of oxytocin and vasopressin in subconscious chemosignaling in humans. It shows that chemosensory communications of masculinity and femininity can be blocked by a competitive antagonist of these neuropeptides. Oxytocin modulates the decoding of sex-specific information in a manner that is dose-dependent, nonmonotonic, and contingent upon social proficiency of the recipients.
Review
Physiology
Tanvirul Hye, Pankaj Dwivedi, Wei Li, Tim Lahm, Eva Nozik-Grayck, Kurt R. Stenmark, Fakhrul Ahsan
Summary: Sex disparities in pulmonary arterial hypertension (PAH) are postulated to be due to the diverse roles of sex hormones in disease etiology, with estrogen associated with cardiovascular protection and testosterone linked to increased cardiovascular burden in animal models. Both sexes show varying responses to current therapies.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Environmental Sciences
Rongyan Yang, Xiao Wang, Jingwen Wang, Pengyu Chen, Qing Liu, Wenjue Zhong, Lingyan Zhu
Summary: The study found that EHDPHP displayed sex-dependent reproductive toxicity on zebrafish, with lesser impacts on females and significant changes in sex hormones and VTG in males after exposure.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Angela M. Marulanda-Gomez, Kristina Bayer, Lucia Pita, Ute Hentschel
Summary: This study developed a quantitative in-vivo phagocytosis assay in sponges and demonstrated that sponges can differentiate between different types of microorganisms through phagocytosis. The study also found a positive correlation between the phagocytic activity of sponge cells and particle concentration in the seawater.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Medicine, General & Internal
Shen Zhong, Juergen Borlak
Summary: Women have a higher risk of developing non-small cell lung cancer (NSCLC). Hormone receptors play a key role in gene regulation, suggesting potential for molecular targeted therapies.
Review
Biology
Jeremy Chung Bo Chiang, Maitreyee Roy, Juno Kim, Maria Markoulli, Arun V. Krishnan
Summary: In-vivo corneal confocal microscopy is a powerful imaging technique that allows clinicians and researchers to observe microstructures at the ocular surfaces in significant detail.
COMMUNICATIONS BIOLOGY
(2023)
Review
Surgery
Yao Xiao, Andreas Schroeter, Friederike Martin, Tomohisa Matsunaga, Keita Nakamori, Maximilian J. Roesel, Marlena Habal, Anita S. Chong, Hao Zhou, Stefan G. Tullius
Summary: Biological sex has a broad impact on the immune system, affecting the incidence and severity of autoimmune diseases, infections, and malignancies. It also independently impacts the outcomes of solid organ transplantation, which are further influenced by age. The potential mechanisms may involve hormonal, genetic, and epigenetic factors.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Endocrinology & Metabolism
Jhanvee Patel, Song Chen, Torey Katzmeyer, Yixuan Amy Pei, Ming Pei
Summary: Despite recognition of sex-based differences in cartilage biology, the implications for study design and treatment efficacy remain unclear. This paper summarizes current findings on sex-dependent variation in knee anatomy, sex hormones' effect on cartilage, and cartilaginous degeneration and regeneration, with a focus on stem cell therapies. The contribution of both stem cell donor and recipient sex to sex-related differences in treatment efficacy is highlighted. More research is needed to optimize strategies for cartilage regeneration, taking sex into account for more effective and personalized treatments.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Chemistry, Multidisciplinary
Shizhen Chen, Long Xiao, Yu Li, Maosong Qiu, Yaping Yuan, Rui Zhou, Conggang Li, Lei Zhang, Zhong-Xing Jiang, Maili Liu, Xin Zhou
Summary: FCy7-NO2, a novel dual-mode NIR fluorescence and F-19 MRI agent, is proposed for imaging tumor hypoxia, showing rapid monitoring of nitroreductase in tumors and sensitive detection over a broad concentration range without limits to imaging depth by integrating two complementary imaging technologies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Cell Biology
Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Roecken, Krzysztof Marycz
Summary: Studies have shown that SHBG plays a role in protecting against ER stress development and progression, and regulates the expression of lipolytic genes. By conducting experiments on HepG2 cells and post-mortem liver tissue samples, it was found that SHBG decreased the expression levels of IRE1 alpha, ATF6, CHOP, and BIP. Furthermore, the research introduces a novel large-animal model for translational research on SHBG in human diseases.
Article
Multidisciplinary Sciences
Aleisha M. Moore, Lique M. Coolen, Michael N. Lehman
Summary: The hypothalamic pulse generator in the arcuate nucleus controls the episodic release of GnRH and LH, and consists of synchronized KNDy neurons. These episodes of synchronization precede LH pulses and occur in a temporal order, with certain subsets of KNDy cells serving as leaders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Vincenzo Carafa, Angela Nebbioso, Francesca Cuomo, Dante Rotili, Gilda Cobellis, Paola Bontempo, Alfonso Baldi, Enrico P. Spugnini, Gennaro Citro, Angela Chambery, Rosita Russo, Menotti Ruvo, Paolo Ciana, Luca Maravigna, Jani Shaik, Enrico Radaelli, Pasquale De Antonellis, Domenico Tarantino, Adele Pirolli, Rino Ragno, Massimo Zollo, Hendrik G. Stunnenberg, Antonello Mai, Lucia Altucci
CLINICAL CANCER RESEARCH
(2018)
Article
Chemistry, Multidisciplinary
M. Garofalo, H. Saari, P. Somersalo, D. Crescenti, L. Kuryk, L. Aksela, C. Capasso, M. Madetoja, K. Koskinen, T. Oksanen, A. Makitie, M. Jalasvuori, V. Cerullo, P. Ciana, M. Yliperttula
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Endocrinology & Metabolism
Sara Della Torre, Gianpaolo Rando, Clara Meda, Paolo Ciana, Luisa Ottobrini, Adriana Maggi
JOURNAL OF ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
N. Rizzi, A. Villa, V. Benedusi, E. Brunialti, N. Cesari, P. Ciana, A. Maggi
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Article
Neurosciences
Nicoletta Rizzi, Electra Brunialti, Silvia Cerri, Greta Cermisoni, Giovanna Levandis, Nicoletta Cesari, Adriana Maggi, Fabio Blandini, Paolo Ciana
NEUROBIOLOGY OF DISEASE
(2018)
Article
Chemistry, Multidisciplinary
M. Garofalo, A. Villa, N. Rizzi, L. Kuryk, B. Rinner, V Cerullo, M. Yliperttula, V Mazzaferro, P. Ciana
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Virology
Mariangela Garofalo, Alessandro Villa, Nicoletta Rizzi, Lukasz Kuryk, Vincenzo Mazzaferro, Paolo Ciana
Article
Oncology
Giulia Dell'Omo, Daniela Crescenti, Cristina Vantaggiato, Chiara Parravicini, Aurora Paola Borroni, Nicoletta Rizzi, Mariangela Garofalo, Andrea Pinto, Camilla Recordati, Eugenio Scanziani, Fabio Domenico Bassi, Giancarlo Pruneri, Paola Conti, Ivano Eberini, Adriana Maggi, Paolo Ciana
BRITISH JOURNAL OF CANCER
(2019)
Article
Neurosciences
Nicolo Carrano, Tanmoy Samaddar, Electra Brunialti, Luca Franchini, Elena Marcello, Paolo Ciana, Daniela Mauceri, Monica Di Luca, Fabrizio Gardoni
MOLECULAR NEUROBIOLOGY
(2019)
Review
Endocrinology & Metabolism
Elisabetta Vegeto, Alessandro Villa, Sara Della Torre, Valeria Crippa, Paola Rusmini, Riccardo Cristofani, Mariarita Galbiati, Adriana Maggi, Angelo Poletti
Article
Immunology
Electra Brunialti, Alessandro Villa, Marianna Mekhaeil, Federica Mornata, Elisabetta Vegeto, Adriana Maggi, Donato A. Di Monte, Paolo Ciana
Summary: A study demonstrated a neuroprotective mechanism mediated by microglia-neuron interaction through actin structures, which activates the Nrf2 pathway in neurons and plays a crucial role in drug detoxification, redox balance, autophagy, and neuroinflammation. Depletion of microglia in the brain led to impaired neuroprotection, suggesting potential therapeutic strategies to address microglial dysfunction associated with GBA mutations.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Endocrinology & Metabolism
Adriana Maggi
Summary: The article explores the sex differences in liver metabolic activities and their evolutionary origins. In mammals, females have adapted their liver functions to support reproductive needs and energy storage. Considering the importance of liver and energy metabolism in diseases, a better understanding of the differences between male and female liver functions could help personalize medicine and pharmacology.
Article
Cell Biology
Electra Brunialti, Alessandro Villa, Marco Toffoli, Sara Lucas Del Pozo, Nicoletta Rizzi, Clara Meda, Adriana Maggi, Anthony H. V. Schapira, Paolo Ciana
Summary: Microglia are heterogenous cells in the nervous system that have distinct populations contributing to specific processes, including neuroprotection. Our study found that male microglia tend to have a more pro-inflammatory phenotype, while female microglia are more sensitive to glucocerebrosidase inhibition. Furthermore, glucocerebrosidase inhibition impaired the ability of female microglia to enhance the Nrf2-dependent detoxification pathway in neurons.
Article
Medicine, Research & Experimental
Mariangela Garofalo, Alessandro Villa, Daniela Crescenti, Monica Marzagalli, Lukasz Kuryk, Patrizia Limonta, Vincenzo Mazzaferro, Paolo Ciana
